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Highly efficient photocatalytic reduction of nitrogen into ammonia by single Ru atom catalyst supported by BeO monolayer

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Chinese Chemical Letters 2022年第1期33卷 399-403页

作者： saifei Yuan Beixi Xu Shujuan Li Wenbiao Zhu Shulai Lei Wenyue Guo Hao Ren School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China Institute of Mathematics Free University of BerlinArnimallee 6D-14195 BerlinGermany

Ammonia(NH_(3))is one of the most important building blocks of the chemical industry and a promising sustainable energy *** production of NH_(3)via the Haber-Bosch process requires high temperature and high pressure,which is energy demanding and suffers safety *** nitrogen reduction reaction(NRR)is a green and sustainable route for NH_(3) production,and has been expected to be an alternative for NH_(3)production under mild ***,solar-driven N_(2)activated has appeared as the bottleneck for photocatalytic *** this work,we propose that single Ru atom supported by BeO monolayer is a promising photocatalytic single atom catalyst(SAC)for efficient N_(2)activation with visible *** high efficiency originates from the enhanced absorption in the visible range,as well as the back-donation mechanism when N_(2)were adsorbed on the *** results show that N_(2)can be efficiently activated by the Ru/BeO SAC and be reduced to NH_(3) with extremely low limiting potential of-0.41 *** NRR process also exhibits dominate selectivity respect to hydrogen evolution.

关键词： Nitrogen reduction reaction Single atom catalyst Monolayer Ab initio Optical absorption spectra

Performance improvement of air-breathing proton exchange membrane fuel cell(PEMFC) with a condensing-tower-like curved flow field

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Chinese Chemical Letters 2023年第4期34卷 507-512页

作者： Hanqing Jin Siyi Zou Qinglin Wen Yali Li Fandi Ning Pengpeng Xu saifei Pan Xiaochun Zhou Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China Division of Advanced Nanomaterials Suzhou Institute of Nano-tech and Nano-bionicsChinese Academy of Sciences(CAS)Suzhou 215123China School of Nano Technology and Nano Bionics University of Science and Technology of ChinaHefei 230026China College of sciences Shanghai UniversityShanghai 200444China Key Lab of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences(CAS)Suzhou 215123China

Air-breathing proton exchange membrane fuel cells(PEMFCs) are very promising portable energy with many advantages. However, its power density is low and many additional supporting parts affect its specific power. In this paper, we aim to improve the air diffusion and fuel cell performance by employing a novel condensing-tower-like curved flow field rather than an additional fan, making the fuel cell more compact and has less internal power consumption. Polarization curve test and galvanostatic discharge test are carried out and proved that curved flow field can strengthen the air diffusion into the PEMFC and improve its performance. With appropriate curved flow field, the fuel cell peak power can be 55.2%higher than that of planar flow field in our study. A four-layer stack with curved cathode flow field is fabricated and has a peak power of 2.35 W(120 W/kg).

关键词： Curved flow field 3D print Air-breathing PEMFC Air convection Condensing tower

IL-33介导M2巨噬细胞在口腔黏膜上皮-间充质转化中的相关作用机制

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西部医学 2024年第6期36卷 826-831页

作者：吴丹刘寻谢塞飞朱可可谭劲湖南中医药大学第一附属医院口腔科湖南长沙410000

目的探讨白细胞介素33(IL-33)介导M2巨噬细胞在口腔黏膜上皮-间充质转化(EMT)中的相关作用机制。方法将25只雄性BALB/c小鼠分为口腔黏膜成纤维化(OSF)组(20只)和对照组(5只)。OSF组通过槟榔碱刺激建立OSF小鼠模型,对照组使用PBS注射液... 详细信息

目的探讨白细胞介素33(IL-33)介导M2巨噬细胞在口腔黏膜上皮-间充质转化(EMT)中的相关作用机制。方法将25只雄性BALB/c小鼠分为口腔黏膜成纤维化(OSF)组(20只)和对照组(5只)。OSF组通过槟榔碱刺激建立OSF小鼠模型,对照组使用PBS注射液在相同部位给药。观察口腔黏膜组织巨噬细胞表型、IL-33以及转化生长因子-β1(TGF-β1)/Smad通路表达水平;培养人口腔黏膜细胞并与M2巨噬细胞相互作用体外模型,使用IL-33添加剂和TGF-β受体抑制剂,观察EMT标志物表达水平。结果HE染色和Masson染色证实了口腔黏膜纤维化模型建立成功,与对照组比较,OSF组口腔黏膜组织中E-钙黏蛋白(E-cadherin)表达水平降低,波形蛋白(Vimentin)表达水平升高(均P<0.05)。此外,观察到IL-33和TGF-β水平升高以及TGF-β1/Smad通路激活,巨噬细胞在口腔黏膜组织中聚集且表型为M2巨噬细胞。与空白对照组比较,IL-33组E-cadherin水平降低,Vimentin的表达增高(均P<0.05);LY-2109761+IL-33组与IL-33组相比,E-cadherin的表达增高,Vimentin的水平降低(均P<0.05)。Western blot检测TGF-β、p-Smad2和Smad2的表达水平提示,与IL-33组相比,LY2109761+IL-33组IL-33对TGF-β有促进作用(P<0.05);IL-33组与空白对照组相比,p-Smad2水平显著提高(P<0.05);LY-2109761+IL-33组与IL-33组相比,p-Smad2水平显著降低(P<0.05)。结论IL-33通过介导M2巨噬细胞调控TGF-β1/Smad通路促进口腔黏膜上皮间质转化。

关键词：白细胞介素33 转化因子-β1/Smad信号通路 M2巨噬细胞上皮-间充质转化

Activation of PXR causes drug interactions with Paxlovid in transgenic mice

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4502-4510页

作者： saifei Lei Alice Guo Jie Lu Qian Qi Aaron S.Devanathan Junjie Zhu Xiaochao Ma Center for Pharmacogenetics Department of Pharmaceutical SciencesSchool of PharmacyUniversity of PittsburghPittsburghPA 15261USA School of Nursing University of PennsylvaniaPhiladelphiaPA 19104USA Department of Pharmacy and Therapeutics School of PharmacyUniversity of PittsburghPittsburghPA 15261USA

Paxlovid is a nirmatrelvir(NMV)and ritonavir(RTV)co-packaged medication used for the treatment of coronavirus disease 2019(COVID-19).The active component of Paxlovid is NMV and RTV is a pharmacokinetic *** work aimed to investigate the drug/herb-drug interactions associated with Paxlovid and provide mechanism-based guidance for the clinical use of *** using recombinant human cytochrome P450s(CYPs),we confirmed that CYP3A4 and 3A5 are the major enzymes responsible for NMV *** role of CYP3A in Paxlovid metabolism were further verified in Cyp3a-null mice,which showed that the deficiency of CYP3A significantly suppressed the metabolism of NMV and *** X receptor(PXR)is a ligand-dependent transcription factor that upregulates CYP3A4/5 *** next explored the impact of drug-and herb-mediated PXR activation on Paxlovid metabolism in a transgenic mouse model expressing human PXR and CYP3A4/*** found that PXR activation increased CYP3A4/5 expression,accelerated NMV metabolism,and reduced the systemic exposure of *** summary,our work demonstrated that PXR activation can cause drug interactions with Paxlovid,suggesting that PXR-activating drugs and herbs should be used cautiously in COVID-19 patients receiving Paxlovid.

关键词： Paxlovid Nirmatrelvir Ritonavir Pregnane X receptor CYP3A4/5 Rifampicin Rhynchophylline Drug/herb-drug interactions

Top gate engineering of field-effect transistors based on wafer-scale two-dimensional semiconductors

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Journal of Materials Science & Technology 2022年第11期106卷 243-248页

作者： Jingyi Ma Xinyu Chen Yaochen Sheng Ling Tong Xiaojiao Guo Minxing Zhang Chen Luo Lingyi Zong Yin Xia Chuming Sheng Yin wang saifei Gou Xinyu wang Xing Wu Peng Zhou David Wei Zhang Chenjian Wu Wenzhong Bao State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai200433China In Situ Devices Center Shanghai Key Laboratory of Multidimensional Information ProcessingEast China Normal UniversityShanghai 200241China School of Electronic Information Soochow UniversitySuzhou215006China

The investigation of two-dimensional(2D)materials has advanced into practical device applications,such as cascaded logic ***,incompatible electrical properties and inappropriate logic levels remain enormous *** this work,a doping-free strategy is investigated by top gated(TG)MoS_(2) field-effect transistors(FETs)using various metal gates(Au,Cu,Ag,and Al).These metals with different work functions provide a convenient tuning knob for controlling threshold voltage(V_(th))for MoS_(2) *** instance,the Al electrode can create an extra electron doping(n-doping)behavior in the MoS_(2) TG-FETs due to a dipole effect at the gate-dielectric *** this work,by achieving matched electrical properties for the load transistor and the driver transistor in an inverter circuit,we successfully demonstrate wafer-scale MoS_(2) inverter arrays with an optimized inverter switching threshold voltage(V_(M))of 1.5 V and a DC voltage gain of 27 at a supply voltage(V_(DD))of 3 *** work offers a novel scheme for the fabrication of fully integrated multistage logic circuits based on wafer-scale MoS_(2) film.

关键词： Two-dimensional semiconductor MoS_(2) Top gate Field effect transistor Logic inverter

一种融合多尺度混合注意力的建筑物变化检测模型

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测绘工程 2024年第1期33卷 47-56页

作者：于海洋滑志华宋草原谢赛飞景鹏河南理工大学自然资源部矿山时空信息与生态修复重点实验室河南焦作454003 黄河勘测规划设计研究院有限公司郑州450000

针对高分辨率遥感图像非真实变化所引起的错误检测问题,提出一种新颖的轻量化孪生神经网络建筑物变化检测模型。其中轻量化的特征提取模块可以获取不同尺度的局部上下文信息,使其充分学习局部和全局特征。由通道和空间注意力组成的混合... 详细信息

针对高分辨率遥感图像非真实变化所引起的错误检测问题,提出一种新颖的轻量化孪生神经网络建筑物变化检测模型。其中轻量化的特征提取模块可以获取不同尺度的局部上下文信息,使其充分学习局部和全局特征。由通道和空间注意力组成的混合注意力模块可以充分利用周围丰富的时空语义信息,以实现变化建筑物的准确提取。针对变化建筑物尺度跨度较大,容易导致建筑物边缘细节提取粗糙、小尺度建筑物漏检等问题,引入多尺度概念,将提取到的特征图划分为多个子区域,并分别引入混合注意力模块,最终将不同尺度的输出特征进行加权融合,以加强边缘细节提取能力。模型在WHU-CD、LEVIR-CD公开数据集进行实验,并分别取得87.8%和88.1%的F 1值,相较于6种对比模型具有更高的变化检测精度。

关键词：建筑物变化检测混合注意力机制多尺度分割轻量化孪生神经网络高分辨率遥感图像

2022年浙江省天台县农村人群钩虫感染流行病学研究

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上海预防医学 2024年第4期36卷 364-367页

作者：葛君华褚江朱贵威丁斌彬庞彩霞罗赛飞庞天兰阮卫浙江省天台县疾病预防控制中心浙江台州317200 浙江省疾病预防控制中心浙江杭州310000

【目的】了解浙江省天台县农村人群钩虫感染状况及相关行为因素,为制订钩虫病的防治策略和措施提供科学依据。【方法】以≥3周岁常住人口为调查对象,采用分层整群随机抽样法,按地理方位划分为5个片区,每片区在1个行政村开展调查。粪检... 详细信息

【目的】了解浙江省天台县农村人群钩虫感染状况及相关行为因素,为制订钩虫病的防治策略和措施提供科学依据。【方法】以≥3周岁常住人口为调查对象,采用分层整群随机抽样法,按地理方位划分为5个片区,每片区在1个行政村开展调查。粪检采用改良加藤厚涂片法;钩虫卵阳性者以试管滤纸培养法鉴定钩虫种类,3~9周岁儿童加做透明胶纸肛拭法检测蛲虫卵。危险因素采用回顾性问卷调查。【结果】共开展5个乡镇监测点,调查1 013人,钩虫病共检出39例,总感染率为3.85%。所检出虫种均为美洲钩虫,其他线虫均未检出。在所检乡镇中,南屏乡感染率最高(10.95%),不同乡镇人群感染率差异有统计学意义(χ^(2)=48.32,P<0.05);各年龄组间,70岁以上组最高(9.75%);年龄组间差异有统计学意义(χ^(2)=65.65,P<0.05)。随着文化程度的提高,人群总体感染率呈下降趋势;使用新鲜粪便施肥(χ^(2)=6.87,P<0.05)、赤脚赤手下地劳动(χ^(2)=157.69,P<0.05)与钩虫感染存在统计学关联。【结论】天台县钩虫总体感染率较低,流行虫种以美洲钩虫为主,不同乡镇、不同文化程度人群感染率差异较明显。应重点加强对农民钩虫病防治知识宣传,改变生产生活方式,提高自我防护意识。

关键词：钩虫感染率相关因素行为流行病学

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Contact optimisation strategy for wafer-scale field-effect transistors based on two-dimensional semiconductors

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Journal of Materials Science & Technology 2023年第2期133卷 230-237页

作者： Ling Tong Xiaojiao Guo Zhangfeng Shen Lihui Zhou Jingyi Ma Xinyu Chen Honglei Chen Yin Xia Chuming Sheng saifei Gou Die wang Xinyu wang Xiangqi Dong Yuxuan Zhu Xinzhi Zhang David Wei Zhang Sheng Dai Xi Li Peng Zhou Yangang wang Wenzhong Bao State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing 314001China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China

Two-dimensional(2D)semiconductors can be utilized to continually miniaturize nanoscale electronic ***,achieving a practical solution for satisfying electrical contact with 2D semiconductors remains *** this study,we developed a novel contact structure with transferred multilayer(t-ML)MoS 2 by integrating both edge and top *** in-situ plasma treatment for the edge of the MoS 2 channel and successive metal deposition,we achieved 16 times lower contact resistivity(22.8 kΩμm)than that of the top contacted *** thickness-dependent electrical measurement indicates that edge contact is highly effective with thick MoS 2 due to the alleviated current-crowding effect re-sulting from the small contact *** temperature-dependent transport measurement further confirms the effective minimization of the influence from the Schottky barrier and tunnelling ***,the simplified resistor network model and energy-band diagram were proposed to understand the carrier transport *** work provides a practical strategy for achieving excellent electrical contact between bulk metals and 2D semiconductors,paving the way for future large-scale 2D electronic devices.

关键词： Edge contact 2D materials Field-effect transistors Schottky barrier Contact resistance

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高血压治疗的分析

按摩与康复医学 2010年第34期1卷 80-80页

作者：王赛飞江苏省淮安市清浦区武墩社区卫生服务中心淮安223006

高血压是严重危害我国人民身体健康和生活质量的慢性病。治疗高血压的主要目的是最大限度地降低心脑血管病的病残率和死亡率。原发性高血压占高血压病人的95％。目前还没有能清除原发性高血压的病因，所有降压药都只有在服药期间才有效... 详细信息

高血压是严重危害我国人民身体健康和生活质量的慢性病。治疗高血压的主要目的是最大限度地降低心脑血管病的病残率和死亡率。原发性高血压占高血压病人的95％。目前还没有能清除原发性高血压的病因，所有降压药都只有在服药期间才有效，停药后血压又会回升。已确诊的高血压患者如果停止治疗，血压迟早会回到治疗前水平；有些病人还会出现血压迅速反跳，诱发更为严重的心脑血管疾患。因此，要对高血压治疗进行分析，在医生指导下，长期坚持服药，且勿凭自我的感觉，仅在有症状时才服药，血压降下来后随意停药。高血压的治疗不仅仅是使血压降低．更主要的是预防及控制心脑血管疾病的发生和发展。抗高血压治疗的目标是将血压降低至正常（低于140／90〉mmug）或理想水平（低于120／80mmng），单纯收缩压升高者也应将收缩压控制在140mmng以下，这样就可以较好地预防心脑血管疾病的发生。

关键词：高血压治疗分析