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Leadless cardiac pacemaker implantations after infected pacemaker system removals in octogenarians

Journal of Geriatric Cardiology 2021年第7期18卷 505-513页

作者： Satoshi higuchi Ayako Okada Morio Shoda Daigo Yagishita Satoshi saito Miwa Kanai Shohei Kataoka Kyoichiro Yazaki hiroaki Tabata hideki Kobayashi Wataru Shoin Takahiro Okano Koji Yoshie Koichiro Ejima Koichiro Kuwahara Nobuhisa hagiwara Department of Cardiology Tokyo Women’s Medical UniversityKawada-choShinjuku-ku 8-1Tokyo 162-8666Japan Department of Cardiovascular Medicine Shinshu UniversitySchool of Medicine3-1-1 AsahiMatsumotoNagano 390-8621Japan Department of Cardiovascular Surgery Tokyo Women’s Medical UniversityKawada-cho 8-1Shinjuku-kuTokyo 162-8666Japan

Background Management of pacemaker(PM)infections among advanced aged patients possesses particular clinical challenges due to higher rates of concurrent cardiovascular disease and medical *** leadless cardiac pacemakers(LCPs)may provide new opportunities for better management options in this population,however,there is limited data especially in Asian populations to guide the decision *** We reviewed 11 octogenarians(median age:86[minimum 82–maximum 90]years;male:73%;median body mass index(BMI):20.1 kg/m^(2))who received Micra Transcatheter Pacing System(Medtronic Inc,Minneapolis,MN)implantations following transvenous lead extractions(TLEs)for PM *** All patients had more than two medical comorbidities(average 3.7 comorbidities).The indications for LCP implantations were atrioventricular block in four patients,atrial fibrillation bradycardia in five,and sinus node dysfunction in *** patients(73%)were bridged with temporary pacing using active fixation leads(median interval of 14.0 days),while one with severe dementia underwent a concomitant LCP implantation and TLE during the same *** TLEs and LCP implantations were successfully accomplished in all without any *** median time from the TLE procedure to discharge was 22 days(minimum 7–maximum 136).All patients remained free of infections during a mean follow-up period of 17.2±6.5 *** LCP implantations were safe and effective after removing the entire infectious PM system in all *** novel LCP technology may offer an alternative option for considering a re-implantation strategy after transvenous PM infections in elderly patients,particularly those with severe frailty and PM dependency.

关键词： implantation cardiac removing

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PVC抗冲改性剂—MBS树脂的新发展

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齐鲁石油化工 1988年第5期 33-38页

作者： A·TAKAKI h·hOSOI K·saito 张素心

一、引言按定义,MBS是将MMA(甲基丙烯酸甲酯)和苯乙烯接枝到SBR(丁二烯、苯乙烯橡胶)或BR(丁二烯橡胶)胶乳上制备的共聚物。 50年代中期,为了开辟PVC硬制品在特殊透明包装材料方面的用途,开发了

关键词： PVC MBS 抗冲改性剂树脂

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增强透明PVC的高含胶量增韧剂MBS

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聚氯乙烯 1988年第3期 51-55页

作者： A.Takkaki h.hosoi K.saito 李远芬上海高桥石化公司化工厂

用甲基丙烯酸甲酯、丁二烯、苯乙烯的接枝共聚物(MBS)增韧PVC,即使MBS中丁二烯含量比较高,仍可保持PVC薄膜和板材的透明性。经调整的接枝体颗粒结构消除了会发生光散射的缩孔的形成,这些缩孔使材料表面丧失其透明度。五十年代发展起来... 详细信息

用甲基丙烯酸甲酯、丁二烯、苯乙烯的接枝共聚物(MBS)增韧PVC,即使MBS中丁二烯含量比较高,仍可保持PVC薄膜和板材的透明性。经调整的接枝体颗粒结构消除了会发生光散射的缩孔的形成,这些缩孔使材料表面丧失其透明度。五十年代发展起来的MBS增韧剂,能够改善PVC的抗冲强度,为硬聚氯乙烯开拓了透明包装的市场。然而若要求材料具有

关键词：接枝共聚物增韧剂 MBS PVC 丁二烯橡胶光散射颗粒结构硬聚氯乙烯接枝聚合物含胶量

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一例罕见的伴多处转移的恶性上皮样周围神经鞘瘤的免疫组织化学诊断

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 49-50页

作者： Tsuchiya D. Takamura h. saito K. 肖颖 Department of Ophthalmology Yamagata University School of Medicine 2- 2- 2 Iidanishi Yamagata 990- 9585 Japan

Background: The epithelioid variant of malignant peripheral nerve sheath tumor (MPNST) is a rare tumor with poor prognosis that sometimes involves the head and neck. The diagnosis is based principally on the histological examination, and it is generally very difficult to reach the correct diagnosis. Case: An 84- year-old Japanese woman presented with a tumor mass of 2 week’ s duration in the right medial canthal region. Observations: Although the tumor was excised surgically,metastases occurred three times on her face and head, and the patient died of distant systemic multiple metastases. In the histopathological analysis, the tumor showed a composite pattern comprising spindle or polygonal cells arranged in irregular bands, and a population of larger epithelioid cells in solid sheets and nests. In the immunohistochemical analysis, the tumor cells were positive for S-100 protein, vimentin, and nerve growth factor receptor (NGFR), and negative for cytokeratin and hMB 45 (melanoma-associated antigen). These findings confirmed the diagnosis of MPNST. Conclusions: Epithelioid MPNST has complex histopathological findings and histopathological features similar to other epithelioid tumors, especially malignant melanoma. Immunohistochemical examination using NGFR and hMB-45 is important in the differential diagnosis.

关键词：神经鞘瘤免疫组织化学组织学检查细胞角蛋白生长因子受体瘤细胞肿瘤相关抗原组织病理学恶性黑色素瘤内眦

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回肠结肠淋巴瘤:16例系列报道

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 21-22页

作者： saito T. Toyoda h. Yamaguchi M. 陈瑜 Department of Endoscopic Medicine Mie University School of Medicine 2-174 Edobashi Tsu Mie Prefecture Dr.514-8507 Japan Dr.

Background: Colonoscopic and clinical differences between primary ileocolonic mucosa-associated lymphoid tissue (MALT) lymphoma and mantle cell lymphoma (MCL) have not been defined. Methods: We reviewed colonoscopic and clinical features in eight patients with primary MALT lymphoma and eight patients with MCL in the terminal ileum and/or colorectum. All cases were examined for CD5 and/or cyclin D1 expression. Results: Endoscopic features of MALT lymphoma were characterized as protrusions that were covered with normal-appearing mucosa with or without ulceration. The gross appearances of MALT lymphomas were categorized as solitary (4 patients), multiple (3 patients), and multiple lymphomatous polyposis (MLP) (1 patient). The gross features of MCL at endoscopy were categorized as multiple protrusions (2 patients), and MLP (6 patients). The clinical stages of patients with MCL were more advanced than in patients with MALT lymphoma. Conclusions: Solitary or multiple protrusions at an early clinical stage is the most common presentation pattern of patients with MALT lymphoma, but an MLP appearance at an early stage is also possible. On the other hand, MLP appearance with an advanced clinical stage is the main presentation pattern in patients with MCL, although multiple protrusions with an early clinical stage is also possible. histological and immunohistochemical investigation including that of cyclin D1 and CD5 expression is essential to make the final diagnosis.

关键词：结肠淋巴瘤套细胞淋巴瘤结肠直肠细胞周期蛋白正常黏膜多发性淋巴瘤结肠镜淋巴样组织肠结回肠末端

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极低温处理提高γ射线照射水稻种子的诱变效率

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原子能农业译丛 1981年第1期 18-22页

作者： h.Nakai M.saito 田禾李淑娴日本静冈大学农学系日本京都大学原子反应堆实验所

在极低温（-196℃）下,用（60）Co γ射线照射了含水量约为13％的水稻干种子。发现冷冻处理时M-植株成活率、幼苗高度和结实方面的损伤,均明显地小于未处理的对照。M2代叶绿素及抽穗期的突变频率并未因此受到影响,采用较高剂量结合冷冻... 详细信息

在极低温（-196℃）下,用（60）Co γ射线照射了含水量约为13％的水稻干种子。发现冷冻处理时M-植株成活率、幼苗高度和结实方面的损伤,均明显地小于未处理的对照。M2代叶绿素及抽穗期的突变频率并未因此受到影响,采用较高剂量结合冷冻处理,可以显著地提高突变频率。还发现,M2代不育或半不育突变体的频率,在冷冻处理中显著地低于未冷冻的对照。

关键词：突变率抽穗期诱变效率冷冻处理突变频率突变体突变型水稻种子自由基游离基结实率叶绿素射线剂量染色体畸变辐射损伤生物辐射效应极低温

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新生儿早期血清脂质结合素的浓度

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 49-50页

作者： Kamoda T. saitoh h. saito M. 贺莉 Department of Pediatrics University of Tsukuba 1-1-1 Tennoudai Tsukuba 305-8575 IbarakiJapan

通过对28例小于胎龄儿(SGA)和34例适于胎龄儿(AGA)的足月儿的血清脂质结合素水平的检测,来了解胎儿的生长与脂质结合素水平有何种关系。生后第1 个24 h内采集测定脂质结合素的血液样本。以上新生儿(SGA和AGA)的血清脂质结合素水平显著... 详细信息

通过对28例小于胎龄儿(SGA)和34例适于胎龄儿(AGA)的足月儿的血清脂质结合素水平的检测,来了解胎儿的生长与脂质结合素水平有何种关系。生后第1 个24 h内采集测定脂质结合素的血液样本。以上新生儿(SGA和AGA)的血清脂质结合素水平显著高于正常孩子(28.7±17.0 mg/L t vs 9.3±6.1 mg/L,P< 0.01)。在SGA和AGA之间,脂质结合素水平也有显著性差异(23.2±14.8 mg/L vs 33.2±17.5 mg/L,P =0.02)。所有新生儿的血清脂质结合素水平与出生体重和头围呈正相关,分别为(r=0.27,P<0.05)和(r=0.30,P<0.05)。血清脂质结合素水平与胎龄、出生身长、血糖水平、生后采集血液样本的时间无关。所有新生儿脂质结合素水平在男婴和女婴的浓度分别为30.0±19.7 mg/L vs 28.0±15.5 mg/L,无性别差异。结果表明:血清脂质结合素水平与出生体重的正相关关系和高脂血症不能仅凭机体脂肪的低百分数解释。SGA比AGA的脂质结合素水平更低,并不表示宫内发育迟缓的婴儿在生后早期有胰岛素抵抗,但可能成为将来发展成胰岛素抵抗或者2型糖尿病的因素。

关键词：血清脂质小于胎龄儿宫内发育迟缓胰岛素抵抗血液样本头围适于胎龄儿有显著性差异机体脂肪脂血症

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蚊涎腺萃取物对hMB患者经CD4+T细胞诱导E-BV感染的NK细胞肿瘤形成

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 21-22页

作者： Asada h. saito-Katsuragi M. Niizeki h. 朱国兴 Department of Dermatology Nara Medical University 840 Shijo-cho Kashihara Nara 634- 8522 Japan Dr.

Severe hypersensitivity to mosquito bites (hMB) is characterized by intense local skin reactions and systemic symptoms such as high fever, lymphadenopathy, and hepatosplenomegaly. Patients with hMB often have natural killer (NK) cell lymphocytosis associated with Epstein-Barr virus (EBV) infection. here we investigated whether mosquito bites have any influence on the oncogenesis of EBV-infected NK cells. We examined six hMB patients with EBV-infected NK cell lymphocytosis. We first demonstrated that CD4+ T cells, but not NK cells, proliferated well in response to mosquito salivary gland extracts (SGE), especially to SGE of Aedes albopictus. When NK cells were cocultured with autologous CD4+ T cells stimulated by mosquito SGE, the expression of viral oncogene latent membrane protein 1 (LMP1) was remarkably enhanced. Next, we stimulated mononuclear cells of the patients with mosquito SGE, and NK cell counts were monitored for 28 d. The counts changed little from initial levels in the culture with mosquito SGE, whereas they decreased steadily in the culture without the extracts. Furthermore, we detected LMP1 mRNA in the skin lesion induced by mosquito SGE. These results suggest that mosquito bites can induce expression of the viral oncogene LMP1 in NK cells via mosquito antigen-specific CD4+ T cells, which is involved in the oncogenesis of NK cells in vivo.

关键词： CD4^+T细胞 EBV感染白纹伊蚊 NK细胞肿瘤形成萃取物 Epstein-Barr病毒细胞诱导患者涎腺

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Prognostic predictors on the efficacy of oral appliance therapy for obstructive sleep apnea syndrome

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Open Journal of Stomatology 2012年第3期2卷 210-221页

作者： Tadashi Iwamoto Yoshiyuki Takata Nobutaka Kitamura Daichi hasebe Tadaharu Kobayashi Chikara saito Division of Information Science and Biostatistics Department of Imformatics and Pharmaceutics Course for Community Disease Control Graduate School of Medical and Dental Sciences Niigata University Niigata Japan Division of Reconstructive Surgery for Oral and Maxillofacial Region Department of Tissue Regeneration and Reconstruction Graduate School of Medical and Dental Sciences Niigata University Niigata Japan

Objectives: The aim of this study was to identify independent prognostic predictors of the efficacy of oral appliance (OA) therapy for obstructive sleep apnea syndrome (OSAS). Materials and methods: The subjects consisted of 89 patients (77 males and 12 females) in whom OSAS had been treated with an OA. The mean age of the subjects was 52.4 years (range: 20 to 78 years) and mean body mass index (BMI) was 23.9 kg/m2 (range: 17.3 to 32.2 kg/m2). Lateral cephalograms were taken and 15 angle, 15 distance and 5 area measurements were calculated by means of a computerized program. Overnight polysomnography (PSG) was performed before treatment and several months after titration of OA therapy. OA therapy was considered effective if the apnea-hypopnea index several months after titration was under 15 events/h and was reduced to at least 50% of that before treatment. The examined data such as patient age, sex, BMI, data from cephalometric analyses, Epworth sleepiness scale, and data for pretreatment PSG were analyzed statistically, and multivariate logistic regression analysis was performed to clarify predictive variables for treatment outcome. Results: LFh (OR = 0.350;p = 0.035) and McN-A (OR = 0.276;p = 0.057) were selected as independent predictors from the explanatory variables. The predictive accuracy of the calculated logistic regression model was 74.2%. Conclusion: This results show that OA therapy for OSAS is more effective in patients with large anteroposterior diameter of the maxilla and large lower facial height.

关键词： Obstructive Sleep Apnea Syndrome Oral Appliance Therapy Predictors of Response

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Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy

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World Journal of Gastroenterology 2013年第11期19卷 1673-1682页

作者： Junichi Iwamoto Yoshifumi saito Akira honda Yasushi Matsuzaki Department of Gastroenterology Tokyo Medical UniversityIbaraki Medical CenterIbaraki 300-0395Japan

Low-dose aspirin(LDA) is clinically used for the prevention of cardiovascular and cerebrovascular events with the advent of an aging *** the other hand,a very low dose of aspirin(10 mg daily) decreases the gastric mucosal prostaglandin levels and causes significant gastric mucosal *** incidence of LDAinduced gastrointestinal mucosal injury and bleeding has *** has been noticed that the incidence of LDA-induced gastrointestinal hemorrhage has increased more than that of non-aspirin non-steroidal anti-inflammatory drug(NSAID)-induced *** pathogenesis related to inhibition of cyclooxygenase(COX)-1 includes reduced mucosal flow,reduced mucus and bicarbonate secretion,and impaired platelet *** pathogenesis related to inhibition of COX-2 involves reduced angiogenesis and increased leukocyte *** pathogenic mechanisms related to direct epithelial damage are acid back diffusion and impaired platelet *** factors associated with an increased risk of upper gastrointestinal(GI) complications in subjects taking LDA are aspirin dose,history of ulcer or upper GI bleeding,age > 70 years,concomitant use of non-aspirin NSAIDs including COX-2-selective NSAIDs,and helicobacter pylori(***) ***,no significant differences have been found between ulcer and non-ulcer groups in the frequency and severity of symptoms such as nausea,acid regurgitation,heartburn,and *** has been shown that the ratios of ulcers located in the body,fundus and cardia are significantly higher in bleeding patients than the ratio of gastroduodenal ulcers in patients taking *** pump inhibitors reduce the risk of developing gastric and duodenal *** contrast to NSAIDinduced gastrointestinal ulcers,a well-tolerated histamine h2-receptor antagonist is reportedly effective in prevention of LDA-induced gastrointestinal *** eradication of *** is equivalent to treatment with omeprazole in preventing recurrent b

关键词： Gastroduodenal ulcer Upper gastrointestinal bleeding Low-dose aspirin Non-steroidal antiinflammatory drugs

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