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Global environmental health:an interview with sally Perreault Darney

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National Science Review 2016年第4期3卷 459-462页

作者： Li Xu Bin zhao the Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Pollution-induced health problems are of concern across the *** China,the recent and rapid surge of economic development has been associated with public health problems as well as environmental *** recently spoke with sally Perreault Darney,Ph.D.,the Editor-in-Chief of Environmental Health Perspectives(EHP),the foremost journal about environmental *** by the

关键词： Global environmental health EHP NSR

Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2522-2532页

作者： Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUnited Arab Emirates China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUnited Arab Emirates G42 Healthcare Abu DhabiUnited Arab Emirates

The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster *** conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as *** groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV *** assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control *** Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous *** results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and *** heterologous and homologous boosters have a good safety *** and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster *** findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron.

关键词： phase neutral GMT

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

法律多元主义的概念困境:涵义、成因与理论影响

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环球法律评论 2022年第4期44卷 146-161页

作者：赵英男中国政法大学比较法学研究院

法律多元主义指的是某个社会群体拥有不止一种规范其社会行为的有效法律体系。作为一种事实,法律多元主义现象无所不在。在相关研究中,学者们大多将法律多元主义视为无可争议、理所当然的概念,却忽略了它所遭遇的困境:一方面,法律不止... 详细信息

法律多元主义指的是某个社会群体拥有不止一种规范其社会行为的有效法律体系。作为一种事实,法律多元主义现象无所不在。在相关研究中,学者们大多将法律多元主义视为无可争议、理所当然的概念,却忽略了它所遭遇的困境:一方面,法律不止是国家法,还包括其他社会规范;另一方面,法律与其他社会规范的界限不明,导致法律概念过于宽泛。这一困境是任何法律多元主义理论都面临的深层概念难题,有观点因此悲观地认为应当放弃对于法律的界定。这种困境与悲观论断的根源,在于学者忽略了法律本身是一个民间概念。民间概念植根于各种各样的历史与现实语境,无法用精确的语言加以表述。但这并不意味着法律不可界定,而是指不存在有关法律的普遍必然主张。把握法律的民间概念特征,有助于我们走出法律多元主义研究的理论困境,也有助于我们反思一般法理学中有关法律性质的本质必然主张的合理性。

关键词：法律多元主义法律概念规范秩序民间概念一般法理学

基于TOPSIS的出行方案评价指标权重的确定方法

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交通运输系统工程与信息 2009年第2期9卷 122-128页

作者：王爽赵鹏北京交通大学交通运输学院北京100044

旅客出行偏好选择问题是旅客出行行为分析理论的一个重要部分,而旅客对出行方案的选择是基于对各种方案的评价指标的综合分析.但旅客对各评价指标的侧重程度,即属性权重的计算,目前常用方法都有一定的局限性.本文以旅客出行偏好选择为背... 详细信息

旅客出行偏好选择问题是旅客出行行为分析理论的一个重要部分,而旅客对出行方案的选择是基于对各种方案的评价指标的综合分析.但旅客对各评价指标的侧重程度,即属性权重的计算,目前常用方法都有一定的局限性.本文以旅客出行偏好选择为背景,借助多指标评价方法TOPSIS的评价准则,以实际的大规模旅客调查数据为基础,分析、确定旅客对出行方案各属性指标的权重,为旅客出行行为分析提供重要、客观、可靠的依据.经过实例验证,证明了该方法的有效性,并将计算结果代入多项Logit模型,进一步验证了计算结果的合理性.此外,该方法计算简便、易于实现,对于各种交通方式下的旅客出行偏好选择问题具有普遍适用性.

关键词：客运专线旅客出行偏好 TOPSIS

Analysis on the Image of Orlando From the Perspective of the Feminism Film Theory

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海外英语 2016年第5期 160-162页

作者：赵玲玲哈尔滨远东理工学院

Feminism is a social movement which has had a large effect on film *** paper aims to analyze the image of sally Potter’s Orlando from the perspective of the Feminism Film Theory.

关键词： Feminism Orlando the Feminism Film Theory

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萨丽·摩根的《我的位置》中土著性的重建

安徽冶金科技职业学院学报 2013年第4期23卷 105-108页

作者：聂朝晖马钢技师学院外国语系安徽马鞍山243003

萨丽·摩根的《我的位置》通过她的家庭三代人的回忆记录,向所有人,包括不了解情况的土著人后代和很多对此一无所知的白人,揭露了土著黑人令人震惊的真实过去,使之几乎成与白人虚构的历史相对抗的另一部历史。由此说明,只有在这样的重... 详细信息

萨丽·摩根的《我的位置》通过她的家庭三代人的回忆记录,向所有人,包括不了解情况的土著人后代和很多对此一无所知的白人,揭露了土著黑人令人震惊的真实过去,使之几乎成与白人虚构的历史相对抗的另一部历史。由此说明,只有在这样的重述历史、重构历史中,土著人(包括萨丽·摩根及其他叙述者们)才能找到他们的位置,重新修复他们的土著性这个被白人政府强行割断的文化身份。作者通过分析主人公悲剧的原因,试图揭示出压制土著人的复杂主流白人文化和父权制作用的真实一面。

关键词：后殖民土著性文化霸权重建

Real-world Effectiveness and Tolerability of Interferonfree Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C:A Multinational Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 646-658页

作者： Fanpu Ji sally Tran Eiichi Ogawa Chung-Feng Huang Takanori Suzuki Yu Jun Wong Hidenori Toyoda Dae Won Jun Liu Li Haruki Uojima Akito Nozaki Makoto Chuma Cheng-Hao Tseng Yao-Chun Hsu Masatoshi Ishigami Takashi Honda Masanori Atsukawa Hiroaki Haga Masaru Enomoto Huy Trinh Carmen Monica Preda Phillip Vutien Charles Landis Dong Hyun Lee Tsunamasa Watanabe Hirokazu Takahashi Hiroshi Abe Akira Asai Yuichiro Eguchi Jie Li Xiaozhong Wang Jia Li Junping Liu Jing Liang Carla Pui-Mei Lam Rui Huang Qing Ye Hongying Pan Jiajie Zhang Dachuan Cai Qi Wang Daniel Q.Huang Grace Wong Vincent Wai-Sun Wong Junyi Li Son Do Norihiro Furusyo Makoto Nakamuta Hideyuki Nomura Eiji Kajiwara Eileen L.Yoon Sang Bong Ahn Koichi Azuma Kazufumi Dohmen Jihyun An Do Seon Song Hyun Chin Cho Akira Kawano Toshimasa Koyanagi Aritsune Ooho Takeaki Satoh Kazuhiro Takahashi Ming-Lun Yeh Pei-Chien Tsai Satoshi Yasuda Yunyu zhao Yishan Liu Tomomi Okubo Norio Itokawa Mi Jung Jun Toru Ishikawa Koichi Takaguchi Tomonori Senoh Mingyuan Zhang Changqing zhao Raluca Ioana Alecu Wei Xuan Tay Pooja Devan Joanne Kimiko Liu Ritsuzo Kozuka Elena Vargas-Accarino Ai-Thien Do Mayumi Maeda Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Ramsey Cheung Maria Buti Junqi Niu Wen Xie Hong Ren Seng Gee Lim Chao Wu Man-Fung Yuen Jia Shang Qiang Zhu Yoshiyuki Ueno Yasuhito Tanaka Jun Hayashi Ming-Lung Yu Mindie H.Nguyen Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of General Internal Medicine Kyushu University HospitalFukuokaJapan Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Hepatitis Research Center College of Medicine and Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoyaJapan Gastroenterology&Hepatology Changi General HospitalSinghealthSingapore Singhealth Duke-NUS Medicine Academic Clinical Program Singapore Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Department of Internal Medicine Hanyang UniversityCollege of MedicineSeoulKorea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoulKorea Department of Hepatology The Third People's Hospital of Kunming CityKunmingYunnanChina Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaJapan Gastroenterological Center Yokohama City University Medical CenterYokohamaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineE-Da Cancer HospitalKaohsiung Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Nippon Medical SchoolTokyoJapan Department of Gastroenterology Yamagata University Faculty of MedicineYamagataJapan Department of Transfusion Medicine and Department of Hepatology Osaka Metropolitan University Graduate School of MedicineOsakaJapan San Jose Gastroenterology San JoseCAUSA Gastroenterology&Hepatology Department Clinic Fundeni InstituteBucharestRomania Division of Gastroenterology and Hepatology University of WashingtonSeattleWAUSA Department of

Background and Aims:As practice patterns and hepatitis C virus(HCV)genotypes(GT)vary geographically,a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination *** study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs,focusing on GT3 and ***:We analyzed the sustained virological response(SVR12)of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific,North America,and Europe between 07/01/2014–07/01/***:The mean age was 62±13 years,with 49.6%*** demographic breakdown was 91.1%Asian(52.9%Japanese,25.7%Chinese/Taiwan residents,5.4%Korean,3.3%Malaysian,and 2.9%Vietnamese),6.4%White,1.3%Hispanic/Latino,and 1%Black/***,34.8%had cirrhosis,8.6%had hepatocellular carcinoma(HCC),and 24.9%were treatment-experienced(20.7%with interferon,4.3%with direct-acting antivirals).The largest group was GT1(10,246[64.6%]),followed by GT2(3,686[23.2%]),GT3(1,151[7.2%]),GT6(457[2.8%]),GT4(47[0.3%]),GT5(1[0.006%]),and untyped GTs(261[1.6%]).The overall SVR12 was 96.9%,with rates over 95%for GT1/2/3/6 but 91.5%for ***12 for GT3 was 95.1%overall,98.2%for GT3a,and 94.0%for ***12 was 98.3%overall for GT6,lower for patients with cirrhosis and treatment-experienced(TE)(93.8%)but≥97.5%for tretment-naive patients regardless of cirrhosis *** multivariable analysis,advanced age,prior treatment failure,cirrhosis,active HCC,and GT3/4 were independent predictors of lower SVR12,while being Asian was a significant predictor of achieving ***:In this diverse multinational realworld cohort of patients with various GTs,the overall cure rate was 96.9%,despite large numbers of patients with cirrhosis,HCC,TE,and GT3/***12 for GT3/6 with cirrhosis and TE was lower but st

关键词： Hepatitis C virus Liver cirrhosis Hepatocellular carcinoma Genotype DAA REAL-C

几种蔷薇和‘月月粉’与现代月季杂交亲和性评价

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浙江农业学报 2012年第6期24卷 1026-1032页

作者：王泽翻韩倩林毅雁崔娇鹏刘恒星赵世伟赵惠恩北京林业大学园林学院北京100083 北京植物园北京100093

以报春刺玫、单瓣黄刺玫、‘月月粉’和疏花蔷薇等抗性强、早花的蔷薇属资源作为父本,以大田栽培的现代月季作为母本进行杂交育种试验。结合前期育种工作,筛选出杂交亲和的组合有22个:‘Eyeopener’×报春刺玫、‘Berk Shire’×单瓣黄... 详细信息

以报春刺玫、单瓣黄刺玫、‘月月粉’和疏花蔷薇等抗性强、早花的蔷薇属资源作为父本,以大田栽培的现代月季作为母本进行杂交育种试验。结合前期育种工作,筛选出杂交亲和的组合有22个:‘Eyeopener’×报春刺玫、‘Berk Shire’×单瓣黄刺玫、‘sally Holmes’×单瓣黄刺玫、‘Partidge’×单瓣黄刺玫、‘Partidge’×报春刺玫、‘Partidge’×‘月月粉’、‘Partidge’×疏花蔷薇、‘Cambridgeshire’×单瓣黄刺玫、‘Robin Red-breast’×报春刺玫、‘Summer Sunrise’×报春刺玫、‘Tess of The Durbervilles’×报春刺玫、‘Petal Pushers’×报春刺玫、‘Laura Ford'×单瓣黄刺玫、‘Jill Dando'×单瓣黄刺玫、‘Jill Dando'×报春刺玫、‘Twenty-fifth'×报春刺玫、‘Phea Sant'×报春刺玫、‘Grouse'×单瓣黄刺玫、‘Grouse'×报春刺玫、‘Summer Sunset’×单瓣黄刺玫、‘Anna Zinkeisen'×单瓣黄刺玫、‘Anna Zinkeisen'×疏花蔷薇。

关键词：远缘杂交花粉萌发杂交组合杂交种