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Astragaloside IV derivative HHQ16 ameliorates infarctioninduced hypertrophy and heart failure through degradation of lncRNA4012/9456

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5454-5469页

作者： Jingjing Wan Zhen Zhang hennan Wu saisai tianbei zang Ge Jin Qingyan Sun Pin Wang Xin Luan Yili Yang Xuelin Zhan Lingyu Linda Ye Dayue Darrel Duan Xia Liu Weidong Zhang School of Pharmacy Second Miltary Medical UniversityShanghaiPR China China Institute of Pharmaceutical Industry ShanghaiPR China Key Laboratory of Medical Immunology and Institute of Immunology Second Military Medical UniversityShanghaiPR China Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghaiPR China China Regional Research Centre International Centre of Genetic Engineering&BiotechnologyTaizhouPR China State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjinPR China Center for Phenomics of Traditional Chinese Medicine Hospital of Traditional Chinese Medicine Affliated to Southwest Medical UniversitySouthwest Medical UniversityLuzhouPR China Key Laboratory of Autoimmune Diseases and Precision Medicine People's Hospital of Ningxia Hui Autonomous RegionYinchuanPR China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingPR China

Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction(MI)heart failure(HF).Here,we report a novel small molecule HHQ16,an optimized derivative of astragaloside IV,which effectively reversed infarction-induced myocardial remodeling and improved cardiac function by directly acting on the cardiomyocyte to reverse *** effect of HHQ16 was associated with a strong inhibition of a newly discovered Egr2-affliated transcript Inc9456 in the *** minimally expressed in normal mouse heart,Inc9456 was dramatically upregulated in the heart subjected to left anterior descending coronary artery ligation(LADL)and in cardiomyocytes subjected to hypertrophic *** critical role of Inc9456 in cardiomyocyte hypertrophy was confirmed by specific overexpression and knockout in vitro.A physical interaction between Inc9456 and G3BP2 increased NF-kB nuclear translocation,triggering hypertrophy-related ***16 physically bound to Inc9456 with a high-affinity and induced its ***-specific Inc9456 overexpression induced,but knockout prevented LADL-induced,cardiac hypertrophy and ***16 reversed the effect of Inc9456 overexpression while lost its protective role when Inc9456 was deleted,further confirming Inc9456 as the bona fide target of *** further identified the human ortholog of Inc9456,also an Egr2-affliated transcript,***,Inc4012 was significantly upregulated in hypertrophied failing hearts of patients with dilated ***16 also specifically bound to Inc4012 and caused its degradation and antagonized its hypertrophic *** degradation of pathological increased Inc4012/lnc9456 by small molecules might serve as a novel promising strategy to regress infarction-induced cardiac hypertrophy and HF.

关键词： hypertrophy infarction protective

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Deep3DSketch-im:rapid high-fidelity AI 3D model generation by single freehand sketches

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 149-159页

作者： Tianrun CHEN Runlong CAO Zejian LI Ying zang Lingyun SUN College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China School of Software Technology Zhejiang UniversityHangzhou 310027China School of Information Engineering Huzhou UniversityHuzhou 313000China

The rise of artificial intelligence generated content(AIGC)has been remarkable in the language and image fields,but artificial intelligence(AI)generated three-dimensional(3D)models are still under-explored due to their complex nature and lack of training *** conventional approach of creating 3D content through computer-aided design(CAD)is labor-intensive and requires expertise,making it challenging for novice *** address this issue,we propose a sketch-based 3D modeling approach,Deep3DSketch-im,which uses a single freehand sketch for *** is a challenging task due to the sparsity and ***3DSketch-im uses a novel data representation called the signed distance field(SDF)to improve the sketch-to-3D model process by incorporating an implicit continuous field instead of voxel or points,and a specially designed neural network that can capture point and local *** experiments are conducted to demonstrate the effectiveness of the approach,achieving state-of-the-art(SOTA)performance on both synthetic and real ***,users show more satisfaction with results generated by Deep3DSketch-im,as reported in a user *** believe that Deep3DSketch-im has the potential to revolutionize the process of 3D modeling by providing an intuitive and easy-to-use solution for novice users.

关键词： Content creation Sketch Three-dimensional(3D)modeling 3D reconstruction Shape from X Artificial intelligence(AI)

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A Novel Multi-Attribute Decision-Making Method Based on Probabilistic Hesitant Fuzzy Soft Set and Its Application

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Journal of Systems Science and Information 2024年第2期12卷 294-308页

作者： Zhenchun zang Jielu LI Meng WEI College of Computer and Information Engineering Henan University of Economics and LawZhengzhou 450046China

The probabilistic hesitant fuzzy multi-attribute group decision-making method introduces probability and hesitation into decision-making problems at the same time,which can improve the reliability and accuracy of decision-making results,and has become a research hotspots in recent ***,there are still many problems,such as overly complex calculations and difficulty in obtaining probability *** on these,the paper proposes a multi-attribute group decision-making model based on probability hesitant fuzzy soft ***,the definition of probabilistic hesitant fuzzy soft set is ***,based on soft set theory and probabilistic hesitant fuzzy set,the similarity measure of probabilistic hesitant fuzzy soft set is proposed,and the two measures are further ***,it is applied to the construction of multi-attribute group decision-making model,and the effectiveness and rationality of the model are verified by an *** example shows that the new similarity calculation formula and algorithm model in this paper have higher accuracy,and the calculation process is more simple,it provides a feasible method for multi-attribute group decision making problems.

关键词： probabilistic hesitant fuzzy soft sets similarity multi-attribute group decision-making model

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Security Constrained Distributed Transaction Model for Multiple Prosumers

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 834-843页

作者： Haiteng Han Sichen Shen Zhinong Wei Mohammed Olama Haixiang zang Guoqiang Sun Yizhou Zhou School of Electrical and Power Engineering Hohai UniversityNanjing 211100China Oak Ridge National Laboratory Oak RidgeTN 37831 USA

Massive access of renewable energy has prompted demand-side distributed resources to participate in regulation and improve flexibility of power systems. With large-scale access of massive, decentralized, and diverse distributed resources, demand-side market members have transformed from traditional “consumers” to “prosumers”. To explore the distributed transaction model of prosumers, in this paper, a multi-prosumer distributed transaction model is proposed, and the Conditional Value-at-Risk (CVaR) theory is applied to quantify potential risks caused by the stochastic characteristics inherited from renewable energy. First, a prosumer model under constraints of the distribution network including photovoltaic units, fuel cells, energy storage system, central air conditioning and flexible loads is established, and a multi-prosumer distributed transaction strategy is proposed to achieve power sharing among multiple prosumers. Second, a prosumer transaction model based on CVaR is constructed to measure risks inherited from the uncertainty of PV output within the prosumer and ensure safety of system operation in extreme PV output scenarios. Then, the alternating direction multiplier method (ADMM) is utilized to solve the constructed model efficiently. Finally, distributed transaction costs of prosumers are distributed fairly based on the generalized Nash equilibrium to maximize social benefits. Simulation results show the multi-prosumer distributed transaction mechanism established under the proposed generalized Nash equilibrium method can encourage power sharing among prosumers, increasing their own income and social benefits. Also, the CVaR can assist decision making of prosumers in weighting the risks and benefits, improving system resilience through energy management of prosumers.

关键词： Alternating direction multiplier method Conditional Value-at-Risk distributed transaction generalized Nash equilibrium prosumer

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Full-Stokes metasurface polarimetry requiring only a single measurement

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Photonics Research 2024年第3期12卷 514-521页

作者： CHENGLONG ZHENG HUI LI JINGYU LIU MENGGUANG WANG HUAPING zang YAN ZHANG JIANQUAN YAO Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Key Laboratory of Opto-Electronics Information Technology(Tianjin University) Ministry of EducationSchool of Precision Instruments and Opto-Electronics EngineeringTianjin UniversityTianjin 300072China Beijing Key Laboratory for Metamaterials and Devices Key Laboratory of Terahertz OptoelectronicsMinistry of Educationand Beijing Advanced Innovation Center for Imaging TechnologyDepartment of PhysicsCapital Normal UniversityBeijing 100048China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

Polarization is crucial in various fields such as imaging,sensing,and substance detection.A compact,fast,and accurate polarization detection device is vital for these ***,we demonstrate a multifocus metalens for terahertz polarization detection that requires only a single measurement to obtain complete polarization parameters and reconstruct the polarization state of the incident *** individual subarrays of this metalens convert each of the six polarized components into the same polarization,which in turn links the Stokes parameters to these six *** incident linear polarizations and elliptical polarizations are characterized by Stokes parameters and polarization *** and experimental results show that the scheme can accurately detect the incident polarization with a single *** proposed metasurface polarimetry may find applications in the fields of real-time terahertz detection and integrated optics.

关键词： field incident polar

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Uncertainty quantification of inverse analysis for geomaterials using probabilistic programming

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 895-908页

作者： Hongbo Zhao Shaojun Li Xiaoyu zang Xinyi Liu Lin Zhang Jiaolong Ren School of Civil Engineering and Geomatics Shandong University of TechnologyZibo255000China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

Uncertainty is an essentially challenging for safe construction and long-term stability of geotechnical *** inverse analysis is commonly utilized to determine the physico-mechanical ***,conventional inverse analysis cannot deal with uncertainty in geotechnical and geological *** this study,a framework was developed to evaluate and quantify uncertainty in inverse analysis based on the reduced-order model(ROM)and probabilistic *** ROM was utilized to capture the mechanical and deformation properties of surrounding rock mass in geomechanical *** programming was employed to evaluate uncertainty during construction in geotechnical engineering.A circular tunnel was then used to illustrate the proposed framework using analytical and numerical *** results show that the geomechanical parameters and associated uncertainty can be properly obtained and the proposed framework can capture the mechanical behaviors under ***,a slope case was employed to demonstrate the performance of the developed *** results prove that the proposed framework provides a scientific,feasible,and effective tool to characterize the properties and physical mechanism of geomaterials under uncertainty in geotechnical engineering problems.

关键词： Geological engineering Geotechnical engineering Inverse analysis Uncertainty quantification Probabilistic programming

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Contact detumbling toward a nutating target through deformable effectors and prescribed performance controller

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Journal of Systems Engineering and Electronics 2024年第3期35卷 753-768页

作者： zang Yue ZHANG Yao HU Quan LI Mou CHEN Yujun School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China China Academy of Space Technology Beijing 100029China

Detumbling operation toward a rotating target with nutation is meaningful for debris removal but challenging. In this study, a deformable end-effector is first designed based on the requirements for contacting the nutating target. A dual-arm robotic system installed with the deformable end-effectors is modeled and the movement of the end-tips is analyzed. The complex operation of the contact toward a nutating target places strict requirements on control accuracy and controller robustness. Thus, an improvement of the tracking error transformation is proposed and an adaptive sliding mode controller with prescribed performance is designed to guarantee the fast and precise motion of the effector during the contact ***, by employing the proposed effector and the controller,numerical simulations are carried out to verify the effectiveness and efficiency of the contact detumbling toward a nutating target.

关键词： nutating target contact detumbling dual-arm space robot deformable end-effector prescribed performance controller

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Effect of post heat treatment on microstructure, mechanical property and corrosion behavior of AlSi10Mg alloy fabricated by selective laser melting

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Progress in Natural Science:Materials International 2024年第1期34卷 89-101页

作者： Yang Zheng Zihao Zhao Ruize Xiong Guochun Ren Minghui Yao Wei Liu Libin zang School of Aeronautics and Astronautics Tiangong University School of Mechanical Engineering Tiangong University 3D Printing Research&Engineering Technology Center AECC Beijing Institute of Aeronautical Materials Tianjin Institute of Aerospace Mechanical and Electrical Equipment

The microstructure, mechanical property and corrosion behavior of the AlSi10Mg alloy fabricated by selective laser melting(SLMed-AlSi10Mg) after different post heat treatment(PHT) of direct aging(DA), solid solution(T4)and solid solution + aging(T6) were investigated. The microstructural characterization revealed that the porosity of the SLMed-AlSi10Mg was increased from 0.41 ± 0.04 % to 3.09 ± 0.11 % with increasing temperature. The Asbuilt and DA-treated samples exhibited a microstructure of α-Al matrix surrounded with continuous Si networks,whereas the T4-treated and T6-treated samples presented a microstructure of α-Al matrix surrounded with discrete Si particles. The microhardness, strength and work hardening rate of the SLMed-AlSi10Mg increased in the order of T4-treated sample < T6-treated sample < As-built sample < DA-treated sample(a reverse order was found for the elongation), which was due to the precipitation of nanoscale Si particles after DA treatment and the softening of α-Al matrix after T4 and T6 treatments. The corrosion resistance of the SLMed-AlSi10Mg was obviously deteriorated after T4 and T6 treatments compared with DA treatment, which was caused by the changes in Si morphology, residual stress and porosity.

关键词： Selective laser melting AlSi10Mg alloy Post heat treatment Microstructure Mechanical property Corrosion behavior

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The Impact of Sleep Determination on Procrastination before Bedtime:The Role of Anxiety

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International Journal of Mental Health Promotion 2024年第5期26卷 377-387页

作者： Na Liu Junxiu Wang Wanli zang School of Sociology and Ethnology University of Chinese Academy of Social SciencesBeijing102488China School of Mental Health Wenzhou Medical UniversityWenzhou325000China Institute of Psychosocial Services Kangning Hospital of Wenzhou Medical UniversityWenzhou325000China Postgraduate School Harbin Sport UniversityHarbin150008China

Objective:The importance of good sleep for energy recovery and overall physical and mental health cannot be ***,the increasing competitiveness of society,diversifying lifestyles,and the rapid spread of the internet and electronic devices have significantly impacted people’s sleep patterns,particularly through bedtime ***,this study aims to investigate the relationship and underlying mechanisms between sleep determination,anxiety,and bedtime procrastination among the Chinese ***:The study utilized data from a national survey—the China Residents’Sleep Condition Survey(November 2021,with 6,037 participants).By constructing mediation and moderation models,it analyzed the relationship and mechanisms between sleep determination and bedtime procrastination,highlighting the dual role of anxiety:as a mediator between sleep determination and bedtime procrastination,and as a moderator of their ***:There was a negative correlation between sleep determination and bedtime procrastination;anxiety was related to an increase in bedtime procrastination behaviors;In the interplay between sleep determination and pre-bedtime procrastination,the regulatory effect of anxiety is found to be more pronounced than its intermediary role,with anxiety significantly diminishing the inverse relationship between sleep determination and procrastination before ***:Bedtime procrastination can lead to sleep issues,thus reducing sleep *** sleep determination or alleviating pre-sleep anxiety can help inhibit bedtime procrastination *** and reducing bedtime procrastination is one of the effective measures to improve sleep quality.

关键词： Sleep determination bedtime procrastination anxiety mediation moderation

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Enhanced wide-angle third-harmonic generation in flat-band-engineered quasi-BIC metagratings

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 81-87页

作者： Yijia zang Ruoheng Chai Wenwei Liu Zhancheng Li Hua Cheng Jianguo Tian Shuqi Chen The Key Laboratory of Weak Light Nonlinear Photonics Ministry of EducationSchool of Physics and TEDA Institute of Applied PhysicsNankai UniversityTianjin 300071China School of Materials Science and Engineering Smart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350China The Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Nonlinear metasurfaces and photonic crystals provide a significant way to generate and manipulate nonlinear signals owing to the resonance-and symmetry-based light-matter interactions supported by the artificial ***,the nonlinear conversion efficiency is generally limited by the angular dispersion of optical resonances especially in nonparaxial ***,we propose a metagrating realizing a quasi-bound-state in the continuum in a flat band to dramatically improve the third harmonic generation(THG)efficiency.A superior operating angular range is achieved based on the interlayer and intralayer couplings,which are introduced by breaking the mirror symmetry of the *** demonstrate the relation of angular dispersion between the nonlinear and linear responses at different incident *** also elucidate the mechanism of these offaxis flat-band-based nonlinear conversions through different mode *** scheme provides a robust and analytical way for nonparaxial nonlinear generation and paves the way for further applications such as wide-angle nonlinear information transmission and enhanced nonlinear generation under tight focusing.

关键词： nonlinear metasurfaces quasi-bound-state in the continuum angular dispersion third harmonic generation efficiency

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