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Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics

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Asian Journal of Urology 2019年第1期6卷 65-81页

作者： Gina Chia-Yi Chu Leland W.K.Chung Murali Gururajan Chia-Ling Hsieh sajni josson Srinivas Nandana Shian-Ying Sung Ruoxiang Wang Jason Boyang Wu Haiyen E.Zhau Uro-Oncology Research Department of Medicine and Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Bristol-Myer Squibb Company PrincetonNJUSA Department of Urology Emory University School of MedicineAtlantaGAUSA Oncoveda Cancer Research Center Genesis Biotechnology GroupHamiltonNJUSA Texas Tech University Health Sciences Center Department of Cell Biology and BiochemistryLubbockTXUSA Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical SciencesWashington State UniversitySpokaneWAUSA

This article describes cell signaling network of metastatic prostate cancer(PCa)to bone and visceral organs in the context of tumor microenvironment and for the development of novel *** article focuses on our recent progress in the understanding of:1)The plasticity and dynamics of tumorestroma interaction;2)The significance of epigenetic reprogramming in conferring cancer growth,invasion and metastasis;3)New insights on altered junctional communication affecting PCa bone and brain metastases;4)Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy;5)Geneticbased therapy to co-target tumor and bone stroma;6)PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis;7)The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis;and 8)Characterization of imprinting cluster of microRNA,in tumorestroma *** article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical *** article referenced the details of the various approaches and discoveries described herein in peer-reviewed *** dedicate this article in our fond memory of *** *** who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine.

关键词： Prostate cancer Castration resistance Metastasis Cancer-stromal interaction Targeted therapy

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