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World Journal of Cardiology 2016年第12期8卷 695-702页

作者： Emily Cerier Brent C Lampert Arman Kilic Asia McDavid salil v deo Ahmet Kilic Division of Cardiac Surgery The Ohio State University Wexner Medical Center Division of Cardiovascular Medicine the Ohio State University Wexner Medical Center Division of Cardiovascular Surgery Hospital of the University of Pennsylvania Harrington Heart and vascular Institute University HospitalsCase Western Reserve University

Advanced heart failure has been traditionally treated via either heart transplantation,continuous inotropes,consideration for hospice and more recently via left ventricular assist devices(LvAD).Heart transplantation has been limited by organ availability and the futility of other options has thrust LvAD therapy into the mainstream of therapy for end stage heart *** in technology and survival combined with improvements in the quality of life have made LvADs a viable option for many patients suffering from heart *** question of when to implant these devices in those patients with advanced,yet still ambulatory heart failure remains a controversial *** discuss the current state of LvAD therapy and the risk vs benefit of these devices in the treatment of heart failure.

关键词： Left ventricular assist device Mechanical circulatory support Heart failure Cardiomyopathy Diastolic dysfunction

Chronic ischemic mitral valve regurgitation and surgical perspectives

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World Journal of Cardiology 2018年第10期10卷 141-144页

作者： Salah Eldien Altarabsheh salil v deo Abeer Rababa'h Yagthan M Obeidat Osama Haddad Division of Cardiovascular Surgery Queen Alia Heart Institute Division of Cardiovascular Surgery Harrington Heart and Vascular InstituteCase Western Reserve University Department of Clinical Pharmacy Jordan University of Science and Technology Department of Cardiac Surgery AlMana General Hospital Department of Thoracic and Cardiovascular Surgery Cleveland Clinic

Chronic ischemic mitral valve regurgitation is a result of disturbed left ventricular geometry secondary to myocardial ischemia in the absence of intrinsic mitral valve pathology. It is a common complication after myocardial infarction, and patients who have ischemic mitral regurgitation(IMR) have a worse prognosis compared to patients who have ischemic heart disease alone, and this is directly related to the severity of IMR. Medical therapy has limited efficacy, and surgical options including various repair techniques and valve replacement had been tried with variable success. Still there is intense debate among surgeons whether to interfere with moderate degree IMR at the time of coronary artery revascularization.

关键词： Mitral regurgitation Myocardial infarction Ring annuloplasty valve replacement

Liquid injectivity in a SAG foam process:Effect of permeability

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Petroleum Science 2024年第1期21卷 302-314页

作者： Jia-Kun Gong Yuan Wang Ridhwan-Zhafri B.Kamarul Bahrim Raj-deo Tewari Mohammad-Iqbal Mahamad Amir Rouhi Farajzadeh William Rossen College of Mechanics and Materials Hohai UniversityNanjing210098JiangsuChina College of Water Conservancy&Hydropower Engineering Hohai UniversityNanjing210098JiangsuChina PETRONAS Kuala Lumpur50088Malaysia Department of Geoscience and Engineering Delft University of Technology2628 CNDelftthe Netherlands Shell Global Solutions International B.v. 1031 HWAmsterdamthe Netherlands

Foam is utilized in enhanced oil recovery and CO_(2) ***-alternating-gas(SAG)is a preferred approach for placing foam into reservoirs,due to it enhances gas injection and minimizes corrosion in *** previous studies with similar permeability cores show that during SAG injection,several banks occupy the area near the well where fluid exhibits distinct ***,underground reservoirs are heterogeneous,often *** is crucial to understand the effect of permeability on fluid behaviour and injectivity in a SAG *** this work,coreflood experiments are conducted in cores with permeabilities ranging from 16 to 2300 *** observe the same sequence of banks in cores with different ***,the speed at which banks propagate and their overall mobility can vary depending on *** higher permeabilities,the gas-dissolution bank and the forced-imbibition bank progress more rapidly during liquid *** total mobilities of both banks decrease with *** utilizing a bank-propagation model,we scale up our experimental findings and compare them to results obtained using the Peaceman *** findings reveal that the liquid injectivity in a SAG foam process is misestimated by conventional simulators based on the Peaceman *** lower the formation permeability,the greater the error.

关键词： Foam Enhanced oil recovery Surfactant-alternating-gas Injectivity Permeability

Distinct Role of Core Promoter Architecture in Regulation of Light-Mediated Responses in Plant Genes

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Molecular Plant 2014年第4期7卷 626-641页

作者： Rakesh Srivastava Krishan Mohan Rai Meenal Srivastava verandra Kumar Bindu Pandey Sudhir P. Singh Sumit K. Bag Brahma deo Singh Rakesh Tuli Samir v. Sawant Plant Molecular Biology and Genetic Engineering Division CSIR-National Botanical Research Institute Rana Pratap Marg Lucknow-226001 (U.R) India School of Biotechnology Faculty of Science Banaras Hindu University Varanasi India National Agri-Food Biotechnology Institute (DBT) C-127 Industrial Area Phase VIII Mohali India Academy of Scientific & Innovative Research New Delhi India

In the present study, we selected four distinct classes of light-regulated promoters. The light-regulated promoters can be distinctly grouped into either TATA-box-containing or TATA-less （initiator-containing） promoters. Further, using either native promoters or their swapped versions of core promoter elements, we established that TATA-box and Inr （Initiator） elements have distinct mechanisms which are involved in light-mediated regulation, and these elements are not swappable. We identified that mutations in either functional TATA-box or Inr elements lead to the formation of nucleosomal structure. The nucleotide diversity in either the TATA-box or Inr element in Arabidopsis ecotypes proposes that the nucleotide variation in core promoters can alter the gene expression. We show that motif overrepresentation in light-activated promoters encompasses different specific regulatory motifs present downstream of TSS （transcription start site）, and this might serve as a key factor in regulating light promoters which are parallel with these elements. Finally, we conclude that the TATA-box or Inr element does not act in isolation, but our results clearly suggests the probable involvement of other distinct core promoter elements in concurrence with the TATA-box or Inr element to impart selectivity to light-mediated transcription.

关键词： TATA-box initiator element nucleosome cis-regulatory elements nucleotide polymorphism light transcription.

Parametric Study for Replacement of Sand by Fly Ash for Better Packing and Internal Curing

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Open Journal of Civil Engineering 2015年第1期5卷 118-130页

作者： Shirish v. deo Arun D. Pofale Civil Engineering Department National Institute of Technology Raipur Raipur India Civil Engineering Department Visvesvaraya National Institute of Technology Nagpur India

The use of fly ash as replacement of sand is an economical solution for making green and denser concrete. The paper presents a concrete mix design procedure for partial replacement of sand with fly ash. Present method could produce additional compressive and flexural strength for concrete with partial replacement of sand with fly ash over control concrete, with higher slump. Addition of 0.5% super plasticizer could further improve compressive and flexural strength with higher slump over control concrete. Concrete with sand replaced by fly ash was also found to be economical without and with super plasticizer, when cost per N/mm2 was compared. The beneficial effect may be attributed to better packing, pozzolanic activity of fly ash and internal curing by fly ash as partial replacement of sand. Based on experimental results, correlations are developed to predict compressive strength, flexural strength and cost per N/mm2 for percentage sand replacement with fly ash.

关键词： Fly Ash Compressive Strength Flexural Strength Flow Density Internal Curing

Acute Toxicity and Cardio-Respiratory Effects of 2-deoxy-D-Glucose: A Promising Radio Sensitiser

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Biomedical and Environmental Sciences 2006年第2期19卷 96-103页

作者： R.vIJAYARAGHAvAN deo KUMAR SN DUBE R.SINGH KS.PANDEY BC.BAG MP.KAUSHIK K.SEKHAR BS.DWARAKANATH T.RAvINDRANATH Defence Research and Development Establishment Gwalior-474002 Institute of Nuclear Medicine and Allied Sciences Delhi-110054 India

Objective To evaluate the acute toxicity of 2-deoxy-D-glucose （2DG） by oral （p.o.） and intravenous （i.v.） routes, and also the cardio-respiratory effects following high doses of 2DG in animal models. Methods The LD50 of 2DG （in water） was determined in rats and mice by p.o. route and in mice by i.v. route. The effect of 2-DG （250 mg/kg, 500 mg/kg, and 1000 mg/kg, i.v.） was studied on various cardio-respiratory parameters viz., mean arterial blood pressure, heart rate and respiratory rate in anaesthetised rats. The effect of 2DG （500 mg/kg, 1000 mg/kg, and 2000 mg/kg, p.o.） was also studied on various respiratory parameters viz., respiratory rate and tidal volume in conscious rats and mice using a computer program. Results The p.o. LD50 of 2DG was found to be 〉8000 mg/kg in mice and rats, and at this dose no death was observed. The LD50 in mice by i.v. route was found to be 8000 mg/kg. At this dose 2 out of 4 mice died and the death occurred within 6 h. A significant increase in the body weight was observed after p.o. administration of 2DG in rats at 500 mg/kg, 1000 mg/kg, and 2000 mg/kg doses. There was no significant change in the body weight at 4000 mg/kg and 8000 mg/kg by the p.o. route in rats and up to 8000 mg/kg by p.o. as well as i.v. routes in mice. Intravenous administration of 2DG （250 mg/kg, 500 mg/kg, and 1000 mg/kg） in anaesthetised rats showed a time-dependent decrease in the mean arterial blood pressure. There was no change in the heart rate in any of the treatment groups. The tidal volume was not changed significantly by p.o administration in conscious rats, but a significant decrease in the respiratory frequency at 500 mg/kg and 1000 mg/kg doses was observed. In the mice also there was no change in the tidal volume after p.o, administration, but the respiratory frequency decreased significantly at 2000 mg/kg dose. Conclusion 2DG is a safe compound but can cause a fall in the blood pressure and a decrease in respiratory frequency at high doses.

关键词： 2-deoxy-D-glucose Glucose analogue Radio sensitizer Acute toxicity Blood pressure Heart rate Respiration

Bellman—Bihari积出不等式的某些推广

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吉首大学学报(自然科学版) 1981年第1期 71-77页

作者： v.D.Dhongade ,S.G.deo ,常微

由Bellman〔1,P.31〕所得到的不等式出现之后,许多数学家都致力于进一步推广这一不等式,和在数学系统的分析中应用这些不等式.Chandra和Fleishman〔3〕最近的论文给出了这一不等式的各种推广的综合文献目录.这种形式的不等式,特殊地支... 详细信息

由Bellman〔1,P.31〕所得到的不等式出现之后,许多数学家都致力于进一步推广这一不等式,和在数学系统的分析中应用这些不等式.Chandra和Fleishman〔3〕最近的论文给出了这一不等式的各种推广的综合文献目录.这种形式的不等式,特殊地支配着常微分方程和偏微分方程的研究.本文的目的在于得到Bellman—Bihari型积分不等式〔1,2〕的某些进一步推广.

关键词：不等式线性项引理 Bellman Bihari

Tropical forest canopies and their relationships with climate and disturbance： results from a global dataset of consistent field-based measurements

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Forest Ecosystems 2018年第1期5卷 77-90页

作者： marion pfeifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.paine rob marchant andrew burt kim calders colin courtney-mustaphi aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía pieter i.olivier petri pellikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler pantaleo k.t.munishi thomas martin abdul mustari philip j.platts school of natural and environmental sciences newcastle universityUpon TyneNewcastle NE1 7RUUK department of geography and planning university of torontoONCanada land and water commonwealth scientific and industrial research organisationYarralumlaACTAustralia school of mathematical and geospatial sciences rmit universityGPO Box 2476VMelbourneVIC 3001Australia department of biology geologyphysics and inorganic chemistryuniversidad rey juan carlosE-28933 MostolesMadridSpain tropical forest and peopleresearch centre university of the sunshine coastsippy DownsAustralia environment department university of yorkYorkUK flamingo land ltd. MaltonUK the institute of biological and environmental sciences environmental modelling groupuniversity of aberdeenAberdeenUK biological and environmental sciences university of stirlingStirling FK9 4L AUK york institute for tropical ecosystems environment departmentuniversity of yorkYork YO10 5NGUK department of geography university college londonGower StreetLondon WC1E 6BTUK earth observation climate and optical groupnational physical laboratoryHampton RoadTeddingtonMiddlesex TW11 0LWUK department of archaeology and ancient history uppsala universitetP.O.Box 256-751 05 UppsalaSESweden center for macroecology evolution and climateuniversity of copenhagenUniversitetsparken 152100 CopenhagenDKDenmark durrell institute of conservation and ecology(dice) school of anthropology and conservationuniversity of kentCanterbury CT2 7NRUK department of biology college of natural sciencesjimma universityJimmaEthiopia wageningen university&research laboratory of geo-information science and remote sensingDroevendaalsesteeg 36708 PB Wageningenthe Netherlands center for international forestry research(cifor) Situ GedeSindang BarangBogor 16680Indonesia departamento de biología área de botánicauniversidad autónoma de madridcalle Darwin 2-28049 MadridESSpain conservation ecology research unit university of pretoriaHatfieldPretoriaSouth Af

Background： Canopy structure, defined by leaf area index （LAI）, fractional vegetation cover （FCover） and fraction of absorbed photosynthetically active radiation （fAPAR）, regulates a wide range of forest functions and ecosystem services. Spatially consistent field-measurements of canopy structure are however lacking, particularly for the tropics. Methods： Here, we introduce the Global LAI database： a global dataset of field-based canopy structure measurements spanning tropical forests in four continents （Africa, Asia, Australia and the Americas）. We use these measurements to test for climate dependencies within and across continents, and to test for the potential of anthropogenic disturbance and forest protection to modulate those dependences. Results： Using data collected from 887 tropical forest plots, we show that maximum water deficit, defined across the most arid months of the year, is an important predictor of canopy structure, with all three canopy attributes declining significantly with increasing water deficit. Canopy attributes also increase with minimum temperature, and with the protection of forests according to both active （within protected areas） and passive measures （through topography）. Once protection and continent effects are accounted for, other anthropogenic measures （e.g. human population） do not improve the model. Conclusions： We conclude that canopy structure in the tropics is primarily a consequence of forest adaptation to the maximum water deficits historically experienced within a given region. Climate change, and in particular changes in drought regimes may thus affect forest structure and function, but forest protection may offer some resilience against this effect.

关键词： Leaf area index Fractional vegetation cover Fraction of absorbed photosynthetically active radiation,Human population pressure Protected areas Drought Climate change

Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions

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International Journal of Oral Science 2013年第3期5卷 130-140页

作者： Carol L Fischer Katherine S Walters David R Drake Deborah v Dawson Derek R Blanchette Kim A Brogden Philip W Wertz Dows Institute for Dental Research College of Dentistry The University of Iowa Central Microscopy Research Facility College of Dentistry The University of Iowa Department of Endodontics College of Dentistry The University of Iowa Department of Pediatric Dentistry College of Dentistry The University of Iowa Department of Periodontics College of Dentistry The University of Iowa Department of Oral Pathology Radiology & Medicine College of Dentistry The University of Iowa

Oral mucosal and salivary lipids exhibit potent antimicrobial activity for a variety of Gram-positive and Gram-negative bacteria;however,little is known about their spectrum of antimicrobial activity or mechanisms of action against oral *** this study,we examine the activity of two fatty acids and three sphingoid bases against Porphyromonas gingivalis,an important colonizer of the oral cavity implicated in *** inhibitory concentrations,minimal bactericidal concentrations,and kill kinetics revealed variable,but potent,activity of oral mucosal and salivary lipids against ***,indicating that lipid structure may be an important determinant in lipid mechanisms of activity against bacteria,although specific components of bacterial membranes are also likely *** micrographs showed ultrastructural damage induced by sapienic acid and phytosphingosine and confirmed disruption of the bacterial plasma *** information,coupled with the association of treatment lipids with *** lipids revealed via thin layer chromatography,suggests that the plasma membrane is a likely target of lipid antibacterial *** a combination of two-dimensional in-gel electrophoresis and Western blot followed by mass spectroscopy and N-terminus degradation sequencing we also show that treatment with sapienic acid induces upregulation of a set of proteins comprising a unique *** stress response,including proteins important in fatty acid biosynthesis,metabolism and energy production,protein processing,cell adhesion and *** or therapeutic lipid treatments may be beneficial for intervention of infection by supplementing the natural immune function of endogenous lipids on mucosal surfaces.

关键词： antimicrobial lipid fatty acid Porphyromonasgingivalis sphingoid base sphingolipid ultrastructure

印度烤烟种植区土壤肥力和水质评价的判断保护系统

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中国烟草学报 2005年第4期11卷 38-38页

作者： KRISHNAMURTHY v． RAvISANKAR H． deo SINGH K．徐秋萍（译）中央烟草研究所 RajahmundryAndhra Prodesh 533105印度．不详