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Spectrofluorimetric and Spectrophotometric Stability- Iwndicating Methods for the Analysis of Veralipride in Presence of Its Degradants and in Spiked Human Plasma

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Chinese Journal of Chemistry 2012年第1期30卷 183-189页

作者： salama,nahla nour el din ahmed Salem,Maissa Yacoub Abd el Halim,Lobna Mohammed Abdel Fattah,Laila EI-Sayed National Organization for Drug Control and Research(NODCAR) 6 Abu Hazem StreetPyramids AveP.O.Box 29GizaEgypt Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyMisr University for Science and Technology6th of OctoberEgypt

Spectrofluorimetric and spectrophotometric stability-indicating methods were developed and validated for analysis of veralipride （Ver） in presence of its hydrolytic and oxidative degradants. The spectrofluorimetric method was based on direct measurement of the intrinsic fluorescence of Ver at 366 nm after excitation at 299 nm using sodium lauryl sulfate （SLS） as micelle enhancer. The fluorescence intensity plot was linear over the concentration range 1.0-10.0 ***-1. The high sensitivity of the method allowed its successful application to the analysis of Ver in spiked human plasma. Two other methods were developed. They are based on the oxidative coupling reac- tion of Vet with 3-methyl benzothiazolin-2-one hydrazone （MBTH） hydrochloride in presence of ceric ammonium sulphate in an acidic medium. The first method depends on spectrophotometric measurement of the stable green colored oxidative coupling product at 660 nm. The different experimental parameters affecting the reaction were optimized. Linearity range is 10.0--100.0 ~tgomL-1. The second method depends on a fluorescence quenching effect of Vet on the fluorescence of Ce3＋. The difference in fluorescence intensity was measured at 380 nm after excitation at 300 nm. This method is applicable over the concentration ranges 0.25-2.50 pg-mL-1. The methods were validated according to the ICH guidelines. They were successfully applied for the analysis of Ver in drug substance, drug product and in laboratory prepared mixtures containing different percentages of hydrolytic and oxidative degradants.

关键词： veralipride micelle-enhanced fluorescence MBTH validation stability fluorescence quenching Ce3+

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Building Custom Spreadsheet Functions with Python: End-User Software Engineering Approach

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Journal of Software Engineering and Applications 2024年第5期17卷 246-258页

作者： Tamer Bahgat elserwy Atef Tayh nour el-din Raslan Tarek Ali Mervat H. Gheith Department of Software Engineering Faculty of Graduate Studies for Statistical Research (FGSSR) Cairo University Giza Egypt Department of Information Systems Higher Institute of Advanced Studies Giza Egypt

End-user computing empowers non-developers to manage data and applications, enhancing collaboration and efficiency. Spreadsheets, a prime example of end-user programming environments widely used in business for data analysis. However, Excel functionalities have limits compared to dedicated programming languages. This paper addresses this gap by proposing a prototype for integrating Python’s capabilities into Excel through on-premises desktop to build custom spreadsheet functions with Python. This approach overcomes potential latency issues associated with cloud-based solutions. This prototype utilizes Excel-DNA and IronPython. Excel-DNA allows creating custom Python functions that seamlessly integrate with Excel’s calculation engine. IronPython enables the execution of these Python (CSFs) directly within Excel. C# and VSTO add-ins form the core components, facilitating communication between Python and Excel. This approach empowers users with a potentially open-ended set of Python (CSFs) for tasks like mathematical calculations, statistical analysis, and even predictive modeling, all within the familiar Excel interface. This prototype demonstrates smooth integration, allowing users to call Python (CSFs) just like standard Excel functions. This research contributes to enhancing spreadsheet capabilities for end-user programmers by leveraging Python’s power within Excel. Future research could explore expanding data analysis capabilities by expanding the (CSFs) functions for complex calculations, statistical analysis, data manipulation, and even external library integration. The possibility of integrating machine learning models through the (CSFs) functions within the familiar Excel environment.

关键词： End-User Software Engineering Custom Spreadsheet Functions (CSFs)

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Enhancing Data Analysis and Automation: Integrating Python with Microsoft Excel for Non-Programmers

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Journal of Software Engineering and Applications 2024年第6期17卷 530-540页

作者： Osama Magdy Ali Mohamed Breik Tarek Aly Atef Tayh nour el-din Raslan Mervat Gheith Software Engineering Department Faculty of Graduate Studies for Statistical Research Cairo University Giza Egypt

Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.

关键词： Python End-User Approach Microsoft Excel Data Analysis Integration Spreadsheet Programming Data Visualization

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Delayed Grafting as a Valid Technique in Burn Management: Experience from a Burn Unit in Oman

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Modern Plastic Surgery 2024年第1期14卷 9-14页

作者： Taif Alsafy Joe Jacob Anish Thadathil elias ahmed Salah el din Salim Mohammed Ghawas Majid Tariq Saud Albusaidi ahmed Al Jabri Al Anood Al Hadhrami Mutazz Obeid Al Khaldi Moath Abdelhamid Shummo Karim Mohamed Haridi Aml Eid Saleh Said Al-Busaidi Department of Plastic and Reconstructive Surgery Sultan Qaboos Hospital Salalah Oman ENT Department Al Nahdha Hospital Muscat Oman Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Oman

Background: Early excision and grafting has been the preferred method of managing major burns around the world since 1970. Considering the advances in health care and the development of new antibiotics over the past 50 years, delayed grafting as a technique for the management of burns over 15%-20% of total body surface area (TBSA) could have comparable results to that of early excision. This study aims to highlight the outcomes of practicing delayed grafting in burn patients. Methods: A case series analysis was performed of 51 patients who were admitted to the burns unit in Sultan Qaboos Hospital Salalah with over 20% TBSA between January 2014 and December 2019. The patients received prophylactic antibiotics and silver sulphadiazine dressing until the burn eschar had completely separated, followed by grafting. Results: Two patients were lost during the entire duration of the study. The mortality rate was comparable to that of early excision, while the rate of hypertrophic scarring was lower than the range reported by other studies. Conclusion: In the management of patients with over 20% TBSA, delayed grafting after complete separation of eschar is still a valid technique.

关键词： Burns Burn Units Burn Management Delayed Grafting Major Burns Treatment Efficacy

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Impacts of climate change on water quantity, water salinity, food security, and socioeconomy in Egypt

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Water Science and Engineering 2021年第1期14卷 17-27页

作者： Mohie el din Mohamed Omar ahmed Moustafa ahmed Moussa Reinhard Hinkelmann National Water Research Center Fum Ismailiya CanalShoubra El-Kheima 13411Egypt International Center for Agricultural Research in the Dry Areas Cairo 2416Egypt Nile Research Institute(NRI) National Water Research CenterEl-Qanater 13621Egypt Department of Water Engineering Technische Universit€at Berlin(TU Berlin)Campus El GounaEl Gouna 84513Egypt

Climate change might have direct impacts on water quantity in Egypt and lead to indirect effects on Mediterranean saltwater intrusion to groundwater,which exposes agriculture to *** study investigated impacts of climate change on agriculture,with particular regard to food security and socioeconomy,and quantified the effectiveness of cropping pattern adaptation measures by integrating three mathematical *** BlueM model was used for hydrological simulations of Nasser Lake under flooding scenarios to predict the water supply from the High Aswan *** water and salinity balance(WB-SAL)model was adopted to estimate the water salinity in the Nile *** simulated results from the BlueM and WB-SAL models were integrated with the agricultural simulation model for Egypt(ASME)to project cropping patterns,food security,and socioeconomy throughout the *** results showed that future climate change will directly affect the total crop area;crop areas for 13 crop types;the self-sufficiency of wheat,rice,cereal,and maize supplies;and socioeconomic *** proposed cropping pattern adaptation measures focus on fixing the crop areas of rice and orchards and providing half of the population with lentils,maize,onion,vegetables,milk,and *** adaptation measures have the potential to promote food security without causing deterioration of the socioeconomic ***,water availability has much more significant effects on food security and socioeconomy than cropping pattern adaptation measures ***,the country should rationalize water use efficiency and increase water supply.©2021 Hohai *** and hosting by elsevier *** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Climate change Water quantity Salinity Cropping pattern adaptation measures Food security Socioeconomy

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Characterization and Catalytic Activity of New Metal-organic Frameworks Resulted from Self-assembly of Ph3SnCI, K[Cu（CN）2] and Nitrogen Donor Ligands

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Chinese Journal of Chemistry 2011年第7期29卷 1401-1410页

作者： Etaiw, Safaa el-din H. elsherbiny, Abeer S. Badr el-din, ahmed S. Chemistry Department Faculty of Science Tanta University Tanta Egypt

Five new metal-organic frameworks （MOFs） of the general composition [Ph3SnCu（CN）2.L], where L= pyrazine （pyz）（1）, methylpyrazine （mepyz）（2）, 4,4＇-bipyridine （bpy）（3）, trans-l,2-bis（4-pyridyl）ethene （tbpe）（4） or 1,2-bis（4-pyridyl）ethane （bpe）（5）, have been synthesized and characterized to test their potential applications as catalysts. The structures of the MOFs 1--5 mainly consist of Cu（CN）2 building blocks connected by the Ph3Sn cations and the bipodal ligand forming polymeric networks. They exhibit strong fluorescence in the solid state. Also, they are used as heterogeneous catalysts for the degradation of azo-dyes, metanil yellow （MY） by diluted solution of hydrogen peroxide as oxidant. The reaction is first order with respect to MY dye, while the factors affecting the rate constant of the degradation reaction are investigated. The activation parameters of the reaction have been estimated and a possible mechanism has been proposed.

关键词： copper tin heterogeneous catalyst metanil yellow hydrogen peroxide

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Voltage imbalance mitigation in an active distribution network using decentralized current control

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Protection and Control of Modern Power Systems 2023年第2期8卷 68-84页

作者： ahmed M.M.nour ahmed A.Helal Magdi M.el-Saadawi ahmed Y.Hatata Alexandria Higher Institute of Engineering and Technology(AIET) AlexandriaEgypt Department of electrical and Control Engineering Arab Academy for Science and Technology and Maritime TransportAlexandriaEgypt Department of electrical Engineering Faculty of EngineeringMansoura UniversityMansouraEgypt Department of electrical Engineering College of EngineeringShaqra UniversityShaqraKingdom of Saudi Arabia

Voltage imbalance(VI)is caused by the difference in connected single-phase load or generation in a low voltage distribution network(DN).VI increase in a smart distribution grid is due to the current practice of increasing single-phase distributed generators such as photovoltaic(PV)*** paper proposes a decentralized control method to mitigate VI using distributed batteries included in smart grid interfaced residential PV *** mitigate VI using the batteries in this way,five challenges must be overcome,i.e.,equalizing all battery stress currents within the DN,mitigating VI in abnormal conditions such as signal loss among bus controllers,being immune from the distorted feedback measurements,minimizing the steady-state error at different loads,and overcoming the insufficient number or capacity of the distributed batteries at the same *** fuzzy logic controllers(FLC)are proposed at each bus to overcome these five tasks based on a decentralized control *** proposed decentralized control based on FLC is compared with centralized control based on a PI *** proposed control method is tested and verified using simulations in the MATLAB/Simulink software,and the results validate the ability of the scheme to alleviate VI on a smart distribution network under both normal and abnormal conditions.

关键词： Fuzzy controller Distributed batteries Decentralized control Voltage imbalance Distributed PV

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Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression

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World Journal of Gastroenterology 2005年第42期11卷 6624-6630页

作者： Abdel-Rahman N Zekri Mohammed S el-din Ashour ahmed Hassan Hanaa M Alam el-din Amal MR el-Shehaby Maha A Abu-Shady Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Egypt Microbiology Department Faculty of Pharmacy Azhar University Egypt Microbiology and Immunology Department Sohag Faculty of Medicine South Valley University Egypt Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Egypt Biochemistry Department el-Kaser el-Aini School of Medicine Cairo University Egypt

AIM： To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression. METHODS： We measured the cytokine levels of Thl （IL-2 and IL-2R）, Th2 （IL-10） and the pro-inflammatory cytokines （IL-6 and IL-6R and TNF and TNF-RI and II） by the elISA technique in the sera of 33 hepatocellular carcinoma （HCC） patients and 20 chronic liver disease （CLD） patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus（HCV） markers served as controls. RESULTS： Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases. On the other hand, HCV viremia was detected using RT- PCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases. Also bilharziaI-Ab was positive in 55% of HCC cases, 65% of CLD cases and in 70% of asymptomatic carriers （ASC）. HCC patients had significantly higher values of IL- 2R, TNF-RII （P〈0.001）, and TNF-RI （P〉0.05）, but lower TNFα （P〈0.001） and IL-6 （P = 0.032） in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RI and TNF-RII, but lower TNF-α （P〈0.001）. CLD patients had higher IL-2R, TNF-RI, and TNF-RII （P〈0.001） than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RI and TNF-RII, but lower TNF-α （P〈0.001）. IL-10 was higher （though not significantly） in HCC and CLD patients than in symptomatic carriers and non-cancer controls. CONCLUSION： Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R, TNF-RI, and TNF-RII could be used as potential markers.

关键词： Cytokine HCV Genotype-4 Liver disease

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Differential Evolution with Arithmetic Optimization Algorithm Enabled Multi-Hop Routing Protocol

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Computer Systems Science & Engineering 2023年第5期45卷 1759-1773页

作者： Manar ahmed Hamza Haya Mesfer Alshahrani Sami Dhahbi Mohamed K nour Mesfer Al Duhayyim elSayed M.Tag el din Ishfaq Yaseen Abdelwahed Motwakel Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversityAbha62529Saudi Arabia Department of Computer Science College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Computer Science College of Sciences and Humanities-AflajPrince Sattam bin Abdulaziz UniversitySaudi Arabia Department of electrical Engineering Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo11845Egypt

Wireless Sensor Networks(WSN)has evolved into a key technology for ubiquitous living and the domain of interest has remained active in research owing to its extensive range of *** spite of this,it is challenging to design energy-efficient *** routing approaches are leveraged to reduce the utilization of energy and prolonging the lifespan of *** order to solve the restricted energy problem,it is essential to reduce the energy utilization of data,transmitted from the routing protocol and improve network *** this background,the current study proposes a novel Differential Evolution with Arithmetic Optimization Algorithm Enabled Multi-hop Routing Protocol(DEAOA-MHRP)for *** aim of the proposed DEAOA-MHRP model is select the optimal routes to reach the destination in *** accomplish this,DEAOA-MHRP model initially integrates the concepts of Different Evolution(DE)and Arithmetic Optimization Algorithms(AOA)to improve convergence rate and solution ***,the inclusion of DE in traditional AOA helps in overcoming local optima *** addition,the proposed DEAOA-MRP technique derives a fitness function comprising two input variables such as residual energy and *** order to ensure the energy efficient performance of DEAOA-MHRP model,a detailed comparative study was conducted and the results established its superior performance over recent approaches.

关键词： Wireless sensor network routing multihop communication arithmetic optimization algorithm fitness function

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Novel Analytical Thermal Performance Rate Analysis in ZnO-SAE50 Nanolubricant: Nonlinear Mathematical Model

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Computers, Materials & Continua 2021年第4期67卷 477-489页

作者： Adnan Abbasi Umar Khan Naveed ahmed Syed Tauseef Mohyud-din Ilyas Khan el-Sayed M.Sherif Department of Mathematics Mohi-ud-Din Islamic UniversityNerian SharifAJ&K12080Pakistan Department of Mathematics and Statistics Hazara UniversityMansehra21120Pakistan Department of Mathematics HITEC UniversityTaxilaCantt47070Pakistan University of Multan Multan66000Pakistan Department of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh City72915Vietnam Department of Mechanical Engineering College of EngineeringKing Saud UniversityAl-Riyadh11421Saudi Arabia Department of Physical Chemistry Electrochemistry and Corrosion LaboratoryNational Research CentreCairo12622Egypt

The investigation of local thermal transport rate in the nanolubricants is *** lubricants are broadly used in environmental pollution,mechanical engineering and in the paint industry due to high thermal performance ***,thermal transport in ZnO-SAE50 nanolubricant under the impacts of heat generation/absorption is *** colloidal suspension is flowing between parallel stretching disks in which the lower disk is positioned at z=0 and upper disk apart from distance *** problem is transformed in dimensionless version via described similarity *** the next stage,an analytical technique(VPM)is implemented for the solution *** graphical results against multiple flow parameters were furnished over the region of interest and explained *** is imperative to mention that the results are plotted for ZnO-SAE50 and conventional liquid as ***,rapid motion of the fluid is perceived against high Reynolds andγ*** wall shear stresses at the upper end rises for multiple Reynolds andγwhile;decrement is detected at the lower *** significant contribution of an internal heat source is noted for thermal performance rate at the upper ***,the local heat transport rate declines at the lower *** altering Reynolds number,prompt heat transfer rate is gained at the upper disk and increasing behavior of the local heat transport rate is slow at the lower *** the study,it is concluded that the nanolubricants have high thermal ***,such fluids are reliable to use in above stated areas.

关键词： Zno-SAE50 nanolubricant thermal performance local heat transport numerical algorithm skin friction

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