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Ductal prostate cancer:Clinical features and outcomes from a multicenter retrospective analysis and overview of the current literature

引用

Current Urology 2022年第4期16卷 218-226页

作者： salvatore cozzi Lilia Bardoscia Masoumeh Najafi Sefik Igdem Luca Triggiani Stefano Maria Magrini Andrea Botti Ferran Guedea Laura Melocchi Patrizia Ciammella Cinzia lotti Cristina Gutierrez Department of Radiation Oncology Azienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly Department of Radiation Oncology S.Luca HospitalHealthcare Company Tuscany NorthwestLucca55100Italy Department of Radiation Oncology Shohadaye Haft-e-Tir Hospital Iran University of Medical ScienceTeheranIran Department of Radiation Oncology Istanbul Bilim UniversityFaculty of MedicineIstanbulTurkey Department of Radiation Oncology University of Brescia and Spedali Civili HospitalBresciaItaly Department of Medical Physics Azienda AUSL-IRCCS di Reggio EmiliaReggio EmiliaItaly Department of Radiation Oncology Catalan Institute of OncologyUniversity of BarcelonaBarcelonaSpain Department of Pathology Fondazione Poliambulanza HospitalBresciaItaly

Objective:The aim of the study is to evaluate clinical features and outcomes after different therapeutic strategies for ductal prostate adenocarcinoma(DPC),a rare but aggressive subtype of invasive prostate cancer(PCa)accounting for,in the pure and mixed form,1%or less and 5%or less,respectively,of all the newly diagnosed *** and methods:Patients with a proven diagnosis of DPC undergoing surgery,radiotherapy,and androgen deprivation therapy,alone or in combination,were considered for this multicenter,retrospective *** study assessed overall survival(OS),disease-free survival(DFS),and age-related disease-specific ***:Eighty-one patients met the study inclusion *** DPC was found in 29 patients(36%)and mixed ductal-acinar-PCa in 52 patients(64%).After a median follow-up of 63 months(range,3-206 months),3-and 5-year OS rates were 84%and 67%,respectively,and 3-and 5-year DFS rates were 54%and 34%,*** were no significant differences in OS or DFS between the pure and mixed DPC *** DPC was associated with a higher rate of metastatic disease at *** 74 years or younger had better disease-specific survival(p=0.0019).A subgroup analysis favored radiotherapy as the primary treatment for nonmetastatic,organ-confined DPC(3-and 5-year DFS of 80%and 50%,respectively,compared with 5-year DFS of 35%for surgical patients;p=0.023).Conclusions:Our study found DPC to be rarer,more aggressive,more likely to metastasize,and have a worse prognosis than the common acinar variant,especially in its pure *** series are encouraged to obtain large data sets,or propensity score matching analyses with patients with conventional PCa are desirable to understand the best therapeutic approach and improve outcomes.

关键词： Androgen deprivation therapy Mixed ductal-acinar prostate cancer Pure ductal carcinoma of the prostate Radiotherapy Surgery

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