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Making Giving Easier

ChinAfrica 2016年第5期8卷 20-21页

作者： hou Weili

LIANG Tao is nothing if not tenacious. The 64-year-old former chairman of the Audiology Devel- opment Foundation of China （ADFC）, which works for the hearing-impaired, still recalls how difficult it was to register the foundation more than two decades ago. It took him 26 trips from Xuzhou, his hometown in east China＇s Jiangsu Province, to Beijing, countless filing of applications and negotiations with government departments at all levels before he was finally granted approval.

关键词： Making Giving Easier

Value-Added Rural Vision

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ChinAfrica 2018年第5期10卷 14-17页

作者： hou Weili

Wen Tiejun, 67, sees himself as a typical middle class man. Five years ago, very much a wealthy urbanite, he made a decision which shocked those around him by selling the family＇s multi-million yuan property in downt...

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Rutaecarpine Inhibits Intimal Hyperplasia in A Balloon-Injured Rat Artery Model

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Chinese Journal of Integrative Medicine 2018年第6期24卷 429-435页

作者： XU Yang CHEN Xiu-ping ZHANG Feng hou Hua-hua ZHANG Jing-yi LIN Shu-xian SUN An-sheng Key Laboratory of Basic Pharmacology of Guizhou and Department of Pharmacology Zunyi Medical College Molecular Oncology Laboratory Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Institute of Chinese Medical Sciences University of Macao

Objective： To investigate the effect and potential mechanisms of rutaecarpine （Rut） in a rat artery balloon-injury model. Methods： The intimal hyperplasia model was established by rubbing the endothelia with a balloon catheter in the common carotid artery （CCA） of rats. Fifty rats were randomly divided into five groups, ie. sham, model, Rut （25, 50 and 75 mg/kg） with 10 rats of each group. The rats were treated with or without Rut （25, 50, 75 mg/kg） by intragastric administration for 14 consecutive days following injury. The morphological changes of the intima were evaluated by hematoxylin-eosin staining. The expressions of proliferating cell nuclear antigen （PCNA） and smooth muscle （SM） oL-actin in the ateries were assayed by immunohistochemical staining. The mRNA expressions of c-myc, extracellular signal-regulated kinase 2 （ERK2）, MAPK phosphatase-1 （MKP-1） and endothelial nitric oxide synthase （eNOS） were determined by real-time reverse chain reaction. The protein expressions of MKP-1 and phosphorylated ERK2 （p-ERK2） were examined by Western blotting. The plasma contents of nitric oxide （NO） and cyclic guanosine 3＇,5＇-monophosphate （cGMP） were also determined. Results： Compared with the model group, Rut treatment significantly decreased intimal thickening and ameliorated endothelial injury （P〈0.05 or P〈0.01）. The positive expression rate of PCNA was decreased, while the expression rate of SM α -actin obviously increased in the vascular wall after Rut （50 and 75 mg/kg） administration （P〈0.05 or P〈0.01）. Furthermore, the mRNA expressions of c-myc, ERK2 and PCNA were downregulated while the expressions of eNOS and MKP-1 were upregulated （P〈0.05 or P〈0.01）. The protein expressions of MKP-1 and the phosphorylation of ERK2 were upregulated and downragulated after Rut （50 and 75 mg/kg） administration （P〈0.05 or P〈0.01）, respectively. In addition, Rut dramatically reversed balloon injury-induced decrease of NO and cGMP in the plasma （P〈0.05 or P〈0.01）. Conclusion： Rut c

关键词： rutaecarpine balloon-injury intimal hyperplasia extracellular signal-regulated kinase 2 nitric oxide

ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4733-4747页

作者： Mingjin Wang Weida Wang Shen You Zhenyan hou Ming Ji Nina Xue Tingting Du Xiaoguang Chen Jing Jin Department of Pharmacology State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Glioblastoma(GBM)is a highly aggressive and lethal brain tumor with an immunosuppressive tumor microenvironment(TME).In this environment,myeloid cells,such as myeloid-derived suppressor cells(MDSCs),play a pivotal role in suppressing antitumor *** is closely related to the function of myeloid ***,our study reports that acetyl-CoA acetyltransferase 1(ACAT1),the key enzyme of fatty acid oxidation(FAO)and ketogenesis,is significantly downregulated in the MDSCs infiltrated in GBM *** investigate the effects of ACAT1 on myeloid cells,we generated mice with myeloid-specific(LyzM-cre)depletion of *** results show that these mice exhibited a remarkable accumulation of MDSCs and increased tumor progression both ectopically and *** mechanism behind this effect is elevated secretion of C-X-C motif ligand 1(CXCLI)of macrophages(Mo).Overall,our findings demonstrate that ACAT1 could serve as a promising drug target for GBM by regulating the function of MDSCs in the TME.

关键词： Glioblastoma Myeloid cells Myeloid-derived suppressor cells Acetyl-CoA acetyltransferase 1 CXCL1 Tumor microenvironment Lipid metabolism Macrophages

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The Wonders of Dance

China Today 2014年第2期63卷 60-61页

作者： hou RUIL

SEVERAL months ago,Chen Wei and former university classmate Hu Yulin got *** back on their lives together in university,Hu had a crush on her,but she had no feelings for him–*** into an impoverished rural family,Hu Yulin was quite small when he became entranced by the melodies of a flute vender,so he bought a flute for two *** recalls,"From then on,I taught myself,for there was no one to teach me."At the age of 17,Hu went to Beijing to be *** Chen e oking their t feelings mpoverished rural famquite small when he d f o e n on,or there was e."7,Hu went to ntored.

关键词：中国经济建设经济发展国民收入幸福指数

Xie Haizhou,an Expert on Internal Medicine

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China Today 1994年第4期43卷 60-61页

作者： $$$$hou RUILI

Ｓｎａｋｅ＆ＧｅｃｋｏＩｍｍｕｎｉｔｙＤｒｕｇＤＲＵＧＳＩＮｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ（Ｔｃｍ）ｍａｋｅｕｓｅｏｆｐｒｅｐａｒａｔｉｏｎｐｒｏｃｅｓｓｏｆａｎａｎｉｍａｌｂａｓｅｄｄｒｕｇｕ... 详细信息

Ｓｎａｋｅ＆ＧｅｃｋｏＩｍｍｕｎｉｔｙＤｒｕｇＤＲＵＧＳＩＮｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ（Ｔｃｍ）ｍａｋｅｕｓｅｏｆｐｒｅｐａｒａｔｉｏｎｐｒｏｃｅｓｓｏｆａｎａｎｉｍａｌｂａｓｅｄｄｒｕｇｕｓｕａｌｌｙｄｅｓｔｒｏｙｓａｇｒ...

关键词： Snake Immunity 月课

The Systematic Evaluation of Physicochemical and Biological Properties In Vitro and In Vivo for Natural Silk Fibroin Nanoparticles

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Advanced Fiber Materials 2022年第5期4卷 1141-1152页

作者： Xinyi Li Mengjie Ye Yong‑E.Gao Shengxin hou Peng Jia Peng Xue Yuejun Kang Zhigang Xu State Key Laboratory of Silkworm Genome Biology School of Materials and Energy and Chongqing Engineering Research Center for Micro‑Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715People’s Republic of China Chongqing Key Laboratory of Soft‑Matter Material Chemistry and Function Manufacturing Southwest UniversityChongqing 400715People’s Republic of China

Nanoparticle-based theranostics has served as a preferential technology for diagnosis and treatment of ***,there are still massive challenges in constructing the ideal platform,which hopefully integrate various characteristics such as easy preparation,multiple utilization,and high therapeutic effect and safety into a single ***,we reported a drug delivery system-based on natural silk fibroin(denoted as SF NPs),and systematically evaluated the physicochemi-cal properties,biological properties and the biosafety assessment of SF *** in vitro and in vivo experimental results confirmed that SF NPs showed high stability,low blood hemolysis and the universal delivery ability of ***,the SF NPs could rapidly enter into cells due to its nanoscale size,and had a weak cytotoxicity against MCF-7,4T1 and L929 ***,the SF NPs showed enhanced tumor permeability in a simulative model of multicellular spheroids,combined with excellent in vivo biosafety and the negligible organ injury,demonstrate that SF-based nanomedicine presents the utilization potentiality for drug delivery and may provide a new view for cancer treatment.

关键词： Silk fibroin Drug delivery Biocompatibility Cytotoxicity Nanotheranostics

Enhanced uplink non-orthogonal multiple access for 5G and beyond systems

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Frontiers of Information Technology & Electronic Engineering 2018年第3期19卷 340-356页

作者： Wen-jia LIU Xiao-lin hou Lan CHEN DOCOMO Beijing Communications Laboratories Co. Ltd.

Uplink non-orthogonM multiple access （NOMA） is a promising technique to meet the requirements of the fifth generation （5G） and beyond systems. Various NOMA schemes have been proposed in both academia and industry. However, most existing schemes assume equal average received power, which limits the performance. We propose three enhancements of uplink NOMA to achieve the requirements of massive connectivity and high reliability in 5G, where unequal average received power is exploited as part of the multiple access signature. First, the optimal sequences targeting to generalized Welch-bound equality （GWBE） are obtained for unequal average received power. Then user grouping with multi-level received powers is proposed for better successive interference cancellation （SIC） at the receiver. Finally, sequence grouping based on the cross-correlation properties of sequences is proposed to reduce inter-and intra-group interference. Simulation results show that by incorporating multi-level received powers and sequence grouping into existing NOMA schemes, for an NOMA system with 400% overloading and fixed signature allocation, 3 dB and 10 dB signal-to-noise ratio （SNR） gains at 0.1 block error rate （BLER） target can be achieved compared with existing NOMA schemes and orthogonal multiple access （OMA）, respectively. Besides, 0.01 BLER target can be achieved while an error floor exists in existing NOMA schemes. Under random sequence selection, collision probability is reduced by multi-level powers. In addition, GWBE sequences achieve lower BLER than existing sequences and the gain is large especially for low BLER requirements. This shows that the proposed scheme can support larger connectivity and higher reliability.

关键词： Uplink non-orthogonal multiple access Generalized Welch-bound equality Multi-level received powers Sequence grouping

基于多目标粒子群算法的船舶主尺度优化设计研究

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船舶力学 2011年第7期15卷 784-790页

作者：侯磊海军驻武汉四三八厂军事代表室武汉430060

粒子群优化是一种新兴的进化计算技术。文章基于多目标粒子群优化算法讨论了船舶主尺度论证中的多目标优化和决策问题。对于多目标优化问题,采用基于Pareto占优方法的多目标粒子群算法得到最优解,然后采用距离理想解最近的方法对这些Par... 详细信息

粒子群优化是一种新兴的进化计算技术。文章基于多目标粒子群优化算法讨论了船舶主尺度论证中的多目标优化和决策问题。对于多目标优化问题,采用基于Pareto占优方法的多目标粒子群算法得到最优解,然后采用距离理想解最近的方法对这些Pareto最优解给出排序。应用文中给出的两个阶段求解方法,对散装货船概念设计阶段主尺度确定的问题进行了分析。结果表明,综合多目标粒子群优化和决策技术,能够迅速、客观地选择合理的船舶主尺度,可以给设计人员提供更多的选择。这种综合方法也能够广泛用于船舶其他设计领域。

关键词：多目标粒子群算法进化算法决策船舶主尺度