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Effects of Heliotropium indicum L.on Uterine Involution and Its Underlying Mechanisms:An in vivo and in vitro Study

Chinese Journal of Integrative Medicine 2023年第11期29卷 980-988页

作者： Sayah Ongsricharoenbhorn Pakanit kupittayanant Kanjana Thumanu Griangsak Eumkeb Suthida Chanlun Pittaya Papirom Susan Wray sajeera kupittayanant School of Preclinical Sciences Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima(30000)Thailand School of Animal Technology and Innovation Institute of Agricultural TechnologySuranaree University of TechnologyNakhon Ratchasima(30000)Thailand Synchrotron Light Research Institute Nakhon Ratchasima(30000)Thailand Department of Pathobiology Faculty of Veterinary MedicineKhon Kaen UniversityKhon Kaen(40002)Thailand Department of Women's and Children's Health Harris-Wellbeing Preterm Birth CentreUniversity of LiverpoolLiverpoolL87SSUK

Objective:To investigate the effect of Heliotropium indicum L.(H.indicum L.)on uterine involution and its underlying mechanisms in both in vivo and in vitro study.Methods:For in vivo studies,postpartum rats were randomly divided into 2 groups(n=24 for each):control group and treated group which were orally and daily administered with ethanolic extract of H.indicum L.(250 mg/kg body weight)until day 5 of postpartum.Uteri were collected for analysis of weight,cross-sectional area,collagen cross-sectional area,and collagen content on postpartum day 1,3,and 5(n=8 for each)from both groups.Blood samples were collected for hepatotoxicity and 17?-estradiol(E_(2))measurement.For in vitro studies,the extract effects on uterine contraction at half maximum effective concentration of 2.50 mg/mL were studied in organ bath system for at least 20 min.Results:Uterine parameters were significantly decreased after treated with extract of H.indicum L.(P<0.05).H.indicum L.extract significantly accelerated the reduction of those parameters and significantly decreased E_(2)(P<0.05).The extract facilitated uterine involution with no hepatotoxicity.H.indicum L.extract significantly stimulated uterine contraction(P<0.05)and synergized with oxytocin,prostaglandin and its precursor,linoleic acid.By investigating the different sequencing of the extract with the additional stimulants(added before or after),the two showed antagonistic effects,but still showed potentiated force when compared with control(without the stimulants).Conclusions:The underlying mechanisms by which H.indicum L.facilitated uterine involution might be due to reducing E_(2)which induces collagenase activity,leading to decreases in uterine weight and size and stimulating uterine contraction.Our study provides new findings for future drug development for facilitating uterine involution with H.indicum L.

关键词： measurement contraction sectional

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Lipid-lowering effect of Oroxylum indicum(L.)Kurz extract in hyperlipidemic mice

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 148-155页

作者： Tanaporn Hengpratom sajeera kupittayanant Seekaow Churproong Griangsak Eumkeb Division of Health and Applied Sciences Faculty of SciencePrince of Songkla UniversityThailand School of Preclinical Sciences Institute of ScienceSuranaree University of TechnologyNakhon RatchasimaThailand Department of Family Medicine and Community Medicine Institute of MedicineSuranaree University of TechnologyNakhon RatchasimaThailand

Objective:To investigate the effect of Oroxylum indicum fruit extract on high-fat diet-induced hyperlipidemic mice.Methods:The phytochemical composition of Oroxylum indicum fruit extract was determined by liquid chromatographymass spectrometry/mass spectrometry(LC-MS/MS)and gas chromatography-mass spectrometry.Forty-two male mice were used.The mice were divided into six groups:normal control,high-fat diet control,simvastatin treatment(20 mg/kg BW/day),and Oroxylum indicum fruit extract(100,200,300 mg/kg BW/day)treatment groups.Food intake,body weight,serum parameters,lipid profile,and histopathological lesions of the kidney,liver,and epididymal fat were observed.Results:LC-MS/MS results revealed four major components of Oroxylum indicum fruit extract:luteolin,apigenin,baicalein,and oroxylin A.Twenty-seven volatile oils were identified from Oroxylum indicum fruit extract.Daily oral administration of Oroxylum indicum fruit extract at 100 to 300 mg/kg BW/day significantly reduced the body weight,total cholesterol,triglyceride,and low-density lipoprotein cholesterol level(P<0.05),whereas high-density lipoprotein cholesterol was higher than the high-fat diet control group.Treatment with 300 mg/kg BW/day Oroxylum indicum fruit extract reduced the pathological lesion and prevented fat accumulation in the kidney and liver.Conclusions:Oroxylum indicum fruit extract has hypolipidemic effect in hyperlipidemic mice,and the active ingredients of Oroxylum indicum fruit extract,both flavonoids and volatile oils,should be further explored as an antihyperlipidemic agent.

关键词： Oroxylum indicum Hyperlipidemia Lipid-lowering effect Extract Mice Anti-adipogenesis Antihyperlipidemic Flavonoids Volatile oils

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The Onset of Puberty in Indigenous Gilts in the North-East of Thailand Confirmed by the First Ovulation

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Journal of Agricultural Science and Technology(A) 2011年第8期1卷 1318-1321页

作者： C. Samklong P. Na-Lampang S. Katavatin P. kupittayanant K. Vasupen Department of Animal Science Faculty of Natural Resources Rajamangala University of Technology lsan Sakon Nakhon Campus Sakon Nakhon 47160 Thailand School of Animal Production Technology Institution of Agricultural Technology Suranaree University of Technology Nakhon Ratchasima 30000 Thailand Department of Animal Science Faculty of Agriculture Khon Kaen University Khon Kaen 40000 Thailand

This experiment was aimed to investigate some changes of ovarian structure in order to confirm the onset of puberty in Thai indigenous gilts. Fifty female animals collected from the North-Eastern area of Thailand were slaughtered in the different age groups as 0, 1, 2, 3, 3.5, 4, 4.5, 5, 5.5 and 6 months of age, respectively (each group = 5 pigs), for monitoring corpus luteum (CL) occurrence on ovarian surface and some changes of reproductive structure. CL was clearly found for the first time in the 4.5 months age group (P 2.0 mm in diameter appeared for the first time in the 3.5 month age group (P < 0.05). For other conformations, size of uterine horns, oviducts or ovaries, including weight of ovaries or whole reproductive tracts, were significantly developed (P < 0.05) that was initially taken place in the 3.5 months age group onwards. Thus, it was summarized that the onset of puberty in Thai indigenous gilts, affirmed by CL appearance at the first time, should be happened between 4.0 and 4.5 months of age; however, the development of reproductive structure and follicles to prepare in approaching puberty should be started before 3.5 months of age.

关键词：东北部地区青春期母猪泰国土著排卵发病卵巢结构

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