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Journal of Rare Earths 2012年第5期30卷 507-514页

作者： K.F.khan Shamim A.Dar saif A.khan Department of Geology Aligarh Muslim UniversityAligarh-202002Uttar PradeshIndia

The rare earth element（REE） data from the Paleoproterozoic Bijawar basin,Sonrai phosphorites were used to interpret the depositional conditions of the *** post archean Australian shales（PAAS） normalized REE patterns of the Sonrai phosphorites were characterized by negative Ce and positive Eu *** rare earth elements（MREE）-enrichment was a characteristic *** showing the diagenetic effects on the REE patterns were *** observed Eu anomaly was indicative of an anoxic（or sulphate reducing） diagenetic environment of phosphate *** of sea water and upwelling during the Paleoproterozoic was responsible for the recording of positive Eu and negative Ce anomalies in the Sonrai phosphorites.

关键词： rare earth elements geochemistry phosphorites Sonrai Bijawar basin Ce anomaly Eu anomaly

RePizer：a framework for prioritization of software requirements

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Frontiers of Information Technology & Electronic Engineering 2016年第8期17卷 750-765页

作者： saif Ur Rehman khan Sai Peck LEE Mohammad DABBAGH Muhammad TAHIR Muzafar khan Muhammad ARIF Department of Software Engineering Faculty of Computer Science and Information Technology University of Malaya Kuala Lumpur 50603 Malaysia Faculty of Computing and Information Technology University of Jeddah Jeddah 21589 Saudi Arabia College of Computer and Information Sciences (Muzahmiyah Branch) King Saud University Riyadh 11362 Saudi Arabia Department of Computer Science University of Gujrat Gujrat 50700 Pakistan

The standard software development life cycle heavily depends on requirements elicited from stakeholders. Based on those requirements, software development is planned and managed from its inception phase to closure. Due to time and resource constraints, it is imperative to identify the high-priority requirements that need to be considered first during the software development process. Moreover, existing prioritization frameworks lack a store of historical data useful for selecting the most suitable prioritization technique of any similar project domain. In this paper, we propose a framework for prioritization of software requirements, called Re Pizer, to be used in conjunction with a selected prioritization technique to rank software requirements based on defined criteria such as implementation cost. ReP izer assists requirements engineers in a decision-making process by retrieving historical data from a requirements repository. Re Pizer also provides a panoramic view of the entire project to ensure the judicious use of software development resources. We compared the performance of Re Pizer in terms of expected accuracy and ease of use while separately adopting two different prioritization techniques, planning game（PG） and analytical hierarchy process（AHP）. The results showed that Re Pizer performed better when used in conjunction with the PG technique.

关键词： Software requirements Requirements prioritization techniques Prioritization framework Planning game Analytical hierarchy process

Role of salivary matrix metalloproteinase-8 （MMP-8） in chronic periodontitis diagnosis

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Frontiers of Medicine 2015年第1期9卷 72-76页

作者： Namita Gupta N.D. Gupta Akash Gupta saif khan Neha Bansa Department of Periodontics and Community Dentistry Dr. Z. A. Dental College Aligarh Muslim University Aligarh U.P. India Department of Biochemistry Rama Medical College and Hospital Pilakhua Hapur. U.P. India

Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases （MMPs） secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups： group I consisted of 20 periodontally healthy subjects （controls） while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth （PPD）, clinical attachment level （CAL）, gingival index （GI）, and plaque index （PI）. Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA （Windows version 6） software. Salivary MMP-8 levels of groups I and II were 190.91 ± 143.89 ng/ml and 348.26± 202.1 ng/ml, respectively. The MMP-8 levels and periodontal status （PPD, CAL, GI, and PI） of groups I and II showed positive and significant correlations （for PPD, r = 0.63, P 〈 0.001; for CAL, r = 0.54, P 〈 0.001; for GI, r = 0.49, P 〈 0.001; and for PI, r = 0.63, P 〈 0.001）. The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

关键词： matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index

Identification of chemical compositions from“featureless”optical absorption spectra:Machine learning predictions and experimental validations

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Nano Research 2023年第3期16卷 4188-4196页

作者： Tiankai Chen Jiali Li Pengfei Cai Qiaofeng Yao Zekun Ren Yixin Zhu saif khan Jianping Xie Xiaonan Wang Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Singapore Singapore-MIT Alliance for Research and Technology(SMART) 1 CREATE WaySingapore 138602Singapore Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Rapid and accurate chemical composition identification is critically important in *** it can be achieved with optical absorption spectrometry by comparing the experimental spectra with the reference data when the chemical compositions are simple,such application is limited in more complicated scenarios especially in nano-scale *** is due to the difficulties in identifying optical absorption peaks(i.e.,from“featureless”spectra)arose from the *** this work,using the ultraviolet-visible(UV-Vis)absorption spectra of metal nanoclusters(NCs)as a demonstration,we develop a machine-learningbased method to unravel the compositions of metal NCs behind the“featureless”*** implementing a one-dimensional convolutional neural network,good matches between prediction results and experimental results and low mean absolute error values are achieved on these optical absorption spectra that human cannot *** work opens a door for the identification of nanomaterials at molecular precision from their optical properties,paving the way to rapid and high-throughput characterizations.

关键词： gold nanoclusters composition identification optical absorption machine learning convolutional neural network

Genetic association study of P2x7 A1513C(rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1126-1134页

作者： Eyad M.A.Alshammari Raju K.Mandal Mohd Wahid Sajad A.Dar Arshad Jawed Mohammed Y.Areeshi saif khan Md.Ekhlaque Ahmed khan Aditya K.Panda Shafiul Haque Department of Clinical Nutrition College of Applied Medical SciencesUniversity of Ha’il Research and Scientific Studies Unit College of Nursing & Allied Health SciencesJazan University The University College of Medical Sciences & GTB Hospital (University of Delhi) Centre for Life Sciences Central University of Jharkhand

Objective:To summarize the precise association between pulmonary tuberculosis(PTB) and P2x7 A1513 C gene ***:PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513 C polymorphism and PTB risk.A meta-analysis was performed for the selected case-control studies and pooled odds ratios(ORs) and 95%confidence intervals(95%CIs) were calculated for all the genetic ***:Eleven studies comprising 2 678 controls and 2 113 PTB cases were included in this *** observed overall no significant risk in all the five genetic *** stratified population by the ethnicity,Caucasian population failed to show any risk of PTB in all the genetics *** Asian ethnicity,variant allele(C vs.A:P=0.001;QR=1.375,95%CI=1.159-1.632) and heterozygous genotype(AC ***:P=0.001;OR=1.570,95%CI=1.269-1.944) demonstrated significant increased risk of ***,recessive genetic model(CC+AC ***:P=0.001;OR=1.540,95%CI= 1.255-1.890) also demonstrated increased risk of PTB in ***:Our meta-analysis did not suggest the association of P2x7 A1513 C polymorphism with PTB risk in overall or separately in Caucasian ***,it plays a significant risk factor for predisposing PTB in *** larger sample and expression studies are needed to validate this association.

关键词： Genetic model Meta-analysis Polymorphism P2x7 gene Pulmonary tuberculosis

Fractional synergetic tracking control for robot manipulator

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Journal of Control and Decision 2024年第1期11卷 139-152页

作者： Asma saif Raouf Fareh saif Sinan Maamar Bettayeb Department of Electrical Engineering University of SharjahSharjahUAE Department of Electrical Engineering École de technologie supérieureMontrealCanada CEIES King Abdulaziz UniversityJeddahSaudi Arabia

This work takes advantage of synergetic control theory and fractional calculus to develop and propose fractional synergetic control(FSC)strategy for Four Degrees of Freedom(4-DOF)robot *** proposed fractional synergetic control is designed to track a joint space as well as workspace desired *** calculus gives more flexibility in the design since it has a wider stability *** to that,as stated in the literature,compared to a similar approach such as sliding mode control,the synergetic control approach converges faster to the equilibrium point,without chattering with a fast *** paper proposes a new control strategy that takes advantage of fractional calculus and synergetic control *** proposed control strategy is tested experimentally on a 4-DOF manipulator to study the performance of the proposed control *** stability of the closed-loop system is proved using the Lyapunov *** experimental results have shown that the proposed FSC design has achieved a good tracking performance.

关键词： Synergetic control robust control robot manipulator fractional controller

Two-step machine learning enables optimized nanoparticle synthesis

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npj Computational Materials 2021年第1期7卷 498-507页

作者： Flore Mekki-Berrada Zekun Ren Tan Huang Wai Kuan Wong Fang Zheng Jiaxun Xie Isaac Parker Siyu Tian Senthilnath Jayavelu Zackaria Mahfoud Daniil Bash Kedar Hippalgaonkar saif khan Tonio Buonassisi Qianxiao Li Xiaonan Wang Department of Chemical and Biomolecular Engineering National University of SingaporeSingaporeSingapore Singapore-MIT Alliance for Research and Technology SMART SingaporeSingapore Institute for Infocomm Research Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Institute of Materials Research&Engineering SingaporeSingapore Department of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore Massachusetts Institute of Technology CambridgeMAUSA Department of Mathematics National University of SingaporeSingaporeSingapore Institute of High Performance Computing SingaporeSingapore

In materials science,the discovery of recipes that yield nanomaterials with defined optical properties is costly and *** this study,we present a two-step framework for a machine learning-driven high-throughput microfluidic platform to rapidly produce silver nanoparticles with the desired absorbance *** a Gaussian process-based Bayesian optimization(BO)with a deep neural network(DNN),the algorithmic framework is able to converge towards the target spectrum after sampling 120 *** the dataset is large enough to train the DNN with sufficient accuracy in the region of the target spectrum,the DNN is used to predict the colour palette accessible with the reaction *** remaining interpretable by humans,the proposed framework efficiently optimizes the nanomaterial synthesis and can extract fundamental knowledge of the relationship between chemical composition and optical properties,such as the role of each reactant on the shape and amplitude of the absorbance spectrum.

关键词： spectrum synthesis. synthesis

Benchmarking the performance of Bayesian optimization across multiple experimental materials science domains

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npj Computational Materials 2021年第1期7卷 1742-1751页

作者： Qiaohao Liang Aldair E.Gongora Zekun Ren Armi Tiihonen Zhe Liu Shijing Sun James R.Deneault Daniil Bash Flore Mekki-Berrada saif A.khan Kedar Hippalgaonkar Benji Maruyama Keith A.Brown John Fisher III Tonio Buonassisi Massachusetts Institute of Technology CambridgeMAUnited States Boston University BostonMAUnited States Singapore-MIT Alliance for Research and Technology SingaporeSingapore Air Force Research Laboratory DaytonOhioUnited States Agency for Science Technology and Research(A*STAR)SingaporeSingapore National University of Singapore SingaporeSingapore Present address:Aalto University EspooFinland Present address:Northwestern Polytechincal University(NPU) Xi’anShaanxi P.R.China

Bayesian optimization(BO)has been leveraged for guiding autonomous and high-throughput experiments in materials ***,few have evaluated the efficiency of BO across a broad range of experimental materials *** this work,we quantify the performance of BO with a collection of surrogate model and acquisition function pairs across five diverse experimental materials *** defining acceleration and enhancement metrics for materials optimization objectives,we find that surrogate models such as Gaussian Process(GP)with anisotropic kernels and Random Forest(RF)have comparable performance in BO,and both outperform the commonly used GP with isotropic *** with anisotropic kernels has demonstrated the most robustness,yet RF is a close alternative and warrants more consideration because it is free from distribution assumptions,has smaller time complexity,and requires less effort in initial hyperparameter *** also raise awareness about the benefits of using GP with anisotropic kernels in future materials optimization campaigns.

关键词： optimization performance acceleration

Acute pancreatitis:pathogenesis and emerging therapies

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Journal of Pancreatology 2024年第1期7卷 10-20页

作者： saif Zaman Fred Gorelick Department of Internal Medicine Yale School of MedicineNew HavenCT 06511 Veteran’s Administration Healthcare System West HavenCT 06516 Department of Cell Biology Yale School of MedicineNew HavenCT 06511

Acute pancreatitis is a severe inflammatory disorder with limited treatment *** understanding of disease mechanisms has led to new and potential *** we summarize what we view as some of the most promising new therapies for treating acute pancreatitis,emphasizing the rationale of specific treatments based on disease *** pharmacologic interventions are *** explore potential treatment benefits and risks concerning reducing acute injury,minimizing complications,and improving long-term *** associated with acute pancreatitis initiation,perpetuation,and reconstitution are highlighted,along with potential therapeutic targets and how these relate to new treatments.

关键词： Acinar cell Acute pancreatitis Calcium signaling Transporters Treatment

Non-Diabetic Kidney Disease in Type 2 Diabetes Mellitus: A Study of 82 Patients and Review of the Literatures

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Open Journal of Nephrology 2022年第1期12卷 169-186页

作者： Ehab Mohammed Issa Al Salmi Dawood Al Riyami saif khan Marwa Al Riyami Fatma Al Rahbi Suad Hannawi The Renal Medicine Department The Royal Hospital Muscat Oman The Medicine Department Oman Medical Specialty Board Muscat Oman The Renal Medicine Department SQUH Muscat Oman The Pathology Department SQUH Muscat Oman The Medicine Department MOHAP Dubai UAE

Background: Worldwide, diabetic nephropathy-DN is the leading cause of end-stage kidney disease-ESKD, DN is a common cause of renal failure with a reported frequency of 10% - 15% in type-2-diabetes-mellitus-T2DM patients, however there is a great discrepancy between countries. The aim of the pre-sent study is to evaluate the findings of kidney biopsies performed on diabetic patients. Materials and Methods: We studied native kidney histopathological findings in the period from January 2016 till end of December 2018 done for patients with T2DM with chronic kidney diseases-CKD. Results: A total of 82 DM-patients, 50 males (61%) and 32 females (39%) with age mean (95% CI) of 50.8 (47.1 - 55.2) years for all patients, ranged between 15 to 65 years. Histological findings showed that 57.3% of patients had DN. While focal-segmental-glomerulosclerosis-FSGS was present in 20.7%—primary in 8.6% and secondary in 12.1%. IgA represented 4.9%, while Lupus nephritis, Membranous and drug induced interstitial nephritis were each present in 3.7%. MCD was present in 2.4%. Lastly diffuse proliferative GN, ANCA associated glomerulonephritis, and hypertensive nephrosclerosis accounted for 1.2%. Conclusion: The prevalence of NDKD is remarkably frequent in DM patients who underwent kidney biopsy and FSGS was the most frequent diagnosis. To get a proper histopathological diagnosis, an adequate tissue biopsy is needed with an adequate number of glomeruli. There is a great need for more consideration to biopsy diabetic patients, as the finding of NDKD requires a different therapeutic approach. This, hopefully, will help to manage these patients better and therefore, ameliorate the progression to ESKD over time and therefore delay the need for RRT.

关键词： Diabetic Nephropathy Diabetic Kidney Disease Histopathology Light Microscopy Electron Microscopy Immunofluorescence Non-Diabetic Kidney Diseases Renal Replacement Therapy (RRT)