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Epidemiological, Clinical Aspects and Factors Associated with Typical Gastroesophageal Reflux Disease in the General Population of Parakou, Republic of Benin

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Open Journal of Gastroenterology 2024年第2期14卷 41-58页

作者： sak. Khadidjatou Tamou Sambo Bio Elie Zinsou Jocelyne Abla Dovonou Comlan Albert Sehonou Jean Kodjoh Nicolas Department of Medicine and Medical Specialties Faculty of Medicine University of Parakou Parakou Benin Department of Surgery and Surgical Specialties Faculty of Medicine University of Parakou Parakou Benin Teaching and Research Unit of Gastroenterology Faculty of Health Sciences University of Abomey-Calavi Abomey-Calavi Benin

Introduction: Gastroesophageal reflux disease (GERD) is a benign and chronic disease that can impair the quality of life. Objective: To study the epidemiological, clinical aspects and factors associated with typical GERD in the general population of Parakou in the Republic of Benin. Methods: This was a descriptive and analytical cross-sectional study with prospective data collection which took place from May 1, 2019 to June 30, 2019. The study population consisted of any subject aged at least 15 years and living in Parakou. Subjects aged at least 15 years, present on the day of the survey and having given their free and informed verbal consent were included. The Short form of QRS®(Reflux-Qual Short form) questionnaire and the “Hospital Anxiety and Depression” score were used to assess the quality of life and anxiety/depression, respectively. The sampling was probabilistic through a 2-stage cluster sampling. The variable of interest was the presence of GERD. Results: Out of 390 subjects surveyed, 28 had symptoms of typical GERD, representing a prevalence of 7.18%. The average age of these subjects was 27.11 ± 7.88 years. Fifteen subjects (53.57%) were male, giving a sex ratio of 1.15. Fourteen (50%) had a secondary level of education, 12 (42.86%) were pupils/students, 18 (64.29%) were single. The monthly income of 22 subjects (78.57%) was lower than the guaranteed interprofessional minimum wage (40,000 FCFA). The average duration of progression of symptoms was 15.89 ± 4.97 months. Symptoms occurred less than twice a week in 22 subjects (78.57%). The clinical manifestations were both diurnal and nocturnal in 12 subjects (42.86%). None of the 28 subjects with GERD had clinical warning signs. Asthma, diabetes, consumption of high fat or spice foods, carbonated drinks, non-steroidal anti-inflammatory drugs, alcoholic beverages and tobacco were statistically associated with the occurrence of GERD. Each of the 28 subjects had at least one associated factor. A significant i

关键词： Gastroesophageal Reflux Disease Epidemiology General Population Associated Factors Quality of Life Parakou

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Frequency and Factors Associated with Gender-Based Violence in the Northern Region of Benin from 2016 to 2022

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Open Journal of Internal Medicine 2024年第3期14卷 287-298页

作者： Comlan Albert Dovonou Cossi Adébayo Alassani Khadidjatou sak. Alassan Sero Tamou Cossi Angelo Attinsounon Séraphin Ahoui Finangnon Armand Wanvoegbe Departmental University Hospital Center of Borgou and Alibori Parakou Benin Departmental University Hospital Center of Oum and Plateau Porto-Novo Benin

Introduction: Gender-based violence constitutes a public health problem. The objective of this study is to determine the frequency and factors associated with gender-based violence. Study Framework and Method: This was a retrospective, descriptive, cross-sectional study with an analytical aim over the period from January 2016 to December 2022. The study took place in the Integrated Support Center for Victims and Survivors of Gender-Based Violence located in the Departmental University Hospital Center of Borgou and Alibori. The study population consisted of people who were victims of gender-based violence in the northern region of Benin, regardless of their age and gender. Results: The study population consisted of 1198 subjects. The average age of the victims was 21.76 ± 10.02;female victims represented 96.4%, with a sex ratio equal to 0.037 (43/1155). Sexual violence was the most represented (50.25%), followed by psychological (29.30%), physical (24.37%), economic (13.77%) and property (2%). The factors associated with violence were married people and monthly income (physical violence), minors, female gender and single people (sexual violence), polygamous households and monthly income (economic violence), the absence of children burden, married people and monthly income (psychological violence), married people (property violence). Conclusion: Gender-based violence is frequent in the North of Benin and is dominated by sexual violence. The victims are mainly female.

关键词： Frequency Gender-Based Violence North Benin

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Quantification of non-coding RNA target localization diversity and its application in cancers

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Journal of Molecular Cell Biology 2018年第2期10卷 130-138页

作者： Lixin Cheng Kwong-sak.Leung Department of Computer Science and Engineering The Chinese University of Hong Kong Shatin New Territories Hong Kong SAR China

SubceUular localization is pivotal for RNAs and proteins to implement biological functions. The localization diversity of protein interactions has been studied as a crucial feature of proteins, considering that the protein-protein interactions take place in vari- ous subceltutar locations. Nevertheless, the localization diversity of non-coding RNA （ncRNA） target proteins has not been sys- tematically studied, especially its characteristics in cancers. In this study, we provide a new algorithm, non-coding RNA target localization coefficient （ncTALENT）, to quantify the target localization diversity of ncRNAs based on the ncRNA-protein interaction and protein subcellular localization data. ncTALENT can be used to calculate the target localization coefficient of ncRNAs and measure how diversely their targets are distributed among the subcellular locations in various scenarios. We focus our study on long non-coding RNAs （IncRNAs）, and our observations reveal that the target localization diversity is a primary characteristic of IncRNAs in different biotypes. Moreover, we found that IncRNAs in multiple cancers, differentially expressed cancer IncRNAs, and IncRNAs with multiple cancer target proteins are prone to have high target localization diversity. Furthermore, the analysis of gastric cancer helps us to obtain a better understanding that the target localization diversity of IncRNAs is an important feature closely related to clinical prognosis. Overall, we systematically studied the target localization diversity of the IncRNAs and uncovered its association with cancer.

关键词： long non-coding RNAs RNA-protein interactions target localization diversity subcellular localization gastric cancer

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Epidemiological and Diagnostic Profile of Patients with Chronic Hepatitis B Virus from 2017 to 2021 in Parakou, Republic of Benin

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Advances in Infectious Diseases 2024年第1期14卷 147-161页

作者： Khadidjatou sak. Cossi Angelo Attinsounon Aboudou Raϊmi Kpossou Morayo Omm Ani Salami Astrid Alexandrine Hountondji Kofi-Mensa Savi de Tovè Rhonel Ahanhanzo-Glèlè Kpémahoun René Kèkè Sossa Edmond Gbédo Jean Sehonou Nicolas Kodjoh Department of Medicine and Medical Specialties Faculty of Medicine University of Parakou Parakou Benin Department of Medicine and Medical Specialties Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Health Program to Fight AIDS Cotonou Benin National Program for the Control of Hepatitis Cotonou Benin

Introduction: Viral hepatitis B is a public health problem worldwide. The objective of this study was to determine the epidemiological and diagnostic profile of chronic carriers of hepatitis B virus seen for gastroenterology consultations in Parakou, Republic of Benin. Patients and Methods: This was a cross-sectional and descriptive study with retrospective data collection. Patients seen for gastroenterology consultations from January 1, 2017 to June 30, 2021 at the Regional Teaching Hospital of Borgou/Alibori (CHUD-B/A) and having been diagnosed as chronic carriers of hepatitis B virus were included. A minimum initial assessment was required to be included. The minimum sample size was calculated with Schwartz formula. The variable of interest was the detection of HBsAg twice and at least 6 months apart. The other variables studied were sociodemographic, clinical and paraclinical data. The data collected were analyzed using SPSS 17 software. Results: A total of 2786 patients were seen for gastroenterology consultations, including 1126 (40.4%) HBsAg-positive patients. Among them, 417 patients met the inclusion criteria and were the subject of the present study. The average age of the patients was 34.8 ± 10.5 years. Two hundred and forty-seven patients (65.7%) were male, representing a sex ratio of 1.9. The discovery of positive HBsAg status was made during systematic screening in 231 patients (55.4%). Scarifications were noted in 373 patients (89.4%). Asthenia was reported in 184 patients (44.1%). Co-infections with human immunodeficiency virus, hepatitis C and D viruses were 0% (0 in 92), 2.8% (4 in 146) and 14.3% (2 in 146), respectively. During the initial assessment, 274 patients (65.7%) were sero-negative for chronic HBeAg infection, 21 (5%) had clinically significant fibrosis including 16 (3.8%) at the stage of cirrhosis and 7 patients (5.4%) had hepatocellular carcinoma. Conclusion: In Parakou, chronic hepatitis B virus infection is common and affects young pe

关键词： Chronic Infection HBV Epidemiology Diagnosis Parakou

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Intrapulmonary calcifying fibrous pseudotumour of the lung

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Chinese Medical Journal 2012年第21期125卷 3918-3919页

作者： Pinar Bicakcioglu Serpil Dizbay sak.Riza Dogan Department of Thoracic Surgery Ataturk Training and Research Hospital for Chest Disease and Thoracic SurgeryKecioren 06280AnkaraTurkey Department of Pathology Ankara University Medical FacultyAnkaraTurkey Department of Thoracic and Cardiovascular Surgery I lacetlepe University Medical FacultyAnkaraTurkey

Lalcifying fibrous pseudotumor （CFP） is one of the most unusual benign lesions and its histopathological appearance defined only during the last 15 years. It is characterized by dense, hyalinised collagenous tissue interspersed with benign spindle cells,lymphoplasmocytic psammomatous and/or infiltrate and particularly, dystrophic *** exhaustive search has shown that only 70 cases of this rare entity have been recorded in English：

关键词： calc!fying fibrous pseudotumour pulmonary nodule benign

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准分子激光角膜原位磨镶术后1年角膜内皮细胞变化 …

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美国医学会眼科杂志（中文版） 1998年第2期10卷 83-88页

作者： sak.,HF 金红颖

目的：研究人类准分子激光角膜原位磨镶术矫正高度近视后角膜内皮细胞的变化。方法对３１例接受准分子激光角膜原位磨镶术矫正了－８．２５－１８．５０Ｄ视的患者，术前和术后用角膜内皮显微镜系列地了角膜中央区内皮细胞。其中２１例... 详细信息

目的：研究人类准分子激光角膜原位磨镶术矫正高度近视后角膜内皮细胞的变化。方法对３１例接受准分子激光角膜原位磨镶术矫正了－８．２５－１８．５０Ｄ视的患者，术前和术后用角膜内皮显微镜系列地了角膜中央区内皮细胞。其中２１例，为接触镜配载者为１０例为未曾配过接触镜者，分析中央部内皮细胞的密度，细胞大小的变异系数和六边形状，对所有组将术后３，６和１２月获取的数据与术前进行比较。

关键词： LASIK 角膜内皮细胞眼科手术近视

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Acupuncture Enhances Chances of Pregnancy in Unexplained Infertile Patients Who Undergo A Blastocyst Transfer in A Fresh-Cycle

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Chinese Journal of Integrative Medicine 2019年第4期25卷 298-302页

作者： Hakan ?oksüer Mert Ula Barut Murat BozkurT Elif Agacayak Sibel sak.Mustafa Demir Eray Cal?skan Diyarlife IVF Center Department of Obstetrics and Gynecology Harran University School of Medicine Department of Obstetrics and Gynecology Bahcesehir University Department of Obstetrics and GynecologyVM Medikalpark Pendik Hospital Dicle University School of Medicine Department of Obstetrics and Gynecology Bahcesehir University Department of Obstetrics and Gynecology

Objective: To analyze the effects of acupuncture on in vitro fertilization patients with unexplained ***: We retrospectively analyzed the charts of a total of 302 cycles performed in 273 patients attending Assisted Reproductive Technology(ART) Centre from August 2013 to August *** the study period,embryo transfer with acupuncture(Acupuncture group,46 cases) and without acupuncture(Control group,42 cases) were *** to embryo transfer,the following points were used in the acupuncture group: Neiguan(CX 6),Diji(SP 8),Taichong(Liv 3),Baihui(Gv 20),and Guilai(S 29).These sessions were carried out two times before and after embryo transfer in a single *** addition,auricular acupuncture was also performed at ear points,including ear point 55(Shenmen),ear point 58(Zhigong),ear point 22(Neifenmi)and ear point 34(Naodian).The biochemical pregnancy rate and clinical pregnancy rate after transplantation were compared between two ***: The clinical pregnancy rate in the acupuncture group was higher than that in the control group [60.9%(28/46) vs.33.3%(14/42),respectively,P<0.05].Likewise,the live birth rate in the acupuncture group was also higher than that in the control group [71.7%(33/46) vs.31.0%(12/42),P<0.01).Conclusion: Administration of acupuncture on the day of embryo transfer dramatically improved fertility results in women who underwent in vitro fertilization/intra-cytoplasm sperm injection for reproduction.

关键词： acupuncture assisted reproduction embryo transfer pregnancy rate

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Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis

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World Journal of Hepatology 2021年第12期13卷 2071-2080页

作者： Jarosław Jerzy sak.Andrzej Prystupa PawełKiciński Dorota Luchowska-Kocot Ewa Kurys-Denis Hanna Bis-Wencel Chair and Department of Humanities and Social Medicine Medical University of LublinLublin 20-093Poland Department of Internal Medicine Medical University of LublinLublin 20-081Poland Department of Experimental Hematooncology Medical University of LublinLublin 20-080Poland Department of Medical Chemistry Medical University of LublinLublin 20-093Poland The Second Department of Radiology Medical University of LublinLublin 20-081Poland Department of Microbiology and Reproductive Biology University of Life Sciences in LublinLublin 20-950Poland

BACKGROUND The importance of early diagnosis of alcoholic liver disease underscores the need to seek better and especially non-invasive diagnostic *** cellderived chemotaxin-2(LECT2)has been widely studied to determine its usefulness in monitoring the course of non-alcoholic fatty liver disease but not for alcoholic liver cirrhosis(ALC).AIM To determine the concentration of LECT2 in the blood serum of patients in relation to progressive stages of ALC,its relation to fibroblast growth factor 1(FGF-1)and FGF-21,and to examine the possible wider use of LECT2 in diagnosing *** A retrospective case-control study was conducted with 69 ALC cases and 17 controls with no *** were recruited from the region of Lublin(eastern Poland).Liver cirrhosis was diagnosed based on clinical features,history of heavy alcohol consumption,laboratory tests,and abdominal *** degree of ALC was evaluated according to Pugh-Child criteria(the Pugh-Child score).Blood was drawn and,after centrifugation,serum was collected for ***2,FGF-1,and FGF-21 were determined using enzyme-linked immunosorbent assay *** The LECT2 Levels in the control group were 18.99±5.36 ng/*** the study groups,they declined with the progression of cirrhosis to 11.06±6.47 ng/mL in one group and to 8.06±5.74 ng/mL in the other(P<0.0001).Multiple comparison tests confirmed the statistically significant differences in LECT2 Levels between the control group and both test groups(P=0.006 and P<0.0001).FGF-21 Levels were 44.27±64.19 pg/mL in the first test group,45.4±51.69 pg/mL in the second(P=0.008),and 13.52±7.51 pg/mL in the control *** difference between the control group and the second test group was statistically significant(P=0.007).CONCLUSION We suggest that LECT2 may be a non-invasive diagnostic factor for alcoholinduced liver *** usefulness of LECT2 for non-invasive monitoring of alcohol-induced liver cirrhosis was indirectly confirmed b

关键词： Leukocyte cell-derived chemotaxin-2 Fibroblast growth factor 21 Fibroblast growth factor 1 Alcoholic liver cirrhosis Pugh-Child score

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Induction of Quadratic Decision Trees using Genetic Algorithms

Induction of Quadratic Decision Trees using Genetic Algorith...

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2003年中国智能自动化会议

作者： Sai Cheong Ng Kwong sak.Leung Department of Computer Science & Engineering The Chinese University of Hong Kong

Binary Tree-Genetic Algorithm (BTGA) is applied successfully in various classification tasks. At each non-terminal node, genetic algorithms (GAs) are employed to find the optimal hyperplane to partition samples into two disjoint subsets. A novel decision tree, called genetic algorithm-based quadratic decision tree (GA-based QDT), is proposed by extending the BTGA. In the GA-based QDT, GAs are applied to evolve the optimal quadratic hyper-surface at each non-terminal node. The performance of the GA-based QDT is evaluated and compared with several well known decision tree algorithms, including the BTGA.

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The Role of Oropharyngeal Barotrauma as a Cause of Pneumomediastinum: Report of a Case

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Open Journal of Thoracic Surgery 2012年第4期2卷 136-138页

作者： Hakki Ulutas Erdal Yekeler Zafer Hasan Ali sak.Bayram Altuntas Department of Pulmonary Medicine School Of Medicine Harran University Sanliurfa Turkey Department of Thoracic Surgery Ataturk Training and Research Hospital for Chest Disease and Chest Surgery Ankara Turkey Department of Thoracic Surgery Faculty of Medical University of Inonu Malatya Turkey Department of Thoracic Surgery Regional Training and Research Hospital Erzurum Turkey

Free air or gas in mediastinum is defined as pneumomediastinum. This is a rare condition which orginates from over distention of alveolus and alveolar rupture by barotrauma. A 6-year-old boy was admitted to our department with sudden onset, swelling of neck and face that developed during drinking water from tap by using his mouth. Physical examination revealed the presence of subcutaneous emphysema over the two side of the face that extended toward the neck bilaterally. The chest X-ray and CT of the thorax, when performed, revealed the diagnosis of pneumomediastinum and extrathoracic subcutaneous emphysema. Interestingly neither trachea-bronchial nor esophageal pathology was found by emergent rigid bronchoscopy and endoscopy for etiology of pneumomediastinum. Antibiotic treatment and oxygen therapy were given to the patient with chest pain and dyspnea. During the following days, the patient’s condition improved notably, with almost total resolution of the cervical emphysema and pneumomediastinum confirmed by daily chest X-ray and control thorax CT. He was discharged home after 6 days. The emphysema gradually resolved. Pneumomediastinum caused by barotrauma is a rare condition and only conservative treatment is required when the other causes are ruled out.

关键词： Oropharyngeal Barotrauma Pneumomediastinum

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