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Postoperative Regulatory T-Cells and Natural Killer Cells in Stage I Nonsmall Cell Lung Cancer Underwent Video-assisted Thoracoscopic Lobectomy or Thoracotomy

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Chinese Medical Journal 2015年第11期128卷 1502-1509页

作者： sai Zhang sai-Bo Pan Qing-Hua Lyu Pin Wu Guang-ming Qin Qi Wang Zhong-Liang He Xue-ming He ming Wu Gang Chen Department of Thoracic Surgery Second Affiliated Hospital of Zhejiana Univers tv. Schoo of Medicine. Hangzhou Zhejiana 310009. China Flow Cytometry Chamber The Institute of Cancer Research of Zhejiang University Hangzhou Zhejiang 310009 China Clinical Laboratory Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Cardiothoracic Surgery Tongde Hospital of Zhejiang Province Hangzhou Zhejiang 310012 China

Background： Regulatory T-cells （Treg） play key roles in suppressing cell-mediated immunity in cancer patients. Little is known about perioperative Treg fluctuations in nonsmall cell lung cancer （NSCLC）. Video-assisted thoracoscopic （VATS） lobectomy, as a minimal invasive procedure for treating NSCLC, may have relatively less impact on the patient＇s immune system. This study aimed to observe perioperative dynamics of circulating Treg and natural killer （NK） cell levels in NSCLC patients who underwent major Iobectomy by VATS or thoracotomy. Methods： Totally, 98 consecutive patients with stage I NSCLC were recruited and assigned into VATS or thoracotomy groups. Peripheral blood samples were taken on 1-day prior to operation, postoperative days （PODs） I, 3, 7, 30, and 90. Circulating Treg and NK cell counts were assayed by flow cytometry, defined as CD4＋CD25＋CD127w cells in CD4＋ lymphocytes and CD56＋I6＋CD3 cells within CD45＋ leukocytes respectively. With SPSS software version 21.0 （SPSS Inc., USA）, differences between VATS and thoracotomy groups were determined by one-way analysis of variance （ANOVA）, and differences between preoperative baseline and PODs in each group were evaluated by one-way ANOVA Dunnett t-test. Results： In both groups, postoperative Treg percentages were lower than preoperative status. No statistical difference was found between VATS and thoracotomy groups on PODs 1, 3, 7, and 30. On POD 90, Treg percentage in VATS group was significantly lower than in thoracotomy group （5.26 ± 2.75 vs. 6.99 ±3.60, P = 0.012）. However, a higher level of NK was found on all PODs except on POD 90 in VATS group, comparing to thoracotomy group. Conclusions： Lower Treg level on POD 90 and higher NK levels on PODs 1, 3, 7, 30 in VATS group might imply better preserved cell-mediated immune function in NSCLC patients, than those in thoracotomy group.

关键词： Natural Killer Cell Regulatory T-cell Surgical Invasiveness Tumor Immunology Video-assisted ThoracoscopicLobectomy

A Layer-Based Mesh Generator and Scheme for 3D Printing Simulation

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Computer Modeling in Engineering & Sciences 2019年第8期120卷 363-374页

作者： ming-Hsiao lee Shou-I Chen Wen-Hwa Chen Ying Mao National Center for High-performance Computing NARLHsinchu 30013Taiwan China University of Technology TaipeiTaiwan National Tsing Hua University Hsinchu 30013Taiwan

3D Printing,also called Additive Manufacturing,has become a promising manufacturing method to produce parts in various fields as it can produce parts even with very irregular shapes in a relatively shorter process and ***,during the printing process,some problems could decrease the accuracy and quality of the printed parts,such as warpage due to thermal strains,deformation due to inadequate supports,*** finite element method is most commonly adopted to evaluate engineering problems in advance to reduce possible failures;however,the element meshes,needed for analyses,are always irregularly distributed,especially for irregular objects,and cannot match the layer-by-layer growing shapes of the printed parts in the 3D printing *** a proper element mesh,the analysis cannot be *** overcome this problem,a layer-based mesh generator combined with a corresponding scheme for the 3D Printing simulation is proposed and *** the proposed methods,the analysis models can be designed and generated to match the growing shapes,i.e.,layer-by-layer,and used to simulate the layer-by-layer growing behavior in the 3D printing ***,the proposed schemes directly adopt the Stereo-Lithography(STL)formatted geometric data as the geometry model on which the mesh generation and simulation are *** makes them even easier to use since the STL geometry format is a De facto standard format used in the 3D printing *** simulation cases have been conducted to demonstrate the effectiveness and efficiency of these proposed schemes.

关键词： 3D printing mesh generator layer-by-layer layer-based

Reflectionless spatial beam benders with arbitrary bending angle by introducing optic-null medium into transformation optics

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Chinese Physics B 2021年第3期30卷 242-247页

作者： Fei Sun Yi-Chao Liu Yi-Biao Yang Hong-ming Fei Zhi-Hui Chen sai-Ling He Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi ProvinceCollege of Physics and OptoelectronicsTaiyuan University of TechnologyTaiyuan 030024China National Engineering Research Center for Optical Instruments Center for Optical and Electromagnetic ResearchZhejiang UniversityHangzhou 310058China

By introducing an optic-null medium into the finite embedded transformation,a reflectionless spatial beam bender is designed,which can steer the output beam by a fixed pre-designed angleβfor an arbitrary incident *** bending angleβof the beam bender is determined by the geometrical angle of the device,which can be changed by simply choosing different geometrical *** various bending angles,the designed spatial beam bender can be realized by the same materials(i.e.,an optic-null medium),which is a homogenous anisotropic *** simulations verify the reflectionless bending effect and rotated imaging ability of the proposed beam bender.A reduction model of the optic-null medium is studied,which can also be used for a reflectionless spatial beam bender with a pre-designed bending angle.

关键词： spatial beam benders optic-null medium transformation optics

Optimal Design of Equivalent Water Depth Truncated Mooring System Based on Baton Pattern Simulated Annealing Algorithm

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China Ocean Engineering 2014年第1期28卷 67-80页

作者：张火明黄赛花管卫兵 College of Metrology Technology and Engineering China Jiliang University Department of Ocean Science and Engineering Zhejiang University The Second Institute of Oceanography China State Oceanic Administration

The highest similarity degree of static characteristics including both horizontal and vertical restoring force-displacement characteristics of total mooring system, as well as the tension-displacement characteristics of the representative single mooring line between the truncated and full depth system are obtained by annealing simulation algorithm for hybrid discrete variables （ASFHDV, in short）. A“baton” optimization approach is proposed by utilizing ASFHDV. After each baton of optimization, if a few dimensional variables reach the upper or lower limit, the boundary of certain dimensional variables shall be expanded. In consideration of the experimental requirements, the length of the upper mooring line should not be smaller than 8 m, and the diameter of the anchor chain on the bottom should be larger than 0.03 m. A 100000 t turret mooring FPSO in the water depth of 304 m, with the truncated water depth being 76 m, is taken as an example of equivalent water depth truncated mooring system optimal design and calculation, and is performed to obtain the conformation parameters of the truncated mooring system. The numerical results indicate that the present truncated mooring system design is successful and effective.

关键词： hybrid model testing deep sea platforms equivalent water depth truncation FPSO optimization design baton optimization approach

Revealing the crystallization process and realizing uniform 1.8 eV MA-based wide-bandgap mixed-halide perovskites via solution engineering

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Nano Research 2019年第5期12卷 1033-1039页

作者： Yue-Min Xie Chunqing Ma Xiuwen Xu Menglin Li Yuhui Ma Jing Wang Hrisheekesh Thachoth Chandran Chun-Sing lee sai-Wing Tsang Department of Materials Science and Engineering City University of Hong KongHong Kong SARChina City University of Hong Kong Shenzhen Research Institute Shenzhen 518057China Center of Super-Diamond and Advanced Films (COSDAF) City University of Hong KongHong Kong SARChina

Wide-bandgap perovskites are recently drawing tremendous attention in the community for high-efficiency all-perovskite tandem solar ***,the formamidinium (FA^+) and methylammonium (MA^+) based wide-bandgap mixed halide perovskites suffered from high density of traps and pin-holes,*** understanding on the crystallization and film formation processes are keys to overcome those challenges but not yet clearly *** this study,an in-situ photoluminescence technique was used to investigate the perovskite crystallization during the thermal annealing *** is found that the crystallization of a mixed halide perovskite with bromide (Br^-) and iodine (I^-) ions following the Ostward ripening crystal ***,it is found that the initial nucleation reaction is quickly completed in the first few seconds,however,leaving the small crystals with inhomogeneous *** different aggregation affinities of such inhomogeneous small crystals provoke the formation of pin-holes during the thermal annealing *** engineering the precursor solution to control the nucleation rate,the chemical composition of the small crystals has become *** pin-hole free high Br-composited wide-bandgap MA0.9Cs0.1Pb(I0.6Br0.4)3 perovskite films with bandgap energy of 1.8 eV have been *** corresponding photovoltaic devices have achieved an encouraging device efficiency of 15.1% with superb photostability.

关键词： in-situ photoluminance wide-bandgap perovskite pin-holes solution engineering

Are life insurance futures a safe haven during COVID‑19?

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Financial Innovation 2023年第1期9卷 397-423页

作者： Kuan‑Min Wang Yuan‑ming lee Department of Finance Overseas Chinese University100 Chiao Kwang RoadTaichung 40721Taiwan Department of Finance Southern Taiwan University of Science and TechnologyNo.1Nantai StYung‑Kang CityTainanTaiwan

This study aims to examine whether life insurance futures can serve as a hedge against the COVID-19 pandemic and whether they have the characteristics of a safe haven under the impact of the health shocks of the COVID-19 *** chose three life insurance stock futures in India and one in Taiwan as samples,including the market index of the two countries and the number of confirmed COVID-19 cases as sample *** used the growth rate of COVID-19 cases as the threshold variable,esti-mated the asymmetric threshold vector autoregression model,and found that insur-ance futures in the regime with a significant growth rate of confirmed COVID-19 cases can hedge against COVID-19 risks;therefore,insurance futures are a safe haven for the *** further estimated the time-varying parameter vector autoregression model,and the impulse response results showed that insurance futures are a safe haven for COVID-19 pandemic risks.

关键词： Insurance futures TVAR TVP-VAR Safe haven Impulse response

A case study on multi-lane roundabouts under congestion:Comparing software capacity and delay estimates with field data

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第2期3卷 154-165页

作者： Xuanwu Chen ming S.lee Department of Civil and Environmental Engineering Florida International UniversityMiamiFL 33174USA Issaquah WA 98029USA

Existing studies on modern roundabouts performance are mostly based on data fron： singe lane roundabouts that are not heavily congested. For planners and designers interested in building multilane roundabouts for intersections with potential growth i~ future traffic, there has been a lack of existing studies with field data that provide reference values in terms of capacity and delay measurements. With the intent of providing such reference values, a case study was conducted by using the East DowlinC Road Roundabouts in Anchorage, Alaska, which are currently operating with extensive queues during the evening peak hours. This research used multiple video camcorders t（ capture vehicle turning movements at the roundabouts as well as the progressior~ of vehicle queues at the roundabout entrance approaches. With these video records, the number of vehicles in the queues can be accurately counted in any single minute during the peak hours. This study shows that unbalanced entrance flow patterns （i.e., ~ne entrance has significant higher flow than others） can intensify the queue and delay fo., the overall roundabouts. Then various software packages including RODEL, SIDRA and VISSIM were used to estimate several performance measurements, such as capacity. queue length, and delay, compared with the collected field data. With the comparison, it is found that all the three software packages overestimate multi-lane roundabout ca pacity before calibration. With default parameters, SIDRA and VISSIM tend to underes timate delays and queue lengths for the multi-lane roundabouts under congestion, while RODEL results in higher delay and queue length estimations at most of the entrance approaches.

关键词： Multi-lane roundabout Roundabout performance Capacity Delay Queue length Traffic simulation

Self-Assembled Al Nanostructure/ZnO Quantum Dot Heterostructures for High Responsivity and Fast UV Photodetector

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Nano-Micro Letters 2020年第9期12卷 96-108页

作者： Sisi Liu ming‑Yu Li Jianbing Zhang Dong Su Zhen Huang Sundar Kunwar Jihoon lee School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Science Wuhan University of TechnologyWuhan 430070People’s Republic of China Wuhan National Laboratory for Optoelectronics(WNLO)and School of Engineering Sciences Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China College of Electonics and Information Kwangwoon UniversityNowon-guSeoul 01897Republic of Korea Institute of Nanoscale Science and Engineering University of ArkansasFayettevilleAR 72701USA

Light confinement induced by spontaneous near-surface resonance is inherently determined by the location and geometry of metallic nanostructures(NSs),offering a facile and effective approach to break through the limitation of the light-mater interaction within the photoactive ***,we demonstrate high-performance Al NS/ZnO quantum dots(Al/ZnO) heterostructure UV photodetectors with controllable morphologies of the self-assembled Al *** Al/ZnO heterostructures exhibit a superior light utilization than the ZnO/Al heterostructures,and a strong morphological dependence of the Al NSs on the optical properties of the *** inter-diffusion of Al atoms into ZnO matrixes is of a great benefit for the carrier ***,the optimal photocurrent of the Al/ZnO heterostructure photodetectors is significantly increased by 275 times to ~1.065 mA compared to that of the pristine ZnO device,and an outstanding photoresponsivity of 11.98 A W-1 is correspondingly achieved under 6.9 MW cm-2 UV light illumination at 10 V *** addition,a relatively fast response is similarly witnessed with the Al/ZnO devices,paving a path to fabricate the high-performance UV photodetectors for applications.

关键词： Al/ZnO heterostructure photodetectors Plasmonic enhancement ZnO quantum dots Self-assembled Al nanostructures

基于事件触发非线性多智能体系统的固定时间一致性

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控制理论与应用 2019年第10期36卷 1606-1614页

作者：陈世明邵赛华东交通大学电气与自动化工程学院

本文研究了在有向拓扑下,带有非线性动力学多智能体系统的固定时间一致性问题.提出了一种新的基于事件触发机制的非线性控制策略,对于每个智能体给出了基于状态信息的事件触发条件,当状态误差满足所给条件时才触发事件,能有效的减小系... 详细信息

本文研究了在有向拓扑下,带有非线性动力学多智能体系统的固定时间一致性问题.提出了一种新的基于事件触发机制的非线性控制策略,对于每个智能体给出了基于状态信息的事件触发条件,当状态误差满足所给条件时才触发事件,能有效的减小系统的能量耗散和控制器的更新频次.利用Lyapunov稳定性理论和代数图论,证明在该控制策略下,多智能体系统在固定时间能实现领导跟随一致性,且不存在Zeno行为.相较于有限时间一致性策略,采用固定时间一致性策略系统的收敛时间不再依赖于系统的初始状态.最后,仿真实例验证了理论结果的有效性.

关键词：多智能体系统事件触发控制固定时间一致性有向拓扑