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缓和曲线对交通安全的影响分析

重庆交通大学学报（自然科学版） 2008年第5期27卷 758-762,838页

作者：王福建吴国雄赛德.M.伊萨浙江大学土木系交通工程研究所浙江杭州310027 重庆交通大学土木建筑学院重庆400074 瑞尔森大学土木工程系

对比分析文献表明，不合理的缓和曲线长度会影响驾驶行为和交通安全。调查分析了上三高速公路的39个弯道和2001年—2004年事故资料、沪杭高速公路浙江段的5个弯道和1999年—2004年事故资料、杭宁高速公路浙江段的6个弯道和2001年—2004... 详细信息

对比分析文献表明，不合理的缓和曲线长度会影响驾驶行为和交通安全。调查分析了上三高速公路的39个弯道和2001年—2004年事故资料、沪杭高速公路浙江段的5个弯道和1999年—2004年事故资料、杭宁高速公路浙江段的6个弯道和2001年—2004年事故资料，其中缓和曲线交通事故并没有出现异常现象，表明其缓和曲线长度设计是合理的、可行的，没有对交通安全造成明显影响。在所调查的半径范围[400m，3819．516m]，缓和曲线参数A与圆曲线半径R之比（A／R）随半径增大而呈现较好的负次幂递减规律，而且其变化范围基本上在1／3—1／2．这与传统认识及最近文献调查相一致。这一基本规律可为设计提供更明确的量化参考依据。

关键词：缓和曲线圆曲线交通安全交通事故弯道错觉

Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 453-462页

作者： Sameh Hany Emile Hossam Ayman Elfeki Hosam Ghazy Elbanna Mohamed Youssef Waleed Thabet Tito M Abd El-Hamed Basem said Ahmed Lotfy General Surgery Department Colorectal Surgery Unit Mansoura Faculty of Medicine Mansoura University

AIM: To evaluate the efficacy and safety of botulinum toxin type A(BTX-A) in the management of patients with anismus. METHODS: An organized search of published literature was conducted using electronic databases including: Pub Med/MEDLINE, and Cochrane Central Register of Control ed Trials, also an internet-based search using "Google Scholar" service was conducted. Both comparative and observational studies were included. We excluded irrelevant articles, editorials, case reports, reviews, and meta-analyses. The studies that followed the patients less than 6 mo were excluded. Variables collected were demographic data of the patients, technique of BTX-A injection and number of sessions, short-term and longterm clinical improvement, post-injection changes in electromyography(EMG), defecography, manometry, and balloon expulsion test, and complications recorded after BTX-A ***: Seven studies comprising 189 patients were included in the review. The median age of the patients was 41.2 years and female-to-male ratio was 1.3:1. The median dose of BTX-A injected per procedure was 100 IU(range, 20-100 IU). Lateral injection was done in five trails and combined lateral and posterior injections in two trials. Three studies used endorectal ultrasonographyguided technique, one study used EMG-guided technique,whereas the remaining three studies used manual palpation with the index finger. The median percentage of patients who reported initial improvement of symptoms was 77.4%(range 37.5%-86.7%), this percentage declined to a median of 46%(range 25%-100%) at 4 mo after injection of BTX-A. Rates of improvement evaluated by balloon expulsion test, EMG, and defecography ranged between(37.5%-80%),(54%-86.7%), and(25%-86.6%), respectively. Fourteen(7.4%) patients developed complications after injection of BTX-A. Complication rates across the studies ranged from 0% to 22.6%. CONCLUSION: Initial satisfactory improvement of symptoms after BTX-A injection remarkably deteriorate

关键词： Botulinum toxin Botulinum toxin type A Botox Anismus Puborectalis syndrome Efficacy

Socio-Demographic Determinant of Yellow Fever Patient: A Retrospective Study (2020), Federal Medical Center, Asaba

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Journal of Biosciences and Medicines 2022年第12期10卷 225-238页

作者： Ngozi Esther Ezunu Joy Ifeyinwa Egeonu Ajiri Henry Osihro Uyi-Oghosa Onyemushani said Abdulkareem Omole Clementina Oyakhire Onyema Edith Wayemeru Chidera Olivia Okey-Ezufo Chikadibia Eze-Otulaka Faith Inegbejie Clever Ajiri Oghale Diana Chinenye Ofomata Grace Nnenna Onubogu Orhomuromo Paul Okpomo Eguolo Unique Okorhi Onobhase Theresa Agbele Anastacia Okwudili Ojimba Adesuwa Queen Aigbokhaode Francis Chinedu Ugoeze Victor Azubike Osiatuma Emmanuel Okechukwu Ezunu Obianuju Nkemjika Jisieike Erhinyaye Omoyibo Efe Department of Nursing Federal Medical Centre Asaba Nigeria CCDRC Federal Medical Centre Asaba Nigeria Department of Internal Medicine Federal Medical Centre Asaba Nigeria Department of Radiology Federal Medical Centre Asaba Nigeria Department of Health Information Management Federal Medical Centre Asaba Nigeria Department of Pediatrics Federal Medical Centre Asaba Nigeria

Background: Yellow fever is transmitted primarily to humans and non-human primates through the bite of an infected female mosquito Aedes Spp. It is prevented mainly by vaccination. Method: This retrospective observational study at the Center for Communicable Disease Control and Research (CCDCR) Federal Medical Center Asaba (F.M.C) was conducted on all patients diagnosed and managed with yellow fever in the year 2020. We studied a total number of 57 patients’ case files seen within the period. A chi-square test was done to test the null and alternative hypotheses. Result: About 48 (84.2%) males and female 9 (15.8%) females were mostly affected and gender was significant with a chi-squared value of 26.6 and p-value of 0.00. Conclusion: To eradicate this virus, vaccination and health promotions should be encouraged by the health care workers supported by the government. This is to ensure that a greater proportion of the affected community can be immunized.

关键词： Yellow Fever Socio-Demograpic Determinants Asaba

Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project

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World Journal of Hepatology 2015年第22期7卷 2418-2426页

作者： Iman I Salama Samia M Sami Zeinab Nabil Ahmed said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally Community Medicine Research Department National Research Center Child Health Department National Research Center Micro--biology and Immunology Department Faculty of Medicine (for girls)Al-Azhar University Pediatrics Department Faculty of MedicineAin-Shams University Dermatology and Venereology Department National Research Center Environmental and Occupational Medicine Department National Research Center

AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated ***:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory.

关键词： Hepatitis B virus Immunization Seroprotection Brea

多发性骨髓瘤患者浆细胞浸润外周神经所致多发性神经病变

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 49-49页

作者： Denier C. Lozeron P. Adams D. G. said 刘凯 Department of Neurology Hopital Bic.etre 94275 Le Krem- lin- Bic.etre France Dr.

Patients with multiple myeloma (MM) can manifest a variety of neurologic complications. The authors report two patients who had development of a multifocal neuropathy related to infiltration of peripheral nerves by ma... 详细信息

关键词：多发性骨髓瘤骨髓瘤浆细胞瘤外周神经细胞浸润神经病变患者

一种非复制尿嘧啶营养缺陷型弓形虫的构建及其表型鉴定

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热带医学杂志 2021年第12期21卷 1502-1508页

作者：鄂立林杨子帆赛迪韦霞李文洁周兴旺中山大学中山医学院广东广州510080 中山大学附属第一医院广东广州510080 中山大学热带病防治研究教育部重点实验室广东广州510080

目的构建并验证一种可用作生物免疫治疗载体的非复制尿嘧啶营养缺陷型弓形虫(NRTUA),并鉴定其表型。方法通过经典的基于同源重组的基因敲除技术构建稳定的NRTUA虫株;构建p-OM1-HXGPRT-OM2、pOM1-OM2和p-UP1-HXGPRT-UP2质粒用于敲除RHΔk... 详细信息

目的构建并验证一种可用作生物免疫治疗载体的非复制尿嘧啶营养缺陷型弓形虫(NRTUA),并鉴定其表型。方法通过经典的基于同源重组的基因敲除技术构建稳定的NRTUA虫株;构建p-OM1-HXGPRT-OM2、pOM1-OM2和p-UP1-HXGPRT-UP2质粒用于敲除RHΔku80Δhxgprt弓形虫中的乳清苷-5’-磷酸脱羧酶(OMPDC)基因和尿苷磷酸化酶(UP)基因,并通过电转染的方法转染到RHΔku80Δhxgprt弓形虫中,最后经过药物筛选和极限稀释得到RHΔku80ΔompdcΔup::HXGPRT弓形虫(NRTUA虫株)。利用PCR实验和全基因组测序对其进行基因结构验证,然后通过噬斑实验鉴定NRTUA虫株的细胞表型,并通过NRTUA虫株感染小鼠的毒力实验检测其在正常小鼠体内的毒性。结果p-OM1-HXGPRT-OM2、p-OM1-OM2和p-UP1-HXGPRT-UP2质粒进行酶切鉴定,经Nde I酶切后,三种质粒酶切后的骨架DNA片段均为3.0 kb左右。RHΔku80Δompdc::HXGPRT弓形虫和RHΔku80ΔompdcΔhxgprt弓形虫中OMPDC基因被敲除;而RHΔku80ΔompdcΔup::HXGPRT弓形虫中OMPDC基因和UP基因均被敲除。其中敲除的OMPDC基因序列为3.3 kb左右,敲除的UP基因序列为3.1 kb左右,与理论值相吻合。成功构建并通过全基因组测序验证了弓形虫NRTUA株,噬斑实验显示NRTUA虫株在未添加尿嘧啶的培养基中没有噬斑形成,在添加尿嘧啶的培养基中能产生噬斑。小鼠毒力实验中,活的NRTUA虫株感染小鼠后直到实验周期结束无小鼠死亡,对照原株弓形虫感染小鼠后从第7~9天所有小鼠均死亡。结论NRTUA虫株在体外尿嘧啶缺乏的条件下无法在宿主细胞内增殖且在正常小鼠体内不具有致死毒性,是一种减毒甚至基本无毒的弓形虫活疫苗,具有作为生物免疫治疗载体的应用潜力。

关键词：非复制尿嘧啶营养缺陷型弓形虫全基因组测序生物免疫治疗载体

行不孕症检查的男性患者中吸烟与精子质量的关系

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 35-35页

作者： said T. M. Ranga G. Agarwal A. 张剑萍(译) Dr. A. Agarwal Center for Advanced Research in Human Reproduction Infertility and Sexual Function Glickman Urological Institute Department of Obstetrics and Gynecology 9500 Euclid Avenue Cleveland OH 44195 United States 不详

Male fertility is affected by a variety of lifestyle habits that include tobacco use. A large population of Indian men is addicted to tobacco chewing. The Abstract of our study was to assess the relationship between tobacco chewing in these Indian men - who were part of an infertile couple and their sperm characteristics. Design: Retrospective study. Setting: Private infertility clinic. Patient(s): Six hundred thirty-eight male patients undergoing infertility evaluations were grouped according to the frequency of their tobacco chewing habit: mild (6 times/day, n = 197). Intervention(s): None. Main Outcome Measure(s): Sperm characteristics (concentration, motility, morphology, and viability). Result(s): Sperm concentration, percentage motility, morphology, and percentage viability were significantly higher in the mild group vs the moderate group and in the moderate group vs the severe group. The percentage of men with azoospermia rose with the level of addiction (1% , 3% , and 14% ) as did the percentage of men with oligoasthenoteratozoospermia (2% , 8% , and 29% ), although the differences were not statistically significant. Conclusion(s): In our study, use of chewing tobacco by a group of Indian men who were undergoing infertility evaluation was strongly associated with a decrease in sperm quality and to a lesser extent with oligoasthenozoospermia or azoospermia. Infertile men should be counseled about the adverse effects of tobacco chewing on sperm quality.

关键词：不孕症患者重度吸烟男性患者精子质量检查少弱畸形精子症男性生育能力精子浓度生活方式观察指标

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音乐的极境——萨义德音乐随笔

音乐传播 2014年第3期 126-126页

作者：萨义德[美] 彭淮栋

文集《音乐的极境》不但以新颖的角度赏析了一些经典音乐作品,还以广博的知识品题了不少为人冷落的当代作曲家作品。萨义德还批评纽约大都会过于保守,也惋惜帕瓦罗蒂虽有超级巨星之名,但＂将歌剧演出的智慧贬到最低,把要价过高的噪音推... 详细信息

文集《音乐的极境》不但以新颖的角度赏析了一些经典音乐作品,还以广博的知识品题了不少为人冷落的当代作曲家作品。萨义德还批评纽约大都会过于保守,也惋惜帕瓦罗蒂虽有超级巨星之名,但＂将歌剧演出的智慧贬到最低,把要价过高的噪音推到最大＂。另外,他也思考以色列禁演瓦格纳作品的问题、音乐节越来越显得浮滥的令人担忧的趋势,以及以马尔孔生平为主题的歌剧、音乐与女性主义的关系、钢琴家古尔德的特殊之处等。他以内行人的造诣、权威的身份,书写精辟犀利的评论文字。他在音乐里看出文学与历史理念的反映,并密切观察其构成和创造的潜力。

关键词：音乐随笔萨义德音乐作品歌剧演出帕瓦罗蒂女性主义历史理念作曲家

Association of gene variants with susceptibility to type 2 diabetes among Omanis

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World Journal of Diabetes 2015年第2期6卷 358-366页

作者： Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee said Al-Yahyaee Mohammed Hassan Deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed Rizvi Yengo Loic Philippe Froguel Riad Bayoumi Department of Biochemistry College of Medicine and Health SciencesSultan Qaboos University Genomics and Metabolic Disease Institute Pasteur of Lille Lille2 University

AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among ***:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,*** control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical *** difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this *** all volunteers questioned had a relativewith diabetes *** of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%*** was collected from June 2010 to February ***:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),P<0.001],[TCF7L2(rs7903146),P<0.001],[CDKAL1(rs10946398),P<0.05],[CDKN2A/B(rs10811661),P<0.05]}.The highest genotype variation%between diabetics and controls was found at KCNJ11(2.07%)and TCF7L2(1.62%).This study was not able to detect an as

关键词： Type 2 diabetes Genetics Oman Casecontrol Association Gene Variants