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Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1175-1186页

作者： Azza A.Matloub Hadeer A.Aglan Sahar salah Mohamed el Souda Mona elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed Pharmacognosy Department National Research Centre Hormones Department National Research Centre Chemistry of Natural Compounds Department National Research Centre Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group) National Research Centre Therapeutical Chemistry Department National Research Centre Laboratory of Immune and Biomarkers for Infection the Center of Excellence for Advanced SciencesNational Research Centre

Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical ***:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,*** polysaccharide extracts(20 mg/kg *** 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were ***:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,*** polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC ***,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),*** bioactive polysaccharides in HCC induced rats improved the humoral immune *** photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological ***,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/***,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic ***:The pronounced antitumor activi

关键词： Jania rubens Pterocladia capillacea Enteromorpha intestinalis Polysaccharide-protein complexes Anti-tumor activity Anti-angiogenesis

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Assessing the Suitability of Various Physiological Traits to Screen Wheat Genotypes for Salt Tolerance

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Journal of Integrative Plant Biology 2007年第9期49卷 1352-1360页

作者： salah E. EI-Hendawy Yuncai Hu Urs Schmidhalter Chair of Plant Nutrition Technical University Munich D-85350 Freising-Weihenstephan Germany Agronomy Department Faculty of Agriculture Suez Canal University Ismalia Egypt

Success of improving the salt tolerance of genotypes requires effective and reliable screening traits in breeding programs. The objective was to assess the suitability of various physiological traits to screen wheat genotypes for salt tolerance. Thirteen wheat genotypes from Egypt, Germany, Australia and India were grown in soil with two salinity levels （control and 150 mmol/L NaCI） in a greenhouse. The physiological traits （ion contents in leaves and stems, i.e. Na^＋, Cl^-, K^＋, Ca^2＋）, the ratios of K^＋/Na^＋ and Ca^＋/Na^＋ in the leaves and stems, net photosynthesis rate, stomatal conductance, transpiration rate, chlorophyll content （SPAD value）, and leaf water relations, were measured at different growth stages. The physiological traits except for Na^＋ and Cl^- in stems and the leaf transpiration rate at 150 mmol/L NaCI showed a significant genotypic variation, indicating that the traits that have a significant genotypic variation may be possibly used as screening criteria. According to the analysis of linear regression of the scores of the physiological traits against those of grain yield, however, the physiological traits of Ca^2＋ and Ca2^＋/Na^＋ at 45 d and final harvest with the greatest genotypic variation were ranked at the top. From a practical and economic point of view, SPAD value should be considered to be used as screening criteria and/or there is a need to develop a quick and practical approach to determine Ca^2＋ in plant tissues.

关键词： physiological traits salinity screening wheat genotypes.

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Parameter Estimation of a Distributed Hydrological Model Using a Genetic Algorithm

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Open Journal of Modern Hydrology 2016年第3期6卷 151-167页

作者： Jasmin Boisvert Nassir el-Jabi André St-Hilaire salah-Eddine el Adlouni Faculty of Engineering Department of Civil Engineering Université de Moncton Moncton Canada INRS Centre Eau-Terre-Environnement Québec City Canada Department of Mathematics and Statistics Faculty of Sciences Université de Moncton Moncton Canada

Water is a vital resource, and can also sometimes be a destructive force. As such, it is important to manage this resource. The prediction of stream flows is an important component of this management. Hydrological models are very useful in accomplishing this task. The objective of this study is to develop and apply an optimization method useful for calibrating a deterministic model of the daily flows of the Miramichi River watershed (New Brunswick). The model used is the CEQUEAU model. The model is calibrated by applying a genetic algorithm. The Nash-Sutcliffe efficiency criterion, modified to penalize physically unrealistic results, was used as the objective function. The model was calibrated using flow data (1975-2000) from a gauging station on the Southwest Miramichi River (catchment area of 5050 km2), obtaining a Nash-Sutcliffe criterion of 0.83. Model validation was performed using flow data (2001-2009) from the same station (Nash-Sutcliffe criterion value of 0.80). This suggests that the model calibration is sufficiently robust to be used for future predictions. A second model validation was performed using data from three other measuring stations on the same watershed. The model performed well in all three additional locations (Nash-Sutcliffe criterion values of 0.77, 0.76 and 0.74), but was performing less well when applied to smaller sub-basins. Nonetheless, the relatively strong performance of the model suggests that it could be used to predict flows anywhere in the watershed, but caution is suggested for applications in small sub-basins. The performance of the CEQUEAU model was also compared to a simple benchmark model (average of each calendar day). A sensitivity analysis was also performed.

关键词： Hydrological Modeling Genetic Algorithm CEQUEAU Model Beta Function Miramichi River

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Intensive care unit readmission in adult Egyptian patients undergoing living donor liver transplant:A single-centre retrospective cohort study

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World Journal of Hepatology 2022年第6期14卷 1150-1161页

作者： Manar salah Iman Fawzy Montasser Hanaa A el Gendy Alaa A Korraa Gamal M elewa Hany Dabbous Hossam R Mahfouz Mostafa Abdelrahman Mohammed Hisham Goda Mohamed Mohamed Bahaa el-Din Mahmoud el-Meteini Heba A Labib Department of Tropical Medicine Ain Shams Center for Organ TransplantationAin Shams UniversityCairo 11566Egypt Department of Anaesthesia and Critical Care Ain Shams Centre for Organ TransplantationAin Shams UniversityCairo 11566Egypt Department of General Surgery and Liver Transplantation Ain Shams Centre for Organ TransplantationAin Shams UniversityCairo 11566Egypt

BACKGROUND Patients who undergo living donor liver transplantation(LDLT)may suffer complications that require intensive care unit(ICU)*** To identify the incidence,causes,and outcomes of ICU readmission after *** A retrospective cohort study was conducted on patients who underwent *** collected data included patient demographics,preoperative characteristics,intraoperative details;postoperative stay,complications,causes of ICU readmission,and *** were divided into two groups according to ICU readmission after hospital *** factors for ICU readmission were identified in univariate and multivariate *** The present study included 299 ***-one(10.4%)patients were readmitted to the ICU after *** who were readmitted to the ICU were older in age(53.0±5.1 vs 49.4±8.8,P=0.001)and had a significantly higher percentage of women(29%vs 13.4%,P=0.032),diabetics(41.9%vs 24.6%,P=0.039),hypertensives(22.6%vs 6.3%,P=0.006),and renal(6.5%vs 0%,P=0.010)patients as well as a significantly longer initial ICU stay(6 vs 4 d,respectively,Pelp provide optimal care and tailor follow-up to reduce the rate of ICU readmission.

关键词： Intensive care units Liver transplantation Patient readmission Risk factors

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The effect of cryotherapy application before versus after subcutaneous anticoagulant injection on pain intensity and hematoma formation: A quasi-experimental design

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International Journal of Nursing Sciences 2018年第3期5卷 223-229页

作者： Dalia salah el-Deen Naglaa F.A.Youssef Medical-Surgical Nursing Department Faculty of NursingCairo UniversityEgypt Medical-Surgical Nursing Department College of NursingPrincess Nourah bint Abdulrahman UniversityKingdom of Saudi Arabia

Objective:To investigate the effect of cryotherapy application before versus after subcutaneous anticoagulant injection(SCAI)on pain intensity and hematoma ***:A quasi-experimental design was utilized.A convenient sample of 105 adult patients,who were admitted to one of the biggest teaching hospitals in Cairo and receiving SCAI,were recruited over a period of six *** were randomly allocated into three groups:A Control group who received the routine hospital care(G1,n=35)and two intervention group who received cryotherapy for 5-min(G2:cryotherapy applied before SCAI,n=35;G3:cryotherapy applied after SCAI,n=35).Demographic and medical history data sheet,Pain Numeric Rating Scale and Hematoma Formation and Size Assessment Scale were used to collect the ***:The pain intensity among the patients in the two intervention groups(G2:Median=1.0;G3:Median=0)was significantly lower than in the control group(G1,Median=3.0).No significant difference was found between G2 and G3(P=0.728).Applying cryotherapy after SCAI(G3)decreased the frequency of hematoma formation(48hrs=31.4%&72hrs=28.5%)compared to applying it before injection(G2,100%)or not applying it(G1,100%).The size of hematoma in G3 was smaller than that in G2(P<0.01).Conclusion:Applying cryotherapy significantly decreased pain intensity and hematoma occurrence/*** cryotherapy after injection was more effective in preventing hematoma formation and decreasing its size than applying it before injection.

关键词： Anticoagulants Cryotherapy Hematoma Injections Subcutaneous Pain

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Biostratigraphy,Depositional and Diagenetic Processes in Carbonate Rocks from Southern Lebanon:Impact on Porosity and Permeability

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Acta Geologica Sinica(English Edition) 2021年第5期95卷 1668-1683页

作者： Hammad Tariq JANJUHAH Josep SANJUAN Mohammad ALQUDAH Mohamed K.salah Department of Geology American University of BeirutRiad El-SolhBeirut 11072020Lebanon Department of Geology Shaheed Benazir Bhutto UniversitySheringalDir Upper 18050Pakistan Department of Earth and Environmental Sciences Yarmouk UniversityIrbid 21163Jordan

Carbonate rocks contain prolific hydrocarbon reserves all over the world,particularly in the Middle *** exploration and production strategies,it is essential to understand carbonate reservoirs in terms of their internal characteristics,depositional environment,relative age,diagenetic processes and impact on petrophysical *** study has been performed on exposed Cretaceous,Paleocene and Miocene marine carbonate sedimentary sequences in two localities(Maghdoucheh and Qennarit)near the city of Sidon(Southern Lebanon).It represents the first comprehensive study that takes into consideration the carbonate reservoir facies,diagenetic history and reservoir quality in the *** at Maghdoucheh are mainly dominated by limestone beds showing sedimentary structures and erosive bases alternating with microfossil-rich silty marls,related to a shallowing upward sequence in a restricted marine platform *** of benthic foraminifera and mollusks dominate the fossil assemblage extracted from the studied *** microfossil and nannofossil assemblage detected in the Maghdoucheh sections indicates a middle Miocene *** at Qennarit are composed of mudstone/wackestone limestone beds rich in planktonic foraminifera and nannofossils related to open marine *** on the nannofossil content,rocks from Qennarit 1 and 2 are Paleocene and Cretaceous in age,*** main types of microfacies have been identified,i.e.(1)microbioclastic peloidal calcisiltite,(2)pelagic lime mudstone and wackestone with planktonic microfossils,(3)grainstone/packstone with abundant foraminifera and(4)fenestral bindstones,mudstones and packstones with porostromate *** porosity-permeability(poro-perm)analysis of representative samples reveals moderate to good porosity but very low *** is mainly due to the presence of large moldic pores that are isolated in *** diagenetic features are dominated by micritization and dissolut

关键词： lithofacies diagenesis microfossils nannofossils reservoir quality Middle East carbonates

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GIS, Forest Fire Prevention and Risk Matrix in the National Forest of Khoudida, Sidi Bel Abbes, Algeria

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Open Journal of Ecology 2020年第6期10卷 356-369页

作者： Mayssara el Bouhissi salah Eddine Bachir Bouidjra Khé loufi Benabdeli Laboratoire Ecodé veloppement des espaces Universit&#233 Djillali Liabes de Sidi Bel Abbes Sidi Bel Abbes Algeria Laboratoire Gé o-Environnement Universit&#233 Stambouli de Mascara Mascara Algeria

Forest fires in Algeria are ravaging an average of more than 32,000 hectares annually despite the prevention and control plan put in place. They are the most damaging factor of degradation of the forest and weigh heavily on the environment and the local economy. Conventional methods for fire prevention and control are time consuming and are not always reliable in view of the complexity and diversity of forest ecosystems. The main idea behind this study is to use the GIS and remote sensing for the development of a fire risk map of the Khoudida State Forest (Algeria). The approach adopted involves three parameters that control the fire behavior, which are: the top-morphology of the field, the combustibility of the plant cover and hazards. For each factor its correlation with risk was evaluated;the combination of the slope, altitude and exposure parameters in the topo-morphological index and the hazard map made it possible to evaluate the average risk for an area of more than 2132 hectares, 1521 hectares high and only 493 hectares, respectively 51.4%, 36.7% and 11.9%.

关键词： Fire GIS Remote Sensing Vulnerability Forest Hazard Khoudida Risk

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Effect of Catharanthus roseus (Vince rosea) and Turmeric (Curcuma longa) Extracts as Green Corrosion Inhibitors for Mild Steel in 1 M HCl

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Materials Sciences and Applications 2016年第10期7卷 654-671页

作者： Rabab Mohamed Abou Shahba Abd el-Aziz el-Sayed Fouda Azza el-Sayed el-Shenawy Amina salah Mohamed Osman Department of Chemistry Faculty of Science El-Azhar University Nasr city Egypt Department of Chemistry Faculty of Science El-Mansoura University El-Mansoura Egypt

The corrosion inhibition of mild steel by Catharanthus roseus (Vince rosea) and Turmeric (Curcuma longa) extracts as green inhibitors in 1 M HCl solutions has been investigated by using potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), hydrogen evolution measurements and scanning electron microscope (SEM) techniques. Results obtained show that these investigated compounds are good inhibitors and act as mixed type inhibitors. The inhibition efficiencies increase with increasing inhibitor concentration. The SEM results show the formation of protective film on the mild steel surface in the presence of Catharanthus roseus and Turmeric extracts. The results obtained from different tested techniques are in good agreement.

关键词： Catharanthus roseus Extract Turmeric Extracts Mild Steel

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Positive Definite Solutions for the System of Nonlinear Matrix Equations X+ A*Y-nA= I, Y+ B*X-mB= I

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Applied Mathematics 2014年第13期5卷 1977-1987页

作者： salah M. el-Sayed Asmaa M. Al-Dubiban Department of Scientific Computing Faculty of Computers and Informatics Benha University Benha Egypt Faculty of Science and Arts Qassim University Qassim KSA

In this paper, some properties of the positive definite solutions for the nonlinear system of matrix equations X + A*Y-nA = I, Y + B*X-mB = I are derived. As a matter of fact, an effective iterative method to obtain the positive definite solutions of the system is established. These solutions are based on the convergence of monotone sequences of positive definite matrices. Moreover, the necessary and sufficient conditions for the existence of the positive definite solutions are obtained. Finally, some numerical results are given.

关键词： System of Nonlinear Matrix Equations Iterative Methods Monotonic Sequence Positive Definite Matrices

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Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

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World Journal of Gastroenterology 2016年第16期22卷 4168-4182页

作者： Abdel-Rahman Nabawy Zekri Amira salah el-Din Youssef Yasser Mabrouk Bakr Reham Mohamed Gabr Ola Sayed Ahmed Mostafa Hamed elberry Ahmed Mahmoud Mayla Mohamed Abouelhoda Abeer A Bahnassy Molecular Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Systems and Biomedical Engineering Department Faculty of Engineering Cairo University Center for Informatics Sciences Nile University Sheikh Zayed City Pathology Department National Cancer Institute Cairo University

AIM: To develop a mathematical model for the early detection of hepatocellular carcinoma (HCC) with a panel of serum proteins in combination with α-fetoprotein (AFP).METHODS: Serum levels of interleukin (IL)-8, soluble intercellular adhesion molecule-1 (sICAM-1), soluble tumor necrosis factor receptor II (sTNF-RII), proteasome, and β-catenin were measured in 479 subjects categorized into four groups: (1) HCC concurrent with hepatitis C virus (HCV) infection (n = 192); (2) HCV related liver cirrhosis (LC) (n = 96); (3) Chronic hepatitis C (CHC) (n = 96); and (4) Healthy controls (n = 95). The R package and different modules for binary and multi-class classifiers based on generalized linear models were used to model the data. Predictive power was used to evaluate the performance of the model. Receiver operating characteristic curve analysis over pairs of groups was used to identify the best cutoffs differentiating the different ***: We revealed mathematical models, based on a binary classifier, made up of a unique panel of serum proteins that improved the individual performance of AFP in discriminating HCC patients from patients with chronic liver disease either with or without cirrhosis. We discriminated the HCC group from the cirrhotic liver group using a mathematical model (-11.3 + 7.38 × Prot + 0.00108 × sICAM + 0.2574 × β-catenin + 0.01597 × AFP) with a cutoff of 0.6552, which achieved 98.8% specificity and 89.1% sensitivity. For the discrimination of the HCC group from the CHC group, we used a mathematical model [-10.40 + 1.416 × proteasome + 0.002024 × IL + 0.004096 × sICAM-1 + (4.251 × 10-4) × sTNF + 0.02567 × β-catenin + 0.02442 × AFP] with a cutoff 0.744 and achieved 96.8% specificity and 89.7% sensitivity. Additionally, we derived an algorithm, based on a binary classifier, for resolving the multi-class classification

关键词： Mathematical model Hepatocellular carcinoma α -fetoprotein Soluble intercellular adhesion molecule-1 β -catenin Interleukin-8 Soluble tumor necrosis factor receptor II Proteasome

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