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Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention

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Influence of Microbiota on Intestinal Immune System in Ulcer...

Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： sai-long zhang Chao-Yu Miao Department of Pharmacology Second Military Medical University

Ulcerative colitis(UC) is an inflammatory bowel disease(IBD) with chronic and recurrent characteristics caused by multiple *** the pathogenic factors have not been clarified yet,recent studies have demonstrated that intestinal microbiota plays a major role in UC,especially in the immune *** review focuses on the description of several major microbiota communities that affect UC and their interactions with the *** this review,eight kinds of microbiota that are highly related to IBD,including Faecalibacterium prausnitzii,Clostridium clusters Ⅳ and XⅣa,Bacteroides,Roseburia species,Eubacterium rectale,Escherichia coli,Fusobacterium,and Candida albicans are demonstrated on the changes in amount and roles in the onset and progression of *** addition,potential therapeutic targets for UC involved in the regulation of microbiota,including NLRPs,vitamin D receptor as well as secreted proteins,are discussed in this review.

关键词： intestinal microbiota host immune response ulcerative colitis epithelial cells therapeutic targets

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 52-63页

作者： Li zhang sai He Hao Guan Yao Zhao Di zhang Department of General Surgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Department of Breast Cancer Shaanxi Provincial Cancer HospitalXi’an 710000China

Background:Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,is the fourth leading cause of cancer-related deaths *** evidence shows that the expression of circulating RNA ZFR(circZFR)is upregulated in HCC ***,the molecular mechanism of circZFR in HCC is ***:Quantitative reverse transcriptase polymerase chain reaction(qRT-PCR)was employed to detect the expression of circZFR,microRNA-624-3p(miR-624-3p)and WEE1 in HCC tissues and *** R assay and actinomycin D treatment assay were used to analyze the characteristics of *** functional analysis,the capacities of colony formation,cell proliferation,cell apoptosis,migration and invasion were assessed by colony formation assay,5-ethynyl-2-deoxyuridine(EdU)assay,flow cytometry assay and transwell *** blot was used to examine the protein levels of WEE1 and epithelial-mesenchymal transition(EMT)-related *** interactions between miR-624-3p and circZFR or WEE1 were validated by dual-luciferase reporter assay and RNA immunoprecipitation(RIP)*** models were established to determine the role of circZFR in ***:circZFR and WEE1 were upregulated,while miR-624-3p expression was reduced in HCC tissues and *** could sponge miR-624-3p,and WEE1 was a downstream gene of *** of circZFR significantly reduced the malignant behaviors of HCC and that co-transfection with miR624-3p inhibitor restored this *** of WEE1 abolished the inhibitory effect of miR624-3p mimic on HCC ***,circZFR acted as a competitive endogenous RNA(ceRNA)to regulate WEE1 expression by targeting ***,in vivo studies have illustrated that circZFR knockdown inhibited tumor ***:circZFR knockdown reduced HCC cell proliferation,migration and invasion and promoted apoptosis by regulating the miR-624-3p/WEE1 axis,suggesting that the circZFR/miR-624-3p/WEE1 axis might

关键词： Hepatocellular carcinoma circZFR miR-624-3p WEE1 Liver cancer

A Task Scheduling Algorithm Based on Clustering Pre-processing in Space-Based Information Network

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Chinese Journal of Electronics 2024年第1期33卷 217-230页

作者： Yufei WANG Jun LIU Shengnan zhang sai XU Jingyi WANG School of Computer Science and Engineering Northeastern University

With the diversification of space-based information network task requirements and the dramatic increase in demand, the efficient scheduling of various tasks in space-based information network becomes a new challenge. To address the problems of a limited number of resources and resource heterogeneity in the space-based information network, we propose a bilateral pre-processing model for tasks and resources in the scheduling pre-processing stage. We use an improved fuzzy clustering method to cluster tasks and resources and design coding rules and matching methods to match similar categories to improve the clustering effect. We propose a space-based information network task scheduling strategy based on an ant colony simulated annealing algorithm for the problems of high latency of space-based information network communication and high resource dynamics. The strategy can efficiently complete the task and resource matching and improve the task scheduling performance. The experimental results show that our proposed task scheduling strategy has less task execution time and higher resource utilization than other algorithms under the same experimental conditions. It has significantly improved scheduling performance.

关键词： Scheduling algorithms Heuristic algorithms Clustering methods Clustering algorithms Simulated annealing Dynamic scheduling Search problems

Organic Brønsted Acid-Catalyzed Stereoselective Cationic RAFT Polymerization:The Effect of RAFT Agents

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Chinese Journal of Polymer Science 2024年第6期42卷 711-717页

作者： Zheng-Yi zhang Zan Yang Yun Liao sai-Hu Liao Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou350108China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Beijing National Laboratory for Molecular Sciences Beijing100190China

The tacticity of vinyl polymers is a key factor affecting the properties of ***,organic Brønsted acids have been demonstrated as effective catalysts for the development of highly stereoselective cationic reversible addition-fragmentation chain transfer(RAFT)polymerizations of vinyl ethers,in which the use of RAFT agents could allow the control the molecular weight and tacticity of polymer products ***,the effect of RAFT agents on the tacticity-regulation remains elusive and lacks of *** this study,we synthesized four types of RAFT agents and evaluated their influence in the stereoselective cationic polymerization of isobutyl vinyl ether in the presence of PADI as a Brønsted acid catalyst,which unveils that the Z group of RAFT agents could not only affect the polydispersity of the products,but also exert a profound effect on the *** extensive screening of the RAFT agents,high stereoregularity(isotacticity,90%m)was obtained when using dithiocarbonate ester-type RAFT agents with a benzyloxy Z group.

关键词： Bronsted acid catalysis Stereoselective cationic polymerization RAFT polymerization Chain transfer agents Tacticity

Experimental Study on Wire Melting Control Ability of Twin-Body Plasma Arc

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 184-194页

作者： Ruiying zhang Fan Jiang long Xue School of Mechanical Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China Beijing Academy of Safety Engineering and Technology Beijing 102617China College of Mechanical and Energy Engineering Beijing University of TechnologyBeijing 100124China

The twin-body plasma arc has the decoupling control ability of heat transfer and mass transfer,which is beneficial to shape and property control in wire arc additive *** this paper,with the wire feeding speed as a characteristic quantity,the wire melting control ability of twin-body plasma arc was studied by adjusting the current separation ratio(under the condition of a constant total current),the wire current/main current and the position of the wire in the arc axial *** results showed that under the premise that the total current remains unchanged(100 A),as the current separation ratio increased,the middle and minimum melting amounts increased approximately synchronously under the effect of anode effect power,the first melting mass range remained constant;the maximum melting amount increased twice as fast as the middle melting amount under the effect of the wire feeding speed,and the second melting mass range was *** the wire current increased,the anode effect power and the plasma arc power were both factors causing the increase in the wire melting amount;however,when the main current increased,the plasma arc power was the only factor causing the increase in the wire melting *** average wire melting increment caused by the anode effect power was approximately 2.7 times that caused by the plasma arc *** minimum melting amount was not affected by the wire-torch distance under any current separation ratio *** the current separation ratio increased and reached a threshold,the middle melting amount remained constant with increasing wire-torch *** the current separation ratio continued to increase and reached the next threshold,the maximum melting amount remained constant with the increasing wire-torch *** effect of the wire-torch distance on the wire melting amount reduced with the increase in the current separation *** this study,the decoupling mechanism and ability of this innovative

关键词： Twin-body plasma arc Melting control ability Melting amount Current separation ratio

Chien-physics-informed neural networks for solving singularly perturbed boundary-layer problems

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1467-1480页

作者： long WANG Lei zhang Guowei HE The State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China

A physics-informed neural network(PINN)is a powerful tool for solving differential equations in solid and fluid ***,it suffers from singularly perturbed boundary-layer problems in which there exist sharp changes caused by a small perturbation parameter multiplying the highest-order *** this paper,we introduce Chien's composite expansion method into PINNs,and propose a novel architecture for the PINNs,namely,the Chien-PINN(C-PINN)*** novel PINN method is validated by singularly perturbed differential equations,and successfully solves the wellknown thin plate bending *** particular,no cumbersome matching conditions are needed for the C-PINN method,compared with the previous studies based on matched asymptotic expansions.

关键词： physics-informed neural network(PINN) singular perturbation boundarylayer problem composite asymptotic expansion

Improved photocatalytic performance of acetaldehyde degradation via crystal plane regulation on truncated octahedral CeO_(2)

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Rare Metals 2024年第5期43卷 2026-2038页

作者： Bin Xu Lu Jia Hui Yang Yue Wang Si-Yu Fan sai-sai Yuan Qi-Taozhang Ming zhang Teruhisa Ohno School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China College of Environmental Science and Engineering Yangzhou UniversityYangzhou225127China Department of Applied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu804-8550Japan School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212000China National&Local Joint Engineering Research Center for Mineral Salt Deep Utilization Huaiyin Institute of TechnologyHuaian 223003China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471000China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China

In this study,the truncated octahedral CeO_(2)(CeO_(2)-to)with special morphology was prepared by the solvothermal method with oleic acid(OA)and oleamine(OM)as the morphology-directing ***-resolution transmission electron microscopy(HRTEM)results show that CeO_(2)-to exposes composite{100}and{111}facets,while CeO_(2)cubic(CeO_(2)-c)and CeO_(2)octahedral(CeO_(2)-o)only expose single crystal facets of{100}plane and{111}plane,***,this CeO_(2)-to photocatalyst exhibits remarkable photooxidation performance of gaseous acetaldehyde(CH_(3)CHO)degradation,in which CO_(2)generation value reaches 1.78 and 7.97-times greater than that of CeO_(2)-c and CeO_(2)-o,*** addition,the active species trapping experiment signifies that superoxide(·O_(2)^(-))and holes(h^(+))are the main reactive substances during the CH_(3)CHO degradation process,and the electron paramagnetic resonance(EPR)spectra indicates that the former is the major ***,the electron transfer mechanism between CeO_(2)-to{100}and{111}facets and the surface oxygen adsorption ability are revealed via density functional theory(DFT)*** is also confirmed that{100}facets are more conducive to the absorption of acetaldehyde than{111}***,a reasonable mechanism for improved photocatalytic CH_(3)CHO degradation on CeO_(2)-to is proposed based on relevant experiments and DFT *** study demonstrates that the systematic development of surface homojunction structured photocatalysts can efficiently increase the degradation activity for volatile organic compounds(VOCs).It also offers additional direction for optimizing the photocatalytic activity of other ceriumbased photocatalysts.

关键词： Truncated octahedral CeO_(2)(CeO_(2)-to) Composite crystal faces Surface energy level Efficient electrontransfer

Robust Correlation Clustering Problem with Locally Bounded Disagreements

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Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： sai Ji Min Li Mei Liang Zhenning zhang Institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations Research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as *** a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected *** goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most ***,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering *** paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with *** parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite ***,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding

Design Strategies for Aqueous Zinc Metal Batteries with High Zinc Utilization: From Metal Anodes to Anode-Free Structures

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Nano-Micro Letters 2024年第4期16卷 305-349页

作者： Xianfu zhang long zhang Xinyuan Jia Wen Song Yongchang Liu School of Materials Science and Engineering University of Science and Technology Beijing30 College RoadBeijing 100083People’s Republic of China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China

Aqueous zinc metal batteries(AZMBs)are promising candidates for next-generation energy storage due to the excellent safety, environmental friendliness, natural abundance, high theoretical specific capacity, and low redox potential of zinc(Zn) metal. However,several issues such as dendrite formation, hydrogen evolution, corrosion, and passivation of Zn metal anodes cause irreversible loss of the active materials. To solve these issues, researchers often use large amounts of excess Zn to ensure a continuous supply of active materials for Zn anodes. This leads to the ultralow utilization of Zn anodes and squanders the high energy density of AZMBs. Herein, the design strategies for AZMBs with high Zn utilization are discussed in depth, from utilizing thinner Zn foils to constructing anode-free structures with theoretical Zn utilization of 100%, which provides comprehensive guidelines for further research. Representative methods for calculating the depth of discharge of Zn anodes with different structures are first summarized. The reasonable modification strategies of Zn foil anodes, current collectors with pre-deposited Zn, and anode-free aqueous Zn metal batteries(AF-AZMBs) to improve Zn utilization are then detailed. In particular, the working mechanism of AF-AZMBs is systematically introduced. Finally, the challenges and perspectives for constructing high-utilization Zn anodes are presented.

关键词： Aqueous zinc metal batteries Zinc anodes High zinc utilization Depth of discharge Anode-free structures