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坎地沙坦对心力衰竭患者非致死性心肌梗死和心血管死亡的影响

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美国医学会杂志（中文版） 2006年第5期25卷 302-306页

作者： Catherine Demers John J. V. McMurray Karl Swedberg Marc A. Pfeffer Christopher B Bertil Olofsson Robert S. McKelvie Jan OEstergren Eric L. Michelson Peter A. Johansson Duolao Wang salim yusuf, MBBS, DPhil 孙艺红（译）胡大一（校） McMaster University Hamilton Ontario University of Glasgow Glasgow Scotland Sahlgrenska University Hospital/Ostra G6teborg Sweden Cardiovascular Division Brigham and Women＇s Hospital Boston Mass Duke University Medical center Durham NC AstraZeneca Research and Development MOlndal Sweden Karolinska Hospital Stockholm Sweden AstraZeneca LP Wilmington Del London School of Hygiene and Tropical Medicine London England 不详

背景：血管紧张素转换酶（angiotensin-converting enzyme，Ace）抑制剂可降低心肌梗死（myocardial infarction，MI）的危险，但是还不清楚血管紧张素受体拮抗剂是否具有同样的效果。目的：评价血管紧张素受体拮抗剂坎地沙坦对心力衰... 详细信息

背景：血管紧张素转换酶（angiotensin-converting enzyme，Ace）抑制剂可降低心肌梗死（myocardial infarction，MI）的危险，但是还不清楚血管紧张素受体拮抗剂是否具有同样的效果。目的：评价血管紧张素受体拮抗剂坎地沙坦对心力衰竭患者MI和其他冠脉事件的影响。设计、地点和参试者：“坎地沙坦治疗心力衰竭：降低病死率和发病率评价”（Candesartan in Heart Failure：Assessment of Reduction in Mortality and Morbidity，CHARM）计划是一项随机、安慰剂对照研究。研究入选有纽约心脏病协会分级Ⅱ至Ⅳ级症状的患者（平均年龄，66[SD，11]岁）。在心力衰竭最佳治疗的基础上，随机接受坎地沙坦（目标剂量，32mg每天一次）或匹配的安慰剂。患者入选期为1999年3月至2001年3月。分组的7599例患者中，4004例（53％）有MI病史，1808例（24％）患有心绞痛。基线时，服用Ace抑制剂3125例（41％）；服用β-阻滞剂4203（55％）例；降脂药物3153例（42％）；阿斯匹林4246例（56％）；利尿药6286例（83％）。主要观测指标：该分析的主要终点为坎地沙坦或安慰剂组心力衰竭患者心血管死亡和非致死性MI复合发生率。结果：在37．7个月的中位随访期间，坎地沙坦组（775例患者[20．4％]）心血管死亡和非致死性MI主要终点的发生率明显低于安慰剂组（868[22．9％]）（风险比[hazard ratio，HR]，0．87；95％可信区间[confidence interval，CI]，0．79-0．96；P=0．004；所需治疗例数[numbe rneeded to treat，NNT]，40）。与安慰剂组（522[13．8％]）比较，坎地沙坦组（459[12．1％]）单纯非致死性MI也明显降低（HR，0．86；95％CI，0．75-0．97；P=0．02；NNT，59）。在CHARM试验预先设定的不同亚组和分析间，心血管死亡和非致死性MI危险的降低相似。坎地沙坦对不稳定心绞痛或冠脉血运重建导致的住院没有影响。结论：坎地沙坦能明显降低心力衰竭患者发生心血管死亡或非致死性MI复合终点的危险。

关键词：心力衰竭患者致死性心肌梗死坎地沙坦心血管死亡血管紧张素转换酶安慰剂对照 Ace抑制剂

Current systematic reviews and meta-analyses of COVID-19

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World Journal of Virology 2021年第4期10卷 182-208页

作者： Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov salim yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States Department of Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt(IDCARE)Cairo 11221Outside of the USEgypt Department of Medicine Division of NephrologyUniversity of Tennessee Health Science CenterKnoxville CityTN 38103United States Department of Medical St.George's UniversityWest Indies 38901Grenada Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11221Egypt Department of Oncology Broomfiled HospitalMid and South Essex NHS Foundation TrustESSEXChelmsford 12422United Kingdom Department of Critical Care Unit Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States

BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million *** the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of *** To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be *** We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS *** included studies were extracted from Embase,Medline,and Cochrane *** publication timeframe of included studies ranged between January 01,2020,to October 30,*** that were published in languages other than English were not considered for this systematic *** finalized full-text articles are freely accessible in the public *** Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 *** inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 *** screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and ***,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stro

关键词： Systematic review Meta-analyses COVID-19 Review Coronavirinae

CT在临床可疑耳硬化症评估中的诊断疗效和治疗影响

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国际医学放射学杂志 2017年第3期 359-359页

作者： C.Dudau F.salim D.Jiang S.E.J.Connor 邓艳 Department of Neuroradiology King ’s College Hospital NHS Foundation Trust

摘要目的探讨CT在临床疑诊耳硬化症病人评估中的诊断疗效和对治疗的影响。方法回顾性分析接受CT扫描超过5年的临床可疑为耳硬化症的病人,CT诊断与后续手术治疗方式有关。对耳硬化症阳性的病例,判断有明显扩张的耳硬化症与听力测试的关... 详细信息

摘要目的探讨CT在临床疑诊耳硬化症病人评估中的诊断疗效和对治疗的影响。方法回顾性分析接受CT扫描超过5年的临床可疑为耳硬化症的病人,CT诊断与后续手术治疗方式有关。对耳硬化症阳性的病例,判断有明显扩张的耳硬化症与听力测试的关系、诊断与手术结果的关系。结果在CT显示的259例耳硬化症病人中,46%为阳性,49%阴性,5%无法判断。对于33%阴性诊断病人,CT诊断依据充分。每4个CT检查中就有一个实行了针对性外科手术。在41%的CT结果阳性、4%的CT结果阴性的病人中,CT结果

关键词：耳硬化症阳性耳疾病 CT 疗效

玉米或高粱干酒糟及其可溶物对交叉繁殖的肉牛品种生长性能和胴体品质的影响

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饲料博览 2011年第11期21卷 8-8页

作者： Wood K M salim H McewenP L Mandell I B Miller S P Swanson K C 不详

应用裂区设计,对60头交叉繁殖肉牛(安格斯,n=36和夏洛来,n=24)喂食玉米或高粱干酒糟可溶物,研究其对肉牛生长肥育生长性能和胴体性状的影响。肉牛随机分配到各组,在两个饲养阶段中分为3个处理:对照组为豆粕型日粮(n=20,CON);CDDGS组在... 详细信息

应用裂区设计,对60头交叉繁殖肉牛(安格斯,n=36和夏洛来,n=24)喂食玉米或高粱干酒糟可溶物,研究其对肉牛生长肥育生长性能和胴体性状的影响。肉牛随机分配到各组,在两个饲养阶段中分为3个处理:对照组为豆粕型日粮(n=20,CON);CDDGS组在饲料中添加玉米干酒糟及其可溶物200g·kg-1(n=20,CDDGS);SDDGS组在饲料中添加高粱干酒糟及其可溶物200g·kg-1(n=20,SDDGS)。肉牛喂养青贮玉米的基础日粮(750g·kg-1)56d,然后换成高的谷物日粮(150g·kg-1)。测定采食量,每28d进行动物称重和通过超声引导估计背膘。结果表明,对于平均日增重(ADG),各组结果为CON组1.56±0.04kg·d-1,CDDGS组1.54±0.04kg·d-1,SDDGS组1.51±0.04kg·d-1,处理间没有显著差异(P>0.68)。不同干物质日粮组成水平对生长性能无显著影响(P>0.14),但CON组ADG水平低于SDDGS组(P=0.008)和CDDGS组(P=0.02)。成长阶段饲养中CDDGS和SDDGS组有一个较低增长(P=0.04)。在后期阶段,玉米或高粱DDGS的加入对平均日增重、料肉比无显著影响(P>0.41),SDDGS组比CDDGS组(P=0.03)和CON组(P=0.05)需要较少饲料量达到目标背膘性屠宰。结果表明,添加高粱干酒糟及其可溶物200g·kg-1,效果类似玉米酒糟及其可溶性,在生长期和后期中不影响整体增长或负胴体性状,尽管玉米青贮饲料的喂养可能会导致早期育肥效果。

关键词：胴体特性生长性能酒糟肉牛高粱

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

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World Journal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal Mayank Sharma Allison M LeMahieu Andrew C Hanson Phillip J Schulte Marija Bogojevic Neha Deo Simon Zec Diana J Valencia Morales Katherine A Belden Smith F Heavner Margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care Medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes

Prevalence,awareness and control of hypertension in Malaysia from 1980-2018:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2020年第4期8卷 320-344页

作者： Man Jun Soo Zhen yee Chow Siew Mooi Ching Chun Han Tan Kai Wei Lee Navin Kumar Devaraj Hani Syahida salim Vasudevan Ramachandran Poh ying Lim Dhashani Sivaratnam Fan Kee Hoo Ai Theng Cheong yook Chin Chia Department of Family Medicine Universiti Putra MalaysiaSerdang 43400Malaysia Hospital Seberang Jaya Perai 13700Malaysia Malaysian Research Institute on Ageing Universiti Putra MalaysiaSerdang 43400Malaysia Department of Community Health Universiti Putra MalaysiaSerdang 43400Malaysia Department of Surgery Universiti Putra MalaysiaSerdang 43400Malaysia Department of Medicine Universiti Putra MalaysiaSerdang 43400Malaysia Department of Medical Sciences Sunway UniversityBandar Sunway 47500Malaysia

BACKGROUND Hypertension is a common public health problem worldwide and is a well-known risk factor for increased risk of cardiovascular diseases,contributing to high morbidity and ***,there has been no systematic review and meta-analysis of a multiethnic population such as that of *** To determine the trend in prevalence,awareness and control rate of hypertension in *** Systematic searches were conducted in six databases(PubMed,Scopus,Ovid,CINAHL,Malaysian Medical Repository and Malaysia Citation Index)for articles published between 1980 and *** authors reviewed the studies and performed quality assessment and data extraction *** estimates of hypertension prevalence,awareness and control rate were calculated using the DerSimonian-Laird random-effects *** and sensitivity analyses were *** We included 56 studies involving a total of 241796 *** overall pooled prevalence of hypertension aged≥18 years was 29.7%.The prevalence of hypertension was the lowest in the 1980s(16.2%,95%confidence interval(CI):13.4,19.0),increasing up to 36.8%(95%CI:6.1,67.5)in the 1990s,then decreasing to 28.7%(95%CI:21.7,35.8)in the 2000s and 26.8%(95%CI:21.3,32.3)in the *** prevalence of awareness was 51.4%(95%CI:46.6,56.3),while 33.3%(95%CI:28.4,38.2)of those on treatment had achieved control of their blood *** In Malaysia,three in ten adults aged≥18 years have hypertension,while four in ten adults aged≥30 years have *** out of ten people are aware of their hypertension status and only one-third of those under treatment achieved control of their *** efforts by policymakers and healthcare professionals to improve awareness and control of hypertension should be of high priority.

关键词： Prevalence Awareness Control Hypertension Blood pressure Malaysia Systematic review Meta-analysis