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血脂水平与心力衰竭风险的关系

中华高血压杂志 2021年第4期29卷 322-322页

作者：刘青(摘译) 练桂丽(审校) Wittenbecher C Eichelmann F Toledo E Guasch-FerréM Ruiz-Canela M Li j Arós F Lee CH Liang L salas-salvadój Clish CB Schulze MB Martínez González Má Hu FB 不详

已知脂质代谢改变与心力衰竭的发生有关,但没有前瞻性研究探讨全面的脂质组学数据和随后发生心力衰竭的风险的关系。该研究旨在将单一脂质代谢产物和脂质组学网络与心力衰竭的发生风险联系起来。方法与结果:该分析基于PREDIMED(prevenci... 详细信息

已知脂质代谢改变与心力衰竭的发生有关,但没有前瞻性研究探讨全面的脂质组学数据和随后发生心力衰竭的风险的关系。该研究旨在将单一脂质代谢产物和脂质组学网络与心力衰竭的发生风险联系起来。方法与结果:该分析基于PREDIMED(prevención con dieta mediterránea)研究中嵌套的病例对照研究(331例心力衰竭病例和按年龄、性别和研究中心匹配的507名对照人群)的216个目标脂质。

关键词：病例对照研究心力衰竭前瞻性研究脂质代谢脂质组学血脂水平

地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系

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中华高血压杂志 2017年第12期25卷 1108-1108页

作者：黄洁叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra j Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA salas-salvadó j

血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。

关键词：心血管病膳食干预代谢物地中海胆碱风险血浆通路

Chiral Symmetry Breaking for Fermions Charged under Large Lie Groups

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Communications in Theoretical Physics 2019年第4期71卷 410-416页

作者： Felipe j.Llanes-Estrada Alexandre salas-Bernardez Depto.Fisica Teorica Universidad Complutense de Madrid

We reexamine the dynamical generation of mass for fermions charged under various Lie groups with equal charge and mass at a high Grand Uni?cation scale, extending the Renormalization Group Equations in the perturbativ... 详细信息

关键词： standard model group running fermion mass grand unification scale

SMEFT is falsifiable through multi-Higgs measurements(even in the absence of new light particles)

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Communications in Theoretical Physics 2023年第9期75卷 69-74页

作者： Raquel Gómez-Ambrosio Felipe j Llanes-Estrada Alexandre salas-Bernárdez juan j Sanz-Cillero Dipartimento di Fisica Univ.di Torinoand INFNSezione di TorinoVia P.Giuria 1Torino10125Italy 2Univ.Complutense de MadridDept.Fisica Teorica and IPARCOSPlaza de las Ciencias 1Madrid28040Spain

By embedding the Standard Model effective field theory(SMEFT) in the more general Higgs effective field theory(HEFT), we expose correlations among the coefficients of the latter that, if found to be violated in future data, would lead to the experimental falsification of the SMEFT framework. These are derived from the necessary symmetric point of HEFT and analyticity of the SMEFT Lagrangian that allows the construction of the SMEFT expansion, as laid out by other groups, and properties at that point of the Higgs-flare function F(h) coupling Goldstone and Higgs bosons, of the Higgs potential V(h) and of the Higgs-top quark coupling function G(h).

关键词： SMEFT HEFT EFT effective field theories electroweak LHC quantum field theories

Mitochondrial DNA as a Risk Factor for False Positives in Case-Control Association Studies

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journal of Genetics and Genomics 2015年第4期42卷 169-172页

作者： Antonio salas joanna L.Elson Unidade de Xenética Instituto de Medicina Legaland Departamento de Anatomía Patolóxica e Ciencias ForensesFacultad de MedicinaUniversidad de Santiago de CompostelaGalicia 15782Spain Mitochondrial Research Group Institute of Genetic MedicineCentre for LifeNewcastle University Centre for Human Metabolomics North-West University

During the last decade, hundreds of studies have been pub- lished examining whether significant associations exist be- tween mitochondrial DNA （mtDNA） variants and/or haplogroups （clades） and particular diseases （generally com- mon/complex diseases）（Fig. 1）. However, several authors have gathered evidence indicating a high incidence of false positive findings in mtDNA case-control association studies. Raule et al. （2007） and Herrnstadt and Howell （2004） showed various problems affecting mtDNA case-control association studies. salas et al.

关键词： DNA Mitochondrial DNA as a Risk Factor for False Positives in Case-Control Association Studies

Analysing changes in spatial point patterns:A proposal using data from a forest thinning experiment

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Forest Ecosystems 2022年第6期9卷 878-887页

作者： Christian salas-Eljatib joaquín Riquelme-Alarcon Pablo j.Donoso Diego Ponce Daniel P.Soto Centro de Modelacion y Monitoreo de Ecosistemas Escuela de Ingeniería ForestalUniversidad MayorSantiagoChile Vicerrectoría de Investigacion y Postgrado Universidad de La FronteraTemucoChile Departamento de Silvicultura y Conservacion de la Naturaleza Universidad de ChileSantiagoChile Instituto de Bosques y Sociedad Universidad Austral de ChileValdiviaChile Corporacion Nacional Forestal ValdiviaChile Departamento de Ciencias Naturales y Tecnología Universidad de AysenCoyhaiqueChile

Spatial patterns reveal critical features at the individual and community ***,how to evaluate changes in spatial characteristics remains largely *** assess spatial changes in spatial point patterns by augmenting current statistical functions and *** fitted functions to describe unmarked and marked(tree size)spatial patterns using data from a large-scale silvicultural experiment in southern ***,we compute the mingling index to represent spatial tree *** proffer the pair correlation function difference before and after treatment to detect changes in the unmarked-point pattern of trees and the semivariogram-ratio to evaluate changes in the marked-point *** research provides a quantitative assessment of a critical aspect of forest heterogeneity:changes in spatial unmarked and marked-point *** proposed approach can be a powerful tool for quantifying the impacts of disturbances and silvicultural treatments on spatial patterns in forest ecosystems.

关键词： Spatial diversity Marked-point process Spatial heterogeneity Conspecific Variable-density thinning Nothofagus

Pitfalls of barcodes in the study of worldwide SARSCoV-2 variation and phylodynamics

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Zoological Research 2021年第1期42卷 87-93页

作者： jacobo Pardo-Seco Alberto Gómez-Carballa Xabier Bello Federico Martinón-Torres Antonio salas Unidade de Xenética Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigación Sanitaria(IDIS)Hospital Clínico Universitario de Santiago(SERGAS)Galicia 15706Spain Genetics Vaccines and Pediatric Infectious Diseases Research Group(GENVIP)Instituto de Investigación Sanitaria de Santiago(IDIS)and Universidad de Santiago de Compostela(USC)Galicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clínico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain

DEAR EDITOR,Analysis of SARS-CoV-2 genome variation using a minimal number of selected informative sites conforming a genetic barcode presents several *** show that purely mathematical procedures for site selection should be supervised by known phylogeny(i)to ensure that solid tree branches are represented instead of mutational hotspots with poor phylogeographic proprieties,and(ii)to avoid phylogenetic *** propose a procedure that prevents information redundancy in site selection by considering the cumulative informativeness of previously selected sites(as a proxy for phylogenetic-based criteria).This procedure demonstrates that,for short barcodes(e.g.,11 sites),there are thousands of informative site combinations that improve previous *** also show that barcodes based on worldwide databases inevitably prioritize variants located at the basal nodes of the phylogeny,such that most representative genomes in these ancestral nodes are no longer in ***,coronavirus phylodynamics cannot be properly captured by universal genomic barcodes because most SARS-CoV-2 variation is generated in geographically restricted areas by the continuous introduction of domestic variants.

关键词： dynamics properly purely

Acute hepatitis with autoimmune features after COVID-19 vaccine:coincidence or vaccine-induced phenomenon?

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Gastroenterology Report 2022年第1期10卷 628-631页

作者： jose M.Pinazo-Bandera Alicia Hernandez-Albujar Ana Isabel Garcia-Salguero Isabel Arranz-salas Raul j.Andrade Mercedes Robles-Diaz Division of Gastroenterology and Hepatology Instituto de Investigacion Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalagaSpain Division of Anatomical Pathology Hospital Universitario Virgen de la VictoriaMalagaSpain Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd) MadridSpain

Introduction Autoimmune diseases result from a breach of immunological self-tolerance and tissue damage by autoreactive T *** acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is characterized by an inflam... 详细信息

关键词： autoimmune vaccine acute

Biogeographical informativeness of Y-STR haplotypes

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Science Bulletin 2019年第19期64卷 1381-1384页

作者： jacobo Pardo-Seco Alberto Gómez-Carballa Xabier Bello Federico Martinón-Torres Antonio salas Unidade de Xenética Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstitutode Investigaciones Sanitarias(IDIS)Hospital Clínico Universitario de Santiago(SERGAS)GaliciaSpain Grupo de Investigación en Genética VacunasInfecciones y Pediatría(GENVIP)Universidade de Santiago de Compostelaand Hospital Clínico Universitario de Santiago(SERGAS)GaliciaSpain

Research on biogeographical ancestry(BGA)is becoming of growing interest in forensic genetics and in the biomedical literature(1)Thus,for instance,the need to predict ethnicity of an unknown suspect based on DNA profiles found at the crime scene is of maximum interest in criminalistics[2],and several autosomal SNP panels have been designed and tested for BGA investigations[3,4].Most of these panels aim at discriminating three main continental groups(sub-Saharan Africans,Europeans,and Asians)by way of testing a number of ancestry informative markers(AIMs)that run from a few dozens to a few hundred[5](see more background in Supplementary data online).

关键词： BGA STR Biogeographical informativeness of Y-STR haplotypes