检索结果-南通市图书馆

Decoding the genetic landscape of autism:A comprehensive review

World Journal of Clinical Pediatrics 2024年第3期13卷 98-136页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel salah Bediwy Eman A Bediwy Reem Elbeltagi Department of Pediatric Faculty of MedicineTanta UniversityAlghrabiaTanta 31511Egypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12Bahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonMuharraqBusaiteen 15503Bahrain Department of Pulmonology Faculty of MedicineTanta UniversityAlghrabiaTanta 31527Egypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Internal Medicine Faculty of MedicineTanta UniversityAlgharbiaTanta 31527Egypt Department of Medicine The Royal College of Surgeons in Ireland-BahrainMuharraqBusiateen 15503Bahrain

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental condition characterized by heterogeneous symptoms and genetic *** advancements in genetic and epigenetic research have provided insights into the intricate mechanisms contributing to ASD,influencing both diagnosis and therapeutic *** To explore the genetic architecture of ASD,elucidate mechanistic insights into genetic mutations,and examine gene-environment *** A comprehensive systematic review was conducted,integrating findings from studies on genetic variations,epigenetic mechanisms(such as DNA methylation and histone modifications),and emerging technologies[including Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)-Cas9 and single-cell RNA sequencing].Relevant articles were identified through systematic searches of databases such as PubMed and Google *** Genetic studies have identified numerous risk genes and mutations associated with ASD,yet many cases remain unexplained by known factors,suggesting undiscovered genetic *** insights into how these genetic mutations impact neural development and brain connectivity are still *** modifications,particularly DNA methylation and non-coding RNAs,also play significant roles in ASD *** technologies like CRISPR-Cas9 and advanced bioinformatics are advancing our understanding by enabling precise genetic editing and analysis of complex genomic *** Continued research into the genetic and epigenetic underpinnings of ASD is crucial for developing personalized and effective *** efforts integrating multidisciplinary expertise and international collaborations are essential to address the complexity of ASD and translate genetic discoveries into clinical *** unresolved questions and ethical considerations surrounding genetic research will pave the way for improved diagnostic tools and targ

关键词： Autism spectrum disorder Genetics Epigenetics Clustered Regularly Interspaced Short Palindromic Repeats-Cas9 Gene-environment interactions Personalized medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A seismological evidence for the northwestward movement of Africa with respect to Iberia from shear-wave splitting

引用

Geoscience Frontiers 2012年第5期3卷 681-696页

作者： Mohamed K.salah Geology Department Faculty of Science Tanta UniversityTanta 31527Egypt

Seismic anisotropy and its main features along the convergent boundary between Africa and Iberia are detected through the analysis of teleseismic shear-wave splitting. Waveform data generated by 95 teleseismic events recorded at 17 broadband stations deployed in the western Mediterranean region are used in the present study. although the station coverage is not uniform in the Iberian Peninsula and north- west Africa, significant variations in the fast polarization directions and delay times are observed at stations located at different tectonic domains. Fast polarization directions are oriented predominantly NW-SE at most stations which are close to the plate boundary and in central Iberia; being consistent with the absolute plate motion in the region. In the northern part of the Iberian Peninsula, fast velocity direc- tions are oriented nearly E--W; coincident with previous results. Few stations located slightly north of the plate boundary and to the southeast of lberia show E--W to NE-SW fast velocity directions, which may be related to the alpine Orogeny and the extension direction in lberia. Delay times vary significantly between 0.2 and 1.9 s for individual measurements, reflecting a highly anisotropic structure beneath the recording stations. The relative motion between Africa and lberia represents the main reason for the observed NW-SE orientations of the fast velocity directions. However, different causes of anisotropy have also to be considered to explain the wide range of the splitting pattern observed in the western Mediterranean region. Many geophysical observations such as the low Pn velocity, lower lithospheric Q values, higher heat flow and the presence of high conductive features support the mantle flow in the western Mediterranean, which may contribute and even modify the splitting pattern beneath the studied region.

关键词： Shear-wave splitting Seismic anisotropy Iberian Peninsula Northwest Africa Western Mediterranean

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microphallus early management in infancy saves adulthood sensual life:A comprehensive review

引用

World Journal of Clinical Pediatrics 2024年第2期13卷 16-37页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel salah Bediwy Majed A Shaikh Reem Elbeltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511Egypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Department of Pediatric University Medical CenterSulaiman Al Habib Medical GroupManama 26671Bahrain Department of Medical Microbiology Section and Pathology Salmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12Bahrain Department of Medical Microbiology Section and Pathology Irish Royal College of SurgeonBusaiteen 15503Bahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527Egypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Department of Pulmonology University Medical CenterSulaiman Al Habib Medical GroupManama 26671Bahrain Department of Pediatrics Ibn Al Nafees HospitalManama 54533Bahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503Bahrain

Microphallus/Micropenis is a rare condition with significant physical and psychological implications for affected *** article comprehensively reviews micropenis,its etiology,epidemiology,and various treatment *** conducted a thorough literature review to collect relevant information on micropenis and microphallus,as well as related *** primary databases were PubMed,Medline,and Google *** searched for articles published in English between 2000 and *** analysis included 67 review articles,56 research studies,11 case reports,one guideline,and one *** search terms included"microphallus","micropenis","congenital hypogonadotropic hypogonadism","androgen insensitivity syndrome","pediatric management of micropenis","testosterone therapy",and"psychosocial implications of micropenis".We focused on diagnosing micropenis and related conditions,including hormonal assessments,medical and surgical treatment options,psychosocial and psychological well-being,sexual development of adolescents,and sociocultural influences on men's perceptions of penile ***,we explored parenting and family dynamics in cases of micropenis and disorders of sex development,implications of hormonal treatment in neonates,and studies related to penile augmentation procedures and their *** article highlights the importance of early diagnosis and intervention in addressing the physical and psychological well-being of individuals with *** procedures,such as penile lengthening and girth enhancement,and non-surgical approaches like hormonal therapy are *** significance of psychological support,education,and lifestyle modifications is *** management and comprehensive care are crucial for individuals with micropenis,from infancy to adolescence and beyond.A multidisciplinary approach involving urologists,endocrinologists,and mental health professionals is *** assessment of treatment e

关键词： Microphallus Micropenis Hypogonadism Children Adults Sensual life Testosterone therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of gastrointestinal health in managing children with autism spectrum disorder

引用

World Journal of Clinical Pediatrics 2023年第4期12卷 171-196页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel salah Bediwy Reem Elbeltagi Rawan alhawamdeh Pediatric Department Faculty of MedicineTanta UniversityAlgharbiaTanta 31511Egypt Pediatrics Univeristy Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManamaManama 26671Bahrain Medical Microbiology Section Pathology DepartmentSalmaniya Medical ComplexMinistry of HealthManamaManama 12Bahrain Medical Microbiology Section Pathology DepartmentIrish Royal College of SurgeonBahrainMuharraqBusaiteen 15503Bahrain Pulmonology Department Faculty of MedicineTanta UniversityAlgharbiaTanta 31527Egypt Pulmonology Department University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManamaManama 26671Bahrain Medicine The Royal College of Surgeons in Ireland-BahrainMuharraqBusiateen 15503Bahrain Pediatrics Research and Development DepartmentGenomics Creativity and Play CenterManamaManama 0000Bahrain Pediatrics Research and Development DepartmentSENSORYME Dubai 999041United Arab Emirates

Children with autism spectrum disorders(ASD)or autism are more prone to gastrointestinal(GI)disorders than the general *** disorders can significantly affect their health,learning,and development due to various factors such as genetics,environment,and *** causes of GI disorders in children with ASD can include gut dysbiosis,immune dysfunction,food sensitivities,digestive enzyme deficiencies,and sensory processing *** studies suggest that numerous children with ASD experience GI problems,and effective management is *** autism is typically done through genetic,neurological,functional,and behavioral assessments and observations,while GI tests are not consistently *** GI tests may increase the risk of developing ASD or exacerbating *** GI issues in individuals with ASD can improve their overall well-being,leading to better behavior,cognitive function,and educational *** management can improve digestion,nutrient absorption,and appetite by relieving physical discomfort and *** GI symptoms can improve sleep patterns,increase energy levels,and contribute to a general sense of well-being,ultimately leading to a better quality of life for the individual and improved family *** primary goal of GI interventions is to improve nutritional status,reduce symptom severity,promote a balanced mood,and increase patient independence.

关键词： Gastrointestinal disorders Autism spectrum disorders,Children Gut microbiota Ketogenic diet Gluten-free casein-free diet,Dietary management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

May 2022 acute hepatitis outbreak,is there a role for COVID-19 and other viruses?

引用

World Journal of Hepatology 2023年第3期15卷 364-376页

作者： Reem Elbeltagi Mohammed al-Beltagi Nermin Kamal Saeed Adel salah Bediwy Osama Toema Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511Al GharbiaEgypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain Department of Pathology Microbiology SectionSalmaniya Medical ComplexManama 12Bahrain Department of Microbiology Royal College of Surgeons in Ireland-BahrainBusaiteen 15503MuharraqBahrain Department of Chest Diseases Faculty of MedicineTanta UniversityTanta 31527Al GharbiaEgypt Department of Chest Diseases University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain

There has been an increasing number of reported cases of acute hepatitis of unknown origin in previously healthy children since first reported on March 31,*** clinical syndrome is identified by jaundice and markedly elevated liver enzymes with increased aspartate transaminase and/or alanine aminotransa-minase(greater than 500 IU/L).We conducted an inclusive literature review with respect to acute hepatitis outbreaks in children using the search terms acute hepatitis,outbreak,children,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),coronavirus disease 2019(COVID-19),and *** to the cumulative data presented in four main studies,the median age is 4 years,with a male predominance(1.3:1).Jaundice was the most common clinical manifestation(69%),followed by vomiting(63%),anorexia(52.9%),diarrhea(47.2%),abdominal pain(39%),pyrexia(33.3%),pale stool(30%),and dark urine(30%).Coryza and lethargy were reported in 16.6%,while pruritus was reported in 2%of *** liver failure was observed in 25%of *** exact mechanism of this acute hepatitis outbreak is still not entirely *** and SARS-CoV-2 were detected in a significant number of *** with adenovirus and SARS-CoV-2 could be a possible underlying ***,other possible infections and mechanisms must be considered in the pathogenesis of this *** hepatitis of unknown origin in children has been a serious problem since the start of the COVID-19 pandemic but has not yet been sufficiently *** questions remain regarding the underlying mechanisms leading to acute liver failure in children,and it is likely that extensive future research is needed.

关键词： Acute hepatitis of unknown origin Children Adenovirus SARS-CoV-2 COVID-19 Hepatic failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of adaptive intuitionistic fuzzy controller for synchronisation of uncertain chaotic systems

引用

CAAI Transactions on Intelligence Technology 2020年第4期5卷 237-246页

作者： Mohamed Hamdy salah Helmy Mohamed Magdy Department of Industrial Electronics and Control Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf-32952Egypt Department of Mechatronics Engineering Higher Institute of Engineering and TechnologyEl-Mahalla El-Kobra-31951Egypt

This study presents the synchronisation between two non-linear Lorenz chaotic systems using an adaptive intuitionistic fuzzy controller(AIFC).This problem is solved in the presence of external disturbances and *** classes of Lorenz systems have been formulated one as the master and the other as the *** master and slave systems have different initial *** different initial conditions,both systems *** is called the butterfly effect that rules the behaviour of chaotic *** is chosen as a different method that has not been used before to synchronise the chaotic *** scaling factors of the inputs and the output of the intuitionistic fuzzy controller(IFC)are tuned using the artificial bee colony(ABC)algorithm depending on a specified objective *** IFC stability is studied when it is applied to synchronise the Lorenz *** simulation results achieved to assess the adequacy of the proposed control and to exhibit its dependability to synchronise the Lorenz system.

关键词： function. chaotic specified

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel collapse prediction index for voltage stability analysis and contingency ranking in power systems

引用

Protection and Control of Modern Power Systems 2023年第1期8卷 112-138页

作者： salah Mokred Yifei Wang Tiancong Chen Electrical Engineering Department Southeast UniversityNanjing 210096China Electromechanical Engineering School Zhongyuan Institute of Science and TechnologyZhengzhou 450007China

Voltage instability is a serious phenomenon that can occur in a power system because of critical or stressed *** prevent voltage collapse caused by such instability,accurate voltage collapse prediction is necessary for power system planning and *** paper proposes a novel collapse prediction index(NCPI)to assess the volt-age stability conditions of the power system and the critical conditions of *** effectiveness and applicability of the proposed index are investigated on the IEEE 30-bus and IEEE 118-bus systems and compared with the well-known existing indices(Lmn,FVSI,LQP,NLSI,and VSLI)under several power system operations to validate its practicability and *** study also presents the sensitivity assumptions of existing indices and analyzes their impact on voltage collapse *** application results under intensive case studies prove that the proposed index NCPI adapts to several operating power *** results show the superiority of the proposed index in accurately estimating the maximum load-ability and predicting the critical lines,weak buses,and weak areas in medium and large networks during various power load operations and contingencies.A line interruption or generation unit outage in a power system can also lead to voltage collapse,and this is a contingency in the power *** and generation unit outage contingencies are examined to identify the lines and generators that significantly impact system stability in the event of an *** contingencies are also ranked to identify the most severe outages that significantly cause voltage collapse because of the outage of line or generator.

关键词： Voltage stability indices Voltage collapse NCPI Weak buses and critical lines Maximum load-ability Contingency ranking and analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Generalized Green Correspondence of Graded Modules

引用

Chinese Annals of Mathematics,Series B 2009年第4期30卷 413-420页

作者： salah El-Din S. HUSSEIN Department of Mathematics Faculty of Science Ain Shams University Abasaya-Cairo 11566 Egypt.

The author studies the Green correspondence and quasi-Green correspondence for indecomposable modules over strongly graded rings. The motivation is to investigate the influence of induction and restriction processes o... 详细信息

关键词： Vertices Sources Graded rings Graded modules Green correspondence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Innovative surfactant of Gemini-type for dissolution mitigation of steel in pickling HCl medium

引用

Chinese Journal of Chemical Engineering 2021年第6期34卷 125-133页

作者： Medhat Kamel Mohamed Hegazy salah Rashwan Mohamed El Kotb Department of Chemistry Faculty of ScienceSuez Canal UniversityIsmailia 41522Egypt Egyptian Petroleum Research Institute(EPRI) Nasr CityCairo 11727Egypt

A new surfactant of Gemini-type,N,N'-((phthylbis(oxy))bis(ethane-2,1-diyl))bis(N,N-dimethyldodecan-1-aminium bromide)is prepped&*** dissolution suppression impact of the new compound on steel is performed in 1 mol·L^(-1)HCl environment by means of chemical and electrochemical *** prepared surfactant is an agreeable dissolution inhibitor for *** mitigation efficacy rises with the quantity of the *** surfactant belongs to inhibitors of *** adsorption of the synthesized compound followed the Langmuir's *** negative magnitudes of bothΔG_(ads)^(θ) andΔH^(adsθ)indicate that the adsorption process proceeds from its own accord and *** mechanism of adsorption is elucidated by scanning *** is established that the transfer resistance(R_(ct))value rose,where the value of the phase element(CPE)reduced with the amount of synthesized *** to the experimental data arrived by surface tension measurements,the prepared compound is a powerful active agent at the air/water boundary.

关键词： Innovative Gemini surfactant Synthesis Dissolution mitigation Steel Pickling HCl media

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Upper crustal Poisson's ratio and coda-wave attenuation beneath Eastern Anatolia

引用

Earthquake Engineering and Engineering Vibration 2020年第2期19卷 335-347页

作者： Ufuk Aydin Sakir Sahin Mohamed K.salah Atatürk University Oltu Faculty of Earth SciencesMining EngineeringErzurumTurkey Geophysical Engineering Department SDUEngineering and Architecture FacultyIspartaTurkey Department of Geology American University of BeirutRiad El Solh 11072020BeirutLebanon

The attenuation of seismic waves reflects the elastic nature of the media within which the waves *** this study,we calculate the Coda-Q(Qc),frequency dependence(η),Vp/Vs and Poisson's(υ)ratios by using 2621 vertical component seismograms generated by 987 earthquakes recorded by 13 seismic stations in Eastern Anatolia,and creat a 2-D seismic tomographic Qc model for the *** obtained model provides significant information for exploring the boundaries of adjacent tectonic units within the upper crust and interpreting their dynamic *** 2-D Qc model and the other parameters are consistent with the seismotectonic features of Eastern *** heterogeneous Qc values are observed in the study area dividing it into north-south directed bands of low and high *** highestηvalues were obtained beneath the northwestern and eastern parts of the study ***,high and lowυvalues are obtained in the western and eastern parts of the study area,*** spatial variations in the measured parameters are consistent with many geophysical observations including low Pn velocities,efficient Sn blockage,high heat flow,and widespread *** upper crustal thicknesses and inhomogeneous stress distribution along the East and North Anatolian Fault Zones may also contribute to the observed heterogeneities.

关键词： Coda-Q(Qc) Eastern Anatolia Poisson's ratio(υ) seismotectonics upper crustal structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：