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A survey of web resources and tools for the study of TCM network pharmacology

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Frontiers of Electrical and Electronic Engineering in China 2019年第1期7卷 17-29页

作者： Jing Zhao Jian Yang saisai Tian Weidong zhang Institute of Interdisciplinary Complex Research Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Pharmacology Second Military Medical UniversityShanghai 200433China

Background: Traditional Chinese medicine (TCM) treats diseases in a holistic manner, while TCM formulae are multi-component, multi-target agents at the molecular level. Thus there are many parallels between the key ideas of TCM pharmacology and network pharmacology. These years, TCM network pharmacology has developed as an interdisciplinary of TCM science and network pharmacology, which studies the mechanism of TCM at the molecular level and in the context of biological networks. It provides a new research paradigm that can use modern biomedical science to interpret the mechanism of TCM, which is promising to accelerate the modernization and internationalization of TCM? Results: In this paper we introduce state-of-the-art free data sources, web servers and softwares that can be used in the TCM network pharmacology, including databases of TCM, drug targets and diseases, web servers for the prediction of drug targets, and tools for network and functional analysis. Conclusions: This review could help experimental pharmacologists make better use of the existing data and methods in their study of TCM.

关键词： TCM network pharmacology molecular networks signaling pathways databases web servers

pH、氨氮和亚硝酸盐对单环刺螠稚螠耗氧率和排氨率的影响

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水产学杂志 2021年第4期34卷 35-42页

作者：张赛赛董美艳田斌孙阳陈颖周竹君宋晓阳杨婷婷刘彤陈文博大连市现代农业生产发展服务中心辽宁大连116023 瓦房店市渔业事务服务中心辽宁瓦房店116300

在水温14.5~17.0℃、盐度32.17~32.28下,采用静水密闭式呼吸实验法研究不同pH(6.0、7.0、8.0、9.0和10.0)、氨氮(0.0699 mg/L、0.0736 mg/L、0.1560 mg/L和1.0200 mg/L)和亚硝酸盐(0.0198 mg/L、0.0256 mg/L、0.0502 mg/L、0.0738 mg/L和0.4960 mg/L)含量(用氯化铵和亚硝酸钠调制置)对体质量为(1.52±0.12)g的单环刺螠Urechis unicinctus稚螠的耗氧率和排氨率的影响。结果表明,随pH升高,单环刺螠稚螠耗氧率和排氨率先升高后降低,影响显著(P0.05)。随着pH的升高O/N值先升高后降低,范围在3.911~10.484;随着氨氮浓度升高,O/N值呈下降趋势,范围在8.673~28.656;随着亚硝酸盐浓度升高,O/N值先升高后降低,范围在29.376~44.783。本实验条件下,pH低于8时能源物质为蛋白质,高于pH 8能源物质转为蛋白质和脂肪;不同氨氮浓度下脂肪均是能源物质,只是所占比例不同;不同亚硝酸盐浓度下O/N值均大于24.0,能源物质为脂肪和碳水化合物。

关键词：单环刺螠耗氧率排氨率 pH 氨氮:亚硝酸盐

短横轴截割机器人直墙拱形巷道自动成形控制方法

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西安科技大学学报 2024年第3期44卷 418-429页

作者：马宏伟王赛赛王川伟薛力猛张恒孙思雅西安科技大学机械工程学院陕西西安710054 陕西省矿山机电装备智能检测与控制重点实验室陕西西安710054 西安科技大学电气与控制工程学院陕西西安710054

针对掘进机在直墙拱形巷道掘进过程中存在定位难、截割效率低、成形质量差等问题,提出一种短横轴截割机器人及其自动成形控制方法。首先设计了串联式短横轴截割机器人结构,构建了短横轴截割机器人运动学模型,建立了截割臂升降油缸、滑... 详细信息

针对掘进机在直墙拱形巷道掘进过程中存在定位难、截割效率低、成形质量差等问题,提出一种短横轴截割机器人及其自动成形控制方法。首先设计了串联式短横轴截割机器人结构,构建了短横轴截割机器人运动学模型,建立了截割臂升降油缸、滑移油缸及回转油缸伸缩量与截割头末端位姿的数学关系,提出了短横轴截割机器人直墙拱形巷道自动成形控制方法;其次研究分析了短横轴截割机器人截割头包络空间与直墙半圆拱形巷道空间耦合关系,确定了截割过程中截割轨迹关键点位置,提出了基于截割轨迹关键点的“弓”型截割轨迹规划方法;然后根据建立的短横轴截割机器人运动学模型,求解截割头在跟踪截割轨迹的过程中运动控制量和截割、修帮、扫底3个任务各个关节控制时序;最后以模糊PID为例,建立了短横轴截割机器人自动成形控制方法,利用Adams软件对短横轴截割机器人进行截割运动仿真试验。结果表明:利用“弓”型截割轨迹规划方法能够完成直墙拱形巷道的截割轨迹规划,控制截割头对截割轨道进行跟踪控制,实现了直墙拱形巷道断面的自动成形截割,截割成形的巷道最大欠挖量为48 mm,最大超挖量为21 mm,满足煤矿巷道成形质量要求。研究得出短横轴截割机器人可在沿巷道中线不左右移机的情况下,高效率、高质量地完成直墙拱形巷道断面自动成形截割任务。

关键词：定形截割截割机器人拱形巷道轨迹规划模糊PID控制

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Evolutionary dynamics and conserved function of the Tudor domain-containing(TDRD)proteins in teleost fish

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Marine Life Science & Technology 2022年第1期4卷 18-30页

作者： Zeyu Liu saisai Liu Shiyang Guo Wei Lu Quanqi zhang Jie Cheng Key Laboratory of Marine Genetics and Breeding(Ocean University of China) Ministry of EducationQingdao266003China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266237China Laboratory of Tropical Marine Germplasm Resources and Breeding Engineering Sanya Oceanographic InstitutionOcean University of ChinaSanya572000China

Tudor domain-containing(TDRD)proteins,the germline enriched protein family,play essential roles in the process of gametogenesis and genome stability through their interaction with the PIWI-interacting RNA(piRNA)*** studies have suggested the rapid evolution of the piRNA pathway in teleost lineages with striking reproductive ***,there is still limited information about the function and evolution of Tdrd genes in teleost *** this study,through genome wide screening,13 Tdrd family genes were identified in economically important aquaculture fish,including spotted sea bass(Lateolabrax maculatus),Asian sea bass(Lates calcarifer),and tongue sole(Cynoglossus semilaevis).With copy number,structure,phylogeny,and synteny analysis,duplication of Tdrd6 and Tdrd7,as well as loss of Stk31 and Tdrd10,were characterized in teleost *** based molecular evolution analysis indicated faster evolution of teleost Tdrd genes than that in mammals,potentially associated with the accelerated evolution of the piRNA pathway in teleost *** evolutionary diversity of Tdrd genes was also detected between different teleost ***-seq analysis showed that most teleost Tdrd genes were dominantly expressed in gonads,particularly highly expressed in testis,such as Tdrd6,Tdrd7a,Tdrd9,Ecat8,and *** varied expression and evolutionary pattern between the duplicated Tdrd6 and Tdrd7 in teleosts may indicate their functional *** these results suggest a conserved function of teleost Tdrd family in gametogenesis and the piRNA pathway,which could lay a foundation for the evolution of Tdrd genes and be helpful for further deciphering of Tdrd functions in teleosts.

关键词： Tudor domain PIWI interacting RNA Molecular evolution Gametogenesis Teleost

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中医知识库质量评价现状分析及指标构建

中医杂志 2024年第11期65卷 1115-1119,1125页

作者：赵赛赛范雅祺张云王维广陈子杰刘晓峰翟双庆北京中医药大学中医学院北京市100029 北京中医药大学东直门医院电子科技大学

从中医资料类知识库和辅助决策类知识库两个角度,梳理目前中医知识库建设、质量评价现状及其存在的问题,在借鉴其他学科知识库质量评价策略和维度的基础上,探讨中医知识库质量评价指标,初步形成质量评价框架,为中医知识库评价体系的完... 详细信息

从中医资料类知识库和辅助决策类知识库两个角度,梳理目前中医知识库建设、质量评价现状及其存在的问题,在借鉴其他学科知识库质量评价策略和维度的基础上,探讨中医知识库质量评价指标,初步形成质量评价框架,为中医知识库评价体系的完善提供思路。评价指标中,基础性评价维度包括数据来源、数据整理、数据应用;资料类知识库的特异性评价维度为数据质量,辅助决策类知识库的特异性评价维度为数据匹配。各指标中,数据应用维度中的数据量指标根据库中有效数据条目计数评价,其他指标根据“是”“否”或“未知”定性评价后计分,基础评价得分与特异评价得分相加得到总分,根据分数将知识库分级,结果以等级+数字的形式呈现。

关键词：中医知识库资料类知识库辅助决策类知识库质量评价评价指标质量控制

Electron-deficient Cu site catalyzed acetylene hydrochlorination

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Green Energy & Environment 2023年第4期8卷 1128-1140页

作者： Bolin Wang Chunxiao Jin Shujuan Shao Yuxue Yue Yuteng zhang saisai Wang Renqin Chang Haifeng zhang Jia Zhao Xiaonian Li School of Chemical Engineering Northeast Electric Power UniversityJilin132012China Industrial Catalysis Institute of Zhejiang University of Technology Hangzhou310014China Research Center of Analysis Measurement Zhejiang University of TechnologyHangzhou310014China

Rational design of catalytic sites to activate the C≡C bond is of paramount importance to advance acetylene hydrochlorination. Herein, Cu sites with electron-rich and electron-deficient states were constructed by controlling the impregnation solutions. The π electrons flowing from acetylene to Cu site are facilitated over the electron-deficient Cu sites, achieving high activation of C≡C bond. The contradiction between the increased activation of acetylene required for enhanced catalytic activity and the resistance of Cu site to reduction by acetylene required for maintaining catalytic stability can be balanced by establishing strong interactions of Cu site with pyrrolic-N species. The catalytic activity displays a volcano shape scaling relationship as a function of Cu particle size. Tribasic copper chloride is concomitantly generated with the construction of electron-deficient Cu sites. The H–Cl bond of HCl can be activated over the tribasic copper chloride, accelerating the surface reaction of vinyl chloride production. This strategy of inducing electron deficiency provides new insight into the rational design of catalysts for the synthesis of vinyl chloride with a high catalytic performance.

关键词： C≡C bond Acetylene hydrochlorination Cu sites Tribasic copper chloride Electron-deficient

系统性红斑狼疮患者外周血中γδT细胞及其主要功能亚群的变化及临床意义

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实用临床医药杂志 2024年第6期28卷 88-93页

作者：颜云霞张卓亚黄赛赛耿林玉南京大学医学院附属鼓楼医院风湿免疫科江苏南京210008

目的探讨系统性红斑狼疮(SLE)患者外周血中γδT细胞及其主要功能亚群γδT1、γδT17细胞的变化及其临床意义。方法采用流式细胞术检测21例SLE患者(SLE组)、16例健康对照患者(HC组)外周血γδT细胞、γδT1细胞、γδT17细胞的比例及... 详细信息

目的探讨系统性红斑狼疮(SLE)患者外周血中γδT细胞及其主要功能亚群γδT1、γδT17细胞的变化及其临床意义。方法采用流式细胞术检测21例SLE患者(SLE组)、16例健康对照患者(HC组)外周血γδT细胞、γδT1细胞、γδT17细胞的比例及绝对数。采用Pearson相关性分析法分析外周血γδT细胞、γδT1细胞、γδT17细胞与临床指标的相关性。结果SLE患者外周血γδT细胞占淋巴细胞百分率为(2.30±1.10)%,低于HC组的(3.30±1.51)%,差异有统计学意义(P0.05)。SLE患者外周血γδT细胞绝对数为(2.88±2.18)×10^(4)/mL,低于HC组的(7.96±3.96)×10^(4)/mL,差异有统计学意义(P<0.0001);SLE患者外周血γδT1细胞绝对数为(1.20±1.17)×10^(4)/mL,低于HC组的(5.05±3.04)×10^(4)/mL,差异有统计学意义(P<0.0001);SLE患者外周血γδT17细胞绝对数为(1.03±1.08)×103/mL,高于HC组的(0.40±0.24)×103/mL,差异有统计学意义(P<0.05)。SLE患者外周血中γδT17细胞比例与系统性红斑狼疮疾病活动度评分(SLEDAI)(r=0.59,P<0.01)、红细胞沉降率(r=0.65,P<0.01)呈正相关,γδT17细胞绝对数与SLEDAI(r=0.59,P<0.01)呈正相关,与补体C3水平(r=-0.53,P<0.05)呈负相关。结论SLE患者外周血中γδT细胞数量显著下降主要由其γδT1细胞亚群减少所致,γδT17细胞在SLE发病及活动中发挥了重要作用。

关键词：系统性红斑狼疮 γδT细胞干扰素-γ 白细胞介素-17A 系统性红斑狼疮疾病活动度评分

The U-Pb Geochronology and Lu-Hf Isotope Compositions of Detrital Zircons from the Nanhua Group of the Longsheng Region,South China and their Implications for Pan-African Events

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Acta Geologica Sinica(English Edition) 2021年第3期95卷 740-749页

作者： zhang Chenglong QIN Ya YANG Yicheng FENG Zuohai LIU Xijun LI saisai WAN Lei WANG Chunzeng Collaborative Innovation Center for the Exploration of Hidden Nonferrous Metal Deposits and the Development of New Materials in Guangxi&Guangxi Key Laboratory of Hidden Metallic Ore Exploration Guilin University of TechnologyGuilinGuangxi 541004China University of Maine at Presque Isle Maine ME 04769USA

It is unclear whether the South China blocks have an affinity with continental Gondwana due to a lack of direct Pan-African magmatic and metamorphic *** this study,we conducted U-Pb geochronological and Lu-Hf isotopic analyses for detrital zircons from a sandstone of the Chang'an Formation of the Nanhua Group in the Longsheng region of northern Guangxi,with the aim of constraining the timing of sedimentation and information as to its source,as well as seeking evidence for Pan-African events in the South China *** results show that the ages of detrital zircons peaked at 654.7±6.2 Ma,773.2±4.1 Ma and 821.9±6.5 Ma,with some at 920–870 Ma;the youngest age indicates the existence of the Pan-African thermal *** ε_(Hf)(t)and T_(DM2) values demonstrate that the study area has experienced three stages of crustal growth at 3.0–2.4 Ga,2.1–1.5 Ga and 1.3–0.9 *** intensively distributed Neoproterozoic mafic-ultramafic and granitic plutons emplaced at 830–810 Ma along the southwestern section of the Jiangnan Orogenic Belt and positiveεHf(t)values from a large group of zircon grains,it is proposed that the sediments of the Chang'an Formation(of Nanhua Group)were largely sourced from the southeastern margin of the Yangtze *** with the zircon age spectra of the Cathaysian block shows that about 79%of the Pan-African aged detrital zircon grains that have TDM2=1352–1031 Ma andεHf(t)=3.68–8.79,were sourced from the recycled Grenvillian crust of the Cathaysian block,suggesting that the Cathaysian block had a close connection with Gondwana.

关键词： detrital zircon Lu-Hf isotope Pan-African event Guangxi South China

大豆异黄酮通过抑制Wnt/Ca2+信号通路减轻大鼠脑缺血再灌注引起的钙超载

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南方医科大学学报 2024年第6期44卷 1048-1058页

作者：李丽汪梦哲刘赛赛张小楠陈洁陶伟婷李晒秦志文陶泉坊刘奕黄丽赵士弟蚌埠医科大学病理生理学教研室安徽蚌埠233000 蚌埠医科大学心脑血管疾病基础与临床重点实验室安徽蚌埠233000 蚌埠医科大学临床医学院安徽蚌埠233000 南京市第一医院神经内科江苏南京210000

目的探讨大豆异黄酮(SI)减轻脑缺血再灌注(I/R)引起钙超载的作用机制。方法将48只SD大鼠采用随机数法分为4组:假手术组(Sham组)、脑缺血再灌注模型组(I/R组)、病毒空载组(NC组)、Frizzled-2敲低组(Knock down组),12只/组。采用线栓法... 详细信息

目的探讨大豆异黄酮(SI)减轻脑缺血再灌注(I/R)引起钙超载的作用机制。方法将48只SD大鼠采用随机数法分为4组:假手术组(Sham组)、脑缺血再灌注模型组(I/R组)、病毒空载组(NC组)、Frizzled-2敲低组(Knock down组),12只/组。采用线栓法堵塞大脑中动脉2 h,再灌注24 h构建I/R模型。采用Western blot验证病毒敲低效率并检测Wnt/Ca2+信号通路相关蛋白Wnt5a、Frizzled-2和P-CaMKⅡ的变化。采用钙含量显色法检测各组缺血半暗带(IP)区钙离子浓度变化,HE检测各组IP区组织结构变化。另将72只SD大鼠采用随机数法分为3组:Sham组、I/R组、大豆异黄酮预处理组(SI组),24只/组。采用多普勒血流仪检测局部脑血流变化,TTC染色检测脑梗死体积,HE和尼氏染色检测IP区组织变化、免疫荧光检测ROS、Ca2+和细胞凋亡水平、流式检测细胞钙离子浓度,试剂盒检测血清MDA和SOD水平,Western blotting和免疫组化检测IP区Wnt5a、Frizzled-2和P-CaMKⅡ蛋白表达。结果与I/R组比较,Knock down组钙离子浓度(P<0.001)、Wnt5a(P<0.05)、Frizzled-2(P<0.05)和P-CaMKⅡ(P<0.001)表达水平均降低;与I/R组比较,SI组钙离子浓度(P<0.05)、ROS和MDA水平(P<0.001)、细胞凋亡程度(P<0.001)、脑梗死体积(P<0.001)、Wnt5a、Frizzled-2和P-CaMKⅡ表达水平(P<0.05)均降低,SOD水平升高(P<0.001)。结论大豆异黄酮可能通过抑制Wnt/Ca2+信号通路减轻大鼠脑缺血再灌注引起的钙超载。

关键词：大豆异黄酮脑缺血再灌注钙超载 Wnt/Ca2+

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