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作者： CHAHARZAD said abdallah 吉林大学

学位级别：硕士

HPV是公认的致癌病毒,几乎占全球所有宫颈恶性肿瘤的比例。然而,绝大多数HPV感染在三年内被消除,并且只有一小部分感染存活并在未来导致恶性肿瘤。在宫颈癌发展之前,会发生包括LSIL和HSIL在内的宫颈病变。其中,HSIL最容易导致宫颈癌。H... 详细信息

HPV是公认的致癌病毒,几乎占全球所有宫颈恶性肿瘤的比例。然而,绝大多数HPV感染在三年内被消除,并且只有一小部分感染存活并在未来导致恶性肿瘤。在宫颈癌发展之前,会发生包括LSIL和HSIL在内的宫颈病变。其中,HSIL最容易导致宫颈癌。HSIL可以通过切除或消融治疗,在大多数情况下,切除是首选的治疗方法。虽然在宫颈锥体化过程中所有宫颈病变都被切除,但患者在手术后仍然表现出HPV阳性。宫颈病变最重要的过程之一是通过复发性HPV感染在宿主免疫系统中形成免疫稳定。由于HPV持续性与HSIL的发展之间存在很强的关联,因此能够辨别哪些患者在手术后可能继续是HPV阳性是非常重要的。免疫在HPV消除中具有关键功能。事实上,体液和细胞介导的免疫反应根除了大多数宫颈HPV感染。因此,研究阴道免疫反应是最重要的。人们普遍认为,阴道微生物群的改变可以帮助HPV感染的持续存在。细菌性阴道病,例如,改变阴道内的免疫学特征,例如细胞因子/趋化因子,使得子宫颈更容易感染。宿主免疫应答可能是确定HPV感染自然病程的最重要变量之一。虽然对宫颈HPV感染的免疫反应知之甚少,但来自小鼠和人类感染各种细胞内病原体的证据强调了T细胞和辅助细胞衍生的细胞因子在诱导和进展对这些病原体的有效免疫反应中的作用。特别是Th细胞免疫学控制的一个范例已经出现,其中抗原经历的Th细胞转变为形态分化的细胞,这些细胞在它们产生的免疫调节细胞因子的组合中波动。此外,持续的高风险HPV感染导致异常高数量的Treg,宫颈发育不良与促炎细胞因子和趋化因子的增加有关。此外,许多重要类型的CD4+细胞,如Th17和Treg细胞,在介导针对多种感染的宿主防御机制中发挥关键作用。研究了Th17分泌的IL-17,Treg分泌的TGFβ与不同术后HPV结局之间的可能相关性;结果可能有助于术后HPV结局的诊断和预后。目的本研究的重点是调查Th17分泌的IL-17和Treg在锥切术前分泌的TGFβ以及它们与锥切术后HPV结果的相关性。换句话说,这两种细胞因子在HSIL患者接受锥切术前之前进行了研究,并且在手术后3-4个月后,对其进行了HPV的重新测试。从他们的HPV状态,得出术前细胞因子谱与术后HPV最终结果之间是否存在联系的结论。方法根据纳入和排除标准选择研究对象。术前采集阴道灌洗液。通过使用ELISA检测,获得每个患者的阴道灌洗液中每种细胞因子的浓度。手术后几个月,每位患者都接受了HPV检测,以获得他们的个体状态。使用ANOVA比较所有3组的均值。事后Scheffe多重比较方法,以确切地找出哪些组显着不同。Logistic回归分析总结了2种细胞因子与HPV术后结果之间的相关性。ROC和AUC用于根据HPV结果评估IL-17和TGFβ的敏感性。所有统计分析的显着性水平为0.05。结果1.一般临床数据包括年龄,术前HR-HPV状态,手术类型（冷刀,LEEP,补充全子宫切除术）和病理类型在对照组,阴性组和阳性组之间没有显着差异。只有TCT在3组之间显着不同。2.阴性组术后灌洗液中IL-17浓度高于阳性组。相反,对照组显著高于阳性组。然而,阴性组的TGFβ水平显着高于对照组。***-17与术后HPV阳性结果之间的关系成反比。这意味着随着IL-17浓度的增加,持续阳性HPV结果的风险降低。此外,IL-17对术后HPV阴性结果具有良好的敏感性和特异性。4.尽管阴性组和对照组之间TGFβ浓度存在显着差异,但术前TGFβ浓度与术后HPV结局之间没有观察到相关性。结论1.宫颈锥切术前诊断为HSIL的患者的微免疫状况与宫颈锥切术后HPV结果之间存在相关性。2.阴性组的IL-17水平显着高于阳性组。但对照组显着高于阳性组。另一方面,阴性组的TGFβ水平显着高于对照组。3.术前IL-17与术后HPV阳性结果呈负相关。随着术前IL-17水平的增加,术后持续阳性HPV结果的风险降低。因此,IL-17是保护因子。此外,IL-17对术后HPV阴性结果具有良好的敏感性和特异性。4.随着IL-17水平的逐渐增加,特异性也会增加,因为假阴性结果的发生率降低。相反,随着IL-17水平下降,敏感性增加,因为真正的阴性结果的比率变得更高。5.尽管阴性组和对照组之间TGFβ的术后浓度存在显着差异,但术前TGFβ浓度与术后HPV结局之间未观察到相关性。

关键词： HSIL 宫颈锥形切除术 HPV 细胞因子

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Alloyed CdTe0.6S0.4Quantum Dots Sensitized TiO2Electrodes for Photovoltaic Applications

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Materials Sciences and Applications 2014年第1期5卷 27-32页

作者： Ali Badawi Khalid Easawi Najm Al-Hosiny said abdallah Department of Mathematical and Physical Engineering Faculty of Engineering (Shoubra) Benha University Cairo Egypt Department of Physics Faculty of Science Taif University Taif KSA Department of Physics Faculty of Science Taif University Taif KSA Department of Mathematical and Physical Engineering Faculty of Engineering (Shoubra) Benha University Cairo Egypt Department of Physics Faculty of Science Taif University Taif KSA Department of Physics Faculty of Science Aljouf University Aljouf KSA

The photovoltaic performance of alloyed CdTe0.6S0.4 quantum dot sensitized solar cells (QDSSCs) is investigated. Fluorine doped Tin Oxide (FTO) substrates were coated with 20 nm-diameter TiO2 nanoparticles (NPs). Presynthesized colloidal solution of alloyed CdTe0.6S0.4 quantum dots (QDs) of 4.2 nm was deposited onto TiO2 NPs substrates using direct adsorption (DA) technique, by dipping for different times at ambient conditions. The FTO counter electrodes were coated with platinum, while the electrolyte containing I-/I-3 redox species was sandwiched between the two electrodes. Compared to pure CdTe QDs and CdS QDs, CdTe0.6S0.4 QDs showed better photovoltaic performance. The J-V characteristic curves of the assembled QDSSCs were measured at AM 1.5 simulated sunlight. The short current density (Jsc) and efficiency (η) increase with dipping time. At 24 h dipping time, the open-circuit photovoltage Voc, Jsc, fill factor (FF), and η were 0.46 volts, 1.54 mA/cm2, 0.43% and 0.31%, respectively.

关键词： Alloyed CdTe0.6S0.4 Quantum Dot Quantum Dots Sensitized Solar Cell Photovoltaic Cell

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老年性泌尿系统感染的大肠埃希菌毒力因子检测及其与耐药性的关系

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中华传染病杂志 2013年第4期31卷 227-230页

作者：马全玲 Kamai said abdallah 魏殿军天津医科大学第二医院检验科 300211

目的了解引起老年患者泌尿系统感染大肠埃希菌的30种毒力因子与4种常用抗菌药物（左氧氟沙星、庆大霉素、头孢吡肟和哌拉西林／他唑巴坦）耐药性之间的关系。方法收集2009年至2011年天津市三家综合性医院泌尿系统院内感染老年患者尿液... 详细信息

目的了解引起老年患者泌尿系统感染大肠埃希菌的30种毒力因子与4种常用抗菌药物（左氧氟沙星、庆大霉素、头孢吡肟和哌拉西林／他唑巴坦）耐药性之间的关系。方法收集2009年至2011年天津市三家综合性医院泌尿系统院内感染老年患者尿液标本分离的133株大肠埃希菌，采用K—B纸片扩散法检测菌株的药物敏感性，以多重PCR检测133株大肠埃希菌中的30种毒力因子。应用R×C表资料的双侧x2检验对药物敏感结果进行分析，Logistic回归分析毒力因子与抗菌药物耐药性之间的相关性。结果分离的133株大肠埃希菌对左氧氟沙星耐药率最高，为72株，占54．1％，最低的为哌拉西林／他唑巴坦20株，占15．0％（x2=51．57，P〈0．01）。引起老年性泌尿系统感染大肠埃希菌中，毒力因子fimH检出率最高，为79．7％。30种毒力因子与4种常用抗菌药物之间，papC、sfaS、pagGalleleⅡ、papA、papEF、sfa／focDE、hlyA、rfc、cnfl等毒力因子在左氧氟沙星敏感组中多见（P值分别一0．004、0．029、0．001、0．031、0．007、0．001、0．006、0．010和0．013）；iutA，kpsMTⅢ和cva等毒力因子在庆大霉素耐药组中多见（P值分别-0．003、0．010和0．000）；sfa／focDE和K1等毒力因子在庆大霉素敏感组中多见（P值分别-0．007和0．050），kpsMTⅢ在头孢吡肟耐药组中多见（P=0．024），cnfl在头孢吡肟敏感组中更多见（P=0．014）；traT在哌拉西林／他唑巴坦耐药组中多见（P=0．026），kpsMTⅡ在哌拉西林／他唑巴坦敏感组中多见（P=0．024）。结论引起老年性泌尿系统感染的大肠埃希菌同时携带多种毒力因子，大肠埃希菌耐药性与其所携带的毒力因子有关，应引起临床重视。

关键词：泌尿系疾病大肠杆菌毒力因子类药物耐受性

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An Attention-Based Approach to Enhance the Detection and Classification of Android Malware

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Computers, Materials & Continua 2024年第8期80卷 2743-2760页

作者： abdallah Ghourabi Department of Computer Science College of Computer and Information SciencesJouf UniversitySakaka72388Saudi Arabia

The dominance of Android in the global mobile market and the open development characteristics of this platform have resulted in a significant increase in *** malicious applications have become a serious concern to the security of Android *** address this problem,researchers have proposed several machine-learning models to detect and classify Android malware based on analyzing features extracted from Android ***,most existing studies have focused on the classification task and overlooked the feature selection process,which is crucial to reduce the training time and maintain or improve the classification *** current paper proposes a new Android malware detection and classification approach that identifies the most important features to improve classification performance and reduce training *** proposed approach consists of two main ***,a feature selection method based on the Attention mechanism is used to select the most important ***,an optimized Light Gradient Boosting Machine(LightGBM)classifier is applied to classify the Android samples and identify the *** feature selection method proposed in this paper is to integrate an Attention layer into a multilayer perceptron neural *** role of the Attention layer is to compute the weighted values of each feature based on its importance for the classification *** evaluation of the approach has shown that combining the Attention-based technique with an optimized classification algorithm for Android malware detection has improved the accuracy from 98.64%to 98.71%while reducing the training time from 80 to 28 s.

关键词： Android malware malware detection feature selection attention mechanism LightGBM mobile security

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Epidemiologic Investigation of Uropathogenic ***（UPEC） and other sources based on PCR phylogenetic group and fimH single nucleotide polymorphism（SNPs） in China

Epidemiologic Investigation of Uropathogenic ***（UPEC） and...

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第二届中国临床微生物学大会暨微生物学与免疫学三江论坛

作者： KAMAL said abdallah CaoYang WEI Dian-jun Department of Clinical Laboratory Second Hospital of Tianjin Medical University Tianjin Institute of Infection Diseases Second Hospital of Tianjin Medical University

Objective:To investigate the epidemiology of Uropathogenic ***（UPEC） and other sources in China,using the combination method with PCR phylogrouping and mH SNP *** ＆ Methods:116 strains of *** strains including（3 references strains） were *** B,A,and C samples were taken from Urine,sputum,and other sources of patients *** the culture of samples,*** suspected colonies were separated and confirmed by biochemical *** bacteria Genomic DNA of the 113 *** strains collected were extracted;phylogroup and the fimH gene amplifications were determined by two-step triplex PCR-based phylogrouping and simple PCR amplification assay *** the fimH SNPs analysis and phylogenetic analysis and construction of tree were carried out using DNAMAN Version 6.***.3.93 and MEGA4,ClustalW and CLC Bio software respectively for 50 *** strains isolated from clinical sample and 3 references;K—12 *** strain was used as reference ***:For *** strains phylogroup,25%（28/113） were observed to belong to the group A,15%（17/113） were observed to belong to the group B1,14%（16/113） were observed to belong to the group B2,and 46%（52/113） were observed to belong to the group *** comparison of type B strains and type C+A strains in different phylogroups show that group A is statistical significant than Bl in type A+C strains（P＜0.05）,group D is statistical significant than group A in type B strains（P＜0.05）.No significant found between other comparisons.75%（85/113） were fimH *** SNPs analysis for 50 isolated from clinical sample and 3 references with fimH positive found 60 SNPs at 57 polymorphic sites,the nucleotides sequencebased phylogenic tree found 24 terminal groups.12 terminal groups were distinct allelic variants.23 SNPs resulted to 22 amino-acid changes and 37 SNPs were silent *** number of amino-acid variants and silent SNPs were observed more in type B strains than in type A and *** ad

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Multi-locus Sequence Typing and REP-PCR,Characterization of Shigella spp. Over Two Decades In Tianjin-China

Multi-locus Sequence Typing and REP-PCR,Characterization of ...

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第二届中国临床微生物学大会暨微生物学与免疫学三江论坛

作者： Idrissa Laybohr Kamara Kamal said abdallah Wei Dian Jun Department of Clinical Laboratory and Diagnostics Second Teaching Hospital of Tianjin Medical University

OBJECTIVE:To understand the change of the dominant serogroup of Shigella *** dysentery,their antimicrobial resistance over more than two decades in Tianjin,their phylogenetic similarity and to determine their evolutionary biology by using REP-PCR and MLST in order to study their epidemiological ***:96 strains of Shigella spp were isolated and their serogroups identified.16 different kinds of antimicrobial agents were used to study their characters of drug ***-locus Sequence Typing was performed to determine their lineage and phylogenetic *** Extragenic Palindromic Polymerase Chain Reaction（REP-PCR） typing was used to study the homology of their genomic ***:The isolated rate of group D Shigella in 2009 and 2010 had obviously *** susceptibility test results showed that the resistant rates of the 1981-1983 Shigella flexneri to tetracycline,streptomycin and chloramphenicol varied from 76.47 to 100%,but,they were all sensitive to gentamicin,amikacin,the third and fourth Generation Cephalosporins,quinolones and ***,between 2009-2010,the resistance rates of the isolated Shigella flexneri to gentamicin,amikacin,third and fourth Generation Cephalosporins and quinolones had ***-locus Sequence typing results produced five sequence types（ST） and two sequence type ***-PCR showed DNA band similarities between the 1981-1983 and 2009-2010 ***:The dominant serogroup of Shigella in Tianjin has changed from Shigella flexneri to Shigella *** drug resistance of Shigella flexneri is higher than Shigella sonnei because a great variety of antibiotics has been *** sonnei were 100%susceptible to the fourth Generation Cephalosporins and *** MLST results showed that the 1981-1983 strains had the same sequence type（ST）with some of the 2009-2010 ***-PCR was a valid and rapid genotyping method for homological analysis and tra

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Generation of Short Wavelength in Up-Conversion of Tm+3Doped Fluoride Glass and Its Application in Fiber Lasers

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Journal of Modern Physics 2014年第3期5卷 123-127页

作者： Reda Mohamed El-Agmy Najm Masfer Al-Hosiny said abdallah Mohamed Selim Abdel-Aal 1Department of Physics Taif University Taif KSA 2Department of Physics Faculty of Science Al Jouf University Al-Jawf KSA 1Department of Physics Taif University Taif KSA 2Faculty of Science (Physics) Helwan University Helwan Egypt Department of Physics Taif University Taif KSA

We report on the experimental study of the visible and ultraviolet (UV) fluorescence emission in a (1% molar) Thulium (Tm+3)-doped Zirconium fluoride glass sample. From red at 650 nm, blue (453 & 480 nm) and UV at 365 & 284 nm, have been observed under excitation of a Nd:YAG laser at 1.064 μm. The responsible up-conversion mechanisms are investigated based on experimental data. The related problem of photo-degradation associated with formation of color centers is also addressed.

关键词： Fluoride Glass Up-Conversion Pumping Spectroscopy

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Adaptive Segmentation for Unconstrained Iris Recognition

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Computers, Materials & Continua 2024年第2期78卷 1591-1609页

作者： Mustafa AlRifaee Sally Almanasra Adnan Hnaif Ahmad Althunibat Mohammad abdallah Thamer Alrawashdeh Faculty of Architecture and Design Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Computer Studies Arab Open UniversityRiyadh11681Saudi Arabia Faculty of Science and Information Technology Al-Zaytoonah University of JordanAmman11733Jordan

In standard iris recognition systems,a cooperative imaging framework is employed that includes a light source with a near-infrared wavelength to reveal iris texture,look-and-stare constraints,and a close distance requirement to the capture *** these conditions are relaxed,the system’s performance significantly deteriorates due to segmentation and feature extraction ***,a novel segmentation algorithm is proposed to correctly detect the pupil and limbus boundaries of iris images captured in unconstrained ***,the algorithm scans the whole iris image in the Hue Saturation Value(HSV)color space for local maxima to detect the sclera *** image quality is then assessed by computing global features in red,green and blue(RGB)space,as noisy images have heterogeneous *** iris images are accordingly classified into seven categories based on their global RGB *** the classification process,the images are filtered,and adaptive thresholding is applied to enhance the global contrast and detect the outer iris ***,to characterize the pupil area,the algorithm scans the cropped outer ring region for local minima values to identify the darkest area in the iris *** experimental results show that our method outperforms existing segmentation techniques using the UBIRIS.v1 and v2 databases and achieved a segmentation accuracy of 99.32 on UBIRIS.v1 and an error rate of 1.59 on UBIRIS.v2.

关键词： Image recognition color segmentation image processing localization

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不同遗传谱系肠外大肠埃希菌毒力因子检测

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中华微生物学和免疫学杂志 2012年第9期32卷 774-779页

作者：刘双庆曹阳卡马尔魏殿军天津医科大学第二医院检验科 300211

目的通过检测肠外致病性大肠埃希菌（ExPEC）30种毒力因子了解其基因的检出情况及遗传谱系分型情况，并初步探讨两者关系，探究ExPEC的分子流行病学特点。方法210株分离自血液、尿液及其他部位的菌株参与研究，采用多重PCR方法检测临床... 详细信息

目的通过检测肠外致病性大肠埃希菌（ExPEC）30种毒力因子了解其基因的检出情况及遗传谱系分型情况，并初步探讨两者关系，探究ExPEC的分子流行病学特点。方法210株分离自血液、尿液及其他部位的菌株参与研究，采用多重PCR方法检测临床分离菌株毒力因子基因的存在情况并进行遗传谱系分型，比较菌株遗传谱系分型各组间毒力因子基因的检出情况是否有差异。结果ExPEC中毒力基因fimH,fyuA、traT、iutA、kpsMTⅡ、PAI，的检出率较高；遗传谱系分型表明4组百分比分别为24％、11％、29％和36％。在各组之间进行毒力因子基因检出情况比较显示，毒力因子中有8种仅与B2组联系密切，4种仅与D组联系密切，6种与B2组和D组均有关。结论ExPEC遗传潜系分型主要属于B2组和D组，ExPEC毒力因子基因检出情况与菌株遗传谱系分型关系密切。

关键词：肠外致病性大肠埃希菌毒力因子遗传谱系分型

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Search for production of dark fermion candidates in association with heavy neutral gauge boson decaying to dimuon in proton-proton collisions at√s=8 TeV using CMS open data

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.Mahmoud H.abdallah M.T.Hussein S.Elgammal Centre for theoretical physics The British University in EgyptEgypt Physics Department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the CMS experiment during run-I of the LHC in 2012 with a center of mass energy of 8 TeV and an integrated luminosity of 11.6 fb−*** data were gathered from the CMS open *** matter,in the framework of the simplified model(mono-Z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,Z′.Thus,the search was conducted in the dimuon plus large missing transverse momentum *** benchmark scenario of mono-Z′,which is known as light vector,was used for interpreting the CMS open *** evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and Z′at 95%confidence level.

关键词： dark matter large hadron collider CMS open data search for new physics dark fermion

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