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Observations and Modeling of Ice Water Content in a Mixed-Phase Cloud System

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Atmospheric and Oceanic Science Letters 2013年第4期6卷 210-215页

作者： hou Tuan-Jie LEI heng-Chi HU Zhao-Xia FENG Qiu-Juan Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of Sciences Weather Modification Office of Shanxi Province

The ice water content(IWC) distribution in a mixed-phase cloud system was investigated using Cloud-Sat data,aircraft measurements,and the Weather Research and Forecasting(WRF) *** precipitation and IWC were in general agreement with rain gauge,sat-ellite,and aircraft *** cloud case was char-acterized by a predominant cold layer and high IWC throughout the cloud-development and precipitation *** CloudSat-retrieved products suggested that the IWC was distributed from 4.0 to 8.0 km,with the maximum values(up to 0.5 g m-3) at 5.0-6.0 km at the earlymature stage of cloud *** IWC(up to 0.8 g m-3) was also detected by airborne probes at 4.2 and 3.6 km at the late-mature *** WRF model simulation re-vealed that the predominant riming facilitated rapid ac-cumulation of high IWC at 3.0-6.0 km.

关键词： aircraft observation ice water content WRF

Flapwise Bending Vibration Analysis of Rotating Tapered Rayleigh Beams for the Application of Offshore Wind Turbine Blades

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China Ocean Engineering 2021年第4期35卷 544-553页

作者： CHEN Yan-fei ZANG Zhi-peng DONG Shao-hua AO Chuan LIU Hao MA Shang hou Fu-heng FENG Wei School of Mechanical and Transportation Engineering China University of PetroleumBeijing 102249China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China CIMC Offshore Co.Ltd Shenzhen 518000China

The flapwise bending vibrational equations of tapered Rayleigh beam are derived based on Hamilton’s *** corresponding vibrational characteristics of rotating tapered Rayleigh beams are investigated via variational iteration method(VIM).Natural frequencies and corresponding mode shapes are examined under various rotation speed,taper ratio and slenderness ratio focusing on two types of tapered *** convergence of VIM is examined as part of the *** of VIM solution is made by referring to results available in other literature and corresponding results show that VIM is capable of yielding precise results in a very efficient way.

关键词： tapered Rayleigh beam flapwise bending vibration variational iteration natural frequencies convergence

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基于反向最近邻的密度估计聚类算法

计算机工程与应用 2025年第1期61卷 165-173页

作者：许梅梅侯新民中国科学技术大学大数据学院合肥230026 中国科学技术大学数学科学学院合肥230026 中国科学技术大学中国科学院吴文俊数学重点实验室合肥230026 合肥国家实验室合肥230088

基于相互最近邻的密度峰聚类算法(DenMune)通过相互最近邻计算数据点的局部密度,是一种有效的聚类手段。但该算法存在构建聚类骨架不合理的问题,在分配弱点时采用硬投票策略,易产生错误。因此提出一种新的基于反向最近邻的密度估计聚类... 详细信息

基于相互最近邻的密度峰聚类算法(DenMune)通过相互最近邻计算数据点的局部密度,是一种有效的聚类手段。但该算法存在构建聚类骨架不合理的问题,在分配弱点时采用硬投票策略,易产生错误。因此提出一种新的基于反向最近邻的密度估计聚类算法(RNN-DEC)。该算法引入反向最近邻来计算数据点的局部密度,将数据点分成强点、弱点和噪声点。使用强点构建聚类算法的骨架,通过软投票的方式将弱点分配到与其相似度最高的簇中去。提出了一种基于反向最近邻的簇融合算法,将相似度高的子簇融合,得到最终的聚类结果。实验结果表明,在一些合成数据集和UCI真实数据集上,相比较于其他经典算法,该算法具有更好的聚类效果。

关键词：反向最近邻局部密度密度聚类算法子簇融合

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Spatiotemporal transformable nano-assembly for on-demand drug delivery to enhance anti-tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 103-118页

作者： Chenglin Liang Ge Zhang Linlin Guo Xinyi Ding heng Yang Hongling Zhang Zhenzhong Zhang Lin hou School of Pharmaceutical Sciences Key Laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou UniversityZhengzhou 450001China

Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells ***,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific *** detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive *** arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide *** can degrade the extracellularmatrix,leading to the enhanced penetration of *** targets tumor cells,releases DOX to induce senescence,and recruits effector immune ***,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor *** vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice *** work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.

关键词： Cells senescence Tumor stroma Structure transformable Programmed delivery Anti-tumor immunotherapy

FcRn inhibitors:a novel option for the treatment of myasthenia gravis

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Neural Regeneration Research 2023年第8期18卷 1637-1644页

作者： Li-Na Zhu Hai-Man hou sai Wang Shuang Zhang Ge-Ge Wang Zi-Yan Guo Jun Wu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

Myasthenia gravis is an acquired,humoral immunity-mediated autoimmune disease characterized by the production of autoantibodies that impair synaptic transmission at the neuromuscular *** intervention-mediated clearance of immunoglobulin G(IgG)was shown to be effective in controlling the progression of the *** neonatal Fc receptor(FcRn)plays a key role in prolonging the serum half-life of *** FcRn to prevent its binding to IgG can accelerate the catabolism of the latter,resulting in decreased levels of IgG,including pathogenic autoantibodies,thereby achieving a therapeutic *** this review,we detail the substantial research progress,both basic and clinical,relating to the use of FcRn inhibitors in the treatment of myasthenia gravis.

关键词： batoclimab clinical trial efgartigimod FcRn FcRn inhibitors immunoglobulin G(IgG) myasthenia gravis nipocalimab rozanolixizumab

Conformational effect on fluorescence emission of tetraphenylethylene-based metallacycles

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Chinese Chemical Letters 2021年第5期32卷 1691-1695页

作者： Zhewen Guo Jun Zhao Yuhang Liu Guangfeng Li heng Wang Yali hou Mingming Zhang Xiaopeng Li Xuzhou Yan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 578055China State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an 710049China

Herein,we designed and constructed two metallacycles,1 and 2,to illustrate the conformational effect of isomeric AIE fluoropho res on the platfo rm of supramolecular coordination complexe s(SCCs).Specifically,the dangling phenyl rings in TPE units of the metallacycle 1 align completely outside the main cyclic structure,while in the metallacycle 2,these phenyl rings align half inside and half *** experimental results showed that two metallacycles exhibited different behaviors in terms of AIE fluorescence and chemical sensing,which could be attributed to the subtle structural difference of the TPE *** work repre sents the unification of topics such as self-assembly,AIE,and chemical sensing,and further promotes the understanding for the structure-property relationship of isomeric AIE fluorophores.

关键词： Conformational effect Structure-property relationship Aggregation-induced emission Coordination-driven self-assembly Metallacycles

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知识密集型制造业专利创新运营绩效研究

系统工程理论与实践 2017年第7期37卷 1709-1719页

作者：侯建陈恒哈尔滨工程大学经济管理学院哈尔滨150001

利用SFA模型进行分解修正样本投入的偏移量,在此基础上引入Malmquist指数改进,结合Tobit技术,综合考虑环境因素、随机误差与动态变化,将时空异质性和影响因素引入专利创新的运营绩效模型进行动态分析,从方法和内容上深入探究知识密集型... 详细信息

利用SFA模型进行分解修正样本投入的偏移量,在此基础上引入Malmquist指数改进,结合Tobit技术,综合考虑环境因素、随机误差与动态变化,将时空异质性和影响因素引入专利创新的运营绩效模型进行动态分析,从方法和内容上深入探究知识密集型制造业专利创新运营绩效异质性和影响机制.结果表明,考虑处理环境效应和随机误差的专利创新运营绩效出现显著变化,环境因素对专利创新运营绩效影响存在时空异质性;调整后2007-2013年专利创新运营绩效呈现双重升降的波动趋势,各时期差异明显;调整后各地区专利创新运营绩效增长幅度较大,其中技术水平指数均发生不同程度改善,是调整后专利创新运营绩效提升的主要动力;政府支持对知识密集型制造业专利创新运营绩效具有显著的正向影响,而知识产权保护产生显著抑制效应,市场竞争、企业规模和技术消化吸收能力对专利创新运营绩效的推动作用不明显.

关键词：知识密集型制造业专利创新运营绩效时空异质性影响因素环境效应随机误差

A porous hydrogel scaffold mimicking the extracellular matrix with swim bladder derived collagen for renal tissue regeneration

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Chinese Chemical Letters 2021年第12期32卷 3940-3947页

作者： heng Wu Rui Zhang Bianxiang Hu Yutong He Yuehang Zhang Liu Cai Leyu Wang Guobao Wang Honghao hou Xiaozhong Qiu State Key Lab for Organ Failure Research National Clinical Research Center of Kidney DiseaseDivision of NephrologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Biomaterials Research Center School of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China

As a worldwide public health issue, chronic kidney disease still lacks of effective therapeutic approaches due to the challenges in conventional organ transplantation and dialysis. Renal tissue engineering offers an advantageous therapeutic or regenerative option over typical donor organ. However, despite the great progress of decellularized extracellular matrix based scaffold for the renal regeneration, several safety concerns and complex composition still remain to be addressed. Herein, the extracellular matrix-mimicking hydrogel scaffolds were developed through covalent and physical cross-linking between swim bladder-derived natural collagen(COL) and anti-fibrosis chondroitin sulfate(CS) *** biomimetic hydrogels showed proper mechanical property, excellent thermal stability and high biocompatibility both in vitro and in vivo, by altering the mass ratio of COL and CS. When implanted in partially nephrectomized rat model, the 1 COL/2CS scaffold enable it recruit more native kidney cells, reduce the tubular damage, and even induce the regeneration of renal tubular-like tissue and restore renal metabolic function more effectively comparing with the pure 2COL and 2CS scaffold. These results suggest that the biomimetic scaffold is a promising functional platform for treating renal diseases.

关键词： Swim bladder CollagenⅠ Chondroitin sulfate Extracellular matrix-mimicking hydrogel Renal tissue regeneration

四波混频Autler-Townes分裂中的探测光影响

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原子与分子物理学报 2025年第3期42卷 110-115页

作者：裴丽娅侯海龙北京化工大学数理学院北京100029

在双Λ-型四波混频系统中,研究了探测光强度对Autler-Townes(AT)分裂效应的影响.随着弱探测光强度增大,由缀饰态共振产生的AT分裂双峰间隔不变,但却逐渐增宽线宽且减弱直至消失;而在强耦合光失谐条件下,不对称地位于单光子共振峰两侧的A... 详细信息

在双Λ-型四波混频系统中,研究了探测光强度对Autler-Townes(AT)分裂效应的影响.随着弱探测光强度增大,由缀饰态共振产生的AT分裂双峰间隔不变,但却逐渐增宽线宽且减弱直至消失;而在强耦合光失谐条件下,不对称地位于单光子共振峰两侧的AT分裂双峰却会逐渐趋于对称分布.详细讨论了探测光场对原子的缀饰影响,提出通过探测光强度可以调控原子两基态之间的有效Raman相干,从而影响AT分裂双峰的特征.

关键词：四波混频原子相干 Autler-Townes分裂缀饰态横向弛豫率

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