检索结果-南通市图书馆

Assessment of Patient Perceptions about Use of Wepox Pen<sup>TM</sup>(Recombinant Erythropoietin Delivery Device with 30,000 IU Cartridge) in the Management of Anemia in Chronic Kidney Disease Patients

引用

Open Journal of Nephrology 2017年第2期7卷 38-46页

作者： Hanmant Barkate salman motlekar Sameer Rao Sanjay Kamble Department of Medical Affairs Wokhardt LimitedMumbaiIndia

Objective: To assess perceptions about ease of use and other benefits of Wepox PenTM (loaded with 30,000 IU cartridge of recombinant erythropoietin) in the management of anemia in adult chronic kidney disease (CKD) patients. Material and methods: In this prospective, observational, multicentric post marketing surveillance, adult CKD patients treated with erythropoietin were enrolled from November 2015 to December 2016 to understand their opinions about Wepox PenTM. Ease of use of pen, ease of administering accurate dose, confidence in administration and ease of storage and disposal of cartridge were assessed on five points Likert scale: 1. very easy;2. somewhat easy;3. neither easy nor difficult;4. somewhat difficult;5. very difficult. Global assessment was performed on five points scale: 1. excellent;2. very good;3. good;4. average;5. not good. Safety was recorded by checking pain and discomfort and adverse events. Results: A total of 263 patients (mean age 32.87 years;66% male;34% female) were enrolled. Number of patients reporting ease of use as “very easy” from 209 (80.7%) at baseline increased to 245 (94.6%) and 249 (96.1%) at visit 2 (p = 0.001) and visit 3 (p = 0.001) respectively. Number of “very easy” response for accurate dose increased from 236 (91.1%) at visit 1 to 246 (95%) at visit 2 (p = 0.84) and 249 (96.1%) at visit 3 (p = 0.001). Number of the patients with “no pain” at injection site increased from 177 (68.3%) at visit 1 to 205 (79.2%) and 212 (81.9%) at visit 2 (p = 0.001) and visit 3 (p = 0.001) respectively. Improvement in number of patients with “no hurt” at visit 2 (p = 0.538) and visit 3 (p = 0.286) was not statistically significant. Number of patients reporting “somewhat easy” to “very easy” confidence in self injection increased from 251 (96.9%) at visit 2 to 255 (98.5%) at visit 3. Number of patients reporting ease of storage and disposal of cartridge as “somewhat easy” to “very easy” increased from 254 (98.1%) at visit 2 to 256 (98.9%) a

关键词： Anemia Chronic Kidney Disease Erythropoietin Pen Device

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence

引用

Open Journal of Obstetrics and Gynecology 2018年第11期8卷 993-1005页

作者： Parag Biniwale Bhaskar Pal Tripura Sundari Gorakh Mandrupkar Nikhil Datar Amandeep Singh Khurana Amit Qamra salman motlekar Rishi Jain Department of Obstetrics & Gynecology Biniwale Clinic Pune India Department of Obstetrics & Gynecology Apollo Gleneagles Hospital Ltd. Kolkata India Department of Obstetrics & Gynecology Krishna Institute of Medical Sciences Secunderabad India Department of Obstetrics & Gynecology Mandrupkar Clinic Islampur India Department of Obstetrics & Gynecology Cloudnine Hospital Mumbai India Department of Medical Affairs Wockhardt Limited Mumbai India

Iron deficiency anemia is the most frequent nutritional deficiency disorder. Conventionally administered oral iron is associated with gastrointestinal intolerance that affects the outcomes and compliance. Liposomal iron is associated with increased absorption without causing significant adverse effects. In this review, we have discussed the technology of liposomal iron preparation, mechanisms of its absorption and clinical evidence on its utility in iron deficiency states in pregnant and non-pregnant women. Based on the available evidence, we compared liposomal iron to conventional oral iron. Encapsulation of micronized iron in liposomes is associated with lesser exposure to gastric contents, lesser interaction with food contents, no exposure to different digestive juices, targeted delivery of iron and allows lower doses to be administered in lieu of direct absorption without need for protein carriers. The available evidence suggests that liposomal iron significantly increases hemoglobin, ferritin levels in pregnant women as well as in women with iron deficiency.

关键词： Liposomal Iron Microencapsulated Micronized Iron Deficiency Anemia Pregnancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heme Iron Polypeptide in Iron Deficiency Anemia of Pregnancy: Current Evidence

引用

Open Journal of Obstetrics and Gynecology 2017年第4期7卷 420-431页

作者： Bhaskar Pal Hemant Deshpande Tripura Sundari Parag Biniwale Kamlesh Shah Sugandh Goel Amandeep Singh Khurana Amit Qamra salman motlekar Hanmant Barkate Department of Obstetrics & Gynecology Apollo Gleneagles Hospital Ltd. Kolkata India Department of Obstetrics & Gynecology Dr D.Y. Patil Medical College & Hospital Pune India Department of Obstetrics & Gynecology Krishna Institute of Medical Sciences Secunderabad India Department of Obstetrics & Gynecology Biniwale Clinic Pune India Department of Obstetrics & Gynecology Sahyadri Hospital Karad India Department of Medical Affairs Wockhardt Limited Mumbai India

Iron deficiency is the most common nutritional deficiency leading to anemia in pregnancy. Conventionally, non-heme form of iron salts has been the mainstay of treatment. However, patient compliance is an important concern with existing oral iron therapy due to gastrointestinal side effects. Heme iron, a better bioavailable and tolerable form of iron can be suitable form of iron for supplementation in pregnancy. Evidence suggests its utility in pregnancy for treatment of iron deficiency anemia with benefits extending to postpartum period. Effective transfer across placenta to fetus further supports its utility in pregnancy. This review discusses in details the absorption kinetics along with clinical evidence on efficacy, safety, and tolerability of heme-iron supplementation in iron deficiency anemia of pregnancy.

关键词： Heme Iron Pregnancy Iron Absorption Iron Deficiency Anemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：