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Safety and immunogenicity of a mosaic vaccine booster against omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

Agricultural Sciences（农业科学） 2023年第9期

作者： Nizar salah HéloïseLegendre Pauline Peltier Pain Clara Berger Valentin Nenov Francois Machuron Maxime Briche Phileo by Lesaffre Marcq-en-Baroeul France

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian Yang salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including omicron and its sub-lineages.

关键词： phase neutral spectrum

Predictors of long term survival after hepatic resection for hilar cholangiocarcinoma:A retrospective study of 5-year survivors

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World Journal of Gastrointestinal Surgery 2016年第6期8卷 436-443页

作者： Mohamed Abd El Wahab Ayman El Nakeeb Ehab El Hanafy Ahmad M Sultan Ahmed Elghawalby Waleed Askr Mahmoud Ali Mohamed Abd El Gawad Tarek salah Gastroenterology Surgical Center Mansoura University

AIM:To determine predictors of long term survival after resection of hilar cholangiocarcinoma(HC) by comparing patients surviving > 5 years with those who survived 5 ***:There were 34(14%) long term survivors(5 year ... 详细信息

AIM:To determine predictors of long term survival after resection of hilar cholangiocarcinoma(HC) by comparing patients surviving > 5 years with those who survived ospective study of patients with pathologically proven HC who underwent surgical resection at the Gastroenterology Surgical Center,Mansoura University,Egypt between January 2002 and April *** data of the patients were collected from the medical *** were divided into two groups according to their survival:patients surviving less than 5 years and those who survived > 5 ***:There were 34(14%) long term survivors(5 year survivors) among the 243 *** survivors were younger at diagnosis than those surviving less than 5 years(mean age,50.47 ± 4.45 vs 54.59 ± 4.98,p = 0.001).Gender,clinical presentation,preoperative drainage,preoperative serum bilirubin,albumin and serum glutamic-pyruvic transaminase were similar between the two *** level of CA 19-9 was significantly higher in patients surviving onstrated nine variables to be significantly associated with survival > 5 year,includingyoung age(p = 0.001),serum CA19-9(p = 0.0001),non-cirrhotic liver(p = 0.02),major hepatic resection(p = 0.001),caudate lobe resection(p = 0.006),well differentiated tumour(p = 0.03),lymph node status(0.008),R0 resection margin(p = 0.0001) and early postoperative liver cell failure(p = 0.02).CoNCLUSIoN:Liver status,resection of caudate lobe,lymph node status,R0 resection and CA19-9 were demonstrated to be independent risk factors for long term survival.

关键词： Hilar cholangiocarcinoma hepatic resection caudate lobe resection CA19-9 liver cell failure

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中国中山吉宝盛世湾

世界建筑导报 2019年第1期34卷 116-123页

作者： Gordana Jakimovska Joerg Lonkwitz Adriana Rodriguez ossio Alexander Schramm Alice Yi-Ting Chiu Iris Pastor Caroline Filice Smith Jean Chaussavoine Jun Wang Irina Bogdan Leo Xinyu Li Gilles Greis Alexander Meyers Sam Jia Jun Ren Tamim salah EI Negm Evan Jon Shieh Rafael Carbonero Vicario Tom Roe

吉宝盛世湾项目在我们亚洲工作室的努力下于近期大功告成。由UNStudio亚洲工作室由合伙人HannesPfau执掌领衔。我们亚洲的上海工作室目前有约40名员工,正在进行的监建项目有6个,香港工作室目前有约15名员工,3个监建项目。所有图片均由To... 详细信息

吉宝盛世湾项目在我们亚洲工作室的努力下于近期大功告成。由UNStudio亚洲工作室由合伙人HannesPfau执掌领衔。我们亚洲的上海工作室目前有约40名员工,正在进行的监建项目有6个,香港工作室目前有约15名员工,3个监建项目。所有图片均由TomRoe制作。吉宝湾码头吉宝湾新码头位于中国广东省中山市,座落于西江沿岸。该项目总体规划面积达50,000平方米,包括一个直通西江的码头、一座游艇俱乐部、高端住宅别墅以及海关大楼、桥梁、道路和周边外堤等配套基础设施。吉宝湾码头是中国境内首个,也是唯一个外国移民所有的私营港口。

关键词：中国境内中山市游艇俱乐部工作室海关大楼基础设施码头亚洲

儿童自体干细胞移植第1年内的移植后感染并发症

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 36-36页

作者： Ben salah H. Coze C. Gentet J.C. 郭战宏 Centre Apollo-mêdical 8 R. Apollo-11 cite Mahrajene 1082 Tunis Tunisia

Background.-Studies on the infectious complications postengrafment in pediatr ic stem cell transplantation patients are rare. The aim of this study was to ass ess the incidence, types, outcome and factors affecting late infections. Patient s and methods. -A single-institution retrospective analysis was done of infect ions recorded in the first year following engrafment in children who underwent a utologous stem cell transplantation for solid tumors from January 1991 to Decemb er 2000. A systematic antimicrobial chemoprophylaxis of TMP/SMX was administered . Patients who were at high risk for varicellazona virus infection received prop hylactic acyclovir. Results. -Eighty-four assessable patients were enrolled. F ifty-four patients (64%) underwent autologous peripheral blood stem cell trans plantation and 30 patients (36%) underwent bone marrow transplantation. Forty- nine episodes of infections were documented in 39 patients(46%) of whom 27 pati ents (32%) developed infections after the first 100 days post transplantation. Bacterial septicemia occurred in nine patients of whom four patients had a cathe ter-related septicemia. Twelve patients (14%) developed localized herpes zoste r infection. Local fungal infection occurred in five patients. Infection-relate d death occurred in one patient with non-documented pneumonitis. Univariable an alysis showed a correlation between the CD34+cell dose opment of infections (P =0.04). Patients who did not go into remission after transplantation where at high risk for septicemia (P =0.007)-. Multivariate ana lysis showed that a history of varicella or pretransplant varicella-zona positi vity was the only significant factor for development zoster infection (P =0.01). Conclusion. -our study shows that infections in the first year postengrafment following autologous stem cell transplantation for solid tumors have a good prog nosis and that the use of TMP/SMX should be the single systematic antimicrobial pr

关键词：自体干细胞移植感染并发症实性肿瘤无环鸟苷带状疱疹脓毒症水痘病单中心预后良好骨髓移植

Selected Aspects of Camel Immune System and Immune Responses

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小儿特发性膀胱结石的经皮膀胱穿刺取石术:两个发展中国家的155例经验

open Journal of Veterinary Medicine（兽医学） 2021年第6期

作者： Saeed Y. Al Ramadan Kazem T. Al-Mohammed Salem Ibrahim H. Alshubaith Ahmed M. Al-Ali salah Abohelaika Mohammed S. Moqbel Ahmed M. Alluwaimi

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 32-32页

作者： salah M.A. Holman E. Khan A.M. Toth C. 余晓梅 Department of Urology Medical and Health Science Center University of Debrecen Debrecen 4032 Hungary

Purpose: The aim of this study was to evaluate retrospectively our experience with percutaneous cystolithotomy (PCCL) in children having endemic urinary bladder stones. Methods: Between January 1993 and June 2003, 155 children younger than 14 years underwent PCCL. The patients’ age ranged from 8 months to 14 years (average, 4.5 years). one hundred fifteen patients (74.2% ) were 5 years or younger, 31 patients (20% ) were between 6 and 10 years, and 9 patients (5.8% ) were between 11 and 14 years. There were 153 boys and 2 girls. The stone size ranged from 0.7 to 4 (average, 2.3) cm. The procedure was done under general anesthesia. Dilation of the tract was made under fluoroscopy. The instrument was the adult 26F nephroscope, the same that is used for percutaneous nephrolithotomy. Ultrasound disintegration was needed for stones larger than 1 cm. Suprapubic catheter was left for 24 hours. Urethral catheter was kept for 48 hours. Results: All patients became stonefree. The average operating time was 20 (5- 60) minutes. The average hospital stay was 2.7 (2- 5) days. No any severe intra- or postoperative complication was observed. The nucleus and/or the main component of the stones were ammonium acid urate in 144 patients (93% ). Conclusions: Based on our experience, we can conclude that PCCL is a safe and effective method for treatment of endemic bladder stones in children. It reduces morbidity and hospital stay, and thus the cost of treatment. our series proves the nutritional etiology of the endemic pediatric bladder stones.

关键词：膀胱结石膀胱穿刺尿道扩张超声碎石耻骨上引流管肾石取出术食物性手术器械治疗成本术后并

“一带一路”背景下中非应急防护用纺织品储备合作方式

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毛纺科技 2023年第3期51卷 103-109页

作者：文镱澎宋琨丁雪梅埃苏巴卢·德西约斯法特·伊加德瓦·姆瓦夏吉萨拉赫·埃尔丁·埃拉拉比东华大学服装与艺术设计学院上海200051 东华大学现代服装设计与技术教育部重点实验室上海200051 巴赫达尔大学纺织和时尚技术研究所埃塞尔比亚巴赫达尔1037 莫伊大学制造工业和纺织工程系肯尼亚埃尔多雷特30107 杰济拉大学工业工程与技术学院苏丹瓦德迈达尼2667

应急防护用纺织品储备是保障国家公共卫生安全,提高应对突发事件能力的重要措施。为了解中国和非洲国家应急防护用品储备的发展情况,提高相应的储备能力和应对突发事件能力,通过文献研究、实地调研、访谈、研讨和归纳概括的方法,总结出... 详细信息

应急防护用纺织品储备是保障国家公共卫生安全,提高应对突发事件能力的重要措施。为了解中国和非洲国家应急防护用品储备的发展情况,提高相应的储备能力和应对突发事件能力,通过文献研究、实地调研、访谈、研讨和归纳概括的方法,总结出中国和非洲国家在新冠疫情应急条件下防护用纺织品的储备情况,提出在“一带一路”背景下中非间应急防护用纺织品在实物储备、合同储备和生产能力储备3方面的合作方式。文章建议考虑了中国和非洲国家的资源和优势条件,对中非双方有很大益处。

关键词：防护用纺织品应急储备合作模式一带一路中非

An Inventory of Some Relatively Large Marine Mammals, Reptiles, and Fishes Sighted, Caught, By-Caught, or Stranded in the Mediterranean Coast of the Gaza Strip-Palestine

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open Journal of Ecology 2023年第2期13卷 119-153页

作者： Abdel Fattah N. Abd Rabou Kamal E. Elkahlout Kamal J. Elnabris Adel J. Attallah Jehad Y. salah Mohammed A. Aboutair Waleed M. Thabit Sahar K. Serri Hassan G. Abu Hatab Sameeh M. Awadalah Wajdi M. Saqallah Mokhles S. Alhawajri Tariq K. Al-Sammak Bashar S. Jarayseh Sinaa A. Ababsa Daoud I. Al-Hali Aysha A. Rafeea Doaa S. Ghattas Huda E. Abu Amra Israa M. Jaber Nedal A. Fayyad Ashraf A. Shafei Inas A. Abd Rabou othman A. Abd Rabou Mohammed A. Abd Rabou Mazen T. Abualtayef Mohammed R. Al-Agha Yousif K. Ibrahim Rimel M. Benmessaoud Mourad M. Cherif Hashem A. Madkour Department of Biology and Biotechnology Faculty of Science Islamic University of Gaza Gaza Strip Palestine Department of Marine Sciences Faculty of Science Islamic University of Gaza Gaza Strip Palestine Directorate General of Fisheries Ministry of Agriculture Gaza Strip Palestine Environmental Education Center Beit Jala Palestine Wildlife Documenter and Photographer Kafr Kanna Palestine Qimmah Secondary School Jerusalem Palestine Kamal Al-ohood Primary School for Girls North Gaza Education Directorate Gaza Strip Palestine Department of Biology Faculty of Science Al-Aqsa University Gaza Strip Palestine Department of Nursing and Health Sciences University College of Applied Sciences Gaza Strip Palestine Department of Journalism and Media Islamic University of Gaza Gaza Strip Palestine Department of GIS University College of Applied Sciences Gaza Strip Palestine Department of Environmental Engineering Faculty of Engineering Islamic University of Gaza Gaza Palestine Department of Environment and Earth Sciences Faculty of Science Islamic University of Gaza Gaza Palestine Water and Environment Quality Authority Gaza Strip Palestine National Institute of Agronomy of Tunisia Tunis Tunisia National Institute of Marine Sciences and Technologies (INSTM) La Goulette Port Tunis Tunisia National Institute of oceanography and Fisheries Hurghada Egypt

The Mediterranean Sea is home to an interesting biodiversity. The current cumulative and descriptive study aims to enumerate some relatively large marine mammals, reptiles, and fishes that have been spotted, caught, by-caught, or stranded on the coast of the Gaza Strip, Palestine, which extends about 42 km along the Mediterranean Sea. This 20-year study from 2003 to 2022 relied much on frequent field visits, meetings, and discussions with stakeholders, following local media sites and social media pages, and photography. The study recorded at least 26 giants or relatively large marine organisms on the Mediterranean coast of the Gaza Strip, Palestine. Certainly, the coming years may bring other marine organisms of relatively large sizes. Marine mammals included three species of cetaceans with the Fin Whale (Balaenoptera physalus) being the largest mammal and even the largest animal ever recorded in this study. Marine reptiles included three species of sea turtles, the largest of which is the Leatherback Sea Turtle (Dermochelys coriacea), which is in fact the world’s largest sea turtle. The bony fishes were represented by ten species, the largest of which was the ocean Sunfish (Mola mola), which is the largest bony fish in the world. The cartilaginous fishes included ten species with the largest specimens encountered were the Shortfin Shark (Isurus oxyrinchus), Bluntnose Sixgill Shark (Hexanchus griseus), Scalloped Hammerhead Shark (Sphyrna lewini), and Giant Devil Ray (Mobula mobular). Seabirds were not included in the study. The Alexandria Pompano (Alectis alexandrinus) and the Silver-Cheeked Toadfish (Lagocephalus sceleratus), which are bony fishes, appear to be the relatively smallest marine organisms recorded here. In conclusion, the role of the various parties must be coordinated to ensure the sustainability of human activities and their compatibility with the task of conserving local marine biota, including the gigantic or relatively large ones.

关键词： Mediterranean Sea Marine Biodiversity Marine Mammals Sea Turtles Bony Fishes Cartilaginous Fishes Gaza Strip Palestine

An Inventory of Some Relatively Large Marine Mammals, Reptiles, and Fishes Sighted,Caught, By-Caught, or Stranded in the Mediterranean Coast of the Gaza Strip-Palestine

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