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地中海膳食可降低24h动态血压、空腹血糖及血脂:1年随机临床试验

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中华高血压杂志 2014年第7期22卷 699-699页

作者： Doménech M Roman P Lapetra J García de la Corte FJ sala-vila a de la Torre R Corella D salas-Salvadó J Ruiz-Gutiérrez V Lamuela-Raventós RM Toledo E Estruch R Coca A Ros E 赵狄

地中海膳食（MedDiets）添加橄榄油或坚果，较对照组低脂膳食可减少心血管事件，特别是脑卒中，但其心血管保护机制尚不清楚。研究人员进行随机、平行设计、对照试验研究，评估长达1年添加橄榄油或坚果的地中海膳食对24h动态血压、血糖... 详细信息

地中海膳食（MedDiets）添加橄榄油或坚果，较对照组低脂膳食可减少心血管事件，特别是脑卒中，但其心血管保护机制尚不清楚。研究人员进行随机、平行设计、对照试验研究，评估长达1年添加橄榄油或坚果的地中海膳食对24h动态血压、血糖和血脂的影响。膳食时间随意，

关键词： 24h动态血压随机临床试验低脂膳食空腹血糖地中海血脂心血管事件保护机制

Large-area Analysis of Soil Erosion and Landslides Induced by Rainfall: A Case of Unsaturated Shallow Deposits

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Journal of Mountain Science 2015年第4期12卷 783-796页

作者： CUOMO Sabatino DELLA sala Maria Department of Civil Engineering University of Salerno

Unsaturated shallow soil deposits may be affected by either superficial soil erosion or shallow landslides in adjacent or overlapping source areas and in different seasons when a different soil suction *** triggering analysis of both these processes is a relevant issue for the hazard analysis while the literature mostly provides specific approaches for erosion or for *** paper proposes a largearea analysis for a case study of Southern Italy,consisting of unsaturated shallow deposits of loose pyroclastic(air-fall) volcanic soils that have been repeatedly affected by erosion and landslides in special *** a past catastrophic event, the simulated source areas of shallow landslides are smaller than those observed in the field while the simulated eroded areas with thickness greater than 5cm are comparable with the in-situ evidences, if the analysis takes into account high rainfall intensity and a spatially variable soil cover *** in general, the results of the paper are consistent with the previous literature and also provide a methodological contribution about the application of distinct tools over large *** added value is that the paper shows how the combination of distinct large-area analyses may help with understanding the dominant slope instability *** once this goal is fully achieved, can specific physically-based analyses be confidently performed at detailed scales and for smaller specific areas.

关键词： Soil Erosion Landslide Soil Suction Slope instability mechanism Modelling

Clustering and classification of energy meter data: A comparison analysis of data from individual homes and the aggregated data from multiple homes

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Building Simulation 2021年第1期14卷 103-117页

作者： Juan sala Rongling Li Morten H.Christensen Department of Civil Engineering Technical University of DenmarkLyngbyDenmark Department of Electrical Engineering Technical University of DenmarkLyngbyDenmark

The transition towards a more sustainable environment requires the development of new control systems on the demand side to integrate renewable energy sources into the energy *** this purpose,energy meter data of homes have been broadly used in modelling,forecast and optimal control of energy ***,usability and reliability of household energy meter data have not been specifically *** this study,we apply commonly used machine learning methods on the heating consumption data of(1)two individual homes in an apartment building and(2)the district heating substation of the apartment building which includes 72 homes,to identify how the characteristics of data affect the result of data *** clustering approaches were applied using the K-means algorithm to group similar heating daily *** the clustering results,different classification algorithms such as logistic regression and random forest were applied to predict the heating consumption level with regards to the weather *** data analysis process showed that the substation data which is the aggregated heating consumption of the 72 homes is more reliable and valid for energy prediction than the data from two individual *** is due to the large variation and uncertainty in the daily energy use of individual homes.

关键词： smart meter data daily profile clustering classification data usability heat substation

Alexander disease:the road ahead

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Neural Regeneration Research 2023年第10期18卷 2156-2160页

作者： María A.Pajares Elena Hernández-Gerez Milos Pekny Dolores Pérez-sala Department of Structural and Chemical Biology Centro de Investigaciones Biológicas Margarita SalasMadridSpain Laboratory of Astrocyte Biology and CNS Regeneration Center for Brain RepairDepartment of Clinical NeuroscienceInstitute of Neuroscience and PhysiologySahlgrenska Academy at the University of GothenburgGothenburgSweden University of Newcastle NewcastleNSWand the Florey Institute of Neuroscience and Mental HealthParkvilleVICAustralia

Alexander disease is a rare neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein,a type III intermediate filament protein expressed in *** early(infantile or juvenile)and adult onsets of the disease are known and,in both cases,astrocytes present characteristic aggregates,named Rosenthal *** are spread along the glial fibrillary acidic protein sequence disrupting the typical filament network in a dominant *** the presence of aggregates suggests a proteostasis problem of the mutant forms,this behavior is also observed when the expression of wild-type glial fibrillary acidic protein is ***,several isoforms of glial fibrillary acidic protein have been described to date,while the impact of the mutations on their expression and proportion has not been exhaustively ***,the posttranslational modification patterns and/or the protein-protein interaction networks of the glial fibrillary acidic protein mutants may be altered,leading to functional changes that may modify the morphology,positioning,and/or the function of several organelles,in turn,impairing astrocyte normal function and subsequently affecting *** particular,mitochondrial function,redox balance and susceptibility to oxidative stress may contribute to the derangement of glial fibrillary acidic protein mutant-expressing *** study the disease and to develop putative therapeutic strategies,several experimental models have been developed,a collection that is in constant *** fact that most cases of Alexander disease can be related to glial fibrillary acidic protein mutations,together with the availability of new and more relevant experimental models,holds promise for the design and assay of novel therapeutic strategies.

关键词： astrocytes endoplasmic reticulum stress glial fibrillary acidic protein mutants metabolism misassembly misfolding neurodegeneration oxidative stress posttranslational modifications unfolded protein response

Transient occult cardiotoxicity in children receiving continuous beta-agonist therapy

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World Journal of Pediatrics 2014年第4期10卷 324-329页

作者： Christopher L Carroll Melinda Coro Allison Cowl Kathleen A sala Craig M Schramm Department of Pediatrics Connecticut Children's Medical CenterHartfordCTUSA

Background:Continuous beta-agonist therapy,typically in the form of inhaled albuterol,is the first line therapy for the treatment of acute and severe bronchospasm in *** this treatment is commonly used,concerns about cardiotoxicity have been *** aimed to investigate the cardiotoxic effects of continuous beta-agonist therapy in ***:We conducted a retrospective review of children admitted to the intensive care unit(ICU)between May 2008 and April 2009,who were treated with continuous beta-agonist therapy(intravenous and nebulized).Results:Twenty of the 36 children treated with continuous albuterol had repeated serum troponin-T and lactate levels *** patients(55%)were also treated with continuous intravenous *** levels of troponin-T levels were found in 25%of children,and elevated lactate levels were found in 60%.However,all returned to normal levels within 48 hours of ICU admission,despite continued beta-agonist *** children experienced arrhythmias during *** was no association between intravenous terbutaline use and elevated troponin-T[odds ratio(OR),1.3;95%CI,0.2-10.3]or with elevated serum lactate(OR,0.6;95%CI,0.1-3.7).There was also no association between elevated troponin-T or lactate and ICU or hospital length of ***:In this small study,a significant proportion of children had elevated serum troponin-T and lactate levels while receiving inhaled continuous beta-agonist therapy,irrespective of intravenous ***,these abnormal values all returned to normal within 48 hours of ICU admission and were not associated with increased duration of hospitalization.

关键词： asthma beta-agonist pediatric

New technologies as a strategy to decrease medication errors: how do they affect adults and children differently?

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World Journal of Pediatrics 2016年第1期12卷 28-34页

作者： Margarita Ruano Elena Villamañán Ester Pérez Alicia Herrero Rodolfo Álvarez-sala Department of Pharmacy La Paz University HospitalMadridSpain Department of Pneumology La Paz University HospitalMadridSpain

Background:Medication error can occur throughout the drug treatment process,with special relevance in children given the risk of adverse effects resulting from a medication error is more prevalent than in *** significance of medication error in children is also greater because small error that would be tolerated in adults can cause significant damage in ***,the likelihood of injury is higher than in *** sources:Based on the data published,most medication errors take place in prescribing and administration stages in both *** in account that child's risk factors are different from those of adults,with some specific causes to pediatrics,we have reviewed available data about new technologies as a strategy to reduce pediatric medication ***:Even though there is a lack of standardized definitions and terminology that makes studies difficult to compare,we checked that new technologies have proven to be effectives in reducing medication errors,mainly computerized physician order entry(CPOE)and platforms to aid ***,we also observed that the use of these informatic tools can also generate new ***:Implementation of CPOE programs for pediatrics,communication improvement between healthcare professionals taking care of admitted children and the knowledge of these programs should be the mayor priorities for the safety of hospitalized children.

关键词： electronic prescribing new technologies pediatric medication errors

Building Tresigallo:The City of Edmondo Rossoni(1933-1939)

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Journal of Civil Engineering and Architecture 2024年第7期18卷 311-317页

作者： Giorgia sala Department of Architecture University of FerraraFerrara 44121Italy

Between 1933 and 1939 Minister Edmondo Rossoni transformed his hometown,a modest village,into a modern center of industrialized *** wanted to experiment a new economic,political,and social model within the Ferrara countryside and,at the same time,aimed to consolidate his power over the *** Minster asked the young and trusted engineer Carlo Frighi to give substance to his project.A provincial construction site was quickly transformed into a dynamic workshop that attracts many workers and involves designers and craftsmen from all over *** has emerged from a bibliographic and archival survey that refocused the history of a town that still confronts,through its architecture,its history,and a difficult legacy.

关键词： Tresigallo Edmondo Rossoni city of autarky urban refunding

Influence of free fatty acid content and degree of fat saturation on production performance,nutrient digestibility,and intestinal morphology of laying hens

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Animal Nutrition 2023年第2期13卷 313-323页

作者： María Palomar Carlos Garces-Narro Olga Piquer Roser sala Alba Tres Jose AGarcía-Bautista María D.Soler AviFeed Science Department of Animal Production and HealthFacultad de VeterinariaUniversidad CEU Cardenal Herrera e CEU UniversitiesE-46115Alfara de PatriarcaValenciaSpain Animal Nutrition and Welfare Service Department of Animal and Food ScienceFacultat de VeterinariaUniversitat Autonoma de BarcelonaE-08193BellaterraBarcelonaSpain Departament de Nutrici Ciencies de l’Alimentaci i GastronomiaFacultat de Farmacia i Ciencies de l’AlimentaciUniversitat de BarcelonaE-08921Santa Coloma de GramenetBarcelonaSpain

This study was conducted to evaluate the effects of dietary free fatty acid(FFA)content and degree of fat saturation on production performance,lipid and calcium digestibility,and intestinal function of laying *** a 15-week period,a total of 144 laying hens(19 weeks old)were randomly assigned to 8 dietary treatments,which were obtained by gradually replacing crude soybean oil with soybean acid oil(AO),or crude palm oil with palm fatty acid distillate(FAD).Thus,there were 4 soybean and 4 palm diets with 6%added fat varying in their FFA percentage(10%,20%,30%,and 45%),following a 2×4 factorial *** treatment included 6 replicates with 3 birds per *** daily feed intake and final body weight were significantly higher in palm diets(P<0.001),while no differences were found in egg mass and feed conversion *** levels of FFA in soybean diets resulted in lower egg production and higher egg weight(linear,P<0.01).Regarding the degree of fat saturation,hens fed soybean diets presented higher digestibility of ether extract(EE),fatty acids,and calcium than palm diets(P<0.001).The dietary FFA percentage negatively affected the digestibility of EE and calcium(P<0.01),while having little effect on FA *** was a significant interaction in the AME;lower values were reported in soybean diets as the dietary FFA percentage increased(linear,P<0.01),whereas palm diets remained *** experimental diets had little effect on gastrointestinal weight and ***,the jejunum of soybean diets showed higher villus height and higher villus height-to-crypt depth ratio than palm diets(P<0.05),and the dietary FFA percentage increased the crypt depth and decreased the villus height-to-crypt depth ratio(linear,P<0.05).It was concluded that varying dietary FFA content did not affect fat utilization as much as the degree of saturation did,supporting the use of AO and FAD as alternative fat ingredients.

关键词： Acid oil Fat by-product Fatty acid distillate Lipid Calcium

RESTI DI Mammuthus primigenius(BLUMENB.)IN PROVINCIA DI CREMONA

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Natural Disaster Reduction in China 1985年第1期 35-39页

作者： BENEDETTO sala Istitutodi Geologia Universitàdi Ferrara.

New findings of Mammuthusprimigenius are recorded in the Po Valley(Northern Italy:CavaGorini near Formigara,Cremona).Specimens recovered are teeth of at least two *** age can beassigned.

关键词： DI RESTI DI Mammuthus primigenius BLUMENB IN PROVINCIA DI CREMONA