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A Stochastic Flight Problem Simulation to Minimize Cost of Refuelling

Computers, Materials & Continua 2021年第10期69卷 849-871页

作者： said Ali Hassan Khalid Alnowibet Miral H.Khodeir Prachi Agrawal Adel F.Alrasheedi Ali Wagdy mohamed Department of Operations Research and Decision Support Faculty of Computers and Artificial IntelligenceCairo UniversityGiza12613Egypt Department of Statistics and Operations Research College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Department of Mathematics and Scientific Computing National Institute of Technology HamirpurHimachal Pradesh177005India Department of Operations Research Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Wireless Intelligent Networks Center(WINC) School of Engineering and Applied SciencesNile UniversityGizaEgypt

Commercial airline companies are continuously seeking to implement strategies for minimizing costs of fuel for their flight routes as acquiring jet fuel represents a significant part of operating and managing expenses for airline activities.A nonlinear mixed binary mathematical programming model for the airline fuel task is presented to minimize the total cost of refueling in an entire flight route *** model is enhanced to include possible discounts in fuel prices,which are performed by adding dummy variables and some restrictive constraints,or by fitting a suitable distribution function that relates prices to purchased *** obtained fuel plan explains exactly the amounts of fuel in gallons to be purchased from each airport considering tankering strategy while minimizing the pertinent cost of the whole flight *** relation between the amount of extra burnt fuel taken through tinkering strategy and the total flight time is also considered.A case study is introduced for a certain flight rotation in domestic US air transport *** mathematical model including stepped discounted fuel prices is *** problem has a stochastic nature as the total flight time is a random variable,the stochastic nature of the problem is realistic and more appropriate than the deterministic *** stochastic style of the problem is simulated by introducing a suitable probability distribution for the flight time duration and generating enough number of runs to mimic the probabilistic real *** similar real application problems are modelled as nonlinear mixed binary ones that are difficult to handle by exact ***,metaheuristic approaches are widely used in treating such different optimization *** this paper,a gaining sharing knowledge-based procedure is used to handle the mathematical *** algorithm basically based on the process of gaining and sharing knowledge throughout the human *** generated simulation runs of

关键词： Stochastic flight problem cost of refuelling ferrying strategy tankering discounted prices simulation procedure nonlinear mixed binary model metaheuristic algorithm gaining-sharing knowledge-based algorithm

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Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 573-579页

作者： Saber Abdelruhman Sakr mohamed El-said Zoil Samraa Samy El-shafey Zoology Department Faculty of Science Menoufia UniversityEgypt Zoology Department Faculty of Science Benha UniversityEgypt

Objective:To evaluate the ameliorative role of grapefruit juice on the cytogenetic and testicular damage induced by the antiarrythmic drug amiodarone in albino ***:Animals were divided into four *** I was considered as *** II was given grapefruit juice at a dose level of 27 mL/kg body *** III was orally administered amiodarone(18 mg/kg body weight)daily for 5 *** were sacrificed after 5 weeks of *** marrow was collected from the femurs for analysis of chromosomal aberrations and mitotic *** were removed and stained with H&E for histological *** were collected from epidedymis for detection of sperm head *** assay was used to detect DNA ***:Amiodarone treatment caused a significant increase in the percentage of chromosomal aberrations,decreased the mitotic index and increased DNA *** testis showed many histopathological alterations,inhibition of spermatogenesis and morphometric *** number of sperm head abnormalities was *** animals with amiodarone and grapefruit juice caused a reduction in chromosomal aberrations,mitotic index,DNA damage and testicular alterations caused by ***:The results of this study indicated that grapefruit juice ameliorates the cytotoxicty and testicular alterations induced by amiodarone in albino rats and this is may be due to the potent antioxidant effects of its components.

关键词： Amiodarone Grapefruit Chromosome Comet assay Testis

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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Variable range hopping transport and dielectric relaxation mechanism in GdCrO_(3) rare-earth orthochromite perovskite

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Journal of Rare Earths 2024年第7期42卷 1304-1316,I0004页

作者： Muhammad Javed Ayaz Arif Khan Jamal Kazmi Naeem Akbar said Nasir Khisro Amanullah Dar Aleem Dad Khan Tareen Mohd Ambri mohamed Department of Physics The University of Azad Jammu and KashmirMuzaffarabad13100Pakistan Department of Physics University of Kotli Azad Jammu and KashmirKotli11100Pakistan Institute of Microengineering and Nanoelectronics Universiti Kebangsaan Malaysia43600BangiSelangorMalaysia Department of Mathematics University of Kotli Azad Jammu and KashmirKotli11100Pakistan

The polycrystalline GdCrO_(3)(GCO)perovskite orthochromite was synthesized by the sol-gel auto-combustion *** Rietveld refined X-ray diffraction(XRD)profile of GCO confirms that the orthorhombic phase crystallizes in perovskite crystal structure with space group *** transmission electron microscopy and selected area electron diffraction divulge the polycrystalline nature of the perovskite *** field emission scanning electron microscopy(FESEM)images reveal the microstructural polyhedral growth of grains separated by sharp grain *** chemical states of the ions present in the compound were investigated by X-ray photoelectron spectroscopy(XPS)studies,and the electrical pathways were *** impedance studies were carried out in the experimental frequency and temperature ranges of 40 Hz-4 MHz and 178-408 K,*** equivalent circuit model(RGQG)(RGBQGB)resolves the impedance response into two contributions originating from the intra-grain and inter-granular micro-constituents of the *** electrical conduction mechanism is based on the Mott variable range hopping *** complex electric modulus studies demonstrate the short-and long-range mobility of the charge carriers and rule out the presence of electrode effects on the dielectric relaxation mechanism of the *** decreasing pattern of dielectric permittivity with frequency is explained by the Maxwell-Wagner type of *** frequency dependence of the loss factor exhibits the presence of thermally activated relaxation time distribution in the material.

关键词： Auto-combustion Perovskite Electro-ceramic Dielectric Electrical transport Impedance

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Tegumental histological effects of Mirazid~ and myrrh volatile oil on adult Fasciola gigantica

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Asian Pacific Journal of Tropical Biomedicine 2013年第6期3卷 501-504页

作者： Ahmad mohamed Massoud Hatem Abdel Mawgoud Shalaby Rabab mohamed El Khateeb Mona said Mahmoud mohamed Abdel Aziz Kutkat Tropical Medicine Department Faculty of MedicineAl-Azhar University Parasitology and Animal Diseases Department National Research Center Poultry Diseases Department National Research Center

Objective:To evaluated the histological changes within the tegument of adult Fasciola gigantica(***)that led to the gross changes that were visible ***:The effects of oleoresin extract of myrrh(Mirazid^(?)),myrrh volatile oil and triclabendazole sulphoxide(reference drug)on the tegumental structure of adult *** following treatment in vitro had been determined by light ***:The internal changes in the tegument observed in this study were compatible with surface changes seen in the previous scanning electron microscopy study,using the same *** swelling of tegumental syncytium was a particular feature of their action,but its level was much greater with myrrh volatile oil,in which vacuolization of the tegument and loss of spines were ***:The present study demonstrated the fasciocidal properties of Mirazid^(?)oleoresin extract,and it might be possible to reinforce its fasciocidal activity by increasing its content of myrrh volatile oil.

关键词： Fasciola gigantica Mirazid Myrrh volatile oil Histological effect

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Cocktail of Theileria equi antigens for detecting infection in equines

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 977-981页

作者： Shimaa Abd El-Salam El-Sayed mohamed Abdo Rizk mohamed Alaa Terkawi Ahmed Mousa El said El Shirbini El said Gehad Elsayed mohamed Fouda Naoaki Yokoyama Ikuo Igarashi National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary Medicine Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Mansoura University Department of Internal Medicine and Infectious Diseases Faculty of Veterinary Medicine Mansoura University Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Sadat City University

Objective:To use two diagnostic antigens belonging to the frequently associated in Theileria domain,Theileria equi(***)protein 82(Te 82)and *** 104 k Da microneme-rhoptry antigen precursor(Te 43),to diagnose *** infection in horses as compared with equi merozoite antigen-2(EMA-2).Methods:In the current study,we applied a cocktail-ELISA containing two antigens(EMA-2+Te 82)to diagnose *** infection either in experimentally infected horses or in field ***:Our findings have revealed that a cocktail formula of EMA-2+Te 82 provided a more practical and sensitive diagnostic candidate for diagnosing *** infection in horses as compared with Te 82 or Te 43 ***:The ELISA technique using a cocktail formula of EMA-2+Te 82 offers a practical and sensitive diagnostic tool for diagnosing *** infection in horses and using of this promising cocktail formula will be applicable for epidemiological surveys and will help control the infection in horses.

关键词： Theileria equi Equi merozoite antigen-2 Theileria

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Biliary leakage following pancreaticoduodenectomy:Prevalence,risk factors and management

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 67-72页

作者： Ayman El Nakeeb mohamed El Sorogy Hosam Hamed Rami said Mohamad Elrefai Helmy Ezzat Waleed Askar Ahmed M Elsabbagh Gastroenterology Surgical Center Mansoura University

Background: Few studies investigated biliary leakage after pancreaticoduodenectomy(PD) especially when compared to postoperative pancreatic fistula(POPF). This study was to determine the incidence of biliary leakage after PD, predisposing factors of biliary leakage, and its management. Methods: We retrospectively studied all patients who underwent PD from January 2008 to December 2017 at Gastrointestinal Surgery Center, Mansoura University, Egypt. According to occurrence of postoperative biliary leakage, patients were divided into two groups. Group(1) included patients who developed biliary leakage and group(2) included patients without identified biliary leakage. The preoperative data, operative details, and postoperative morbidity and mortality were analyzed. Results: The study included 555 patients. Forty-four patients(7.9%) developed biliary leakage. Ten patients(1.8%) had concomitant POPF. Multivariate analysis identified obesity and time needed for hepaticojejunostomy reconstruction as independent risk factors of biliary leakage, and no history of preoperative endoscopic retrograde cholangiopancreatiography(ERCP) as protective factor. Biliary leakage from hepaticojejunostomy after PD leads to a significant increase in development of delayed gastric emptying, and wound infection. The median hospital stay and time to resume oral intake were significantly greater in the biliary leakage group. Non-surgical management was needed in 40 patients(90.9%). Only 4 patients(9.1%) required re-exploration due to biliary peritonitis and associated POPF. The mortality rate in the biliary leakage group was significantly higher than that of the non-biliary leakage group(6.8% vs 3.9%, P = 0.05). Conclusions: Obesity and time needed for hepaticojejunostomy reconstruction are independent risk factors of biliary leakage, and no history of preoperative ERCP is protective factor. Biliary leakage increases the risk of morbidity and mortality especially if concomitant with POPF. Howeve

关键词： Pancreatic head carcinoma Pancreaticodudenetomy Postoperative pancreatic fistula Biliary leakage

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Efficacy of Intravenous versus Intrathecal Meperidine on Post-Spinal Shivering after Knee Arthroscopy: A Randomized Controlled Study

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Open Journal of Anesthesiology 2022年第6期12卷 197-209页

作者： mohamed said Mostafa Elmeligy mohamed Fouad mohamed Elmeliegy Anaesthesia Department Benha University Benha Egypt

Background and Aims: Hypothermia is considered a common problem with anesthesia. Spinal anesthesia, affects the process of temperature regulation. The aim of this study was to compare the prophylactic effect of intravenous (IV) meperidine with intrathecal (IT) meperidine on the prevention of shivering during spinal anesthesia in patients underwent knee arthroscopy. Aim of the Study: The aim of this work is to study the effect of meperidine either intravenous (IV) vs intrathecal (IT) on controlling postoperative shriving after knee arthroscopy. Materials and Methods: This study will be conducted in accordance with the principles of the ethics committee Benha University hospitals. Full written informed consent will be obtained from all patients before inclusion in the study, and a prospective randomized double-blinded study was conducted in adult patients undergoing knee arthroscopy under spinal anesthesia. Cases are divided into three equal groups (20 patients in each). Group IT: will receive spinal anesthesia (12.5 mg heavy bupivacaine) with intrathecal meperidine (25 mg). Group IV: will receive spinal anesthesia (12.5 mg heavy bupivacaine) with intravenous meperidine (25 mg). Group C: will receive spinal anesthesia (12.5 mg heavy bupivacaine) only postoperatively. Incidence and degree of shivering (SS), sedation score (RSS), pain score (VAS), hemodynamics, and PONV will be measured at the following intervals: 0 min (once arrived at PACU), 20 min later, 40 min later, 80 min later. Results: Shivering was observed in 0%, 0%, and 10.5% of patients in Groups IT, IV, and C, respectively. There was a significant difference between Group IT and IV compared to Group C (P Conclusion: We concluded that IT meperidine and IV meperidine comparably can decrease intensity and incidence of shivering compared to control group as well as decrease the requirement for additional doses of meperidine for shivering control without any hemodynamic side effect. And intrathecal meperidine sh

关键词： Shivering Mepridine Spinal Anesthesia Knee Arthroscopy

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Effect of Height Adjusted Dose of Intrathecal Hyperbaric Bupivacine for Elective Cesarean Section: A Study of 2 Different Concentrations

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Open Journal of Anesthesiology 2023年第12期13卷 241-253页

作者： mohamed Fouad mohamed Elmeliegy mohamed said Mostafa Elmeligy Anaesthesia Department Benha University Benha Egypt

Introduction: Study compare spinal anesthesia using hyperbaric bupivacine (0.5% - 0.75%) between fixed dose and height adjusted dose during elective cesarean section. Methods: Hundred parturients who had given their consent and were scheduled for elective cesarean section under spinal anesthesia, were divided into four groups—first group received 0.5% hyperbaric bupivacine fixed dose, the second group received 0.5% hyperbaric bupivacine in a dose adjusted to the height, the third received 0.75% hyperbaric bupivacine fixed dose, the fourth group received 0.75% hyperbaric bupivacine in a dose adjusted to height. The anesthesia onset time, haemodynamic changes, side effects and fetal outcome observed. Results: Spinal block provide excellent surgical anesthesia in all patients. Anesthesia onset time is longer in adjusted than fixed groups, in 0.5% (5 ± 0.816 vs. 3.84 ± 0.746) (P Conclusion: Adjusting dose of hyperbaric bupivacine (0.5% - 0.75%) to patient’s height, decreases the dose of bupivacine in use, it also provide adequate anesthesia for elective cesarean section with decrease the use of vasopressors, the incidence and severity of maternal hypotention also markedly reduced.

关键词： Cesarean Section Height Spinal Anesthesia Local Anesthesia

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SMILE intraoperative complications: incidence and management

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 280-283页

作者： Abdelmonem M Hamed mohamed Amin Heikal Tarek T.Soliman Ahmed Daifalla Khaled E said-Ahmed Benha University Department of Ophthalmology Menoufia University Department of Ophthalmology

AIM: To report the intraoperative complications associated with small incision lenticule extraction(SMILE) and their management. METHODS: This was a retrospective consecutive interventional clinical study, carried out on patients with myopia and myopic astigmatism, who underwent SMILE procedure. Type of intraoperative complications and their management were recorded. RESULTS: Our study comprised 282 eyes of 141 patients who were enrolled for SMILE surgeries. The intraoperative complications included lost vacuum(18 eyes, 6.38%), treatment decentration(6 eyes, 2.12%), wound bleeding(21 eyes, 7.45%), incomplete bubble separation(black islands)(3 eyes, 1.06%), the epithelial defects(15 eyes, 5.32%). Incision tear(27 eyes, 9.57%), lenticule adherence to the cap(6 eyes, 2.12%), and cap perforation occurred in 2 eyes(0.7%). CONCLUSION: Although SMILE is a promising technique for the correction of myopia and myopic astigmatism with predictable, efficient, safe refractive and visual outcomes, complications can occur. However, most of them are related to inexperience and are included in the learning curve of the technique. More studies with a bigger number of eyes are required to efficiently evaluate the intraoperative complications and standardize their management strategies.

关键词： femtosecond laser intraoperative complication small incision lenticule extraction

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