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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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用次级束流对硅望远镜的时间和能量定标

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核技术 1993年第12期16卷 705-709页

作者：贺智勇 Steckmeyer JC Kerambrun A Angelique JC Bizard G Brou R Cussol D Patry JP Peter J Regimbart R Tamain B Vient E Cabot C Auger G Crema E Peghaire A saint-laurent f Gonin M Hagel K Wada R Eudes P Lebrun C Rosato E Masri Y El 中国科学院近代物理研究所 LPC Caen ISMRAIN2P3-CNRSF-14050 CaenFrance GANIL BP5027F-14021 CaenFrance Cyclotron Institute Texas A and M UniversityCollege StationTX77843USA LPN Universite de Names44072 Nantes Cedex 03France Dipartimento di Scienze fisiche Universita di NapoliI-80125 NaplesItaly ULB BruxellesBelgium

利用95MeV/u的^(16)O束产生的次级束流对半导体硅探测器进行了时间和能量定标。实验结果表明,由于次级束流提供的次级粒子种类多,飞行距离长,因此,能给探测器带来非常精确的定标。

关键词：时间定标能量定标探测器定标

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien francesca Cicchetti frédéric Calon facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and functional foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Removing harvest residues from hardwood stands affects tree growth, wood density and stem wood nutrient concentration in European beech (fagus sylvatica) and oak (Quercus spp.)

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forest Ecosystems 2022年第2期9卷 147-159页

作者： Sanjoy Roy Jean-Michel Leban Bernhard Zeller Gregory van der Heijden Arnaud Reichard Marie-Christine Gehin Philippe Santenoise laurent saint-Andre INRAE BEFF-54000 NancyFrance IGN Laboratoire de l’Inventaire ForestierNancyF-54000France Universite de Lorraine AgroParisTechINRAESILVAF-54000 NancyFrance

Background:Higher exportation of harvest residues from forests due to increased demand for woody biomass,has reportedly diminished soil mineral resources and may lead to degraded tree nutrition as well as ***,as nutrients become less available in the soil,the remobilization of nutrients in biomass tissues(plant internal cycling)helps sustain tree *** study aims to quantify the impact of Removing Harvest Residues and Litter(RHRL)during five years on tree growth,wood density,and stem wood nutrient concentrations in young beech and oak forest ***:Our study found that,RHRL significantly decreased tree growth ring width by 14%,and wood density by 3%,in beech trees,in near bark *** also significantly reduced nutrient concentration in near bark and near pith areas of both studied ***,Na and S were found lower by 44%,76%,and 56%,respectively,in near bark area of beech *** near bark area of oak trees,K,Ca,Mg,Na,S,and fe were lower by 20%,25%,41%,48%,41%,and 16%,respectively.K and Mg concentrations decreased more strongly in near pith area compared to near bark area suggesting internal translocation of these two ***:In beech trees,wood density proved to be an important factor while quantifying the effect of removing harvest residuals on tree growth and *** nutrient loss intensified the remobilization of nutrients con-tained in older tree rings(close to the pith)towards newly formed rings(close to bark).In our study,in beech trees,K was found to be the most recycled major *** results demonstrate the potential of such analysis for providing valuable insight into the effect of RHRL in premature stands on the physiological adaptive strategies of trees and an indication of soil fertility status.

关键词： Harvest residues fagus sylvatica Quercus petraea Dendroecology Dendrochemistry Radial growth Wood density Tree growth Ring width Translocation

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Words as tracers in the history of science and technology:the case of photogrammetry and remote sensing

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Geo-Spatial Information Science 2021年第1期24卷 167-177,I0018页

作者： laurent Polidori CESBIO Universitéde ToulouseCNES/CNRS/INRAE/IRD/UPSToulouseFrance

The evolution of terminology in a given field of science and technology is a good indicator of the context in which inventions originated and how concepts have *** is the case of photogrammetry,remote sensing and related methods,whose terminology evolved,first under the influence of the early inventors Laussedat and Meydenbauer,in french and German,respectively,and then in English and other languages as an international professional community *** development of space remote sensing and analytical photogrammetry led to the modification of old concepts and the renewal of terminology,and more recently,the advent of digital photography has blurred the boundaries between different fields and the meaning of the *** article proposes an analysis of the evolution of technical terms through the Google Ngram Viewer tool,which allows the visualization of the occurrence of terms in documents accessible on the *** its biases,this tool allows an interpretation of the evolution of the terminology over a long period of time,as well as a comparison of the evolution observed in the different *** particular,it makes it possible to highlight the periods when these methods were very popular,as well as a recent decline in the use of classical terms such as photogrammetry and remote sensing in favor of a new vocabulary,due to the blurring of boundaries between disciplines and to the emergence of new solutions related to UAVs,computer vision,etc.,which have renewed the potential of classical methods.

关键词： Photogrammetry remote sensing terminology Ngram Viewer

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Galling phenomena in metal forming

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friction 2021年第4期9卷 665-685页

作者： Kuniaki DOHDA Masahito YAMAMOTO Chengliang HU laurent DUBAR Kornel f.EHMANN Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208-3111USA Manufacturing Engineering Center NSKLtd.Fujisawa-Shi 251-8501Japan Institute of forming Technology and Equipment School of Materials and EngineeringShanghai Jiao Tong UniversityShanghai 200240China LAMIH UMR CNRS 8201 Universite Polytechnique Hauts-de-FranceValenciennes Cedex 959313France

Galling phenomena in metal forming not only affect the quality of the engineered surfaces but also the success or failure of the manufacturing operation *** paper reviews the different galling conditions in sheet and bulk metal forming processes along with their evolution and the effects of temperature on galling.A group of anti-galling methods employed to prevent galling defects are also presented in *** techniques for quantitatively measuring galling are introduced,and the related prediction models,including friction,wear,and galling growth models,are presented to better understand the underlying *** phenomena in other processes similar to those occurring in metal forming are also examined to suggest different ways of further studying galling in metal ***,future research directions for the study of galling in metal forming are suggested.

关键词： galling metal forming friction wear adhesion anti-galling

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Topics on the Geometry of Rational Homogeneous Spaces

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Acta Mathematica Sinica,English Series 2020年第8期36卷 851-872页

作者： laurent MANIVEL Toulouse Mathematics Institute UMR 5219 UPSF-31062 Toulouse Cedex 9France

This is a survey paper about a selection of results in complex algebraic geometry that appeared in the recent and less recent litterature,and in which rational homogeneous spaces play a prominent *** selection is larg... 详细信息

关键词： Calabi-Yau manifold derived category Hyperkahler manifold rational homogeneous space grassmannian flop fano variety abelian surface

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas f.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Auger effect in weakly confined nanocrystals

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Light(Science & Applications) 2023年第8期12卷 1454-1456页

作者： Jiawen Liu laurent Coolen Laboratoire de Physique de I'Ecole Normale Superieure ENSUniversite PSLCNRSSorbonne UniversiteUniversite Paris CiteF-75005 ParisFrance Sorbonne Universite CNRSInstitut de NanoSciences de ParisINSPF-75005 ParisFrance

An extensive analysis of biexciton luminescence in high-quality,large perovskite CsPbBr_(3) nanocrystals shows how the biexciton Auger decay rate deviates from the"universal"volume scaling as the exciton confinement b... 详细信息

关键词： weakly confined perovskite

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Assessing the predictive capabilities of precipitation strengthening models for deformation twinning in Mg alloys using phase-field simulations

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Journal of Magnesium and Alloys 2023年第12期11卷 4525-4541页

作者： Darshan Bamney laurent Capolungo Materials Science&Technology Division Los Alamos National LaboratoryUSA

Precipitation strengthening is a key strategy for improving the overall mechanical properties of Mg alloys. In Mg-Al alloys, basal precipitates are known to strengthen against twinning, resulting in an increase in the critical resolved shear stress(CRSS) necessary for continued deformation. Although several models have been proposed to quantify the influence of precipitate shape, size, and distribution on the CRSS, the accuracy, scope, and applicability of these models has not been fully assessed. Accordingly, the objectives of this study are:(i)to analyze the accuracy of analytical models proposed in the literature for precipitation strengthening against twin thickening and propagation(in Mg-Al alloys) using phase-field(Pf) simulations,(ii) to propose modifications to these model forms to better capture the observed trends in the Pf data, and(iii) to subsequently test the predictiveness of the extended models in extrapolating to experimental strengthening ***, using an atomistically-informed phase-field method, the interactions between migrating twin boundaries(during the propagation and thickening stages) and basal plates are simulated for different precipitate sizes and arrangements. In general, comparison of the increase in CRSS determined from the Pf simulations and the predictions from four precipitation strengthening models reveals that modifications are necessary to the model forms to extend their applicability to precipitation strengthening against both twin thickening and propagation. A subsequent comparison between predictions from the extended models and experimental strengthening data for peak age-hardened samples reveals that the(extended) single dislocation and dislocation wall models provide reasonably accurate values of the increase in ***, the results presented here help elucidate the fidelity and applicability of the various hardening models in predicting precipitation strenghtening effects in technologically important alloys.

关键词： Twinning Twin precipitate interactions Strengthening Magnesium alloys Phase field Mechanical behavior

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