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MIS 5e sea surface temperature estimation;a multi-proxy approach using a marine macrofossil assemblage(Mar Piccolo,Gulf of Taranto,Southern Italy)

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Journal of Palaeogeography 2024年第2期13卷 327-350页

作者： Pierluigi Santagati edoardo Perri Maria Pia Bernasconi Mario Borrelli salvatore Guerrieri salvatore Critelli Dipartimento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipartimento di Ingegneria Ambientale Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is reported a multi-proxy palaeoclimatic study conducted on a MIS 5e calcarenite from the Mar Piccolo Basin(MP),Gulf of Taranto(GT)(Central Mediterranean).The calcarenite returned a rich malacofauna consisting of 120 extant species,including four of the tropical Senegalese Fauna,today absent in the *** biogeographic-climatic affinity of the assemblage shows,compared to today,a double percentage of warm affinity species,while the cold affinity species are nearly equally represented,indicating a warmer but not strictly tropical *** is confirmed by the most recurring preferred SST ranges of the assemblage,indicating an average of 20℃.The skeletal compositions of five well-preserved molluscan and coral specimens were analyzed for trace elements and stable isotopes for further mean SST *** the comparison of the results of several equations available in literature,it appears that only some SST estimations are realistic,converging into similar values of,on average,20.8±0.9℃.Considering all the used proxies,the MIS 5e SST difference compared to today falls in the range 1.2—2.0℃for the GT(being a more reasonable scenario)and 2.0—2.8℃for the *** is not a firmly tropical-like SST setting as suggested by the sole Senegalese fauna,indicating at least 2.7℃—3.5℃more than today’s GT and MP,*** approximations and assumptions made for obtaining SST values with any single proxy indicate the need of a multi-proxy approach to define the best SST estimation.

关键词： MiS 5e Sea surface temperature Palaeoclimate proxy Fossil fauna Gulf of Taranto

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Chitin-glucan improves important pathophysiological features of irritable bowel syndrome

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World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Michaël Genin Veronique Maquet salvatore Modica Pierre Desreumaux Christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITe-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France ULR 2694-MeTRICS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the european Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HeD)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HeD,n=8)*** anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR *** modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the abili

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier Molecular modelling Microbial cell walls chelation

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The formation and growth mechanisms of young back-arc spreading ridges from high-resolution bathymetry:The Marsili Seamount(Tyrrhenian Sea,Italy)

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Geoscience Frontiers 2024年第1期15卷 325-338页

作者： eugenio Nicotra salvatore Passaro Guido Ventura Dipartimento di Biologia ecologia e Scienze della Terra Universitàdella Calabria87036 Arcavacata di RendeCosenzaItaly Istituto di Scienze Marine CNR 80133 NapoliItaly Istituto Nazionale di Geofisica e Vulcanologia 00143 RomaItaly Istituto per lo Studio degli impatti Antropici e Sostenibilitáin ambiente marino CNR 91026 Capo GranitolaTrapaniItaly

The formation and growth mechanisms of Mid-Ocean Ridges(MOR)are relatively well known,whereas those of back-arc spreading ridges are comparatively less known because geophysical,geochemical,and morphological data are scarce and of low *** we present a high-resolution bathymetry of the Marsili Seamount(MS;1 Ma-3 ka),which represents the inflated spreading ridge of the 2 Ma old Marsili back-arc basin associated to the subduction of the Ionian Sea below the Calabrian Arc and Tyrrhenian *** is 70 km long,30 km wide,and its height reaches about 3000 m from surrounding *** new digital bathymetric model has a 5 m grid cell size resolution and covers the MS bathymetry from-1670 mbsl to the top at-491 *** conduct morphometric and morphological analyses of the bathymetry and recognize landforms due to volcanic,tectonic,hydrothermal and gravity *** consists of volcanoes related to fissural and central-type activity,this latter located at the northern and southern tips of the main dike *** swarms represent the surface expression of different ridge segments whose strikes are controlled by the larger scale back-arc spreading processes and by the local occurrence of an active hydrothermal *** latter develops in a flat area between two partly overlapping ridge segments where historical volcanism and extensional processes *** ridges represent the embryonic stage of the formation of transform-like *** volcanoes,the northern of which is characterized by a caldera,form at the tips of MS because the decrease in width of the major volcanic fissures promotes vent localization associated with the formation of sill-like reservoirs from which central-type vents may *** processes affecting the MS flanks are due to shallow seafloor *** collapses affecting the northernmost central-type polygenic volcano must be included in the evaluation of the hazard related to potential *** dipping faul

关键词： Back-arc spreading ridge Morphology Tectonics Volcanism Marsili seamount

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Non-invasive prenatal testing can detect silent cancers in expecting mothers

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Genes & Diseases 2024年第2期11卷 585-588页

作者： Alessandro Ottaiano Monica Ianniello Nadia Petrillo Mariachiara Santorsola Luigia De Falco salvatore Giovanni Castaldi Maria Antonietta Castaldi Valentina Giudice Carmine Selleri Giovanni Savarese Unit of Innovative Therapies for Abdominal Metastases Istituto Nazionale Tumori di NapoliIRCCS “G.Pascale”Via Mariano SemmolaNapoli 80131Italy AMeS Centro Polidiagnostico Strumentale SRLVia Padre Carmine Fico 24Casalnuovo Di Napoli 80013Italy Specialization School of Clinical Pathology Università degli Studi di SalernoVia Giovanni Paolo II 132Fisciano 84084Italy Unit of High-Risk Pregnancy and Prenatal Diagnosis University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Hematology and Transplant Center University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Department of Medicine Surgery and Dentistry“Scuola Medica Salernitana”Via Salvador Allende 43Baronissi 84081Italy

Pregnancy is a unique physiological state in which several changes *** of the most important aspects is the maternal immune system,which sets to tolerate the presence of thedeveloping fetus(a semi-allogeneic organism),while at the same time providing protection against pathogens.1 Pregnancy has long been known to affect the risk of certain cancers including breast cancer in the short term,gestational trophoblastic disease(GTD),cervical cancer,and melanoma.2,3 The reasons for the increased risk of these cancers during pregnancy are not fully understood,but several hypotheses have been proposed as the hormonal and immune system changes.

关键词： mother cancers fetus

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epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella Martini Corrado Magnino salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).ReSULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one noduleents)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis etiology Treatment

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Ferrofluid measurements of bottom velocities and shear stresses

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Journal of Hydrodynamics 2015年第1期27卷 150-158页

作者： MUSUMeCI Rosaria e. MARLeTTA Vincenzo ANDò Bruno BAGLIO salvatore FOTI enrico Department of Civil engineering and Architecture University of Catania Department of electric Electronic and Computer Science Engineering University of Catania

A novel direct measurement strategy of bottom velocities and shear stresses based on the use of ferrofluids is presented. Such a strategy overcomes some of the limits of state-of-the-art instruments. A preliminary experimental campaign has been carried out in the presence of currents in steady flow conditions in order to test the effects of ferrofluid quantity and of the controlling permanent magnetic force. An alternating current （AC） circuit and a direct current （DC） conditioning circuit have been tested. For velocities larger than 0.05 m/s, the near-bottom velocity-output voltage calibration curve has a monotone parabolic shape. The sensitivity of the instrument is increased by a factor of 30 when the DC circuit is used.

关键词： magnetofluids Rosensweig effect flow resistances bed shear stresses bottom velocities

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Detrital zircon ages of Oligocene to Miocene sandstone suites of the Southern Apennines foreland basin system,Italy

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Journal of Palaeogeography 2022年第2期11卷 222-237页

作者： Annamaria Fornelli Francesca Micheletti salvatore Gallicchio Fabrizio Tursi Sara Criniti salvatore Critelli Dipartimento Scienze Della Terra e Geoambientali Universit a Degli Studi“Aldo Moro”BariVia E.Orabona470125BariItal Dipartimento di Biologia Ecologia e Scienze Della TerraUniversit a Della CalabriaVia Pietro Bucci87036Arcavacata di RendeCosenzaItaly

U-Pb spot ages on detrital zircons from turbidite quartzarenites,quartz-feldspathic and volcaniclastic sandstones of the Tufiti di Tusa(TTF),Numidian Flysch(NF),Bifurto(BF),Gorgoglione(GF)and Serra Palazzo(SPF)formations,exposed in southern Italy,were detected to define their provenance signatures aiming to contribute to reconstructing the complex geodynamic evolution of the southern Apennine *** deposition ages of these sandstones range from Rupelian(TTF),Burdigalian p.p.-early Langhian(NF and BF)and Langhian-Serravallian-early Tortonian(GF and SPF).The detrital zircon ages in each deposit show different *** TTF,the zircon age clusters are:610±6 Ma;390±4 Ma;287±3 Ma;157±2 Ma;78±1 Ma and 67±1 Ma;33±1 *** NF and BF formations,the prevalent zircon ages are clustered at 661±10 Ma,607±8 Ma and 547±8 *** GF sandstones,the ages of detrital zircons are clustered around 672±28 Ma,458±9 Ma,297±8 Ma and 24±1 *** sandstones of SPF contain zircons showing age clusters at649±10 Ma,486±7 Ma and 315±5 *** and lithic fragments from TTF display a dominant provenance from Oligocene calc-alkaline effusive products located on western domains of the Mesomediterranean Microplate,and minor detritus from granitoids and metamorphic rocks of Variscan *** of NF and BF indicate a provenance of detritus from the African Craton without evidence of Variscan or Alpine *** from GF and SPF show a provenance from both Variscan crystalline basement rocks forming the Alpine chain(Calabria-Peloritani Terranes)and Variscan magmatic and metamorphic rocks unaffected by Alpine tectonics,similar to Sardinia-Corsica(pro-parte)*** addition,the Oligocene magmatic component dated at 24 Ma in GF sandstones is evidence for the maximum age of sedimentation for these *** light of the recent and preliminary geochronological data acquired,a revised paleogeographic restoration could be inferred for the location of sedimentary basins during the Apennines t

关键词： U-Pb detrital Zircon ages Provenance of sandstones Southern Apennine chain Southern Circum-Mediterranean paleogeography

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Au,Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration

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Regenerative Biomaterials 2020年第5期7卷 461-469页

作者： Giovanna Calabrese salvatore Petralia Claudia Fabbi Stefano Forte Domenico Franco salvatore Guglielmino emanuela esposito salvatore Cuzzocrea Francesco Traina Sabrina Conoci Department of Chemistry Biology Pharmacy and environmental Science University of MessinaPiazza Pugliatti198122 MessinaSiciliaItaly Research and Development Applied Chemical WorksPaternoCataniaItaly Department of Chemical Science Fin-Ceramica FaenzaVia Granarolo 177/3Faenza 48018Italy Istituto Oncologico del Mediterraneo Ricerca ViagrandeCatania 95029Italy Dipartimento Biomorf Universita degli Studi di MessinaMessinaItaly Rizzoli Orthopedic Institute IRCSSBolognaItaly Distretto Tecnologico Micro e Nano Sistemi Sicilia CataniaItaly

Nanotechnology plays a key role in the development of innovative scaffolds for bone tissue engineering(BTe)allowing the incorporation of nanomaterials able to improve cell proliferation and *** this study,Mg-HA-Coll type I scaffolds(Mg-HA-based scaffolds)were nanofunctionalized with gold nanorods(Au NRs),palladium nanoparticles(Pd NPs)and maghemite nanoparticles(MAG NPs).Nanofunctionalized Mg-HA-based scaffolds(NF-HA-Ss)were tested for their ability to promote both the proliferation and the differentiation of adipose-derived mesenchymal stem cells(hADSCs).Results clearly highlight that MAG nanofunctionalization substantially improves cell proliferation up to 70% compared with the control(Mg-HA-based scaffold),whereas both Au NRs and Pd NPs nanofunctionalization induce a cell growth inhibition of 94% and 89%,*** evidences were found for the osteoinductive properties showing relevant calcium deposits(25% higher than the control)for MAG nanofunctionalization,while a decreasing of cell differentiation(20% lower than the control)for both Au NRs and Pd NPs *** results are in agreement with previous studies that found cytotoxic effects for both Pd NPs and Au *** excellent improvement of both osteoconductivity and osteoinductivity of the MAG NF-HA-S could be attributed to the high intrinsic magnetic field of superparamagnetic MAG *** findings may pave the way for the development of innovative nanostructured scaffolds for BTe.

关键词： bone regeneration hydroxyapatite scaffold tissue engineering gold nanoroads Pd nanoparticles maghemite nanoparticles

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Use of cognitive event-related potentials in the management of psychiatric disorders:Towards an individual follow-up and multicomponent clinical approach

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World Journal of Psychiatry 2021年第5期11卷 153-168页

作者： salvatore Campanella Laboratoire de Psychologie Médicale et d’Addictologie ULB Neuroscience Institute(UNI)CHU Brugmann-UniversitéLibre de Bruxelles(U.L.B.)Brussels 1020Belgium

Relapse prevention remains a major challenge in psychiatry,thus indicating that the established treatment methods combining psychotherapy with neuropharmacological interventions are not entirely *** recent years,several intervention strategies have been devised that are aimed at improving psychiatric treatment by providing a complementary set of add-on tools that can be used by clinicians to improve current patient *** these,cognitive eventrelated potentials(eRPs)have been indexed as valuable biomarkers of the pathophysiological mechanisms of various mental ***,despite decades of research,their clinical utility is still controversial and a matter of *** this opinion review,I present the main arguments supporting the use of cognitive eRPs in the management of psychiatric disorders,stressing why it is currently still not the case despite the vast number of eRP studies to date.I also propose a clinically-oriented suitable way in which this technique could—in my opinion—be effectively incorporated into individual patient care by promotion of the use of individual eRP test-retest sessions and the use of a multi-component approach.

关键词： event-related potentials Psychiatry Cognitive disorders Follow-up Multicomponent approach Personalized medicine

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ARBITRARILY SMALL NODAL SOLUTIONS FOR PARAMeTRIC ROBIN(p,q)-eQUATIONS PLUS AN INDeFINITe POTeNTIAL

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Acta Mathematica Scientia 2022年第2期42卷 561-574页

作者： salvatore LeONARDI Nikolaos S.PAPAGeORGIOU Dipartimento di Matematica e Informatica Viale A.Doria695125 CataniaItaly Technical University Department of MathematicsZorografou CampusAthens 15780Greece

We consider a nonlinear Robin problem driven by the(p,q)-Laplacian plus an indefinite potential term and with a parametric reaction *** minimal conditions on the reaction function,which concern only its behavior near zero,we show that,for all λ>0 small,the problem has a nodal solution y_(λ)∈C^(1)(Ω)and we have y_(λ)→0 in C^(1)(Ω)asλ→0^(+).

关键词： (p,q)-Laplacian indefinite potential nonlinear regularity extremal constant sign solutions nodal solutions

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