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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 45-45页

作者： saltik- temizel i.n. Kocak n. Demir H. 徐瑞 Hacettepe University Faculty of Medicine Department of Pediatrics 06100 Ankara Turkey Dr.

Background: More than half of the children with chronic hepatitis B infecti.n.are nonresponders to interferon- α . The aim of this study was to investigate the efficacy of lamivudine and interferon- α combinati.n.therapy after a 3- month lamivudine inducti.n.in children with chronic hepatitis B. Study: Twenty naive children were given lamivudine (4 mg/kg per day; maximum, 100 mg) alone fo r 3 months; then interferon- α (10 MU/m2, thrice weekly) was added to lamivud ine for 6 months. After interferon- α was stopped, lamivudine alone was conti.n.ed for 6 months. Therapy was stopped 6 months after HBeAg seroconversi.n. Ever y 3 months, HBV markers were studied and virologic response was defined as HBV D nA negativity, and HBeAg loss with Anti- HBe seroconversi.n. Results: At the en d of 15 months, virologic response was achieved in 11 (55% ) of pati.n.s and 12 pati.n.s (60% ) cleared hepatitis B e antigen. Therapy was well tolerated. Con clusi.n. Preliminary results of our study seem to indicate that lamivudine and h igh- dose interferon- α combinati.n.therapy after a 3- month lamivudine ind ucti.n.may represent an effective treatment opti.n.for children with chronic hep atitis B.

关键词：干扰素-α 病毒学应答月检查

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Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric pati.n.s with suspected gastroesophageal reflux

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World Journal of Gastroenterology 2016年第43期22卷 9595-9603页

作者： nuray Uslu Kizilkan Murat Fani Bozkurt inci.n.r saltik temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen Divisi.n.of Pediatric Gastroenterology Koc University Hospital Topkapi Istanbul 34010 Turkey Hacettepe University Faculty of Medicine Department of Nuclear Medicine Ankara 06100 Turkey Divisi.n.of Gastroenterology Hepatology and Nutrition Unit Department of Pediatrics Hacettepe University Faculty of MedicineAnkara 06100 Turkey

AiM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(Mii-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive pati.n.s with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined Mii-p HM recording and one hour radi.n.clide scintigraphy during the course of the MiipH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(Ri, percentage of the entire record that esophageal p H is n 4.2% for p HM and number of refluxes more than 50 for 24 h for Mii were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds durati.n.were acquired in the supine positi.n. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluati.n. impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's *** Suffici.n. data was obtained from 60(80%) pati.n.s(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; medi.n. 8.5 years). Chronic cough, nausea, regurgitati.n.and vomiting were the most frequent symptoms. The mean time for recording of Mii-pH M was 22.8 ± 2.4 h(range: 16-30 h; medi.n. 22.7 h). At least one test was positive in 57(95%) pati.n.s. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) pati.n.s by means of p HM, Mii, GES and Mii-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and Mii, GES and Mii-p HM, and Mii and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.

关键词： Gastroesophageal reflux disease Children Multichannel intraluminal impedance Esophageal p H monitoring Scintigraphy

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联合使用拉夫米定和大剂量α-干扰素治疗儿童慢性乙型肝炎

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实用肝脏病杂志 2005年第5期8卷 275-275页

作者： saltik-temizel in[英] 高方（译）王全楚（校）

超过50％的慢性乙型肝炎病毒感染儿童使用α-干扰素治疗是无效的。本项研究的目的是在对慢性乙型肝炎儿童先使用拉夫米定诱导治疗3个月后，再联合使用拉夫米定和α干扰素，观察疗效。方法：对20例儿童患者给予拉夫米定（4mg／kg／d，最... 详细信息

超过50％的慢性乙型肝炎病毒感染儿童使用α-干扰素治疗是无效的。本项研究的目的是在对慢性乙型肝炎儿童先使用拉夫米定诱导治疗3个月后，再联合使用拉夫米定和α干扰素，观察疗效。方法：对20例儿童患者给予拉夫米定（4mg／kg／d，最大剂量100mg）治疗3个月，随后加用α-干扰素（iOMU／m^2．每周两次）联合治疗6个月。停用α-干扰素后继续使用拉夫米定6个月。HBeAg血清转换6个月后停止治疗。[第一段]

关键词：慢性乙型肝炎病毒感染干扰素治疗拉夫米定儿童患者联合使用最大剂量 HBeAg血清转换 α-干扰素诱导治疗

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