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Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats

World Journal of Gastroenterology 2013年第34期19卷 5633-5644页

作者： Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M ahmed Department of Pharmacology andToxicology College of PharmacyKing Saud University Department of Medical Laboratory Sciences College of Applied Medical SciencesSalman bin Abdulaziz University Department of Science and Nutrition College of Food and Agricultural SciencesKing Saud University

AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in ***:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were *** mucus content was estimated using Alcian blue dye binding *** colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were *** activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were *** of nucleic acids(DNA and RNA)and total protein were also estimated in colon *** levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were *** cross section of colitis tissue the histopathological changes were ***:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls *** supplementation,significantly and dose dependently increased the colonic mucus *** elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0

关键词： Naringenin Ulcerative colitis Inflammatory bowel disease Oxidative stress

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Esophageal Cancer Metastasis to the Eye: A Case Report and Literature Review

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Open Journal of Thoracic Surgery（胸外科期刊） 2021年第3期

作者： Ramzi A.Addas ahmed M.Alsabban Abdullah A.Fallatah Aqeel S.Binaqeel salman W.Bafageeh

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Automated Leukemia Screening and Sub-types Classification Using Deep Learning

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Computer Systems Science & Engineering 2023年第9期46卷 3541-3558页

作者： Chaudhary Hassan Abbas Gondal Muhammad Irfan Sarmad Shafique Muhammad salman Bashir Mansoor ahmed Osama M.Alshehri Hassan H.Almasoudi Samar M.Alqhtani Mohammed M.Jalal Malik A.Altayar Khalaf F.Alsharif Department of Computer Science COMSATS University Islamabad44000Pakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia Control Automotive and Robotics LabNational Center of Robotics and Automation(NCRA HEC)MirpurPakistan Mirpur University of Science and Technology(MUST)MirpurPakistan Department of Computer Science Virtual University of PakistanLahore54000Pakistan Department of Clinical Laboratory Sciences College of Applied Medical SciencesNajran UniversityNajran61441Saudi Arabia Department of Information Systems College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

Leukemia is a kind of blood cancer that damages the cells in the blood and bone marrow of the human *** produces cancerous blood cells that disturb the human’s immune system and significantly affect bone marrow’s production ability to effectively create different types of blood cells like red blood cells(RBCs)and white blood cells(WBC),and *** can be diagnosed manually by taking a complete blood count test of the patient’s blood,from which medical professionals can investigate the signs of leukemia ***,two other methods,microscopic inspection of blood smears and bone marrow aspiration,are also utilized while examining the patient for ***,all these methods are labor-intensive,slow,inaccurate,and require a lot of human experience and *** authors have proposed automated detection systems for leukemia diagnosis to overcome these *** have deployed digital image processing and machine learning algorithms to classify the cells into normal and blast ***,these systems are more efficient,reliable,and fast than previous manual diagnosing ***,more work is required to classify leukemia-affected cells due to the complex characteristics of blood images and leukemia cells having much intra-class variability and inter-class *** this paper,we have proposed a robust automated system to diagnose leukemia and its *** have classified ALL into its sub-types based on FAB classification,i.e.,L1,L2,and L3 types with better *** have achieved 96.06%accuracy for subtypes classification,which is better when compared with the state-of-the-art methodologies.

关键词： Healthcare cancer detection deep learning convolutional neural network

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Bilothorax a Rare Incidence in Thoracic Surgery: Case Report and Literature Review

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Open Journal of Thoracic Surgery（胸外科期刊） 2021年第3期

作者： Ramzi A.Addas ahmed M.Alsabban Abdullah A.Fallatah Aqeel S.Binaqeel salman W.Bafageeh Abdullah O.Bawazir

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Role of Apoptosis in Microbial Infection

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Open Journal of Apoptosis 2014年第2期3卷 32-38页

作者： Faris Q. Alenzi ahmed Q. Alotaibi Gdhi M. Almotiri Anwar M. Alanazi Faisal M. Alanazi Mohammed S. Alenazi Khalaf A. Alanazi Mohammed J. Alenzi Shamweel Y. Ahmad Deparment of Medical Laboratory Sciences College of Applied Medical Sciences Salman Bin Abdulaziz University Al-Kharj Saudi Arabia Medical College Al-Jouf University Sakaka Saudi Arabia Ministry of Health Riyadh Saudi Arabia

Apoptosis plays a central role in the pathogenesis of a number of human diseases. Because apoptosis represents a fundamental process in the response to such infections, it may represent a therapeutic target for their treatment. There is thus likely to be future clinical relevance in harnessing our growing knowledge both of apoptotic mechanisms, and their regulation, in the search to achieve modalities for therapeutic benefit. This brief review aims to summarize what we currently know about the role of apoptosis in response to a range of microbial infections (including bacterial and viral).

关键词： Apoptosis Microbial Pathogens Infection Therapy

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Genome editing in cotton: challenges and opportunities

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棉花研究(英文) 2023年第1期

作者： KHAN Zulqurnain KHAN Sultan Habibullah ahmed Aftab IQBAL Muhammad Umar MUBARIK Muhammad salman GHOURI Muhammad Zubair AHMAD Furqan YASEEN Saba ALI Zulfiqar KHAN Asif Ali AZHAR Muhammad Tehseen

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Clinical Practice Guideline for the Management of Overweight and Obesity in Adults in Saudi Arabia

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International Journal of Clinical Medicine 2022年第12期13卷 590-649页

作者： Abdulrahman Alshaikh ahmed Aljedai Assim Alfadda Abdulrahman Alrobayan Abdulwahab Bawahab Shaza Abou Ouf Ali Sultan Amani Alhozali Mohammed Bawazeer Eman Sheshah Fahad Alqahtani Hala Mosli Hussein Elbadawi Khaled Alamri Khalid Alshali Mohammed Aldawish Mohammed Alsofiani Raed Aldahash Rasha Alfawaz Reem Alamoudi Wessam Jamal Hajer Almudaiheem Emad R. Issak Saud Alsifri King Abdulaziz University Hospital Jeddah Saudi Arabia Ministry of Health Riyadh Saudi Arabia King Saud University Medical City Riyadh Saudi Arabia Prince Sultan Military Medical City Riyadh Saudi Arabia King Fahad General Hospital Jeddah Saudi Arabia International Medical Center Jeddah Saudi Arabia King salman Hospital Riyadh Saudi Arabia King Fahad Medical Center Riyadh Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia Saudi Centre for Disease Prevention and Control Riyadh Saudi Arabia Aslam Center Cairo Egypt Al Hada Armed Forces Hospital Taif Saudi Arabia

Obesity and overweight are prevalent in Saudi Arabia (24.95% & 31.80%). Also, childhood obesity in the country is a challenge, with 6% - 10% of preschool and school-age children. The burden of being overweight and obese is disastrous. Therefore, the Saudi Diabetes Scientific Society constituted a team to develop a guideline. The team reviewed the local Clinical Practice Guidelines for the Prevention and Management of Obesity in Saudi Arabia;and conducted a rigorous review of relevant evidence-based scientific literature. After a thorough assessment, a consensus was reached to use the Australian guideline as the main guideline to be adapted and localized to be suitable for the Saudi people. To avoid duplication of efforts, the team adopted the grading of evidence used by the Australian guideline. The updated version was presented in a workshop, and the recommendation of the participants was included. The final draft was distributed for review, and comments were included. This document presents the result of such an effort as a local guideline.

关键词： Obesity Overweight Disease Burden Management Guideline Saudi Arabia

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