检索结果-南通市图书馆

Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease

Neural Regeneration Research 2022年第8期17卷 1666-1674页

作者： Alejandro R.Roda Gabriel Serra-mir Laia Montoliu-Gaya Lidia Tiessler Sandra Villegas Protein Design and Immunotherapy Group Departament de Bioquímica i Biologia MolecularFacultat de BiociènciesUniversitat Autònoma de BarcelonaBellaterraBarcelonaSpain Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska AcademyUniversity of GothenburgSweden

Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018.A large amount of evidence supports the amyloid cascade hypothesis,which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles,and these aggregates lead to inflammation,synaptic impairment,neuronal loss,and thus to cognitive decline and behavioral *** poor correlation found between cognitive decline and amyloid plaques,have led the scientific community to question whether amyloid-beta accumulation is actually triggering neurodegeneration in Alzheimer’s *** occurrence of tau neurofibrillary tangles better correlates to neuronal loss and clinical symptoms and,although amyloid-beta may initiate the cascade of events,tau impairment is likely the effector molecule of ***,it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and,more importantly,that downregulation of tau partially reverses transcriptional *** mounting evidence points to an interplay between amyloid-beta and tau,some factors could independently affect both ***,the dual pathway hypothesis,which states that there are common upstream triggers causing both amyloid-beta and tau abnormalities has been *** others,the immune system seems to be strongly involved in amyloid-beta and tau *** factors,as the apolipoprotein Eε4 isoform has been suggested to act as a link between amyloid-beta and tau ***,amyloid-beta-immunotherapy reduces not only amyloid-beta but also tau levels in animal models and in clinical ***,it has been shown that tau-immunotherapy also reduces amyloid-beta ***,even though amyloid-beta immunotherapy is more advanced than tau-immunotherapy,combined amyloid-beta and tau-directed therapie

关键词： aggregation Alzheimer amyloid-beta dementia immunotherapy inflammation neurodegeneration tau

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Erratum to:Cadmium nanoclusters in a protein matrix:Synthesis,characterization,and application in targeted drug delivery and cellular imaging

引用

Nano Research 2024年第6期17卷 5755-5755页

作者： Morteza Sarparast Abolhassan Noori Hoda Ilkhani S.Zahra Bathaie Maher F.El-Kady Lisa J.Wang Huong Pham Kristofer L.Marsh Richard B.Kaner mir F.Mousavi Department of Chemistry Tarbiat Modares UniversityTehran 14115-175Iran Department of Clinical Biochemistry Faculty of Medical SciencesTarbiat Modares UniversityTehran 14115-111Iran Department of Chemistry and Biochemistry University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Chemistry Faculty of ScienceCairo UniversityGiza 12613Egypt California NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCA 90095USA

The Electronic Supplementary Material available online erroneously only contains the first six pages of the entire supplementary material *** will find the entire supplementary material file online linked to this publisher’s *** publisher apologizes to the authors and readers for this *** Supplementary Material:Supplementary material(detailed description on procedures,and further characterizations,including synthesis,optimization,and characterization of CdNCs,HA-CdNCs,and DOX-HA-CdNCs;calculating quantum yield;a Jellium model for assigning the most valid number of the atoms in the NCs;drug loading and release;cellular uptake and cytotoxicity)is available in the online version of this article at https://***/10.1007/s12274-016-1201-z.

关键词： characterization matrix calculating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bamboo biochar greater enhanced Cd/Zn accumulation in Salix psammophila under non-flooded soil compared with flooded

引用

Biochar 2022年第1期4卷 1072-1088页

作者： Xiaogang Li Yini Cao Jiang Xiao mir Md Abdus Salam Guangcai Chen Research Institute of Subtropical Forestry Chinese Academy of Forestry73Daqiao RdHangzhou 311400ZhejiangChina Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education School of EcologyEnvironment and ResourcesGuangdong University of TechnologyGuangzhou 510006China School of Forest Sciences University of Eastern FinlandYliopistokatu 7P.O.Box 11180100 JoensuuFinland Natural Resources Institute Finland(LUKE) Yliopistokatu 6B80100 JoensuuFinland

As a metal immobilizer,biochar can be used to remediate contaminated ***’s effect on the phytoremediation process in flooded conditions under a scenario of increasing flooding frequency as global climate change is not well *** study investigated bamboo biochar(BBC)effects on growth and metal accumulation of Salix in multi-metal contaminated soil under non-flooded versus flooded *** cuttings were cultivated in pots with severely contaminated soil by Cd and Zn,for 120 days,with four treatments including non-flooded treatment,flooded treatment,non-flooded with 3%BBC application(BBC/soil,w/w),and flooded with 3%BBC ***,flooding,and BBC×flooding significantly decreased the bioavailability of metals in soils(P<0.05).The BBC addition markedly stimulated Cd concentration in leaves under non-flooded(94.20%)and flooded conditions(32.73%)but showed little effect on *** BBC significantly boosted Cd and Zn transport from roots to aboveground parts by 68.85%and 102.27%compared with no BBC amendment under non-flooded treatment,while showing insignificant changes under flooded *** the plant biomass was little affected,BBC significantly increased Cd and Zn accumulation in the whole plant by 52.53%and 28.52%under non-flooded while showing an insignificant impact under flooded *** together,BBC enhanced the phytoremediation efficiency of Salix to Cd and Zn in severely polluted non-flooded soil,while flooding offset this *** results indicated the effects of BBC varied under different soil moisture,which should be considered in the biochar-assisted phytoremediation to variable and complex environments.

关键词： Heavy metals Amendment Salix Phytoremediation Soil flooding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar,Pakistan

引用

Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 886-889页

作者： Arshad Javaid Mazhar Ali khan mir Azam khan Sumaira Mehreen Anila Basit Raza Ali khan Muhammad Ihtesham Irfan Ullah Afsar khan Ubaid Ullah Post Graduate Medical Institute Lady Reading Hospital Programmatic Management of Drug Resistant TB Unit Lady Reading Hospital Peshawar Medical College Kohat University of Science and Technology Kohat

Objective:To assess the profile of TB/multidrug-resistant TB(MDR-TB) among household contacts of MDR-TB ***:Close contacts of MDR-TB patients were traced in the cross-sectional *** clinical,radiological and bacteriological were performed to rule out the evidence of TB/***:Between January 2012 and December 2012,a total of 200 index MDR-TB patients were initiated on MDR-TB treatment,out of which home visit and contacts screening were conducted for 154 index *** 610 contacts who could be studied,41(17.4%) were diagnosed with MDR-TB and 10(4.2%) had *** most common symptoms observed were cough,chest pain and ***:The high incidence of MDR-TB among close contacts emphasize the need for effective contact screening programme of index MDR-TB cases in order to cut the chain of transmission of this disease.

关键词： Tuberculosis Household contacts MDR-TB Peshawar Pakistan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transcranial magnetic stimulation in animal models of neurodegeneration

引用

Neural Regeneration Research 2022年第2期17卷 251-265页

作者： Mohammad Uzair Turki Abualait Muhammad Arshad Woo-Kyoung Yoo Ali mir Reem Fahd Bunyan Shahid Bashir Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University IslamabadPakistan College of Applied Medical Sciences Imam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia Department of Physical Medicine and Rehabilitation Hallym University College of MedicineAnyangSouth Korea Hallym Institute for Translational Genomics&Bioinformatics Hallym University College of MedicineAnyangSouth Korea Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation(TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, and there are few reports on the incisive recovery mechanisms through brain stimulation. Although several studies have recommended the use of non-invasive brain stimulation in clinical neuroscience, with a special emphasis on TMS, the suggested mechanisms of action have not been confirmed directly at the neural level. Insights into the neural mechanisms of non-invasive brain stimulation would unveil the strategies necessary to enhance the safety and efficacy of this progressive approach. Therefore, animal studies investigating the mechanisms of TMSinduced recovery at the neural level are crucial for the elaboration of non-invasive brain stimulation. Translational research done using animal models has several advantages and is able to investigate knowledge gaps by directly targeting neuronal levels. In this review, we have discussed the role of TMS in different animal models, the impact of animal studies on various disease states, and the findings regarding brain function of animal models after TMS in pharmacology research.

关键词： Alzheimer's disease depression glial cells neurorehabilitation Parkinson's disease repetitive transcranial magnetic stimulation transcranial direct current stimulation transcranial magnetic stimulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current perspectives on active surveillance for patients with small renal masses

引用

Asian Journal of Urology 2022年第3期9卷 204-205页

作者： Giacomo Rebez M.Carmen mir Department of Urology University of TriesteTriesteItaly Department of Urology Fundacion Instituto Valenciano OncologiaValenciaSpain

Small renal mass(SRM)incidence has been increasing over last decades due to the widespread access to diagnostic tools and is now accounting for 48%e66%of all renal cell carcinoma(RCC)diagnoses[1].The optimal management of SRM is still debated since approximately 25%of T1a is benign *** role of active surveillance(AS)and the problem of SRM overtreatment are widely described in the current ***,RCC mortality has remained stable over the last 2 *** major strength of AS is the“tetrafecta”concept as it brings renal function preservation,safe oncological outcomes,and no surgical complications,and it maintains quality of *** is nowadays considered as a safe strategy for many SRMs.

关键词： renal mortality patients

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Body Worn Sensors for Health Gaming and e-Learning in Virtual Reality

引用

Computers, Materials & Continua 2022年第12期73卷 4763-4777页

作者： mir Mushhood Afsar Shizza Saqib Yazeed Yasin Ghadi Suliman A.Alsuhibany Ahmad Jalal Jeongmin Park Department of Computer Science Air UniversityIslamabad44000Pakistan Department of Computer Science and Software Engineering Al Ain UniversityAl Ain15551UAE Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Computer Engineering Tech University of Korea237 Sangidaehak-roSiheung-siGyeonggi-do15073Korea

Virtual reality is an emerging field in the whole *** problem faced by people today is that they are more indulged in indoor technology rather than outdoor ***,the proposed system introduces a fitness solution connecting virtual reality with a gaming interface so that an individual can play first-person *** system proposed in this paper is an efficient and cost-effective solution that can entertain people along with playing outdoor games such as badminton and cricket while sitting in the *** track the human movement,sensors Micro Processor Unit(MPU6050)are used that are connected with Bluetoothmodules andArduino responsible for sending the sensor data to the ***,the sensor data is sent to a machine learning model,which detects the game played by the *** detected game will be operated on human gestures.A publicly available dataset named IM-Sporting Behaviors is initially used,which utilizes triaxial accelerometers attached to the subject’s wrist,knee,and below neck regions to capture important aspects of human *** main objective is that the person is enjoying while playing the game and simultaneously is engaged in some kind of sporting *** proposed system uses artificial neural networks classifier giving an accuracy of 88.9%.The proposed system should apply to many systems such as construction,education,offices and the educational *** experimentation proved the validity of the proposed system.

关键词： Artificial neural networks bluetooth connection inertial sensors machine learning virtual reality exergaming

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blockchain-Based Decentralized Authentication Model for IoT-Based E-Learning and Educational Environments

引用

Computers, Materials & Continua 2023年第5期75卷 3133-3158页

作者： Osama A.Khashan Sultan Alamri Waleed Alomoush Mutasem K.Alsmadi Samer Atawneh Usama mir Research and Innovation Centers Rabdan AcademyP.O.Box 114646Abu DhabiUnited Arab Emirates College of Computing and Informatics Saudi Electronic UniversityRiyadh13316Saudi Arabia School of Information Technology Skyline University CollegeP.O.Box 1797SharjahUnited Arab Emirates Department of MIS College of Applied Studies and Community ServicesImam Abdulrahman Bin Faisal UniversityP.O.Box 1982DammamSaudi Arabia Department of Computer Science University of WindsorWindsorN9J3Y1Canada

In recent times,technology has advanced significantly and is currently being integrated into educational environments to facilitate distance learning and interaction between *** the Internet of Things(IoT)into education can facilitate the teaching and learning process and expand the context in which students ***,learning data is very sensitive and must be protected when transmitted over the network or stored in data ***,the identity and the authenticity of interacting students,instructors,and staff need to be verified to mitigate the impact of ***,most of the current security and authentication schemes are centralized,relying on trusted third-party cloud servers,to facilitate continuous secure *** addition,most of these schemes are resourceintensive;thus,security and efficiency issues arise when heterogeneous and resource-limited IoT devices are being *** this paper,we propose a blockchain-based architecture that accurately identifies and authenticates learners and their IoT devices in a decentralized manner and prevents the unauthorized modification of stored learning records in a distributed university *** allows students and instructors to easily migrate to and join multiple universities within the network using their identity without the need for user *** proposed architecture was tested using a simulation tool,and measured to evaluate its *** simulation results demonstrate the ability of the proposed architecture to significantly increase the throughput of learning transactions(40%),reduce the communication overhead and response time(26%),improve authentication efficiency(27%),and reduce the IoT power consumption(35%)compared to the centralized authentication *** addition,the security analysis proves the effectiveness of the proposed architecture in resisting various attacks and ensuring the security requirements of learning data in the unive

关键词： Blockchain decentralized authentication Internet of Things(IoT) E-learning IoT security

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SARS-CoV-2: Has artificial intelligence stood the test of time

引用

Chinese Medical Journal 2022年第15期135卷 1792-1802页

作者： mir Ibrahim Sajid Shaheer Ahmed Usama Waqar Javeria Tariq Mohsin Chundrigarh Samira Shabbir Balouch Sajid Abaidullah Medical College Aga Khan UniversityStadium RoadKarachiPakistan Medlcal Cllege Islamabad Medical and Dental CollegeMain Murree RoadIslamabadPakistan Oral and Maxilofacial Surgery King Edward Medical UniversityNeela GumbadLahorePakistan King Edward Medical University Neela GumbadLahorePakistan North Medical Ward Mayo HospitaNeela GumbadLahorePakistan

Artificial intelligence (AI) has proven time and time again to be a game-changer innovation in every walk of life, including medicine. Introduced by Dr. Gunn in 1976 to accurately diagnose acute abdominal pain and list potential differentials, AI has since come a long way. In particular, AI has been aiding in radiological diagnoses with good sensitivity and specificity by using machine learning algorithms. With the coronavirus disease 2019 pandemic, AI has proven to be more than just a tool to facilitate healthcare workers in decision making and limiting physician-patient contact during the pandemic. It has guided governments and key policymakers in formulating and implementing laws, such as lockdowns and travel restrictions, to curb the spread of this viral disease. This has been made possible by the use of social media to map severe acute respiratory syndrome coronavirus 2 hotspots, laying the basis of the "smart lockdown" strategy that has been adopted globally. However, these benefits might be accompanied with concerns regarding privacy and unconsented surveillance, necessitating authorities to develop sincere and ethical government–public relations.

关键词： Artificial intelligence COVID-19 Machine learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus:A narrative review of randomized control trials

引用

World Journal of Diabetes 2023年第6期14卷 919-929页

作者： Dharmsheel Shrivastav Pradeep Kumar Dabla Jitender Sharma Aroop Viswas Rashid mir Amity Institute of Biotechnology Amity University RajasthanJaipur 303002India Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Department of Medical Lab Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491Saudi Arabia

BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose *** in generation and elimination of free radicals generate oxidative stress which modulates glucose metabolism and insulin regulation,resulting in the occurrence and progression of diabetes and associated *** supplements in T2DM can be seen as a potential preventive and effective therapeutic *** To compare randomized controlled trials(RCTs)in which antioxidants have been shown to have a therapeutic effect in T2DM *** We systematically searched the electronic database PubMed by *** evaluating the effect of antioxidant therapy on glycaemic control as well as oxidant and antioxidant status as primary outcomes were *** outcomes considered were:A reduction in blood glucose;changes in oxidative stress and antioxidant ***-length papers of the shortlisted articles were assessed for the eligibility criteria and 17 RCTs were *** The administration of fixed-dose antioxidants significantly reduces fasting blood sugar and glycated hemoglobin and is associated with decreased malondialdehyde,advanced oxidation protein products,and increased total antioxidant *** Antioxidant supplements can be a beneficial approach for the treatment of T2DM.

关键词： Diabetes Antioxidants Oxidative stress Malondialdehyde Polyphenols Antioxidant therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：