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Synthesis and spectral studies of macrocyclic Pb(Ⅱ),Zn(Ⅱ),Cd(Ⅱ)and La(Ⅲ) complexes derived from 1,4-bis(3-aminopropoxy)butane with metal nitrate and salicylaldehyde derivatives

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Chinese Chemical Letters 2009年第3期20卷 339-343页

作者： salih Ilhan Hamdi Temel salih pasa Department of Chemistry Faculty of Art and SciencesSiirt UniversitySiirtTurkey Department of Chemistry Faculty of EducationDicle UniversityDiyarbakirTurkey

Eight new macrocyclic complexes were synthesized by template reaction of 1,4-bis（3-aminopropoxy）butane with metal nitrate and 1,3-bis（2-formylphenyl）propane or 1,4-bis（2-formylphenyl）butane and their structures were proposed on the basis of elemental analysis, FTIR, UV-vis, molar conductivity measurements, ^1H NMR and mass spectra. The metals to ligand molar ratios of the complexes were found to be 1： 1. The complexes are 1：2 electrolytes for Pb（II）, Zn（II） and Cd（II） complexes and 1：3 electrolytes for La（III） as shown by their molar conductivities （Am） in DMSO at 10^-3 mol L^-1. Due to the existence of free ions in these complexes, such complexes are electrically conductive. The configurations of La（III） and Pb（II） were proposed to probably octahedral and Zn（II） and Cd（II） complexes were proposed to probably tetrahedral.

关键词： Macrocyclic Schiff base Macrocyclic complexes Salicylaldehyde derivatives 1,4-Bis(3-aminopropoxy)butane

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The synthesis of boronic-imine structured compounds and identification of their anticancer, antimicrobial and antioxidant activities

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Journal of Pharmaceutical Analysis 2016年第1期6卷 39-48页

作者： salih pasa Safa Aydln Sadlk Kalaycl Mehmet Boga Metin Atlan Murat Bingul Fikrettin Sahin Hamdi Temel Science and Technology Research and Application Center Dicle University 21280 Diyarbalar Turkey Department of Genetics and Bioengineering Faculty of Engineering and Architecture Yeditepe University Kayisdagi 34755 lstanbul Turkey Department of Pharmaceutical Chemistry Faculty of Pharmacy Dicle University 21280 Diyarbakir Turkey

Boronic acid compounds with different substituted groups were handled to synthesize various ligands encoded as B1, B2, B3, B4, BS, B6, B7 and BS. B5 and B7 were tested for the cytotoxic activity against the prostate cancer cells and it was found that the cell viability of cancer cells was decreased while most of the healthy cells could still be viable. 5 μM solutions of B5 and B7 decreased the cell viability to 33% and 44%; whereas healthy cells were 71% and 95%, respectively, after treatment. Antimicrobial properties were explored against the bacterial and fungal microorganisms with B1, B5 and BZ The inhibition zones were evaluated for all boronic structures, and the growth inhibition zones were determined in a range of 7-13 mm diameter for different microorganism species. Staphylococcus aureus was the common micro- organism that three boronic compounds with imine ligands showed the activity. Antioxidant features of B2, B3, B4, B5, B6, B7 and B8 were investigated by different processes such as Beta-carotene bleaching （BCB）, 2,2-diphenyl picryl hydrazyl （DPPH）, 2,2″-azino-bis（ 3-ethylbenzothiazoline-6-sulphonic acid）（ABTS） and CUPric reducing antioxidant capacity （CLIPRAC） methods. Significant antioxidant activity was achieved by the phenyl boronic based ligands and these compounds demonstrated as much activity as standards （α-Toc and BHT）. In addition, all structures were applied properly without any decomposition during the experiments. They were rather stable both in aqueous media and solid state.

关键词： Boronic compounds Imine base Anticancer activity Antioxidant Antimicrobial

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