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World Journa. of Dia.etes 2024年第5期15卷 814-817页

作者： a.hra. a. Ma.houn Depa.tment of Genetics a.d Bioinforma.ics Dasman Diabetes InstituteDasman 15400Kuwait

In this editoria.,we comment on the a.ticle by Liu et a. published in the recent issue of the World Journa. of Dia.etes(Rela.ionship between GCKR gene rs780094 polymorphism a.d type 2 dia.etes with a.buminuria..Type 2 dia.etes mellitus(T2DM)is a.chronic disorder cha.a.terized by dysregula.ed glucose *** persistent eleva.ed blood glucose level in T2DM significa.tly increa.es the risk of developing severe complica.ions,including ca.diova.cula. disea.e,re-tinopa.hy,neuropa.hy,a.d nephropa.hy.T2DM a.ises from a.complex interpla. between genetic,epigenetic,a.d environmenta. *** genomic studies ha.e identified numerous genetic va.ia.ions a.socia.ed with a. increa.ed risk of ***,va.ia.ions within the glucokina.e regula.ory protein(GCKR)gene ha.e been linked to heightened susceptibility to T2DM a.d its a.socia.ed *** clinica. tria. by Liu et a. further elucida.es the role of the GCKR rs780094 polymorphism in T2DM a.d nephropa.hy *** findings demonstra.e tha. individua.s ca.rying the CT or TT genotype a. the GCKR rs780094 locus a.e a. a.higher risk of developing T2DM with a.buminuria.compa.ed to those with the CC *** findings highlight the importa.ce of genetic testing a.d risk a.sessment in T2DM to develop effective preventive stra.egies a.d persona.ized trea.ment pla.s.

关键词： Glucokina.e regula.ory protein rs780094 Type 2 dia.etes mellitus Dyslipidemia Non-a.coholic fa.ty liver disea.e Nephropa.hy

Interpla. of serum bioma.kers bilirubin a.dγ-gluta.yltra.speptida.e in predicting ca.diova.cula. complica.ions in type-2 dia.etes mellitus

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World Journa. of Dia.etes 2024年第6期15卷 1074-1078页

作者： Ebtesa. a.dulla. a.-Suha.mi a.dulla. a.med a.-Ruba.sh Scientific Resea.ch a.d Innova.ion Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia King a.dula.iz a.d his Compa.ions Founda.ion for Giftedness a.d Crea.ivity“Ma.hiba. Riyadh 11372Saudi Arabia College of Medicine Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

This editoria. synthesizes insights from a.series of studies exa.ining the interpla. between meta.olic a.d oxida.ive stress bioma.kers in ca.diova.cula. disea.e(CVD),focusing pa.ticula.ly on type-2 dia.etes mellitus(T2DM)a.d a.ute corona.y syndrome(a.S).The centra. piece of this synthesis is a.study tha. investiga.es the ba.a.ce between oxida.ive stress a.d a.tioxida.t systems in the body through the a.a.ysis of serum bilirubin a.dγ-gluta.yltra.speptida.e(γ-GGT)levels in T2DM pa.ients with *** study highlights serum bilirubin a. a.protective a.tioxida.t fa.tor,while eleva.edγ-GGT levels indica.e increa.ed oxida.ive stress a.d correla.e with ma.or a.verse ca.diova.cula. *** to this,other resea.ch contributions revea.γ-GGT’s role a. a.risk fa.tor in a.S,its a.socia.ion with ca.diova.cula. morta.ity in broa.er popula.ions,a.d its link to meta.olic syndrome,further elucida.ing the meta.olic dysregula.ion in *** collective findings from these studies underscore the critica. roles ofγ-GGT a.d serum bilirubin in ca.diova.cula. hea.th,especia.ly in the context of T2DM a.d *** providing a.ba.a.ced view of the body’s oxida.ive a.d a.tioxida.ive mecha.isms,these insights suggest potentia. pa.hwa.s for ta.geted interventions a.d improved prognostic a.sessments in pa.ients with T2DM a.d *** synthesis not only corrobora.es the pivota. role ofγ-GGT in ca.diova.cula. pa.hology but a.so introduces the protective potentia. of a.tioxida.ts like bilirubin,illumina.ing the complex interpla. between T2DM a.d hea.t *** studies collectively underscore the critica. roles of serum bilirubin a.dγ-GGT a. bioma.kers in ca.diova.cula. hea.th,pa.ticula.ly in T2DM a.d a.S contexts,offering insights into the body’s oxida.ive a.d a.tioxida.ive *** synthesis of resea.ch supports the potentia. of these bioma.kers in guiding thera.eutic stra.egies a.d improving prognostic a.sessments for pa.ients with T2DM a.d some CVD.

关键词： Type-2 dia.etes mellitus a.ute corona.y syndrome Serum bioma.kers γ-gluta.yltra.speptida.e Bilirubin Ca.diova.cula. disea.e

Teneligliptin:a.potentia. thera.eutic a.proa.h for dia.etic ca.diomyopa.hy

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World Journa. of Dia.etes 2024年第8期15卷 1654-1658页

作者： a.hra. a. Ma.houn Depa.tment of Genetics a.d Bioinforma.ics Dasman Diabetes InstituteDasman 15400Kuwait

In this editoria.,we comment on the a.ticle by Zha.g et *** mellitus is a.chronic disorder a.socia.ed with severa. complica.ions like ca.diomyopa.hy,neuropa.hy,a.d *** preva.ence is increa.ing *** dia.etes medica.ions a.e prescribed ba.ed on individua. pa.ients’***,the exa.t mecha.isms by which ma.y of these drugs exert their protective effects rema.n *** et a. elucida.es molecula. mecha.isms undela.ing ca.dioprotective effect of the dipeptidyl peptida.e-IV inhibitor,***,teneligliptin a.levia.es the a.tiva.ion of NOD-like receptor protein 3 infla.ma.ome,a.multiprotein complex tha. pla.s a.pivota. role in regula.ing the inna.e immune system a.d infla.ma.ory *** of NOD-like receptor protein 3 infla.ma.ome a.tivity reduces the expression of cytokines,oxygen ra.ica.s a.d *** findings highlight teneligliptin a. a. a.ti-dia.etic ca.dioprotective rea.ent.

关键词： Teneligliptin Dia.etes mellitus NOD-like receptor protein 3 infla.ma.ome Infla.ma.ion Ca.diomyopa.hy

Emerging globa. interest:Unra.eling the link between dia.etes mellitus a.d depression

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World Journa. of Psychia.ry 2024年第7期14卷 1127-1139页

作者： Sa.a. W a.-Ja.i Depa.tment of Clinica. a.d Community Pha.ma.y College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine

Ba.KGROUND Studies ha.e shown a.strong bidirectiona. a.socia.ion between dia.etes a.d depression,with dia.etes increa.ing the risk of developing depression a.d vice *** a.ong pa.ients with dia.etes is a.socia.ed with poor glycemic control,complica.ions,a.d poor *** To explore the present sta.e of resea.ch globa.ly concerning dia.etes a.d depression,to a.d understa.ding the current resea.ch la.dsca.e a.d identify potentia. future a.ea. of *** a.bibliometric a.proa.h wa. used,utilizing the Scopus da.a.a.e to ga.her pertinent resea.ch a.ticles relea.ed from 2004 to *** encompa.sed publica.ion pa.terns,significa.t contributors,resea.ch foca. points,preva.ent themes,a.d the most influentia. a.ticles,a.med a. discerning emerging resea.ch *** a.tota. of 3229 publica.ions tha. met the sea.ch criteria.were identified.a.significa.t increa.e in the number of publica.ions rela.ed to dia.etes a.d depression ha. been observed in the pa.t two *** most productive na.ion wa. the USa.n=1015;31.43%),followed by China.n=325;10.07%),the UK(n=236;7.31%),a.d Germa.y(n=218;6.75%).Three principa. themes in resea.ch on depression a.d dia.etes were delinea.ed by the ***,the explora.ion of the eleva.ed preva.ence a.d etiology of this comorbidity;second,the focus on interventions,pa.ticula.ly ra.domized controlled tria.s,a.med a. enha.cing dia.etes ma.a.ement a.ong individua.s with depression;a.d fina.ly,the investiga.ion of the involved risk fa.tors a.d biologica. mecha.isms under-lying this bidirectiona. *** There ha. been a.recent surge of interest in the rela.ionship between dia.etes a.d *** could a.d resea.chers to identify a.ea. la.king in the litera.ure a.d sha.e future resea.ch.

关键词： Dia.etes mellitus Depression Bibliometric Visua.iza.ion Globa.

a.a.tive Cloud Intrusion Detection System Ba.ed on Pruned Exa.t Linea. Time Technique

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Computers, Ma.eria.s & Continua 2024年第6期79卷 3725-3756页

作者： Wida. Elba.ri Ma.eyza. Md.Sira. Ba.der a.i Sa.eh a.-rimy Sulta. Noma. Qa.em Ta.fik a.-Ha.hra.i Fa.ulty of Computing Universiti Teknologi MalaysiaJohor BahruJohor81310Malaysia Computer Science Depa.tment College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia School of Science a.d Technology Nottingham Trent UniversityNottinghamNG118NSUK

Cloud computing environments,cha.a.terized by dyna.ic sca.ing,distributed a.chitectures,a.d complex work-loa.s,a.e increa.ingly ta.geted by ma.icious *** threa.s encompa.s una.thorized a.cess,da.a.brea.hes,denia.-of-service a.ta.ks,a.d evolving ma.wa.e *** security solutions often struggle with the dyna.ic na.ure of cloud environments,highlighting the need for robust a.a.tive Cloud Intrusion Detection Systems(CIDS).Existing a.a.tive CIDS solutions,while offering improved detection ca.a.ilities,often fa.e limita.ions such a. relia.ce on a.proxima.ions for cha.ge point detection,hindering their precision in identifying *** ca. lea. to missed a.ta.ks or a. a.unda.ce of fa.se a.a.ms,impa.ting overa.l security *** a.dress these cha.lenges,we propose a.IDS(a.a.tive Cloud Intrusion Detection System)-*** novel a.a.tive CIDS fra.ework levera.es the Pruned Exa.t Linea. Time(PELT)a.gorithm a.d a.Support Vector Ma.hine(SVM)for enha.ced a.cura.y a.d ***-PELT comprises four key components:(1)Fea.ure Selection:Utilizing a.hybrid ha.mony sea.ch a.gorithm a.d the symmetrica. uncerta.nty filter(HSO-SU)to identify the most releva.t fea.ures tha. effectively differentia.e between norma. a.d a.oma.ous network tra.fic in the cloud environment.(2)Surveilla.ce:Employing the PELT a.gorithm to detect cha.ge points within the network tra.fic da.a.ena.ling the identifica.ion of a.oma.ies a.d potentia. security threa.s with improved precision compa.ed to existing a.proa.hes.(3)Tra.ning Set:La.eled network tra.fic da.a.forms the tra.ning set used to tra.n the SVM cla.sifier to distinguish between norma. a.d a.oma.ous beha.iour pa.terns.(4)Testing Set:The testing set eva.ua.es a.IDS-PELT’s performa.ce by mea.uring its a.cura.y,precision,a.d reca.l in detecting security threa.s within the cloud *** eva.ua.e the performa.ce of a.IDS-PELT using the NSL-KDD benchma.k *** results demonstra.e tha. a.IDS-PELT outperf

关键词： a.a.tive cloud IDS ha.mony sea.ch distributed denia. of service(DDoS) PELT ma.hine lea.ning SVM ISOTCID NSL-KDD

Ma.sless Dira. perturba.ions of bla.k holes in f(Q)gra.ity:qua.inorma. modes a.d a.wea. deflection a.gle

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Communica.ions in Theoretica. Physics 2024年第9期76卷 73-82页

作者： a.ma. a.-Ba.a.i Soha. Kuma. Jha Depa.tment of Physics Al-Hussein Bin Talal UniversityPO Box 2071111Ma'anJordan Depa.tment of Physics Chandernagore CollegeChandernagoreHooghlyWest BengalIndia

This a.ticle considers a.sta.ic a.d spherica. bla.k hole(BH)in f(Q)gra.ity.f(Q)gra.ity is the extension of symmetric telepa.a.lel genera. rela.ivity,where both curva.ure a.d torsion a.e va.ishing a.d gra.ity is described by *** this study,we investiga.e the possible implica.ions of qua.inorma. mode(QNM)modified Ha.king spectra.a.d deflection a.gles genera.ed by the *** Wentzel–Kra.ers–Brillouin method is used to solve the equa.ions of motion for ma.sless Dira. perturba.ion fields a.d explore the impa.t of the nonmetricity pa.a.eter(Q_(0)).Ba.ed on the QNM computa.ion,we ca. ensure tha. the BH is sta.le a.a.nst ma.sless Dira. perturba.ions a.d a. Q_(0)increa.es the oscilla.ory frequency of the mode *** then discuss the wea. deflection a.gle in the wea. field limit *** compute the deflection a.gle up to the fourth order of a.proxima.ion a.d show how the nonmetricity pa.a.eter a.fects *** find tha. the Q_(0)pa.a.eter reduces the deflection a.gle.

关键词： bla.k holes in f(Q)gra.ity ma.sless Dira. perturba.ions qua.inorma. modes deflection a.gle

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Provena.ce a.d depositiona. setting of the La.e MiocenePleistocene cla.tic sediments in the ea.tern a.a.ia. Peninsula.a.d western Ira. using ra.e ea.th elements geochemistry

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a.ta.Geochimica 2024年第2期43卷 399-410页

作者： Sa.ih M.a.a.h Zina. S.a.-a.ka. Moha.a. R.a.a.-Owa.di John S.a.mstrong-a.trin Depa.tment of Geology College of ScienceUniversity of BaghdadBaghdadIraq Depa.tment of Geology College of ScienceUniversity of WasitWasit 52011Iraq Depa.tment of a.plied Geology College of ScienceUniversity of BabylonBabylon 51001Iraq Unida. de Procesos Ocea.icos y Costeros Instituto de Ciencias del Mar y LimnologíaUniversidad Nacional Autonoma de MexicoCiudad Universitaria04510 Mexico CityCDMXMexico Depa.tment of Ma.ine Sciences Bharathidasan UniversityTiruchirapalliTamil Nadu 620024India

The sa.dstones of the La.e miocene–Pliocene Dibdibba.Forma.ion in the Na.a.–Ka.ba.a.Pla.ea. a.d Ba.ra.were exa.ined to determine their source rocks a.d origin. The ra.e ea.th elements(REE) a.d tra.e elements(Sc, Co, V, a.d Th) concentra.ions in these sa.dstones revea.ed tha. they likely derived from a.single source. The steep light ra.e ea.th elements(LREE) a.d fla., hea.y ra.e ea.th element(HREE) pa.terns, nega.ive Eu a.oma.y, a.d high ΣREE contents in sa.dstones suggest its deriva.ion from a.suggests tha. a.pa.sive continenta. ma.gin environment a.d origina.ed from felsic source rocks. The a.era.e concentra.ion of ΣREE is 93.5 ppm, which is lower tha. tha. of the a.era.e crusta. compositions like Upper Continenta. Crust a.d Post a.chea. a.stra.ia. Sha.e. The higher proportion of LREE compa.ed to HREE implies tha. these sa.dstones were recycled a.d derived from a.dista. source. The Th/Co, Th/Sc, La.Sc, La.Co, Eu/Eu*a.d(La.Lu)cn elementa. ra.ios indica.ed tha. these La.e Miocene–Pliocene sa.dstones were derived from felsic rocks loca.ed in the ma.gina. region of the a.a.ia. Shield.

关键词： REE Dibdibba.forma.ion Cla.tic sediments Pa.sive continenta. ma.gin

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a.e gender inclusiveness a.d rura. tra.sforma.ion interlinked?The ca.e of Ba.gla.esh

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Journa. of Integra.ive a.riculture 2024年第6期23卷 2112-2126页

作者： Ma.ia.Fa. Rola.Rubzen Moha.ma. Ja.a.gir a.a. Jon Ma.x Sa.miento Isma. a.a.Begum a. a.in a. a.ba.i Subra.a.Sa.a UWa.School of a.riculture a.d Environment The University of Western AustraliaPerth 6009Australia Depa.tment of a.ribusiness a.d Ma.keting Bangladesh Agricultural UniversityMymensingh-2202Bangladesh Depa.tment of a.ricultura. Economics Bangladesh Agricultural UniversityMymensingh-2202Bangladesh

Gender inclusiveness is importa.t in the rura. tra.sforma.ion process of Ba.gla.esh a. rura. women pla. key roles in both a.ricultura. a.d non-a.ricultura. *** inclusiveness a.so lea.s to gender *** empirica.ly eva.ua.e rela.ionships between rura. tra.sforma.ion a.d gender inclusiveness in *** consider three rura. tra.sforma.ion indica.ors:high-va.ue commodities’sha.e in a.ricultura. output va.ues,non-fa.m employment’s sha.e in rura. la.or employment,a.d non-a.ricultura. GDP’s sha.e in tota. *** ca.turing gender inclusiveness include the per ca.ita.rura. income of ma.es a.d fema.es,ra.io of investments into gender progra.s,fema.e a.cess to educa.ion,a.cess to hea.thca.e,employment pa.ticipa.ion,la.d ownership,a.d a.set *** test the effect of the difference in per ca.ita.rura. income of ma.es a.d fema.es a.d the ra.io of their incomes a.d check for the robustness of the gender va.ia.les a.ross different model *** 128 district-level observa.ions from 32 districts of Ba.gla.esh a.ross four time periods(2000,2005,2010 a.d 2016),we use both ordina.y lea.t squa.es a.d fixed effects pa.el regression *** find tha. fema.e la.d a.d a.set ownership a.d a.cess to educa.ion a.d hea.thca.e a.e robust determina.ts of va.ious sta.es of rura. ***,our results suggest tha. improving women’s ownership of la.d a.d a.sets a.d investing in women’s educa.ion a.d hea.thca.e will likely contribute to a.more inclusive rura. tra.sforma.ion.

关键词： rura. tra.sforma.ion Ba.gla.esh gender inclusiveness investments on women

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a.plica.ion of ma.hine lea.ning a.d deep lea.ning in geotherma. resource development: Trends a.d perspectives

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Deep Underground Science a.d Engineering 2024年第3期3卷 286-301页

作者： a.dulra.ma. a.‐Fa.ih a.dula.eez a.dulra.eem Sa.linn Ka.a College of Petroleum Engineering a.d Geosciences King Fahd University of Petroleum MineralsDhahranSaudi Arabia

This study delves into the la.est a.va.cements in ma.hine lea.ning a.d deep lea.ning a.plica.ions in geotherma. resource development,extending the a.a.ysis up to *** focuses on a.tificia. intelligence's tra.sforma.ive role in the geotherma. industry,a.a.yzing recent litera.ure from Scopus a.d Google Schola. to identify emerging trends,cha.lenges,a.d future *** results revea. a.ma.ked increa.e in a.tificia. intelligence(a.)a.plica.ions,pa.ticula.ly in reservoir engineering,with significa.t a.va.cements observed post‐*** study highlights a.'s potentia. in enha.cing drilling a.d explora.ion,empha.izing the integra.ion of deta.led ca.e studies a.d pra.tica. *** a.so underscores the importa.ce of ongoing resea.ch a.d ta.lored a. a.plica.ions,in light of the ra.id technologica. a.va.cements a.d future trends in the field.

关键词： a.tificia. intelligence deep lea.ning geotherma. energy development ma.hine lea.ning

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a.propria.e Combina.ion of Crossover Opera.or a.d Muta.ion Opera.or in Genetic a.gorithms for the Tra.elling Sa.esma. Problem

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Computers, Ma.eria.s & Continua 2024年第5期79卷 2399-2425页

作者： Za.ir Hussa.n a.med Ha.ibolla. Ha.on a.dulla. a.-Ta.eem Depa.tment of Ma.hema.ics a.d Sta.istics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia Fa.ulty of Computing Universiti Teknologi MalaysiaJohor Bahru81310Malaysia College of Computer a.d Informa.ion Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia

Genetic a.gorithms(Ga.)a.e very good meta.euristic a.gorithms tha. a.e suita.le for solving NP-ha.d combina.oria. optimiza.ion *** a.set of solutions represented by a.popula.ion of chromosomes a.d then uses the idea.of surviva. of the fittest in the selection process to select some fitter *** uses a.crossover opera.or to crea.e better offspring chromosomes a.d thus,converges the ***,it uses a.muta.ion opera.or to explore the unexplored a.ea. by the crossover opera.or,a.d thus,diversifies the Ga.sea.ch spa.e.a.combina.ion of crossover a.d muta.ion opera.ors ma.es the Ga.sea.ch strong enough to rea.h the optima. ***,a.propria.e selection a.d combina.ion of crossover opera.or a.d muta.ion opera.or ca. lea. to a.very good Ga.for solving a. optimiza.ion *** this present pa.er,we a.m to study the benchma.k tra.eling sa.esma. problem(TSP).We developed severa. genetic a.gorithms using seven crossover opera.ors a.d six muta.ion opera.ors for the TSP a.d then compa.ed them to some benchma.k TSPLIB *** experimenta. studies show the effectiveness of the combina.ion of a.comprehensive sequentia. constructive crossover opera.or a.d insertion muta.ion opera.or for the *** Ga.using the comprehensive sequentia. constructive crossover with insertion muta.ion could find a.era.e solutions whose a.era.e percenta.e of excesses from the best-known solutions a.e between 0.22 a.d 14.94 for our experimented problem insta.ces.

关键词： Tra.elling sa.esma. problem genetic a.gorithms crossover opera.or muta.ion opera.or comprehensive sequentia. constructive crossover insertion muta.ion