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Profile of the Blood Count among People Living with HIV Monitored at the Institute of Social Hygiene and the Aristide Le Dantec Hospital in Dakar

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Open Journal of Blood Diseases 2022年第4期12卷 133-141页

作者： Faye Cheikh Ibrahima Coly Mame Ngoné Makalou Demba Sène Abdoulaye sall abibatou Touré Awa Oumar Ly Fatouamata Hematology Laboratory of the Aristide le Dantec Hospital Dakar Senegal Health Sciences Training and Research Unit Hematology Laboratory of the Ziguinchor Peace Hospital Assane Seck University of Ziguinchor Ziguinchor Senegal Training and Research Unit in Health Sciences Hematology Laboratory of the Sickle Cell Disease Control Center of Saint Louis Gaston Berger University of Saint Louis Dakar Senegal Pharmacy and Odontostomatology Faculty of Medicine Cheikh Anta Diop University of Dakar Dakar Senegal Dermatology Department of the Social Hygiene Institute of Dakar Dakar Senegal

Introduction: The human immunodeficiency virus (HIV) is a pandemic of concern to the World Health Organization. It is all the more worrisome because if not properly managed, it can be responsible for several complications, including abnormal blood counts. These abnormalities may also be related to treatment. Objectives: The main objective of this study is to show that adequate antiretroviral therapy can correct various abnormalities exerted by HIV on patients’ blood counts. The specific objective is to determine all the abnormalities we can see in blood count before and during HIV treatment. Materials and Methods: Our study was conducted in the hematology laboratory and the dermatology departments of the Aristide Le Dantec Hospital and the Institute of Social Hygiene. It took place from December 2009 to October 2011. It is a retrospective descriptive and analytical study involving HIV-positive patients (HIV 1 and 2) and under antiretroviral treatment (at least six months of treatment). We included 110 patients in the study. Blood counts were performed at the hematology laboratory of the Aristide le Dantec hospital using a KX21 automaton. Each patient received three blood counts during the first six months of treatment (M0, M3 and M6). A univariate analysis was performed to determine the profile of the abnormalities of the blood count and the chi 2 test was used and a threshold of p 0.05 was considered significant. Results: The mean age of the patients was 38.6 ± 8.6 years (extremes of 18 and 64 years) with a sex ratio of 0.42 (77 females and 33 males). The prevalence of anemia was 80% (n = 88) at M0, 53, 63% at M3 (n = 59), and 38.20% at M6 (n = 42) (p = 0.02). We noted a favorable evolution with treatment. For the other abnormalities, the evolution was favorable for leukopenia (p = 0.011) and thrombocytopenia (p = 0.007). Conclusion: Our study showed a correction of blood count abnormalities in PLHIV with antiretroviral treatment.

关键词： Blood Count Abnormalities Antiretroviral Treatment PLHIV

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A New Observation of Bone Marrow Involvement by Diffuse Large B-Cell Lymphoma Mimicking Myelofibrosis

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Open Journal of Blood Diseases 2022年第2期12卷 39-44页

作者： Fall Seynabou Alioune Badara Diallo Dibor Niang El Hadji Daouda Niang Khadim Sarr Marième Lolita Camara abibatou sall Fatou Samba Ndiaye Department of Hematology Cheikh Anta Diop University Dakar Senegal Department of Pathology Gaston Berger University Saint-Louis Senegal

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma, characterized by high clinical and biological heterogeneity. Patients typically present with progressive lymphadenopathy, extranodal disease and may also experience fever, night sweats and unexplained weight loss. We report here the case of a 16-year-old female with osteoarticular pain, dizziness, and dyspnea on exertion. Clinical examination showed no lymphadenopathy. Complete blood count (CBC) revealed pancytopenia and marrow smears found to be hypocellular. Initial diagnosis favored secondary myelofibrosis. Diagnosis of bone marrow involvement by DLBCL was retained on bone marrow histology and immunohistochemistry which showed infiltration of large B lymphoid cells. The patient was treated by immunochemotherapy R-CHOP regimen. This case highlights a very rare and atypical circumstance of discovery of DLBCL with myelofibrosis as an initial symptom. Prognosis value of this presentation and management difficulties are also discussed.

关键词： Diffuse Large B-Cell Lymphoma Myelofibrosis Rituximab

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