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Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide

World Journal of Gastroenterology 2010年第25期16卷 3120-3132页

作者： Tomohide hori Justin h Nguyen Yasuhiro Ogura Toshiyuki hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R herdt hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto Department of Neuroscience Mayo Clinic Jacksonville Florida FL 32224 United States Division of hepato-Pancreato-Biliary Transplant and Pediatric Surgery Department of Surgery Kyoto University HospitalSakyo-ku Kyoto 606-8507 Japan Division of Transplant Surgery Department of Transplantation Mayo Clinic Jackson-ville Florida FL 32224 United States Institute for Laboratory Animal Science and Ex-perimental Surgery RWTH-Aachen University D-52074 AachenGermany Department of Cellular and Molecular Immu-nology Mie University Graduate School of Medicine Tsu Mie514-8507 Japan New Zealand Liver Transplant Unit Auckland City Hospital Auckland 92024 New Zealand

AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METhODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful ***: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model.

关键词： Animal model Liver transplantation Microsurgery Rat Reperfusion injury Ultra-microsurgery

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Cassegrain and Nasmyth adaptive optics systems of 8.2-m Subaru Telescope

Cassegrain and Nasmyth adaptive optics systems of 8.2-m Suba...

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Photonics Asia 2004;Optics and Lasers

作者： M.Iye h.Takami N.Takato S.Oya Y.hayano O.Guyon S.Colley M.hattori M.Watanabe M.Eldred Y.saito N.saito K.Akagawa S.Wada National Astronomical Observatory Osawa Mitaka Tokyo 181-8588 JAPAN Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place Subaru Telescope NAOJ North A'Ohoku Place National Astronomical Observatory Osawa Mitaka Tokyo 181-8588 JAPAN The Institute of Physical and Chemical Research Wako Saitama 351-0198 Japan The Institute of Physical and Chemical Research Wako Saitama 351-0198 Japan The Institute of Physical and Chemical Research Wako Saitama 351-0198 Japan

The performance of the Cassegrain Adaptive Optics (AO) system of the 8.2 m Subaru Telescope is reported. The system is based on a curvature wavefront sensor with 36 photon-counting avalanche photodiod

关键词： Adaptive Optics, high Resolution Imaging, Laser Guide Star, Wavefront Sensor

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Crucial roles of macrophages in the pathogenesis of autoimmune disease

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World Journal of Immunology 2017年第1期7卷 1-8页

作者： Aya Ushio Rieko Arakaki Akiko Yamada Masako saito Takaaki Tsunematsu Yasusei Kudo Naozumi Ishimaru Department of Oral Mole-cular Pathology Tokushima University Graduate School of Biomedical Sciences Department of human Genetics Tokushima University Graduate School of Biomedical Sciences Department of Pathology and Laboratory Medicine Tokushima University Graduate School of Biomedical Sciences

Macrophages are key players in various immune responses. In addition to functions in innate immunity such as antigen phagocytosis and cytokine production, antigen presentation by macrophage represents a link between innate and acquired immunity. During inflammatory processes, naive monocytes differentiate into pro-inflammatory M1 and anti-inflammatory M2 macrophages. Resident monocytes/macrophages contribute to immune response that maintains tissue-specific homeostasis. In the target organs of autoimmune diseases, macrophages have dual functions in both the induction and suppression of autoimmune responses, which are mediated by production of various cytokines and chemokines, or by interaction with other immune cells. This review focuses on selected autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, and Sjogren’s syndrome, to illustrate the key roles of macrophages in the cellular or molecular patho-genesis of autoimmunity. In addition, the contribution of macrophages to each autoimmune disease is compared.

关键词： Macrophage Autoimmunity Differentiation Cytokines Chemokines

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Depth Profiles of Absorbed hydrogen in Ni-Nb-Zr Amorphous Alloy Ribbons by Glow Discharge Optical Emission Spectroscopy

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Open Journal of Metal 2014年第4期4卷 112-119页

作者： Rie Y. Umetsu Mikiko saito Toshio Sasaki Tetsushi Sekiguchi Jun Mizuno hiroshi Kawarada Institute for Materials Research Tohoku University Sendai Japan Institute for Nanoscience & Nanotechnology Waseda University Tokyo Japan

Depth profiles of absorbed hydrogen introduced by electrochemical charging and light elements were analyzed in Ni-Nb-Zr-h amorphous alloy ribbons using a glow discharge optical emission spectrometer. It was clarified that the absorbed hydrogen was comparatively well-distributed on the sample surface and that the content of the hydrogen decreased with increasing depth from the surface. That is, the amount of absorbed hydrogen on the surface was about 17 at %, while that inside the specimens decreased to several atomic percent. The depth profiles of the hydrogen which were close to the surface were slightly different between those on the roller side and those on the free side in the melt-spun ribbon. The difference is thought to originate from the existence of oxygen impurity on the surface and from the difference of the Zr content.

关键词： Amorphous Ribbon hydrogen Absorption Glow Discharge Optical Emission Spectroscopy Depth Profile

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M(o|¨)ssbauer Spectroscopic Study of Fe-Oxipnictide Superconductors

M(o|¨)ssbauer Spectroscopic Study of Fe-Oxipnictide Superco...

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作者： S.Kitao Y.Kobayashi M.Kurokuzu M.saito Y.Kamihara M.hirano T.Mitsui h.hosono M.Seto Research Reactor Institute Kyoto University CREST Japan Science and Technology Agency ERA TO-SORST Japan Science and Technology Agency Tokyo Institute of Technology Japan Atomic Energy Agency ERATO-SORST Japan Science and Technology Agency

INTRODUCTION:Recently,Kamihara et *** a new series of superconductors in Fe-oxipnictides LaFePO and,successively,F-doped LaFeAsOF with the transition temperature(To) of 26 *** magnetic elements,such as Fe,had been thought to be incompatible with the emergence of superconductivity, these reports surprised many researchers and have brought extensive following ***, first-principles calculations for the Fe-oxipnictides showed that the 3d-bands of Fe are primary components

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ICRF heated Long-Pulse Plasma Discharges in LhD

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Plasma Science and Technology 2006年第1期8卷 28-32页

作者： R. KUMAZAWA T. SEKI T. MUTOh K. saito T. WATARI Y. NAKAMURA M. SAKAMOTO T. WATANABE S. KUBO T. ShIMOZUMA Y. YOShIMURA h. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. NAGAOKA O. KANEKO J. MIYAZAWA S. MORITA K. NARIhARA M. ShOJI S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSON K. SATO T. TOKUZAWA N. AShIKAWA K. NIShIMURA h. FUNABA h. ChIKARAIShI T. NOTAKE Y. TORII h. OKADA M. IChIMURA h. hIGAKI Y. TAKASE h. KASAhARA F. ShIMPO G.NOMURA C.TAKAhAShI M.YOKOTA A. KATO 赵燕平 J. S. YOON J. G. KWAK h. YAMADA K. KAWAhATA N. OhYABU K. IDA Y. NAGAYAMA N. NODA A. KOMORI S. SUDO O. MOTOJIMA National Institute for Fusion Science Toki Japan Kyusyu University Kasuga Japan Nagoya University Faculty of Engineering Nagoya Japan Kyoto University Institute of Advanced Energy Uji Japan Tsukuba University Plasma Research Center Tsukuba Japan Tokyo University Graduate School of Frontier Sciences Tokyo Japan Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China KAERI 150 Deogjin-dong Yuseong-gu Daejeon Korea Rep.

A long-pulse plasma discharge for more than 30 min. was achieved on the Large helical Device （LhD）. A plasma of ne = 0.8 × 10^19 m^-3 and T10 = 2.0 keV was sustained with PICh = 0.52 MW, PECh = 0.1 MW and averaged PNBI = 0.067 MW. Total injected heating energy was 1.3 G J, which was a quarter of the prepared RF heating energy. One of the keys to the success of the experiment was a dispersion of the local plasma heat load to divertors, accomplished by shifting the magnetic axis inward and outward.

关键词： helical/stellarator configuration ICRF heating steady state operation

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In Vivo Development of Fetal Pig Kidneys in Mature Monkeys under Clinically Approved Immunosuppressant Drugs

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Engineering 2022年第3期8卷 65-73页

作者： Tsuyoshi Takamura Kenji Matsui Naoto Matsumoto Yatsumu saito Toshinari Fujimoto Susumu Tajiri Shuichiro Yamanaka Kei Matsumoto Akimitsu Kobayashi Izumi Yamamoto hiroshi Sasaki haruyuki hirayama hitomi Matsunari Kazuaki Nakano hiroshi Nagashima Akihiko Kiyoshi Takao Kuroda Makoto Inoue Takeshi Miyawaki Takashi Yokoo Eiji Kobayashi Division of Nephrology and hypertension Department of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan Department of Urology The Jikei University School of MedicineTokyo 105-8461Japan Department of Plastic and Reconstructive Surgery The Jikei University School of MedicineTokyo 105-8461Japan Meiji University International Institute for Bio-Resource Research Kanagawa 214-8571Japan Sumitomo Dainippon Pharma Co. Ltd.Osaka-fu 564-0053Japan Department of Kidney Regenerative Medicine The Jikei University School of MedicineTokyo 105-8461Japan

Controlling the immune response with only clinically approved immunosuppressant drugs is difficult in renal heterotra ns plantation from pigs to nonhuman ***,to the best of our knowledge,no reports exist on the use of fetal pigs as kidney *** study aimed to compare the degree of transplant rejection between neonatal and fetal kidneys,with genetically unmodified pigs as donors and cynomolgus monkeys as *** left kidneys of the recipient monkeys were removed,followed by transplantation of neonatal as well as fetal pig kidneys,which had undergone vascular anastomosis at the same site,into the *** was performed with only US Food and Drug Administration-approved *** fetal kidneys were transplanted into the omentum and paraaortic regions of cynomolgus ***,the engraftment and development of the transplanted tissues were pathologically examined by sampling over time(twice in each experiment).An acute rejection was observed after a few weeks in neonatal renal grafts with vascular ***,fetal pig kidneys were spared from rejection despite the administration of the same immunosuppressive protocol to the monkeys and the recipient blood vessels flowing into the fetal *** immunogenicity of fetal kidneys in pig-monkey renal heterotransplantation was lower than that of neonatal kidneys.

关键词： Cynomolgus monkey Pig Kidney Fetal kidney Immunosuppression

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好用又漂亮的特别化妆用品都齐聚在这里了！X’mas kit＆限定COLLECTION

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国际服装技术 2007年第12期 148-151页

作者： Masae saito Xiyanfeng（翻译）

化装包照片下的标注是根据编辑调查的化装包的h（高度）XW（宽度）XD（深度），单位是cm。

关键词： COLLECTION 化妆用品 mas kit 齐聚

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Matrix metalloproteinase-2 as a superior biomarker for peritoneal deterioration in peritoneal dialysis

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World Journal of Nephrology 2016年第2期5卷 204-212页

作者： Ichiro hirahara Eiji Kusano Yoshiyuki Morishita Makoto Inoue Tetsu Akimoto Osamu saito Shigeaki Muto Daisuke Nagata Division of Nephrology Department of Internal MedicineJichi Medical University

AIM： To investigate the effcacy of effuent biomarkers for peritoneal deterioration with functional decline in peritoneal dialysis （PD）.METhODS： From January 2005 to March 2013, the subjects included 218 PD patients with end-stage renal disease at 18 centers. Matrix metalloproteinase-2 （MMP-2）, interleukin-6 （IL-6）, hyaluronan, and cancer antigen 125 （CA125） in peritoneal effluent were quantified with enzyme-linked immunosorbent assay. Peritoneal solute transport rate was assessed by peritoneal equilibration test （PET） to estimate peritoneal ***： The ratio of the effuent level of creatinine （Cr） obtained 4 h after injection （D） to that of plasma was correlated with the effluent levels of MMP-2 （ρ = 0.74, P 〈 0.001）, IL-6 （ρ = 0.46, P 〈 0.001）, and hyaluronan （ρ = 0.27, P 〈 0.001）, but not CA125 （ρ = 0.13, P = 0.051）. The area under receiver operating characteristic curve for the effluent levels of MMP-2, IL-6, and hyaluronan against high PET category were 0.90, 0.78, 0.62, and 0.51, respectively. No patient developed new-onset encapsulating peritoneal sclerosis for at least 1.5 years after peritoneal effuent ***： The effuent MMP-2 level most closely reflected peritoneal solute transport rate. MMP-2 can be a reliable indicator of peritoneal deterioration with functional decline.

关键词： Encapsulating peritoneal sclerosis Matrix

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A Novel Dynamic Polymer Synthesis via Chlorinated Solvent Quenched Depolymerization

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CCS Chemistry 2023年第8期5卷 1841-1853页

作者： Jiadeng Zhu Sheng Zhao Jiancheng Luo Wei Niu Joshua T.Damron Zhen Zhang Md Anisur Rahman Mark A.Arnould Tomonori saito Rigoberto Advincula Alexei P.Sokolov Bobby G.Sumpter Peng-Fei Cao Chemical Sciences Division Oak Ridge National LaboratoryOak RidgeTennessee 37831 Departmnet of Chemistry University of TennesseeKnoxvilleTennessee 37996 Department of Chemical and Biomolecular Engineering University of TennesseeKnoxvilleTennessee 37996 Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37831 State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029

Dynamic polymers with both physical interactions and dynamic covalent bonds exhibit superior performance,but achieving such dry polymers in an effi-cient manner remains a ***,we report a novel organic solvent quenched polymer synthesis using the natural molecule thioctic acid(TA),which has both a dynamic disulfide bond and carboxylic *** effects of the solvent type and concentration along with reaction times on the proposed reaction were thoroughly explored for polymer ***-state proton nuclear magnetic resonance(1 h NMR)and first-principles simulations were carried out to investigate the reaction *** show that the chlorinated solvent can efficiently stabilize and mediate the depolymerization of poly(TA),which is more kinetically favorable upon lowering the *** to the numerous dynamic covalent disulfide bonds and noncovalent hydrogen bonds,the obtained poly(TA)shows high extensibility,self-healing,and reprocessable *** can also be employed as an efficient adhesive even on a Teflon surface and 3D printed using the fused deposition modeling *** new polymer synthesis approach of using organic solvents as catalysts along with the unique reaction mechanism provides a new pathway for efficient polymer synthesis,especially for multifunctional dynamic polymers.

关键词： self-healing polymer dynamic sulfide bond 3D printing solvent quenched synthesis dynamic polymer

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