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Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system

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Cellular & Molecular Immunology 2021年第1期18卷 162-170页

作者： Anil K.Singh Mahamudul Haque Kayla O'Sullivan Mukesh Chourasia Madhu M.Ouseph salahuddin ahmed Department of Pharmaceutical Sciences Washington State University College of PharmacySpokaneWAUSA Center for Computational Biology and Bioinformatics Amity Institute of BiotechnologyAmity UniversityNoidaUttar PradeshIndia Department of Pathology Stanford University School of MedicineStanfordCAUSA Division of Rheumatology University of Washington School of MedicineSeattleWAUSA

Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)***,the post-translational mechanisms involved and the role of signaling proteins in this activation are *** the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 ***-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase *** the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 *** MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 *** studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase ***,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 *** of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 *** study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation.

关键词： Monosodium urate crystals Gout TAK1 Ubiquitination 5Z-7-oxozeaenol

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Heat-tolerant maize for rainfed hot,dry environments in the lowland tropics:From breeding to improved seed delivery

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The Crop Journal 2023年第4期11卷 986-1000页

作者： Pervez H.Zaidi Madhumal Thayil Vinayan Sudha K.Nair Prakash H.Kuchanur Ramesh Kumar Shyam Bir Singh Mahendra Prasad Tripathi Ayyanagouda Patil salahuddin ahmed Aamir Hussain Atul Prabhakar Kulkarni Passang Wangmo Mitchell R.Tuinstra Boddupalli M.Prasanna International Maize and Wheat Improvement Center(CIMMYT) Hyderabad 502324India University of Agricultural Sciences Raichur 584104KarnatakaIndia ICAR-Indian Institute of Maize Research Ludhiana 141001BiharIndia National Maize Research Program RampurChitwan 44200Nepal Bangladesh Wheat and Maize Research Institute Dinajpur-5201Bangladesh Maize and Millet Research Institute YusafwalaSahiwal 57000Pakistan Agriculture Research and Development Centre Wengkhar 43001Bhutan Institute of Plant Sciences Purdue UniversityWest LafayetteIN 47906USA International Maize and Wheat Improvement Center(CIMMYT) NairobiKenya

Climate change-induced heat stress combines two challenges:high day-and nighttime temperatures,and physiological water deficit due to demand-side drought caused by increase in vapor-pressure *** is one of the major factors in low productivity of maize in rainfed stress-prone environments in South Asia,affecting a large population of smallholder farmers who depend on maize for their sustenance and *** International Maize and Wheat Improvement Center(CIMMYT)maize program in Asia,in partnership with public-sector maize research institutes and private-sector seed companies in South Asian countries,is implementing an intensive initiative for developing and deploying heat-tolerant maize that combines high yield potential with resilience to heat and drought *** the integration of novel breeding tools and methods,including genomics-assisted breeding,doubled haploidy,fieldbased precision phenotyping,and trait-based selection,new maize germplasm with increased tolerance to heat stress is being developed for the South Asian *** a decade of concerted effort has resulted in the successful development and release of 20 high-yielding heat-tolerant maize hybrids in CIMMYT genetic *** public–private partnerships,eight hybrids are presently being deployed on over 50,000 ha in South Asian countries,including Bangladesh,Bhutan,India,Nepal,and Pakistan.

关键词： Climate change Drought Heat stress Lowland tropics Maize Vapor pressure deficit

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Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts

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Cellular & Molecular Immunology 2022年第10期19卷 1185-1195页

作者： Ruby J.Siegel Anil K.Singh Paul M.Panipinto Farheen S.Shaikh Judy Vinh Sang U.Han H.Mark Kenney Edward M.Schwarz Cynthia S.Crowson Sadik A.Khuder Basil S.Khuder David A.Fox salahuddin ahmed Department of Pharmaceutical Sciences Washington State University College of Pharmacy and Pharmaceutical SciencesSpokaneWAUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Department of Quantitative Health Sciences and Division of Rheumatology Mayo ClinicRochesterMNUSA Department of Medicine and Public Health University of ToledoToledoOHUSA Department of Pathology and Laboratory Medicine Phoenix Children’s HospitalPhoenixAZUSA Department of Medicine Division of Rheumatology and Clinical Autoimmunity Center of ExcellenceUniversity of Michigan Medical SystemAnn ArborMIUSA Division of Rheumatology University of Washington School of MedicineSeattleWAUSA

Extracellular sulfatase-2(Sulf-2)influences receptor-ligand binding and subsequent signaling by chemokines and growth factors,yet Sulf-2 remains unexplored in inflammatory cytokine signaling in the context of rheumatoid arthritis(RA).In the present study,we characterized Sulf-2 expression in RA and investigated its potential role in TNF-α-induced synovial inflammation using primary human RA synovial fibroblasts(RASFs).Sulf-2 expression was significantly higher in serum and synovial tissues from patients with RA and in synovium and serum from hTNFtg *** sequencing analysis of TNF-α-stimulated RASFs showed that Sulf-2 siRNA modulated~2500 genes compared to scrambled *** Pathway Analysis of RNA sequencing data identified Sulf-2 as a primary target in fibroblasts and macrophages in *** blot,ELISA,and qRT‒PCR analyses confirmed that Sulf-2 knockdown reduced the TNF-α-induced expression of ICAM1,VCAM1,CAD11,PDPN,CCL5,CX3CL1,CXCL10,and *** studies identified the protein kinase C-delta(PKCδ)and c-Jun N-terminal kinase(JNK)pathways as key in the TNF-α-mediated induction of proteins related to cellular adhesion and *** of Sulf-2 abrogated TNF-α-induced RASF ***-2 knockdown with siRNA and inhibition by OKN-007 suppressed the TNF-α-induced phosphorylation of PKCδand JNK,thereby suppressing the nuclear translocation and DNA binding activity of the transcription factors AP-1 and NF-κBp65 in human ***,Sulf-2 expression positively correlated with the expression of TNF receptor 1,and coimmunoprecipitation assays demonstrated the binding of these two proteins,suggesting they exhibit crosstalk in TNF-α*** study identified a novel role of Sulf-2 in TNF-αsignaling and the activation of RA synoviocytes,providing the rationale for evaluating the therapeutic targeting of Sulf-2 in preclinical models of RA.

关键词： Sulfatase-2 TNF-α Rheumatoid arthritis Synovial fibroblasts Signal transduction

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Seroconversion of Hepatitis B Vaccine in Young Bangladeshi Children: A Tertiary Centre Experience

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World Journal of Vaccines 2021年第2期11卷 7-18页

作者： salahuddin Mahmud Jahida Gulshan Farhana Tasneem Syed Shafi ahmed Department of Pediatric Gastroenterology Hepatology & Nutrition Bangladesh Institute of Child Health Dhaka Shishu(Children) Hospital Dhaka Bangladesh Institute of Statistical Research and Training University of Dhaka Dhaka Bangladesh Department of Pediatrics BIHS General Hospital Diabetic Association of Bangladesh Dhaka Bangladesh

Background: Hepatitis B virus (HBV) infection is one of the most important global health problems and active immunization is the single most important and effective preventive measure against HBV infection. Several studied show that HBV carrier rate is between 2% - 7% in Bangladesh. Bangladesh introduced hepatitis B vaccination in children through Expanded Program on Immunization (EPI) in 2005 that includes 3 doses which starts from six weeks after birth. Currently booster vaccination is not recommended any more. However, many studies on different countries observed a declined level of HBs-antibody over a period of 3 - 6 years that may even reach to non-protective levels. Objective: To evaluate the status of seroconversion and seroprotection along with non-responders of EPI vaccinated children against HBV and to measure their antibody levels in different age groups. Methods: A cross sectional descriptive study was done in the department of Pediatric Gastroenterology, Hepatology & Nutrition, Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh on 120 cases of EPI vaccinated children enrolled from January-December 2019 while attending the inpatient department without any liver problem. The development of Anti-HBs titre greater than or equal to 10 mIU/mL is considered as protective immunity and any titre less than 10 mIU/mL as non-protective following HBV vaccination. Results: Age of the children was 1 - 12 years with mean age of 5.6 ± 1.7 years and male: female ratio was 1.1:1. Among the children, 56 (46.6%) were from 1 - 5 years age, 36 (30.1%) children from 6 - 10 years age group and 27 (23.3%) children from 11 - 12 years age group. Out of 120 children, presence of Anti-HBs protective titre was in 63 (52.5%) children and non-protective level in 57 (47.5%) children. Among protective level, 34 (60.7%) children were in 1 - 5 years age group, 18 (50.0%) children in 6 - 10 years age group and 11 (39.3%) c

关键词： Hepatitis B Virus Expanded Program on Immunization Immune Response Antibody Titre

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Response of French Bean Cultivars to Plant Spacing Under Agroclimatic Condition of Baffa

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Journal of Northeast Agricultural University(English Edition) 2016年第1期23卷 16-19页

作者： Naveed ahmed Muhammad Razaq Hasnain Alam salahuddin Department of Horticulture University of Agriculture Peshawar Department of Silviculture Northeast Forestry University Department of Bioinformatics and Biotechnology International Islamic University

This experiment was carried out at Mansehra during cropping season of 2013. There were three French bean cultivars and four different plant spacings. The experiment was laid out on a Randomized Complete Block Design （RCBD） with three replications. Different cultivars, plant spacings and their interactions significantly influenced all the parameters studied. Maximum days to flowering （59.33） and seed maturity （97.66） were recorded in cultivar Komal Green grown at 15 cm spacing, while, maximum 100-grain weight （42.20 g） was noted in cultivar Peshawar Local grown at 60 cm spacing. However, maximum fresh pod yield·plant^-1 （109.67 g）, number of seed·pod^-1 （7.99） and seed ***2 （1 4373 kg） were recorded in cultivar Paulista grown at spacing of 45 cm. Whereas, maximum plant height （40.50 cm） was noticed in cultivar Paulista grown at 15 era plant spacing. While, the least number of days to flowering （50.33） and to seed maturity （85.66） were taken by cultivar Paulista grown at 60 cm plant spacing. Likewise, minimum seed yield （311.9 kg·hm^2） was recorded in plants of cultivar Komal Green spaced at 60 cm plant spacing. While, minimum fresh pod weight, plantI （67.00 g） and number of seed·pod^-1 （4.66） were attained in cultivar Peshawar Local grown at 15 cm plant spacing, whereas, minimum plant height （27.59 cm） and 100-grain weight （15.60 g） were recorded for cultivar Komal Green grown at 45 and 15 cm, respectively.

关键词： French bean cultivar plant spacing

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Efﬁciency and safety of sofosbuvir in Bangladeshi children with chronic hepatitis C virus

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iLIVER 2023年第3期2卷 146-150页

作者： salahuddin Mahmud Jahida Gulshan MdBelayet Hossain Madhabi Baidya Rafia Rashid Farhana Tasneem ahmed Rashidul Hasan Tanzila Farhana Mohammed Reaz Mobarak MdJahangir Alam Syed Shafi ahmed Department of Pediatric Gastroenterology Hepatology&NutritionBangladesh Shishu Hospital&InstituteDhakaBangladesh Institute of Statistical Research and Training(ISRT) University of DhakaDhakaBangladesh Department of Pediatric Hematology&Oncology Bangladesh Shishu Hospital&InstituteDhakaBangladesh Department of Pediatric Gastroenterology Dr.M R Khan Shishu Hospital&Institute of Child HealthDhakaBangladesh Department of Pediatrics BIHS General HospitalDiabetic Association of BangladeshDhakaBangladesh Department of Epidemiology&Research Bangladesh Shishu Hospital&InstituteDhakaBangladesh Bangladesh Shishu Hospital&Institute DhakaBangladesh

Background and aims:Currently,treatment with oral direct-acting antivirals is recommended for all hepatitis C virus(HCV)-infected pediatric *** aim of this study was to evaluate the efficacy and safety of sofosbuvir and ribavirin combination ther apy for children and adolescents in Bangladesh who are living with chronic HCV in ***:An experimental study was performed from January 2021 to December *** polymerase chain reaction(PCR)-positive thalassemic children,who were 6–18 years of age,were enrolled by consecutive non-probability *** features were recorded,and investigations were *** patients were initially treated with sofosbuvir(200 mg for 6-to 11-year-olds and 400 mg for 12-to 18-year-olds)and ribavirin(10–15 mg/kg/day)and were assessed clinically on a four-weekly basis,along with liver-function *** total duration of therapy was 24 *** PCR was done at the end of treatment and 12 weeks after the completion of treatment to see the sustained virological ***:There were 26 cases in total,with a mean age of 9.26?2.82 years;14 were males(53.8%),and 12 females(46.2%).Twenty-five(96.15%)patients achieved a sustained virological response,and the end-of-treatment PCR was *** patient(3.85%)was a nonresponder even after 24 weeks of *** medication was well received,with only four patients(15.3%)reporting headaches that were reported ***:The combination of sofosbuvir and ribavirin is effective in treating chronic HCV infection and is not accompanied by any major negative side effects.

关键词： Hepatitis C virus Direct-acting antivirals Sofosbuvir Ribavirin

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Miniaturized Electronically Steerable Parasitic Array Antenna

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Open Journal of Antennas and Propagation 2023年第1期11卷 1-10页

作者： Shafaq Kausar ahmed Kausar Hani Mehrpouyan Muhammad Hadi salahuddin Tariq Department of Electrical and Computer Engineering Boise State University Boise ID USA Arts & Science Division at University of Toronto Toronto Canada School of Engineering Ulster University Belfast United Kingdom Department of Electrical and Computer Engineering University of Texas at Dallas Richardson TX USA

In this article we propose a miniaturized dual-band electronically steerable parasitic array radiator (ESPAR) antenna. The antenna can generate up to two steerable beams. The beam-steering range of the proposed antenna is 360˚ in the azimuth plane. The antenna’s eual-band coverage includes the frequency ranges from 2.3 GHz to 2.53 GHz and from 2.9 GHz to 3.7 GHz. The antenna consists of six folded parasitic monopole elements surrounding an active conical element. The folded monopole element design offers three times lower antenna height than that of the conventional ESPAR antennas. The active element has conical shape and it is larger in length than the parasitic monopole elements, this enables the dual-band operation. Thus, the proposed design is not only smaller than the conventional ESPAR antennas but it also achieves dual-band operation. Despite its compact design, the antenna has a peak gain of 6.3 dBi, which is equivalent to the gain of conventional ESPAR antennas. These characteristics make the antenna a good candidate for next generation communication systems.

关键词： 5G IoT Antenna Phased Array Wifi ESPAR Wireless

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Phytohormone-Induced Resistance against Xanthomonas axonopodisPV. citriin Citrus aurantifolia

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American Journal of Plant Sciences 2017年第5期8卷 1135-1147页

作者： Shahran ahmed Nayem M. salahuddin M. Chowdhury F. M. Aminuzzaman Belal Hossain Sahadat Ali Department of Plant Pathology Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Horticultural Science Technical University of Munich Freising Germany

Citrus canker is a perilous disease caused by Xanthomonas axonopodis pv. citri (Xac) which is hardly manageable. Till now, chemicals used against Xac either proved less effective against the disease or hazardous for environment. In this study, we investigated how phytohormones such as Salicylic acid (SA, 3 mM), Jasmonic acid (JA, 0.3 mM), 3-indolacetonitrile (IAN, 0.6 mM), Nicotinic acid (NA, 5 mM), Folic acid (FA, 0.5 mM) influenced canker disease. Disease severity and lesion diameter were significantly mitigated by exogenous application of these phytohormones compared with water (control) accompanied by the increase of latent period. However, these phytohormones did not show any in vitro antimicrobial properties against Xac. Concomitant with boosted resistance, phytohormones treated leaves showed the higher level of phenyl ammonia lyase (PAL) activity. Besides, total phenolic compounds (TPC) and potassium contents were also higher in phytohormone treated plants compared with control. Phytohormones showed the significant and better performance on disease mitigation than control among which, SA showed the highest performance while JA and INA showed the moderate performance. However, NA and FA showed the lowest performance. This result recommended that application of some phytohormones had elicited some biochemical and physiological events which induced the resistance against Xac.

关键词： Citrus Canker Induce Resistance Phenolic Compounds Phytohormone

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Preoperative Serum Albumin Levels and Postoperative Acute Kidney Injury in Off-Pump Coronary Artery Bypass Surgery: A Single-Center Study in Bangladesh

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World Journal of Cardiovascular Surgery 2024年第8期14卷 131-144页

作者： Ahmad Pear salahuddin Md. Abir Tazim Chowdhury Munama Magdum Dewan Iftakher Reza Chowdhury Nittya Nanda Pal Md. Nahedul Morshed Md. Zafar-Al-Nimari Latifa Nasrin Farooque ahmed Department of Cardiac Surgery National Heart Foundation Hospital and Research Institute (NHFH&RI) Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Dhaka Bangladesh National Institute of Preventive and Social Medicine Dhaka Bangladesh Mother and Child Welfare Center Cumilla Bangladesh

Background: Serum albumin, a vital plasma protein, helps maintain intravascular colloidal osmotic pressure, cardiac output, and renal function. Low preoperative serum albumin is linked to poor outcomes, including acute kidney injury (AKI), after off-pump coronary artery bypass (OPCAB) surgery. This study aimed to assess the relationship between preoperative serum albumin levels and early postoperative renal injury. Methods: This prospective comparative cross-sectional study was conducted from August 2019 to February 2021 at the National Heart Foundation Hospital & Research Institute, Bangladesh. It included 160 adult patients with normal preoperative renal function undergoing OPCAB. Patients were divided into two groups: Group A (serum albumin ≥ 4.0 gm/dl) and Group B (serum albumin Results: Preoperative serum albumin was significantly different between groups (Group A: 4.21 ± 0.05 gm/dl, Group B: 3.69 ± 0.04 gm/dl, p = 0.028). Group B had a higher incidence of hypertension (71.25% vs. 51.25%, p st and 3rd postoperative days were higher in Group B (p th day. Postoperative AKI occurred in 18.75% of Group A and 36.25% of Group B. Multivariate regression indicated that low preoperative serum albumin is an independent risk factor for postoperative AKI (p = 0.012, OR = 1.815, CI: 0.675 - 1.162). Conclusion: Preoperative serum albumin level is a valuable predictor of postoperative renal function. Ensuring high normal serum albumin levels before surgery can help minimize the risk of postoperative AKI.

关键词： Serum Albumin Acute Kidney Injury (AKI) Off-Pump Coronary Artery Bypass Surgery Bangladesh

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Effect of Trimetazidine on Functional Capacity in Patient with Ischaemic Cardiomyopathy (TOFCAPI)

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International Journal of Clinical Medicine 2024年第2期15卷 55-67页

作者： Mohsin ahmed Golam Morshed Mahmood Hasan Khan Md. Arifur Rahman Muhammed Aminur Razzaque Shariful Islam Sayeedur Rahman Khan Chowdhury Md. Kudrat-E-Khuda salahuddin Anis Shiblee Md. Habibur Rahman Department of Cardiology National Institute of Cardiovascular Diseases Dhaka Bangladesh Department of Cardiology Government Employee’s Hospital Dhaka Bangladesh Department of Cardiology Delta Hospital Ltd. Dhaka Bangladesh IPDI Foundation Dhaka Bangladesh

Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.

关键词： Bangladesh Heart Failure Exercise Capacity Trimetazidine Ischaemic Cardiomyopathy

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