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Anti-inflammatory and antipyretic properties of Kang 601 heji,a traditional Chinese oral liquid dosage form

Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 921-927页

作者： Raphael Nammahime Alolga Sarah Wambui Amadi Vitus Onoja Assogba Gabin Assanhou Moses Muyaba said abasse kassim State Key Laboratory of Natural Medicines China Pharmaceutical University Department of Pharmacology China Pharmaceutical University Joint Key Laboratory for Drug Development Department of PharmaceuticsChina Pharmaceutical University Department of Medicinal Chemistry China Pharmaceutical University

Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-in flammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The antiin flammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1b and tumour necrosis factora levels using appropriate reagents and ELISA kits.Results: The results revealed that K-601 reduced the level of in flammations in both antiin flammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1b, tumour necrosis factora and nitric oxide.Conclusions: K-601 has proven anti-in flammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-in flammatory and antipyretic agent in traditional Chinese medicinal practice.

关键词： Kang 601 heji Anti-in flammatory Antipyretic Model

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Spontaneous Pneumothorax Complicating Miliary Tuberculosis: About a Case at the “Centre Medical Principal De La Gendarmerie Nationale Du Mali”

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Journal of Tuberculosis Research 2023年第2期11卷 67-73页

作者： Souleymane Coulibaly Marius Pembé Sanou kassim Sidibe Ladji Mohamed Diaby Lassina Diallo Daouda Amara Traore Salif Kone Ami Diarra Salif Sow abasse Sanogo Salif Satao Mamadou Cherif Kante Mahamadou Coulibaly Aminata Bagayoko Soumaila Keita Polyclinique des Armées Kati Mali Centre Médical Principal de la Gendarmerie Nationale Bamako Mali Centre Médico-Chirurgical des Armées Bamako Mali Service de Pneumologie CHU Point G Bamako Mali

Introduction: Spontaneous pneumothorax is a rare but serious complication of tuberculosis. Miliary tuberculosis (MT) is a severe form of tuberculosis secondary to hematogenous spread of Mycobacterium tuberculosis. Objective: To report a case of MT complicated by pneumothorax. Methodology: This was a 25-year-old patient, farmer, followed up at the Pneumo-phtisiology department of the CHU du Point G for MT whose condition was improving after the introduction of anti-tuberculosis chemotherapy. He consulted again after experiencing chest pain. Clinical and imaging revealed a Spontaneous pneumothorax complicating MT. The treatment combined anti-tuberculosis chemotherapy, chest drainage and respiratory physiotherapy. Outcome was favorable with improvement of clinical and radiological signs. Conclusion: Pneumothorax complicating MT requires a reflective diagnostic approach and rapid management to improve its prognosis.

关键词： Spontaneous Pneumothorax Miliary Tuberculosis Antituberculous Chemotherapy Pleural Drainage Respiratory Physiotherapy

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