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Geospatial epidemiology of leprosy in northwest Bangladesh: a 20-year retrospective observational study

Infectious Diseases of Poverty 2021年第2期10卷 79-79页

作者： Caroline A.Bulstra David J.Blok Khorshed Alam CRuth Butlin Johan Chandra Roy Bob Bowers Peter Nicholls sake jde vlas Jan Hendrik Richardus Department of Public Health Erasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands 不详

Background:Leprosy is known to be unevenly distributed between and within *** risk areas or'hotspots'are potential targets for preventive interventions,but the underlying epidemiologic mechanisms that enable hotspots to emerge,are not yet fully *** this study,we identified and characterized leprosy hotspots in Bangladesh,a country with one of the highest leprosy endemicity levels globally.

关键词： Leprosy Epidemiology Geospatial Hotspots Neglected tropical diseases Patient characteristics

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Burden of onchocerciasis-associated epilepsy:first estimates and research priorities

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Infectious Diseases of Poverty 2018年第1期7卷 1064-1075页

作者： Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe sake jde vlas Andrea S.Winkler Wilma A.Stolk Department of Public Health Erasmus MCUniversity Medical Center RotterdamP.O.box 20403000CARotterdamThe Netherlands Institute for Health Metrics and Evaluation University of Washington23015th AvenueSuite 600SeattleWA 98121USA Global Health Institute University of AntwerpAntwerpBelgium Department of Medical Statistics Informaticsand Health EconomicsMedical University InnsbruckViennaAustria Department of Public Health Institute of Tropical Medicine AntwerpNationalestraat 1552000 AntwerpBelgium Department of Tropical Medicine University of KinshasaKinshasaDemocratic Republic of the Congo Centre for Global Health Institute for Health and SocietyOsloNorway Center for Global Health Department of NeurologyTechnical University of MunichMunichGermany

Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free *** the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an *** we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic *** body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health *** not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities *** used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE *** then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of *** estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated *** total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of *** burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to *** estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases wou

关键词： River blindness Onchocerciasis Epilepsy Burden estimates Years of life lived with disability Review Research priorities Prevalence Disability weight Case definition

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