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MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： Qi-Ying Wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-Bo Cao Zhi-Yan Sun sai-jun mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths *** increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality ***,there is currently no specific and effective marker to predict and treat metastasis in ***(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in *** are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of ***,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic *** review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

Sampled Value Attack Detection for Busbar Differential Protection Based on a Negative Selection Immune System

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Journal of modern Power Systems and Clean Energy 2023年第2期11卷 421-433页

作者： jun mo Hui Yang Guangxi Key Laboratory of Power System Optimization and Energy Technology Guangxi UniversityNanning 530004China

Considering a variety of sampled value(SV)attacks on busbar differential protection(BDP)which poses challenges to conventional learning algorithms,an algorithm to detect SV attacks based on the immune system of negative selection is developed in this *** healthy SV data of BDP are defined as self-data composed of spheres of the same size,whereas the SV attack data,i.e.,the nonself data,are preserved in the nonself space covered by spherical detectors of different *** avoid the confusion between busbar faults and SV attacks,a self-shape optimization algorithm is introduced,and the improved self-data are verified through a power-frequency fault-component-based differential protection criterion to avoid false *** on the difficulty of boundary coverage in traditional negative selection algorithms,a self-data-driven detector generation algorithm is proposed to enhance the detector coverage.A testbed of differential protection for a 110 kV double busbar system is then *** SV attacks of BDP such as amplitude and current phase tampering,fault replays,and the disconnection of the secondary circuits of current transformers are considered,and the delays of differential relay operation caused by detection algorithms are investigated.

关键词： Cyberattack busbar differential protection(BDP) negative selection self-data-driven detector sampled value attacks internal faults

Mechanical behavior of segment rebar of shield tunnel in construction stage

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 888-899页

作者： jun-sheng CHEN Hai-hong mo Department of Civil Engineering South China University of Technology Guang＇zhou 510640 China State Key Laboratory of Subtropical Building Science South China University of Technology Guang＇zhou 510640 China

In this paper, a 3D finite element （FE） program ADINA was applied to analyzing a tunnel with 9 segment tings. The loads acting on these segment tings included the squeezing action of tail brush of shield machine under attitude deflection, the jacking forces, the grouting pressure and the soil pressure. The analyses focused on the rebar stress in two statuses：（1） normal construction status without shield machine squeezing; （2） squeezing action induced by shield machine under attitude deflection. The analyses indicated that the rebar stress was evidently affected by the construction loads. In different construction status, the rebar stress ranges from -80 MPa to 50 MPa, and the rebar is in elastic status. Even some cracks appear on segments, the stress of segment rebar is still at a low level. It is helpful to incorporate a certain quantity of steel fiber to improve the anti-crack and shock resistance performance.

关键词： Shield tunnel Construction Segment Rebar Finite element (FE) analysis

Achieving tunable long persistent luminescence in metal organic halides based on pyridine solvent

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Chinese Chemical Letters 2024年第9期35卷 227-231页

作者： jun-Ting mo Zheng Wang College of Chemistry and Chemical Engineering Key Laboratory of Chemical Additives for China National Light IndustryShaanxi University of Science and TechnologyXi’an 710021China moE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China

The research of long persistent luminescence(LPL)materials has yield brilliant results in many ***,the efforts are still needed for the regulation of the LPL *** this work,a series of LPL metal organic halides with rich halogen-bond interactions,Py-CdX_(2)(X=Cl,Br,I)were synthesized through self-assembly by Cd X_(2)and pyridine *** steady-state emission redshifted and phosphorescence lifetime declined as the halogen atoms are *** halides exhibit adjustable emission from blue to green and multiple phosphorescence from green to yellow at room temperature by changing the excitation ***,Py-CdX_(2)can emit the visible color-tunable LPL from green to yellow after removing different excitation sources at ambient *** the results of theoretical calculation and experimental analysis,it is found that heavy atom effect and the rich intermolecular halogen bond help realize LPL and multiple triplet states originated from the pyridine ring and the halogens.

关键词： Metal organic halide Heavy atom effect Halogen bond Tunable long persistent luminescence Anti-counterfeiting

Estimation Based Adaptive Constraint Control for a Class of Coupled String Systems

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IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1536-1539页

作者： sai Zhang Li Tang Yan-jun Liu College of Science Liaoning University of TechnologyJinzhou 121001China

Dear editor,In this letter,the boundary tension constraint-based adaptive boundary control problem is investigated for a class of flexible string systems with unknown boundary disturbances and unknown parameters,with ... 详细信息

关键词： boundary letter constraint

An unprecedented dumbbell-shaped pentadeca-nuclear W-Er heterometal cluster stabilizing nanoscale hexameric arsenotungstate aggregate and electrochemical sensing properties of its conductive hybrid film-modified electrode

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Nano Research 2022年第4期15卷 3628-3637页

作者： Dan Wang jun Jiang Meng-Ya Cao sai-sai Xie Ya-Min Li Li-Juan Chen jun-Wei Zhao Guo-Yu Yang Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China moE Key Laboratory of Cluster Science School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Cluster-based functional materials have made remarkable progress owing to their wonderful structures and distinctive physicochemical performances,one of on-going advancements of which is basically driven by synthetic chemistry of exploring and constructing novel nanosized gigantic polyoxometalate(POM)*** this article,an unprecedented nanoscale hexameric arsenotungstate aggregate Na_(9)K_(16)H_(4)[Er_(0.5)K_(0.5)(H_(2)O)_(7)][Er_(5)W10O_(2)6(H_(2)O)_(14)][B-α-AsW_(9)O_(33)]_(6)·102H_(2)O(1)has been synthesized by the combined synthetic strategy of simultaneously using the arsenotungstate precursor and simple tungstate material in a highly acidic aqueous ***{[Er_(5)W_(10)O_(26)(H_(2)O)_(14)][B-α-AsW_(9)O_(33)]6}31-polyanion in 1 consists of an intriguing dumbbell-shaped pentadeca-nuclear W-Er heterometal{Er_(5)W10O_(2)6(H_(2)O)_(14)}^(23+)cluster connecting six trilacunary[B-α-AsW_(9)O_(33)]^(9-)moieties,which has never been seen ***,through electropolymerization of 1 and pyrrole on the conductive substrate,a thickness-controllable and robust 1-PPY(PPY=polypyrrole)hybrid film was successfully prepared,which represents the first POM-PPY film assembled from high-nuclear lanthanide(Ln)encapsulated POM and PPY *** 1-PPY film-based electrochemical biosensor exhibits a favorable recognition performance for ochratoxin A in multiple *** work not only provides a feasible combined synthetic strategy of the POM precursor and simple tungstate material for constructing complicated multi-Ln-inserted POM aggregates,but also offers a promising electrochemical platform constructed from POM-based conductive films for identifying trace biomolecules in complex environments.

关键词： polyoxometalate lanthanide-inserted arsenotungstate polyoxometalate-based conductive film

A Task Scheduling Algorithm Based on Clustering Pre-processing in Space-Based Information Network

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Chinese Journal of Electronics 2024年第1期33卷 217-230页

作者： Yufei WANG jun LIU Shengnan ZHANG sai XU Jingyi WANG School of Computer Science and Engineering Northeastern University

With the diversification of space-based information network task requirements and the dramatic increase in demand, the efficient scheduling of various tasks in space-based information network becomes a new challenge. To address the problems of a limited number of resources and resource heterogeneity in the space-based information network, we propose a bilateral pre-processing model for tasks and resources in the scheduling pre-processing stage. We use an improved fuzzy clustering method to cluster tasks and resources and design coding rules and matching methods to match similar categories to improve the clustering effect. We propose a space-based information network task scheduling strategy based on an ant colony simulated annealing algorithm for the problems of high latency of space-based information network communication and high resource dynamics. The strategy can efficiently complete the task and resource matching and improve the task scheduling performance. The experimental results show that our proposed task scheduling strategy has less task execution time and higher resource utilization than other algorithms under the same experimental conditions. It has significantly improved scheduling performance.

关键词： Scheduling algorithms Heuristic algorithms Clustering methods Clustering algorithms Simulated annealing Dynamic scheduling Search problems

Study on effect of segments erection tolerance and wedge-shaped segment on segment ring in shield tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1864-1869页

作者： CHEN jun-sheng mo Hai-hong Department of Civil Engineering South China University of Technology Guangzhou 510640 China

Deformation and dislocations of segments of shield tunnel in construction stage have apparent effect on tunnel structure stress and even cause local cracks and breakage in tunnel. 3D finite element method was used to analyze two segment ring models under uniform injected pressure: (1) segment ring without wedge-shaped segment, which has 16 types of preinstall erection tolerance; (2) segment ring with wedge-shaped segment, which has no preinstall erection tolerance. The analysis results indicate that different erection tolerances can cause irregular deformation in segment ring under uniform injected pressure, and that the tolerance values are enlarged further. Wedge-shaped segment apparently affects the overall deformation of segment ring without erection tolerances. The uniform injected pressure can cause deformation of ring with wedge-shaped segment irregular, and dislocations also appear in this situation. The stress of segment with erection tolerances is much larger than that of segment without erection tolerances. Enlarging the central angle of wedge-shaped segment can make the irregular deformation and dis- locations of segments smaller. The analysis results also provide basis for erection tolerance control and improvement of segment constitution.

关键词： Shield tunnel Segment Erection tolerance 3D finite element analysis

THS-GWNN:a deep learning framework for temporal network link prediction

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Frontiers of Computer Science 2022年第2期16卷 174-176页

作者： Xian mo jun PANG Zhiming LIU College of Computer&Information Science Southwest UniversityChongqing 400715China Faculty of Science Technology and Medicine&Interdisciplinary Centre for SecurityReliability and TrustUniversity of LuxembourgEsch-sur-Alzette L-4364Luxembourg

1 Introduction and main contributions Link prediction for temporal networks aims to evaluate the likelihood of the future linkage among nodes,which has significant applications in social networks,biological networks and traffic analysis[1],*** embedding[2]is an important analytical tool for temporal network link prediction,which helps us better understand network evolution[3].How to encode high-dimensional and non-Euclidean network information is a crucial problem for node embedding in temporal *** of the challenges is to reveal the spatial structure at each timestamp and the temporal property over time[4].Some existing work[5]shows that extracting the spatial relation of each node can be used as a valid feature representation for each ***,the emergence of deep learning techniques[4,5]brings new insights for learning temporal properties,but most models using deep learning still fail to achieve satisfying prediction accuracy.

关键词： network prediction networks