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Hollow micro- and nano-particles by gas foaming

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Nano Research 2014年第7期7卷 1018-1026页

作者： Silvia Orsi Ernesto Di Maio salvatore lannace Paolo A. Netti Center for Advanced Biomaterials for Health Care Istituto Italiano di Tecnologia (IIT@CRIB) Largo Barsanti e Matteucci 50 Napoli 80125 Italy Dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industfiale and Interdisciplinary Research Centre on Biomaterials (CRIB) Universita degli Studi di Napoli Federico II P.le Tecchio 80 Napoli 80125 Italy Institute for Polymers Composites and Biomaterials Consiglio Nazionale delle Ricerche P.le E. Fermi 1 Portici (Na) 80055 Italy

This paper presents the results of a first successful attempt to produce hollow micro- and nano-particles of a large variety of materials, dimensions, shapes and hollow attributes by using an environmentally friendly and cheap technology, common in polymer processing and known as gas foaming. The central role played by ad hoc polymeric hollow micro- and nano-particles in a variety of emerging applications such as drug delivery, medical imaging, advanced materials, as well as in fundamental studies in nanotechnology highlights the wide relevance of the proposed method. Our key contribution to overcome the physical lower bound in the micro- and nano-scale gas foaming was to embed, prior to foaming, bulk micro- and nano-particles in a removable and deformable barrier film, whose role is to prevent the loss of the blowing agent, which is otherwise too fast to allow bubble formation. Furthermore, the barrier film allows for non-isotropic deformation of the particle and/or of the hollow, affording non-spherical hollow particles. In comparison with available methods to produce hollow micro- and nano-particles, our method is versatile since it offers independent control over the dimensions, material and shape of the particles, and the number, shape and open/closed features of the hollows. We have gas- foamed polystyrene and poly-（lactic-co-glycolic） acid particles 200 ~m to 200 nm in size, spherical, ellipsoidal and discoidal in shape, obtaining open or closed, single or multiple, variable in size hollows.

关键词： hollow nanoparticles microparticles gas foaming

Deep Learning and Time Series-to-Image Encoding for Financial Forecasting

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IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 683-692页

作者： Silvio Barra salvatore Mario Carta Andrea Corriga Alessandro Sebastian Podda Diego Reforgiato Recupero Department of Mathematics and Computer Science University of CagliariCagliari 09121Italy

In the last decade,market financial forecasting has attracted high interests amongst the researchers in pattern ***,the data used for analysing the market,and then gamble on its future trend,are provided as time series;this aspect,along with the high fluctuation of this kind of data,cuts out the use of very efficient classification tools,very popular in the state of the art,like the well known convolutional neural networks(CNNs)models such as Inception,Res Net,Alex Net,and so *** forces the researchers to train new tools from *** operations could be very time *** paper exploits an ensemble of CNNs,trained over Gramian angular fields(GAF)images,generated from time series related to the Standard&Poor's 500 index future;the aim is the prediction of the future trend of the ***.A multi-resolution imaging approach is used to feed each CNN,enabling the analysis of different time intervals for a single observation.A simple trading system based on the ensemble forecaster is used to evaluate the quality of the proposed *** method outperforms the buyand-hold(B&H)strategy in a time frame where the latter provides excellent *** quantitative and qualitative results are provided.

关键词： Convolutional neural networks(CNNs) ensemble of CNNs financial forecasting Gramian angular fields(GAF)imaging

Screening for pancreatic cancer-a compelling challenge

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 264-266页

作者： Gabriele Capurso salvatore Paiella Massimo Falconi Pancreato-Biliary Endoscopy and Endosonography Division Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilanItaly General and Pancreatic Surgery Unit Pancreas InstituteUniversity of VeronaVeronaItaly Pancreatic Surgery Unit Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSUniversitàVita-SaluteMilanItaly

Efficacy of pancreatic cancer surveillance programs The publication of the American Gastroenterology Association(AGA)Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals(HRIs)underlines the increasing attention for this topic(1).Secondary prevention(surveillance)for pancreatic ductal adenocarcinoma(PDAC),however,remains a challenge with many unsolved questions(Table 1).

关键词： prevention cancer Cancer

Hepatocellular carcinoma: Will novel targeted drugs really impact the next future?

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World Journal of Gastroenterology 2016年第27期22卷 6114-6126页

作者： Liliana Montella Giovannella Palmieri Raffaele Addeo salvatore Del Prete Medical Oncology Unit "San Giovanni di Dio" Hospital Oncology Unit Department of Clinical Medicine and Surgery "Federico II" University of Naples

Cancer treatment has been revolutionized by the advent of new molecular targeted and immunotherapeutic agents. Identification of the role of tumor angiogenesis changed the understanding of many tumors. After the unsuccessful results with chemotherapy, sorafenib, by interfering with angiogenic pathways, has become pivotal in the treatment of hepatocellular carcinoma. Sorafenib is the only systemic treatment to show a modest but statistically significant survival benefit. All novel drugs and strategies for treatment of advanced hepatocellular carcinoma must be compared with the results obtained with sorafenib, but no new drug or drug combination has yet achieved better results. In our opinion, the efforts to impact the natural history of the disease will be directed not only to drug development but also to understanding the underlying liver disease(usually hepatitis B virus- or hepatitis C virus-related) and to interrupting the progression of cirrhosis. It will be important to define the role and amount of mutations in the complex pathogenesis of hepatocellular carcinoma and to better integrate locoregional and systemic therapies. It will be important also to optimize the therapeutic strategies with existing chemotherapeutic drugs and new targeted agents.

关键词： Hepatocellular carcinoma Targeted therapy Pathway Angiogenesis Sorafenib

Bacterial Infections in Cirrhosis

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Infectious Microbes & Diseases 2021年第3期3卷 117-124页

作者： Marta Tonon Paolo Angeli salvatore Piano State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

Bacterial infections are the most common trigger of acute decompensation of *** occurrence of infections in cirrhosis is associated with the development of organ dysfunctions,failures,and acute on chronic liver *** combination of infections and organ dysfunction/acute on chronic liver failure dramatically increases the mortality risk in these *** in cirrhosis are a big challenge for clinicians,since the mortality from sepsis is increasing in these patients *** rapid and progressive spread of multiresistant bacteria has been blamed for the increased mortality *** studies have shown that early diagnosis and appropriate administration of antibiotic treatment are crucial for improving prognosis in these ***,the prevention and treatment of acute kidney injury and organ failures are fundamental parts of management of infections in *** we provided a concise and updated review of the literature on bacterial infections in patients with cirrhosis.

关键词： liver cirrhosis liver transplantation multidrug resistant sepsis septic shock

Breast cancer liver metastasis:time to resection and criteria

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 749-751页

作者： Francesco Giovinazzo Angela Bucaro salvatore Agnes General Surgery and Liver Transplantation Unit Fondazione Policlinico Universitario Agostino GemelliRomeItaly

A manuscript recently published by Grazi pools outcomes from data on patients undergoing surgical resection for breast cancer liver metastases(BCLMs).In the manuscript,Grazi shows no definitive proof of liver resections(LR)effectiveness for ***,the author suggests surgery may be possible in selected patients(1-3).Several retrospective case series have been published evaluating patients’survival following resection for BCLM,reporting results for 5-year overall and disease-free *** tries to make recommendations based on the data that show which patients have a good prognosis following liver ***,the conclusion that surgical treatment is an option with a survival advantage for selected patients is not evident in the current literature as the criteria for surgery are not well established.

关键词： resection surgery cancer

Thermal Radiation Modelling in Tunnel Fires

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Advances in Applied Mathematics and Mechanics 2011年第3期3卷 327-353页

作者： Paolo Ciambelli Maria Grazia Meo Paola Russo salvatore Vaccaro Department of Industrial Engineering University of Salernovia Ponte don Melillo 84084 Fisciano(SA)Italy

Modelling based on Computational Fluid Dynamics(CFD)is by now effectively used in fire research and hazard *** on the scenario,radiative heat transfer can play a very important role in enclosure combustion events such as tunnel *** this work,the importance of radiation and the effect of the use of different approaches to account for it were ***,small-scale tunnel fire simulations were performed and the results compared with experimental data,then realistic full-scale scenarios were *** results show up the capability of CFD modelling to reproduce with good approximation tunnel *** proved to be noteworthy mainly when the scale of the fire is relatively *** the various approaches employed to simulate radiation,the use of the Discrete Transfer model gave the most accurate results,mainly when the absorption-emission characteristics of the combustion products were taken into ***,the suitability of the use of CFD in quantitative Fire Hazard Analysis is discussed.

关键词： CFD radiation modelling fire hazard analysis tunnel fires

Sexual outcomes after partial penectomy for penile cancer： results from a multi-institutional study

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Asian Journal of Andrology 2017年第1期19卷 57-61页

作者： salvatore Sansalone Mauro Silvani Rosario Leonardi Giuseppe Vespasiani Valerio Iacovelli Department of Experimental Medicine and Surgery - Urology Tor Vergata University of Rome 00133 Rome Italy Department of Urology Biella General Hospital 13900 Biella Italy Musumeci GECAS Clinic Gravina di catania 95127 Catania Italy.

Penile cancer is an uncommon malignancy. Surgical treatment is inevitably mutilating. Considering the strong impact on patients＇ sexual life we want to evaluate sexual function and satisfaction after partial penectomy. The patients in this study （n = 25） represented all those who attended our institutions and were diagnosed and treated for penile cancer from October 2011 to November 2013. All patients underwent partial penectomy and followed-up （mean： 14 months; range： 12-25）. Sexual presurgical baseline was estimated using the International Index of Erectile Dysfunction 15 （IIEF-15）. Sexual outcomes of each patient were estimated considering four standardized and validated questionnaires. We analyzed the means and ranges of IIEF-15 including erectile function （IIEF-1-5 and -15）, orgasmic function （IIEF-9 and -10）, sexual desire （IIEF-11 and -12）, intercourse satisfaction （IIEF-6-8）, and overall satisfaction （IIEF-13 and -14）. Then, we also used Quality of Erection Questionnaire （QEQ）, Erectile Dysfunction Inventory of Treatment Satisfaction （EDITS） and Self-Esteem and Relationship （SEAR） to evaluate the sexual function and satisfaction of our patients. The final results showed that penile cancer leads to several sexual and psychosexual dysfunctions. Nevertheless, patients who undergo partial penectomy for penile cancer can maintain the sexual outcomes at levels slightly lower to those that existed in the period before surgery.

关键词： partial penectomy penectomy penile cancer penile tumor sexual outcomes

Fetal Bradyarrhythmias:Etiopathogenesis,Diagnosis and Treatment:Between Literature Review and Experience of a Tertiary Center

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Congenital Heart Disease 2021年第4期16卷 309-331页

作者： Elio Caruso Silvia Farruggio salvatore Agati Corrado Di Mambro Mediterranean Pediatric Cardiology Center“Bambino Gesù”San Vincenzo Hospital Contrada SirinaTaormina98039Italy

Fetal arrhythmias reach up around 10%of the total third-level perinatal cardiology *** bradycardia is defined as a baseline fetal heart rate(FHR)of less than 110 bpm sustained for at least 10 *** overall incidence of malignant fetal bradyarrhythmias,such as complete atrioventricular block(AVB)and channellopathies,is relatively rare,1:5000 pregnancies,but represents a serious emergency for the gynecologist,neonatologists,and pediatric *** complete AVB is strongly associated with maternal connective tissue disease,but it can be also associated with congenital heart disease and usually with a poorer prognosis with high risk of fetal hydrops and ***,the treatment of severe fetal bradyarrhythmias is principally pharmacological and aims to increase the FHR,besides an early resolution of underlying causes,when possible,and a promptly management of fetal heart *** electrostimulation nowadays is an experimental pioneering method,reserved for limited selected cases.

关键词： Fetal arrhythmias hydrops bradyarrhythmia atrioventricular block