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Immunoglobulin A glomerulonephropathy:A review

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World Journal of Clinical Cases 2024年第8期12卷 1388-1394页

作者： Mohamad El Labban salim Surani Department of Internal Medicine Mayo Cliic Health SystemMankatoMN 56001United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United State

In this editorial,we comment on the article by Meng et al published in the World Journal of Clinical *** comprehensively review immunoglobulin A nephro-pathy(IgAN),including epidemiology,clinical presentation,diagnosis,and ***,also known as Berger's disease,is the most frequent type of primary glomerulonephritis(GN)*** is mostly found among the Asian *** presentation can be variable,from microscopic hematuria to a rapidly progressive *** 50%of patients present with single or recurring episodes of gross *** upper respiratory infection and tonsillitis often precede these *** 30%of patients present microscopic hematuria with or without proteinuria,usually detected on routine *** diagnosis relies on having a renal biopsy for pathology and immunofluorescence *** focus on risk stratification and management of *** provide a review of all the landmark studies to *** to the 2021 KDIGO(kidney disease:Improving Global Outcomes)guidelines,patients with non-variant form IgAN are first treated conservatively for three to six *** approach consists of adequate blood pressure control,reduction of proteinuria with renin-angiotensin system blockade,treatment of dyslipidemia,and lifestyle modifications(weight loss,exercise,smoking cessation,and dietary sodium restrictions).Following three to six months of conservative therapy,patients are further classified as high or low risk for disease ***-risk patients have proteinuria≥1 g/d ory *** experts consider proteinuria≥2 g/d to be very high *** with high and very high-risk profiles are treated with immunosuppressive therapy.A proteinuria level ofy.

关键词： Immunoglobulin A nephropathy Glomerulonephritis Nephritic syndrome Angiotensin-converting enzyme inhibitor Angiotensin receptor blocker Systemic steroids Mycophenolate mofetil

Impact of interfacial tension on oil-water flow in a narrow gap

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Petroleum Research 2024年第2期9卷 219-227页

作者： salim Raza Ian D.Gates Saira Sherin University of Engineering and Technology PeshawarPakistan Department of Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCanada

Numerous researchers have examined the co-current flow of oil-water and aqueous solutions containing polymers and surfactants in thin gaps for oil *** some have focused on charges and forces at the interfaces of oil-surfactant solutions during *** study of flow structures,interface behavior,and relative permeabilities of oil and aqueous phases of surfactant flow through thin gaps has been less *** the first time,this research aims to comprehensively investigate the flow of oil-water and oil-surfactant solutions through a thin gap(Hele-Shaw cell)with a particular focus on the impact of sodium dodecyl sulfate(SDS).The experiments reveal that SDS forms an emulsion near the oil-water interface,capturing oil droplets and enabling their flow along with the SDS *** studies confirm this,showing that when SDS contacts oil,it creates channels through the oil phase,leading to the accumulation and division of oil into small round-shaped droplets,resulting in an oil-in-water *** addition of SDS to the injecting water significantly enhances relative permeabilities,leading to a remarkable 90%increase in oil recovery from the *** research suggests that the optimal SDS concentration range for maximum oil recovery is between 1.5 and 2 wt%,as it achieves the minimum interfacial tension between oil and water.

关键词： Surfactant Co-current flow Narrow gap Interface interactions Relative permeability

Properties of Bark Particleboard Bonded with Demethylated Lignin Adhesives Derived from Leucaena leucocephala Bark

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Journal of Renewable Materials 2024年第4期12卷 737-769页

作者： Rafidah Md salim Jahimin Asik Mohd Sani Sarjadi Wood Testing Laboratory Faculty of Tropical ForestryUniversity of Malaysia SabahKota KinabaluSabah88400Malaysia Industrial Chemistry Program Faculty of Science and Natural ResourcesUniversity of Malaysia SabahKota KinabaluSabah88400Malaysia

Lignin extraction from bark can maximize the utilization of biomass waste,offer cost-effectiveness,and promote environmental friendliness when employed as an adhesive material in bark particleboard *** of fine(0.2 to 1.0 mm),medium(1.0 to 2.5 mm),and coarse(2.5 to 12.0 mm)sizes,derived from the bark of Leucaena leucocephala,were hot-pressed using a heating plate at 175℃for 7 min to create single-layer particleboards measuring 320 mm×320 mm×10 mm,targeting a density of 700 kg/m^(3).Subsequently,the samples were trimmed and conditioned at 20℃and 65%relative *** this study,we compared bark particleboard bonded with urea formaldehyde(UF)adhesive to fine-sized particleboard bonded with demethylated lignin *** results indicated that bark particleboards utilizing demethylated lignin and UF adhesives exhibited similar *** particleboard showed differences in modulus of elasticity(MOE)and modulus of rupture(MOR),while medium-sized particles exhibited significant variations in moisture content(MC)and water absorption(WA).Furthermore,the thickness swelling of coarse and medium-sized particles under wet and oven-dried conditions exhibited notable ***,the demethylated lignin adhesive extracted from *** bark demonstrated similar quality to UF adhesive,with particle size correlating inversely to the strength of the bark particleboard.

关键词： Bark particleboard properties demethylated lignin lignin adhesives Leucaena leucocephala bark particles

Early antiplatelet therapy used for acute ischemic stroke and intracranial hemorrhage

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World Journal of Clinical Cases 2024年第4期12卷 677-680页

作者： Venkata Buddhavarapu Rahul Kashyap salim Surani Department of Medicine Banner Baywood Medical CenterMesaAZ 85206United States Department of Research Wellspan HealthYorkPA 17403United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

In this editorial we comment on the article published by Zhang et al in the recent issue of World Journal of Clinical *** evaluate their claims on the benefit of use of Aspirin in the early management of patients with ischemic *** also comment on their contention of using aspirin in the early management of patients with intracranial hemorrhage,a practice not seen in modern *** clinical trials such as the International Stroke Trial and the Chinese Acute Stroke Trial have shown the benefit of Aspirin use within 48 h of patients with Acute Ischemic *** findings were corroborated in the open-label trial performed by Zhang et al in a smaller sample group of 25 patients where they showed improvement in functional scores at 90 days without an increase in adverse *** such,this intervention is also recommended by the American Heart Association stroke guidelines from *** regard to Intracranial hemorrhage,traditional practice has been to discontinue or avoid antiplatelet therapy in these patient ***,no studies have been done to evaluate this management strategy that is more borne out of the mechanism behind Aspirin’s effect on the coagulation *** et al evaluate the benefits of Aspirin on patients with low-volume intracranial hemorrhage,i.e.,less than 30 mL on computed tomo-graphy imaging,and show no increase in *** caveat of this finding is that all outcomes were pooled into one group for results,and the number of patients was *** more studies with larger patient groups are required,the data from Zhang et al suggests that patients with small-volume intracranial hemorrhages may benefit from Aspirin administration in the acute phase of management.

关键词： Aspirin Ischemic stroke Intracranial hemorrhage CVA Antiplatelet therapy

Investigating causal links between gastroesophageal reflux disease and essential hypertension

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World Journal of Clinical Cases 2024年第14期12卷 2304-2307页

作者： Gowthami Sai Kogilathota Jagirdhar yatinder Bains salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Gastroenterology Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77843United States

Gastroesophageal reflux disease(GERD)is a prevalent global health concern with a rising *** risk factors,including obesity,hiatal hernia,and smo-king,contribute to its *** research suggests associations bet-ween GERD and metabolic syndrome,cardiac diseases,and hypertension(HTN).Mechanisms linking GERD to HTN involve autonomic dysfunction,inflammatory states,and endothelial ***,GERD medications such as pro-ton-pump inhibitors may impact blood pressure ***,antihy-pertensive medications like beta-blockers and calcium channel blockers can exacerbate GERD *** bidirectional causality exists between GERD and HTN,longitudinal studies are warranted to elucidate the precise *** of GERD,including anti-reflux surgery,may positively influence HTN ***,the interplay of lifestyle factors,comorbidities,and medications necessitates further investigation to comprehensively understand this *** this editorial,we comment on the article published by Wei et al in the recent issue of the World Journal of Clinical *** evaluate their claims on the causal association between GERD and HTN.

关键词： Gastroesophageal reflux disease Hypertension Metabolic syndrome Gastro-esophageal reflux disease Hiatal hernia

Removal of intrahepatic bile duct stone could reduce the risk of cholangiocarcinoma

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World Journal of Clinical Cases 2024年第11期12卷 1881-1884页

作者： Gowthami Sai Kogilathota Jagirdhar yatinder Bains salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Gastroenteroly Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77843United States

Hepatolithiasis(HL)poses a significant risk for cholangiocarcinoma(CCA)development,with reported incidences ranging from 5%-13%.Risk factors include older age,smoking,hepatitis B infection,and prolonged HL *** inflammation and mechanical stress on the biliary epithelium contribute to CCA *** reduces CCA risk by removing stones and atrophic liver ***,residual stones and incomplete removal increase CCA *** et al identified carbohydrate antigen 19-9,carcinoembryonic antigen,and stone laterality as CCA risk factors,reaffirming the importance of complete stone ***,challenges remain in preventing CCA recurrence ***-term studies are needed to elucidate CCA risk factors further.

关键词： Hepatolithiasis Cholangiocarcinoma Biliary stone Common bile duct stone Cholangitis

Cancerous cell viability affected by synergism between electric pulses and a low dose of silver nanoparticle:An adaptive neuro-fuzzy inference system

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Medicine in Novel Technology and Devices 2024年第1期21卷 45-52页

作者： salim Mirshahi Behzad Vahedi Kiarash Aryana Ameneh Sazgarnia Department of Mechanical Engineering Sharif University of TechnologyTehranIran Medical Physics Research center Mashhad University of Medical SciencesMashhadIran Functional Neurosurgery Research center Shohada Tajrish Comprehensive Neurosurgical Center of ExcellenceShahid Beheshti University of Medical SciencesTehranIran Department of Mechanical Engineering Ferdowsi University of MashhadMashhadIran

In the current study,applying simultaneously electroporation and silver nanoparticles(SNPs)are ***,one restriction normally assigned to such nanoparticles is their side effects on the vital organs of the *** mitigate such deleterious effects,it is better to use lower dosages of ***,this can result in a decline in the technique's *** compensate for the lower dose of SNPs,one can use secondary method like electroporation to deliver SNPs directly into the cells and reinforces the effect of electric pulses due to the high electrical conductivity of SNPs while having a minimal cytotoxicity effect on normal cells that are not treated with *** the present study,synergism effects of both procedures(SNPs and electroporation)experimentally and theoretically are considered to investigate the property of each technique in increasing the performance with respect to both procedures'*** investigate more,adaptive neuro-fuzzy inference system(ANFIS)is used to predict the percent cell viability of cancerous cells affected by both procedures by considering amplitude and duration as inputs affecting on change of cell viability as an *** results obtained from both experimental and simulation procedures showed that the maximum synergism between nanoparticles and electric pulses was recorded at 700V/cm strength and 100μs ***,Results indicated high correlation between observed and predicted data(r2=0.88).Moreover,the calculated root mean square error for the results of the ANFIS model was equal to *** implies that the model has practical value and can estimate the percent cell viability of cancerous cells influenced by both procedures with varying electric field amplitude and *** method can be proposed for other biophysical or drug delivery applications to save time and resources by utilizing the previous experimental data rather than performing more experiments.

关键词： Electroporation Cancer cell Adaptive neuro-fuzzy inference system Nanoparticle Drug delivery

Investigation of risk factors in the development of recurrent urethral stricture after internal urethrotomy

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World Journal of Clinical Cases 2024年第14期12卷 2324-2331页

作者： Abdullah Gul Ozgur Ekici salim Zengin Deniz Barali Tarik Keskin Department of Urology University of Health SciencesBursa Yüksekİhtisas Education and Research HospitalBursa 16100Türkiye Department of Urology University of Health SciencesBursa City HospitalBursa 16000Türkiye

BACKGROUND Urethral stricture is a condition that often develops with trauma and results in narrowing of the urethral *** endoscopic methods are mostly used in its treatment,it has high recurrence ***,open urethroplasty is recommended after unsuccessful endoscopic *** To investigate the risk factors associated with urethral stricture *** The data of male patients who underwent internal urethrotomy for urethral stricture between January 2017 and January 2023 were retrospectively *** data,comorbidities,preoperative haemogram,and biochemical values obtained from peripheral blood and operative data were *** were divided into two groups in terms of recurrence development;recurrence and *** recorded data were compared between the two *** A total of 303 patients were included in the *** mean age of the patients was 66.6±13.6 *** mean duration of recurrence development was 9.63±9.84(min-max:1-39)months in the recurrence *** did not occur in non-recurrence group throughout the follow-up period with an average time of 44.15±24.07(min-max:12-84)*** the comparison of both groups,the presence of diabetes mellitus(DM),hypertension(HT),and multiple comorbidi-ties were significantly higher in the recurrence(+)group(P=0.038,P=0.012,P=0.013).Blood group,postoperative use of non-steroidal anti-inflammatory drugs,preoperative cystostomy,cause of stricture,iatrogenic cause of stricture,location and length of stricture,indwelling urinary cathater size and day of catheter removal did not differ between the two *** statistically significant difference was observed between the two groups in terms of age,uroflowmetric maximum flow rate value,hemo-gram parameters,aspartate aminotransferase(AST),alanine aminotransferase(ALT),fasting blood sugar,creati-nine,glomerular filtration rate,neutrophil-lymphocyte ratio,platelet-lymphocyte ratio,lymphocyte-

关键词： Inflammation Internal urethrotomy Recurrence Urethral stricture Urethra

Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine

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World Journal of Stem cells 2024年第4期16卷 410-433页

作者： Shafiqa Naeem Rajput Bushra Kiran Naeem Anwar Ali Asmat salim Irfan Khan Dr.Panjwani center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Surgical Unit 4 Dr.Ruth KM Pfau Civil HospitalKarachi 74400Pakistan Department of Physiology University of KarachiKarachi 75270Pakistan center for Regenerative Medicine and Stem cells Research and Department of Ophthalmology and Visual SciencesThe Aga Khan UniversityKarachi 74800SindhPakistan

BACKGROUND Stem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple *** humans,their limited numbers pose a challenge in fulfilling the necessary demands for the regeneration and repair of damaged tissues or *** suggested that mesenchymal stem cells(MSCs),necessary for repair and regeneration via transplantation,require doses ranging from 10 to 400 million ***,the limited expansion of MSCs restricts their therapeutic *** To optimize a novel protocol to achieve qualitative and quantitative expansion of MSCs to reach the targeted number of cells for cellular transplantation and minimize the limitations in stem cell therapy *** Human umbilical cord(hUC)tissue derived MSCs were obtained and *** cultured cells were subjected to the following evaluation pro-cedures:Immunophenotyping,immunocytochemical staining,trilineage differentiation,population doubling time and number,gene expression markers for proliferation,cell cycle progression,senescence-associatedβ-galactosidase assay,human telomerase reverse transcriptase(hTERT)expression,mycoplasma,cytomegalovirus and endotoxin *** Analysis of pluripotent gene markers Oct4,Sox2,and Nanog in recultured hUC-MSC revealed no significant *** immunophenotypic markers CD90,CD73,CD105,CD44,vimentin,CD29,Stro-1,and Lin28 were positively expressed by these recultured expanded MSCs,and were found negative for CD34,CD11b,CD19,CD45,and *** recultured hUC-MSC population continued to expand through passage *** gene expression of Pax6,BMP2,and TGFb1 showed no significant variation between recultured hUC-MSC ***,a significant increase(Pcell cycle was observed in recultured *** senescence markers(hTERT expression andβ-galactosidase activity)did not show any negative effect on recultured hUC-

关键词： Human umbilical cord Mesenchymal stem cells Expansion cell proliferation In vitro expansion Senescence