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Pronounced effect of ZnTe nanoinclusions on thermoelectric properties of Cu_(2-x) Se chalcogenides

Science China Materials 2016年第2期59卷 135-143页

作者： Muhammad umer Farooq sajid Butt 高克玮孙喜贵庞晓露 Asif Mahmood Waqar Mahmood sajid u.khan Nasir Mahmood School of Materials Science and Engineering University of Science and Technology Beijing Department of Materials Science and Engineering Institute of Space Technology State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Department of Material Science and Engineering College of Engineering Peking University Department of Physics Thin Film Technology (TFT) Research LaboratoryCOMSATS Institute of Information Technology Department of Materials Science and Engineering Institute of Space Technology Institute of Superconducting and Electronic Materials Australian Institute of Innovative MaterialsUniversity of Wollongong

Metal chalcogenides especially Cu2-x Se has gained much attention in thermoelectric community due to its complex crystal structure and superionic behavior. Here, we report a facile method to improve the thermoelectric efficiency by introducing Zn Te nanoinclusions into the matrix of Cu2-x Se. As a result, a substantial improvement of 32% in electrical conductivity of Cu2-x Se-Zn Te composite is observed. The increase in electrical conductivity is at the expense of Seebeck coefficient, which slightly decreases the power factor of the composite samples than that of pure Cu2-x Se. Furthermore, the introduction of secondary phase facilitates in declining the total thermal conductivity of Cu2-x Se-Zn Te composite up to 34% by suppressing the lattice thermal contributions. Thus, the moderate power factor and lower thermal conductivity values result in an improved figure of merit(z T) value of ~0.40 in mid-range temperature(750 K) for Cu2-x Se-Zn Te composite with 10 wt.% of Zn Te, which is about 40% higher than that of its pure counterpart. Hence, it is believed that the incorporation of Zn Te nanoinclusions in the matrix of Cu2-x Se may be an important route to improve the thermoelectric properties of Cu2-x Se based compounds.

关键词： ZnTe nanoparticles Cu2S thermoelectric materialas Cu2-xSe-ZnTe composite thermal conductivity

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence

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Virologica Sinica 2024年第3期39卷 369-377页

作者： Shengyao Chen Muhammad Saqib Hafiz sajid khan Yuan Bai usman Ali Ashfaq Muhammad Khalid Mansoor Abulimti Moming Jing Liu Min Zhou Saifullah khan Niazi Qiaoli Wu Awais-ur-Rahman Sial Shuang Tang Muhammad Hassan Sarfraz Aneela Javed Sumreen Hayat Mohsin Khurshid Iahtasham khan Muhammad Ammar Athar Zeeshan Taj Bo Zhang Fei Deng Ali Zohaib Shu Shen Key Laboratory of Virology and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China university of Chinese Academy of Sciences Beijing 100049China Faculty of Veterinary Science University of Agriculture FaisalabadFaisalabad 38040Pakistan The Children's Hospital Faisalabad 38000Pakistan Department of Bioinformatics and Biotechnology Government College University FaisalabadFaisalabad 38000Pakistan f Department of Microbiology Faculty of Veterinary and Animal SciencesThe Islamia University of BahawalpurBahawalpur 63100Pakistan Hubei Jiangxia Laboratory Wuhan 430200China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Armed Forces Institute of Pathology(AFIP) Rawalpindi 46000Pakistan Department of Clinical Studies Faculty of Veterinary&Animal SciencesPir Mehr Ali Shah Arid Agriculture UniversityRawalpindi 46300Pakistan Institute of Microbiology Government College University FaisalabadFaisalabad 38000Pakistan l Atta-ur-Rahman School of Applied Biosciences National University of Science and TechnologyIslamabad 44000Pakistan Department of Clinical Sciences University of Veterinary and Animal SciencesLahore Sub-campusJhang 35200Pakistan Department of Molecular Pathology National Medical Center DHA Phase 1Karachi 75500Pakistan

Infectious diseases caused by arboviruses are a public health concern in ***,studies on data prevalence and threats posed by arboviruses are *** study investigated the seroprevalence of arboviruses in a healthy population in Pakistan,including severe fever with thrombocytopenia syndrome virus(SFTSV),Crimean-Congo hemorrhagic fever virus(CCHFV),Tamdy virus(TAMV),and Karshi virus(KSIV)based on a newly established luciferase immunoprecipitation system(LIPS)assays,and Zika virus(ZIKV)by enzyme-linked immunosorbent assays(ELISA).Neutralizing activities against these arboviruses were further examined from the antibody positive *** results showed that the seroprevalence of SFTSV,CCHFV,TAMV,KSIV,and ZIKV was 17.37%,7.58%,4.41%,1.10%,and 6.48%,respectively,and neutralizing to SFTSV(1.79%),CCHFV(2.62%),and ZIKV(0.69%)were identified,as well as to the SFTSV-related Guertu virus(GTV,0.83%).Risk factors associated with the incidence of exposure and levels of antibody response were ***,co-exposure to different arboviruses was demonstrated,as thirty-seven individuals were having antibodies against multiple viruses and thirteen showed neutralizing ***,individuals aged40 years,and outdoor workers had a high risk of exposure to *** these results reveal the substantial risks of infection with arboviruses in Pakistan,and indicate the threat from co-exposure to multiple *** findings raise the need for further epidemiologic investigation in expanded regions and populations and the necessity to improve health surveillance in Pakistan.

关键词： Arbovirus Pakistan Seroprevalence Tick-borne virus Mosquito-borne virus

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Symmetries,optimal system,exact and soliton solutions of(3+1)-dimensional Gardner-KP equation

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Journal of Ocean Engineering and Science 2024年第2期9卷 178-190页

作者： Amjad Hussain Ashreen Anjum M.Junaid-u-Rehman Ilyas khan Mariam A.Sameh Amnah S.Al-Johani Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-MajmaahP.O Box 66Majmaah 11952Saudi Arabia Electrical Engineering Department Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo 11845Egypt Mathematics Department Faculty of ScienceUniversity of TabukTabukSaudi Arabia

In this research article,the(3+1)-dimensional nonlinear Gardner-Kadomtsov-Petviashvili(Gardner-KP)equation which depicts the nonlinear modulation of periodic waves,is analyzed through the Lie group-theoretic *** the Lie invariance condition,we find the symmetry *** pro-posed model yields eight-dimensional Lie ***,an optimal system of sub-algebras is com-puted,and similarity reductions are *** considered nonlinear partial differential equation is re-duced into ordinary differential equations(ODEs)by utilizing the similarity transformation method(STM),which has the benefit of yielding a large number of accurate traveling wave *** ODEs are further solved to get closed-form solutions of the Gardner-KP equation in some cases,while in other cases,we use the new auxiliary equation method to get its soliton *** evolution profiles of the obtained solutions are examined graphically under the appropriate selection of arbitrary parameters.

关键词： Gardner-KP equation Lie symmetry analysis Optimal system New auxiliary equation method Solitary wave solutions

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Adult neurogenesis:a real hope or a delusion?

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Neural Regeneration Research 2024年第1期19卷 6-15页

作者： Ghulam Hussain Rabia Akram Haseeb Anwar Faiqa sajid Tehreem Iman Hyung Soo Han Chand Raza Jose-Luis Gonzalez De Aguilar Neurochemicalbiology and Genetics Laboratory(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Department of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Department of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neurogenesis,the process of creating new neurons,involves the coordinated division,migration,and differentiation of neural stem *** process is restricted to neurogenic niches located in two distinct areas of the brain:the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle,where new neurons are generated and then migrate to the olfactory *** has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem ***,recent years have seen tremendous progress in our understanding of adult brain neurogenesis,bridging the knowledge gap between embryonic and adult ***,we discuss the current status of adult brain neurogenesis in light of what we know about neural stem *** this notion,we talk about the importance of intra cellular signaling molecules in mobilizing endogenous neural stem cell prolife *** on the current understanding,we can declare that these molecules play a role in targeting neurogenesis in the mature ***,to achieve this goal,we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints,which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

关键词： adult neurogenesis aging brain-derived neurotrophic factor dentate gyrus hippocampus neural stem cells neurotrophic factors Notch oxidative stress stem cells subgranular zone

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Bubble coalescence in interacting system of DNA molecules

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International Journal of Biomathematics 2024年第4期17卷 195-216页

作者： u.A.Rozikov V.I.Romanouskiy Institute of Mathematics 9 Universitet Street100174 Tashkent uzbekistan AKFA university National Park StreetBarkamol MFY Mirzo-Ulugbek District111221 Tashkent uzbekistan National university of uzbekistan 4Universitet Street 100174 TashkentUzbekistan

We consider two models of interacting DNA molecules:First is(four parametric)bubble coalescence model in interacting DNAs(shortly:BCI-DNA).Second is(three parametric)bubble coalescence model in a condensed DNA molecules(shortly BCC-DNA).To study bubble coalescence thermodynamics of BCI-DNA and BCC-DNA models we use methods of statistical ***,we define Hamiltonian of each model and give their translation-invariant Gibbs measures(TIGMs).For the first model,we find parameters such that corresponding Hamiltonian has up to three TIGMs(three phases of system)biologically meaning existence of three states:“No bubble coalescence”,“Dominated soft zone”,“Bubble coalescence”.For the second model,we show that for any(admissible)parameters,this model has unique *** is a state where“No bubble coalescence”phasedominates.

关键词： DNA bubble configuration Cayley tree Gibbs measure Potts model

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Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype

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Genomics, Proteomics & Bioinformatics 2010年第3期8卷 190-199页

作者： Parveen Salahuddin Asad u.khan Distributed Information Sub-Centre Interdisciplinary Biotechnology UnitAligarh Muslim University

Influenza A virus （H1N1）, a genetic reassortment of endemic strains of human, avian and swine flu, has crossed species barrier to human and apparently acquired the capability of human to human transmission. Some strains of H5N1 subtype are highly virulent because NS 1 protein inhibits antiviral interferon α/β production. Another protein NS2 mediates export of viral ribonucleoprotein from nucleus to the cytoplasm through export signal. In this paper, we have studied structure-function relationships of these proteins of H1N1 subtype and have determined the cause of their pathogenicity. Our results showed that non-conservative mutations slightly stabilized or destabilized structural domains of NS1 or NSI-dsRNA complex, hence slightly increased or decreased the function of NS 1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus. NS2 protein of different strains carried non-conservative mutations in different domains, resulting in slight loss of function. These mutations slightly decreased the pathogenicity of the virus. Thus, the results confirm the structure-function relationships of these viral proteins.

关键词： influenza A virus H1N1 pathogenicity NS2 NS1

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Variational data encoding and correlations in quantum-enhanced machine learning

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Chinese Physics B 2024年第9期33卷 298-306页

作者： Ming-Hao Wang Hua L¨u School of Physics Hubei UniversityWuhan 430062China School of Science Hubei University of TechnologyWuhan 430068China

Leveraging the extraordinary phenomena of quantum superposition and quantum correlation,quantum computing offers unprecedented potential for addressing challenges beyond the reach of classical *** paper tackles two pivotal challenges in the realm of quantum computing:firstly,the development of an effective encoding protocol for translating classical data into quantum states,a critical step for any quantum *** encoding strategies can significantly influence quantum computer ***,we address the need to counteract the inevitable noise that can hinder quantum *** primary contribution is the introduction of a novel variational data encoding method,grounded in quantum regression algorithm *** adapting the learning concept from machine learning,we render data encoding a learnable *** allowed us to study the role of quantum correlation in data *** numerical simulations of various regression tasks,we demonstrate the efficacy of our variational data encoding,particularly post-learning from instructional ***,we delve into the role of quantum correlation in enhancing task performance,especially in noisy *** findings underscore the critical role of quantum correlation in not only bolstering performance but also in mitigating noise interference,thus advancing the frontier of quantum computing.

关键词： quantum machine learning variational data encoding quantum correlation

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Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits

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Neural Regeneration Research 2022年第12期17卷 2685-2686页

作者： Mariam Masmudi-Martín Irene Navarro-Lobato Zafar u.khan Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands Laboratory of Neurobiology CIMESUniversity of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain CIBERNED Institute of Health Carlos ⅢMadridSpain

Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to use a new ***,memory deficits not only accompany normal aging but are also comorbid with many psychiatric,neurological,and neurodegenerative *** disability,autism,attention deficit disorder,learning disability,schizophrenia,and depression all have memory deficit components,as do Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and other neurodegenerative diseases(khan et al.,2014).Therefore,a large proportion of the human population is affected by this brain disorder.

关键词： Huntington remember finance

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First Record of Middle Eocene Elephant Ancestors’Footprints in the Gonjo Basin,East Tibet Plateau

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Journal of Earth Science 2024年第4期35卷 1224-1235页

作者： Asma Tahir Huazhou Yao Junaid khan Yangui Li He Zhao Yue Yu Tang Yuan Institute of Geological Survey China University of GeosciencesWuhan430074China Wuhan Center China Geological SurveyWuhan430205China State Key Laboratory of Geological Processes and Mineral Resources Wuhan430078China Chengdu Center China Geological SurveyChengdu610081China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China

It is the first time that the fossil footprints of a group of Middle Eocene elephant ancestors have been discovered in the Gonjo Basin,East Tibet *** Gonjo Formation is attributed to the Middle Eocene Epoch(u-Pb age=44.7±1.2 Ma)and consists mainly of purplish-red,medium-to coarse-grained sandstones,siltstones interbedded with mudstones,and conglomerates with sedimentary structures like ripple marks,rip-up clasts,and trough-cross bedding,suggesting fluvial-lacustrine *** group of fossil footprints has a characteristic oval-concave shape,and the toe impressions are *** fossil footprints are overstepped with a pockmarked texture resembling Proboscipeda *** than 165 fossil footprints of the group are relatively well-preserved with different diameters,which is evidence of highly social behavior and trackmakers of different ages,including calves,juveniles,adolescents,and *** size frequency of the fossil footprints enabled us to deduce the body mass,shoulder height,and hip-height distribution of the trackmakers that crossed the East Tibet Plateau 44.7 Ma *** trackmakers comprised an estimated average hip-height of 111.8 cm,an average shoulder height of 172.8 cm for males/155.9 cm for females,and an average body mass of approximately 1218.1 kg for males/907.8 kg for *** abundance of fossil footprints reveals that in the Middle Eocene Epoch,the environment was extraordinarily conducive for the elephant ancestors to live in the East Tibet region.

关键词： Proboscipeda enigmatica East Tibet Plateau Gonjo Formation fossil footprints fluvial-lacustrine

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