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Assessment of the Quality of Life of Patients with Mycobacterial Pulmonary Diseases

Open Journal of Respiratory Diseases 2022年第2期12卷 56-63页

作者： Khadidia Ouattara Bocar Baya Dianguina Soumaré Tenin Kanouté Mohamed Tolofodie Kafui Komla Gaglo Koudemon salif koné Bassirou Diarra Yaya Sadio Sarro Yacouba Toloba Mamoudou Maiga Pneumology Department CHU Point-G Bamako Mali University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali University Clinical Research Center (UCRC) Bamako Mali

Introduction: Mycobacteria pulmonary diseases are chronic illnesses with various impacts on patients’ health status, and wellbeing. These diseases currently represent a global health issue due to increasing burdens and the lack of new development on therapeutic options. Policies based on the quality of life may help to improve the management of this chronic respiratory disease;this study was designed to assess the quality of life of patients treated for the pulmonary mycobacterial disease. Materials and Methods: Participants diagnosed with a mycobacterial pulmonary disease were selected from the University Clinical Research Centers’ (UCRC) 2019 mycobacterial cohort database. A telephone interview was conducted using the Medical Outcome Study Short Form (SF-36) which has 36 items evaluating physical and mental wellbeing. Scores range from 0 - 100, with higher scores indicating greater Health-related quality of life (HRQOL). Statistical analysis was performed with SPSS 23.0 and the Fisher test was used to compare percentages. A p-value less than 0.05 was considered significant. Results: A total of 26 participants were reached and interviewed by phone. The mean age was 42 ± 10.6 years, and 76.9% (20/26) were male. The most common cause of the mycobacterial pulmonary disease was Mycobacterium tuberculosis, with 84.6% (22/26). Four cases of Non-Tuberculous Mycobacteria (NTM) were diagnosed including one Mycobacterium avium complex strain (MAC). HIV-positive cases were 46.2% (12/26), and the main respiratory sign was cough for all the participants (100%), followed by dyspnea 46.2% (12/26), chest pain 38.5% (10/26). The mean BMI was 19.7 ± 6.9 kg/m2, the mean respiratory rate was 24.7 ± 8.6, and the mean hemoglobin was 11.8 ± 2.2 g/dl. The mean SF-36 score was 75.1 ± 16.6, and impairment was mainly related to mental problems in 59.6%. The mean total score was significantly lower with age more than 42 years than age less than 42 years. But HIV positive and BMI le

关键词： Quality of Life Mycobacteria Lung

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Identifying Risk Factors for Pulmonary Tuberculosis Diagnosis Delays in Mali a West-African Endemic Country

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Journal of Tuberculosis Research 2022年第1期10卷 45-59页

作者： Dianguina Soumare Bocar Baya Khadidia Ouattara Tenin Kanoute Cheick M. Sy Seydou Karembé Ibrahima Guindo Lamine Coulibaly Youssouf Kamian Aime P. Dakouo Fatoumata Sidibe salif koné Drissa kone Oumar Yossi Gaoussou Berthe Yacouba Toloba Service of Pneumology of the University Teaching Hospital of Point-G Bamako Mali University Clinical Research Center (UCRC) University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Non-Government Organization: Sante-Sud Bamako Mali.

Background: Tuberculosis was the deadliest infectious agent before covid-19;1.5 million deaths in 2020. Despite, a variety, of easy and cheap diagnostic tools, detection rates still fall below 90%;diagnosis delays are long exceeding 30 days in many continents. This study aimed to determine risk factors for pulmonary TB diagnosis delays in Mali. Methods: A cross-sectional study was conducted in Bamako to include pulmonary TB patients at treatment initiation centers. Verbal consent was obtained before the interview. Demographics, clinical, treatment cost, and patient, medical, and diagnostic delays were computed using SPSS 25.0 considering a significance level p Results: In total 266 patients were included, 80.8% were male, mean age was 40.5 ± 12 years, primary education level was 50.4%, treatment cost before diagnosis was 100 - 200 thousand CFA in 65.4%, smokers were 42.1%, median patient, medical and total diagnostic delays were 58, 57 and 114 days respectively. Education level below university, social reasons, and non-request of health workers were identified as independent risk factors for diagnostic delay > 100 days in Mali. Conclusion: Diagnostic delay is relatively very long in Mali, there is an urgent need for identification and action to shorten the delays to limit the transmission chain and avoid disabling pulmonary sequels.

关键词： Tuberculosis Diagnosis Delays Risk-Factors Mali

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