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Ingrowing Nail Correction by Advancing Composite Flap of the Nailbed and Periosteum—A Simple and Effective Technique

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Modern Plastic Surgery 2014年第2期4卷 26-31页

作者： Adil Mohammed Hashish Medhat Emil Habib said al-busaidi Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Sultanate of Oman

Ingrowing toenails are common particularly in young adults. They usually result in a prolonged period of discomfort or pain that is sufficient to interfere with working and social activities. Apart from the toes, ingrowing nails can affect the fingers as well. Surgery is still the mainstay of treatment. A number of techniques have been described in the literature. But in all there is a high recurrence rate and sometimes the cosmetic result is not acceptable. In this article we describe our technique of surgical management of ingrowing nails of the toes and fingers. The technique involves excision of a part of the lateral nail fold and raising a composite flap consisting of the nail bed and the underlying periosteum which is then advanced. 105 cases were operated using this technique with very good postoperative results.

关键词： Ingrowing Toenail Fingernail Composite Flap Nailbed

The Combination of Parkland Formula, Using Normal Saline, with Muir &Barclay Formula for Fluid Resuscitation in the Initial Burn Shock Period

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Modern Plastic Surgery 2013年第4期3卷 142-149页

作者： Medhat Emil Habib said al-busaidi Gihan Adly Latif ali Saleem Mehdi C. Thomas Departments of Plastic Surgery and Laboratory Khoula Hospital Muscat Sultanate of Oman

Objectives: Evaluation of the effects of withholding plasma during the initial part of the burn shock period (the shock period in the study is estimated as the first 36 hours following the burns) when it will be lost into the interstitial tissues through the permeable capillaries. During that time crystalloids are administered. Another objective is to evaluate the effect of administering normal saline as the crystalloid resuscitation fluid during the initial part of the shock period. Design: A Retrospective 4 years study compares the use of normal saline as the resuscitative intravenous fluid during the first 12 hours post burns followed by intravenous 5% Purified Plasma Protein Fraction (PPPF) during the rest of the shock period i.e. the remaining 24 hours, with the use of the PPPF throughout the burns shock period according to Muir and Barclay formula. Setting: The Plastic Surgery Department and the Department of Laboratory, Directorate General of Khoula Tertiary Hospital, Muscat, Sultanate of Oman. Patients and Methods: The study included 2 groups of patients;Group A: Patients who received 5% Plasma (Human PPPF) throughout the shock period and Group B: Patients who received crystalloids in the form of normal saline during the first 12 hours post burn followed by plasma for the next 24 hours. Monitoring of the patients in both groups was done by using clinical signs of pulse, blood pressure, temperature and urine output and by using laboratory investigations in the form of the haematocrit value, sodium, potassium, chloride, total proteins and albumin levels in the blood at the time of admission and at the end of the shock period. Results: 140 patients were included in the study;64 in Group A and 76 in Group B. There was no mortality and the vital signs were maintained during the shock period in both groups. The mean values of urine output were nearer to the normal level in Group B compared to Group A. The same was observed regarding the Haematocrit value. In both

关键词： Normal Saline Intravenous Resuscitation Shock Period Burn

12 Years Analysis of Bacterial Isolates and Their Antibiotics Sensitivity in a Tertiary Care Burns Unit

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Modern Plastic Surgery 2016年第3期6卷 11-19页

作者： said Saud al-busaidi Zainab said al-Hashimy Adel Mohamed Hashish Sheikh Mohammad Ashik Iqbal Faruquee Hassan Ahmed Hamouda Ahmed Osama Abdulhamed Fawzi Mohamed Abdul-aleem Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Sultanate of Oman Directorate of Pharmacy and Medical Stores Khoula Hospital Muscat Sultanate of Oman

The aim of this study was to review the changes in distribution of bacterial populations and their antibiotic sensitivity over 12 years in a tertiary care burn unit. Understanding the periodic variation of isolated microorganisms and their antibiotic sensitivity helps in selecting the appropriate antimicrobial therapy before culture and sensitivity are reported. It also aids the design of antibiotics protocols. The study was retrospective. The data were obtained from the computerised hospital medical record system and the burn unit records. Overall, Pseudomonas aeruginosa was the most commonly isolated microorganism followed by Staphylococcus aureus, Meticillin-resistant Staphylococcus aureus (MRSA), and the genus Acinetobacter. Acinetobacter isolation rose rapidly and became more prevalent than P. aeruginosa over the last three years. Other organisms became isolated more frequently, such as Klebsiella pneumoniae, but their overall prevalence was low. Pseudomonas species frequency of isolation declined. P. aeruginosa, MRSA, and other microorganisms showed increasing sensitivity to a number of antibiotics. MRSA remained highly sensitive to vancomycin, and Acinetobacter showed high resistance to all antibiotics tested except colistin. K. pneumoniae was highly resistant to most of the antibiotics tested except the carbapenems, but the resistance to carbapenems increased over time.

关键词： Burn Microorganism Antibiotic Resistance Sensitivity

Delayed Grafting as a Valid Technique in Burn Management: Experience from a Burn Unit in Oman

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Modern Plastic Surgery 2024年第1期14卷 9-14页

作者： Taif alsafy Joe Jacob Anish Thadathil Elias Ahmed Salah El Din Salim Mohammed Ghawas Majid Tariq Saud albusaidi Ahmed al Jabri al Anood al Hadhrami Mutazz Obeid al Khaldi Moath Abdelhamid Shummo Karim Mohamed Haridi Aml Eid Saleh said al-busaidi Department of Plastic and Reconstructive Surgery Sultan Qaboos Hospital Salalah Oman ENT Department Al Nahdha Hospital Muscat Oman Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Oman

Background: Early excision and grafting has been the preferred method of managing major burns around the world since 1970. Considering the advances in health care and the development of new antibiotics over the past 50 years, delayed grafting as a technique for the management of burns over 15%-20% of total body surface area (TBSA) could have comparable results to that of early excision. This study aims to highlight the outcomes of practicing delayed grafting in burn patients. Methods: A case series analysis was performed of 51 patients who were admitted to the burns unit in Sultan Qaboos Hospital Salalah with over 20% TBSA between January 2014 and December 2019. The patients received prophylactic antibiotics and silver sulphadiazine dressing until the burn eschar had completely separated, followed by grafting. Results: Two patients were lost during the entire duration of the study. The mortality rate was comparable to that of early excision, while the rate of hypertrophic scarring was lower than the range reported by other studies. Conclusion: In the management of patients with over 20% TBSA, delayed grafting after complete separation of eschar is still a valid technique.

关键词： Burns Burn Units Burn Management Delayed Grafting Major Burns Treatment Efficacy

Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction

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Neural Regeneration Research 2025年第9期20卷 2464-2479页

作者： said Hashemolhosseini Lea Gessler Institute of Biochemistry Medical FacultyFriedrich-Alexander-University of Erlangen-NürnbergErlangenGermany

Skeletal muscles are essential for locomotion,posture,and metabolic *** understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways that underlie skeletal muscle *** process of muscle contra ction,orchestrated by a complex interplay of molecular events,is at the core of skeletal muscle *** contraction is initiated by an action potential and neuromuscular transmission requiring a neuromuscular *** muscle fibers,calcium ions play a critical role in mediating the interaction between actin and myosin filaments that generate *** of calcium release from the sarcoplasmic reticulum plays a key role in excitation-contraction *** development and growth of skeletal muscle are regulated by a network of molecular pathways collectively known as *** regulators coordinate the diffe rentiation of myoblasts into mature muscle *** pathways regulate muscle protein synthesis and hypertrophy in response to mechanical stimuli and nutrient *** ral muscle-related diseases,including congenital myasthenic disorders,sarcopenia,muscular dystrophies,and metabolic myopathies,are underpinned by dys regulated molecular pathways in skeletal *** interventions aimed at preserving muscle mass and function,enhancing regeneration,and improving metabolic health hold promise by targeting specific molecular *** molecular signaling pathways in skeletal muscle include the canonical Wnt signaling pathway,a critical regulator of myogenesis,muscle regeneration,and metabolic function,and the Hippo signaling *** recent years,more details have been uncovered about the role of these two pathways during myogenesis and in developing and adult skeletal muscle fibers,and at the neuromuscular *** fact,research in the last few years now suggests that these two signaling pathways are interconnected and

关键词： canonical Wnt"Wingless-related integration site"pathway beta-catenin(CTNNB1) Hippo pathway myogenesis myotube neuromuscular junction satellite cell skeletal muscle fiber transcriptional co-activator with PDZ-binding motif(TAZ) T-cell-specific transcription factor/lymphoid enhancer-binding factor(TCF/LEF) TEA domain family member(TEAD) transducin-like enhancer of split(TLE) yes-associated protein 1(YAP1)

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Soil substrate as a cascade of capillary barriers for conserving water in a desert environment:lessons learned from arid nature

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Journal of Arid Land 2014年第6期6卷 690-703页

作者： ali al-MAKTOUMI said al-ISMAILY Anvar KACIMOV Hamed al-busaidi said al-SAQRI Mansour al-HADABI Department of Soils Water and Agricultural EngineeringSultan Qaboos UniversityPO Box 34 Al Khoud 123MuscatSultanate of Oman EcOman Centre Petroleum Development Oman LLC PO Box 81MuscatSultanate of Oman

Interaction between soil pedogenesis, subsurface water dynamics, climate, vegetation and human ingenuity in a desert environment has been found to result in a unique ecohydrological system with an essentially three dimensional sedimentation structure in the bed of a recharge dam in Oman. A 3-D array of silt blocks sand- wiched by dry sand-filled horizontal and vertical fractures was studied in pot experiments as a model of a natural prototype. Pots are filled with a homogenous sand-silt mixture （control） or artificially structured （smart design, SD） soil substrates. Rhodes grass and ivy （Ipomea, Convolvulaceae） were grown in the pots during the hottest season in Oman. Soil moisture content （SMC） was measured at different depths over a period of 20 days without irrigation. SD preserved the SMC of the root zone for both ivy and grass （SMC of around 25%-30% compared to 〈10% for control, 3 days after the last irrigation）. Even after 20 days, SMC was around 18% in the SD and 7% in the control. This, similar to the case of a natural prototype, is attributed to the higher upward capillary movement of water in control pots and intensive evaporation. The capillary barrier of sand sheaths causes discontinuity in moisture mi- gration from the micro-pores in the silt blocks to sand pores. The blocks serve as capillarity-locked water buffers, which are depleted at a slow rate by transpiration rather than evaporation from the soil surface. This creates a unique ecosystem with a dramatic difference in vegetation between SD-pots and control pots. Consequently, the Noy-Meir edaphic factor, conceptualizing the ecological impact of 1-D vertical heterogeneity of desert soils, should be generalized to incorporate 3-D soil heterogeneity patterns. This agro-engineering control of the soil substrate and soil moisture distribution and dynamics （SMDaD） can be widely used by desert farmers as a cheap technique, with significant savings of irrigation water.

关键词： soil capillary barrier infiltration soil heterogeneity ecohydrology hydropedology plant root soil moisture content

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md al Raihan C.Adam Dyker Department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr2TialC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir al-HITI Hiba HASSAN Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of MAX phase material, chromium titanium aluminum carbide（Cr2TialC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers