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Science China Chemistry 2015年第10期58卷 1544-1552页

作者： Junlei Yan sai jiang Shengfu Ji Da Shi Hefei Cheng State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

Metal-organic framework MIL-53(Al) was synthesized by a solvothermal method using aluminum nitrate as the aluminium source and 1,4-benzenedicarboxylic acid(H2BDC) as the organic ligand. The structure of samples was characterized by X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR). The catalytic activity and recyclability of MIL-53(Al) catalyst for the Friedel-Crafts acylation reaction of indole with benzoyl chloride were evaluated. The reaction conditions were optimized and a reaction mechanism was suggested. The results showed that the MIL-53(Al) catalyst exhibited good catalytic activity and recyclability for the Friedel-Crafts acylation reaction. When the molar ratio of indole and MIL-53(Al) catalyst was 1:0.06(n1:ncatalyst), the molar ratio of indole and benzoyl chloride was 1:3, and the solvent was dichloromethane, the conversion of indole could reach 97.1% and the selectivity of 3-acylindole could reach 81.1% at 25 °C after 8 h. The catalyst can be reused without significant degradation in catalytic activity. After the catalyst was reused five times, the conversion of indole was 87.6% and the selectivity of 3-acylindole was 79.5%.

关键词： MIL-53(Al) catalyst Friedel-Crafts acylation indole 3-acylindoles

Low Velocity Impact Localization System Using FBG Array and MVDR Beamforming Algorithm

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Photonic Sensors 2015年第4期5卷 357-364页

作者： Yaozhang sai Mingshun jiang Qingmei SUI Lei JIA Shizeng LU School of Control Science and Engineering Shandong University Jinan 250100 China

This paper proposes an impact localization system based on the fiber Bragg grating （FBG） array and minimum variance distortionless response （MVDR） beamforming algorithm. The linear FBG array, which contains seven FBG sensors, is used for detecting impact signals. Morlet wavelet transform is applied for extracting narrow-band signals of impact signals. According to the MVDR beamforming algorithm, the system realizes single-impact and multi-impact localizations. The localization system is verified on a 500mm×500mm×2mm carbon fiber reinforced polymer （CFRP） plate for single-impact and multi-impact localizations. The average locating error and the maximum locating error are 6.8mm and ***, respectively.

关键词： Fiber Bragg grating minimum variance distortionless response Morlet wavelet transform multi-impact localization

Design,synthesis and anti-HBV activity of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir

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Chinese Chemical Letters 2009年第5期20卷 507-510页

作者： Peng Lu sai Hong jiang jiang Xia Liu Yu She Yang Ru Yun Ji State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institute for Biological Sciences Chinese Academy of Science Shanghai 201203 China Fudan University Shanghai 200032 China

A series of novel bis（trifluoroethyl）phosphonomethyl ether derivatives of acyclovir was synthesized and their in vitro anti-HBV activity was evaluated in HepG2 2.2.15 cells. In contrast to acyclovir, most of the described phosphonates emerged as potent inhibitors of HBV replication. Especially, the most active compound 11 with IC50 value of 2.92 μmol/L was 33 times more potent than acyclovir with ICso value of 100 μmol/L.

关键词： Acyclovir Phosphonate Anti-HBV activity

A Smarter Pavlovian Dog with Optically Modulated Associative Learning in an Organic Ferroelectric Neuromem

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Research 2021年第1期2021卷 1148-1157页

作者： Mengjiao Pei Changjin Wan Qiong Chang Jianhang Guo sai jiang Bowen Zhang Xinran Wang Yi Shi Yun Li National Laboratory of Solid-State Microstructures School of Electronic Science and EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China School of Computing Tokyo Institute of TechnologyTokyo 152-8550Japan School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China

Associative learning is a critical learning principle uniting discrete ideas and percepts to improve individuals’***,enabling high tunability of the association processes as in biological counterparts and thus integration of multiple signals from the environment,ideally in a single device,is ***,we fabricate an organic ferroelectric neuromem capable of monadically implementing optically modulated associative *** approach couples the photogating effect at the interface with ferroelectric polarization switching,enabling highly tunable optical modulation of charge *** device acts as a smarter Pavlovian dog exhibiting adjustable associative learning with the training cycles tuned from thirteen to *** particular,we obtain a large output difference(>10^(3)),which is very similar to the all-or-nothing biological sensory/motor neuron spiking with decrementless *** proof-of-concept demonstrations,photoferroelectric coupling-based applications in cryptography and logic gates are achieved in a single device,indicating compatibility with biological and digital data processing.

关键词： ferroelectric associative proof

Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 506-510页

作者： Min-wei LI Jing MIAO sai-ping jiang Fu-qiang HU Yong-zhong DU Department of Pharmacy the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China State Key Lab for Diagnosis and Treatment of lnfectious Diseases Zhejiang University Hangzhou 310003 China

Herein,solid lipid nanoparticles(SLN)were proposed as a new drug delivery system for adefovir dipivoxil(ADV). The octadecylamine-fluorescein isothiocynate(ODA-FITC)was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by *** SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous *** 15 wt%drug entrapment efficiency(EE)and 3 wt% drug loading(DL)could be reached in SLN loading *** with free ADV,the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen(HBsAg),hepatitis B e antigen(HBeAg)and hepatitis B virus(HBV)DNA levels in vitro were significantly enhanced.

关键词： Adefovir dipivoxil (ADV) Solid lipid nanoparticles (SLN) Octadecylamine-fluorescein isothiocynate (ODA-FITC),Hepatitis B virus (HBV)

Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent

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Chinese Chemical Letters 2007年第7期18卷 817-819页

作者： Xiao Zhong Fu sai Hong jiang Jian Xin Yu She Yang RU Yun Ji School of Pharmacy Guiyang Medical College Guiyang 550004 China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institute for Biological SciencesChinese Academy of Science Shanghai 201203 China Shanghai Fudan-Yueda Bio-Tech Co. Ltd. Shanghai 201203 China

A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 μmol/L and 2530 μmol/L, respectively.

关键词： Acyclic nucleoside phosphonates L-Amino acid Prodrug Anti-HBV activity

In-situ/operando characterization techniques for organic semiconductors and devices

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Journal of Semiconductors 2022年第4期43卷 13-23页

作者： sai jiang Qinyong Dai Jianhang Guo Yun Li School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China National Laboratory of Solid-State Microstructures School of Electronic Science and EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The increasing demands of multifunctional organic electronics require advanced organic semiconducting materials to be developed and significant improvements to be made to device performance. Thus, it is necessary to gain an in-depth understanding of the film growth process, electronic states, and dynamic structure-property relationship under realistic operation conditions, which can be obtained by in-situ/operando characterization techniques for organic devices. Here, the up-todate developments in the in-situ/operando optical, scanning probe microscopy, and spectroscopy techniques that are employed for studies of film morphological evolution, crystal structures, semiconductor-electrolyte interface properties, and charge carrier dynamics are described and summarized. These advanced technologies leverage the traditional static characterizations into an in-situ and interactive manipulation of organic semiconducting films and devices without sacrificing the resolution, which facilitates the exploration of the intrinsic structure-property relationship of organic materials and the optimization of organic devices for advanced applications.

关键词： in-situ/operando characterization organic semiconductors structure-property relationship

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Large-Area Monolayer n-Type Molecular Semiconductors with Improved Thermal Stability and Charge Injection

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Chinese Physics Letters 2023年第3期40卷 68-73页

作者： sai jiang Lichao Peng Xiaosong Du Qinyong Dai Jianhang Guo Jianhui Gu Jian Su Ding Gu Qijing Wang Huafei Guo Jianhua Qiu Yun Li School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China National Laboratory of Solid-State Microstructures School of Electronic Science and EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

We fabricated monolayer n-type two-dimensional crystalline semiconducting films with millimeter-sized areas and remarkable morphological uniformity using an antisolvent-confined spin-coating *** antisolvent can cause a downstream Marangoni flow,which improves the film *** deposited crystalline monolayer films exhibit excellent thermal stabilities after annealing,which reveals the annealing-induced enhancement of *** transistors based on the n-type monolayer crystalline films show linear output characteristics and superior electron *** improved charge injection between monolayer films and Au electrodes results from the energy level shift as the films decrease to the monolayer,which leads to a lower injection *** work demonstrates a promising method for fabricating air-stable,low-cost,high-performance,and large-area organic electronics.

关键词： monolayer crystalline annealing

Panax japonicus and chikusetsusaponins: A review of diverse biological activities and pharmacology mechanism

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Chinese Herbal Medicines 2021年第1期13卷 64-77页

作者： Xiao-Juan Wang Qian Xi Yang Liu sai jiang Wei Li Bin Li Wei Wang Chang-Xiao Liu Hunan Food and Drug Vocational College Changsha 410208China TCM and Ethnomedicine Innovation&Development International Laboratory Innovative Drug Research InstituteSino-Pakistan TCM&Ethnomedicine Research International Cooperation Base(Hunan Province)School of PharmacyHunan University of Chinese MedicineChangsha 410208China Tianjin Institute of Pharmaceutical Research Tianjin 300193China

Panax japonicus, which in the Tujia dialect is known as "Baisan Qi" and "Zhujieshen", is a classic "qi" drug of Tujia ethnomedicine and it has unique effects on disease caused by "qi" stagnation and blood *** paper serves as the basis of further scientific research and development of Panax japonicus. The pharmacology effects of molecular pharmacology were discussed and summarized. P. japonicus plays an important role on several diseases, such as rheumatic arthritis, cancer, cardiovascular agents, and this review provides new insights into P. japonicus as promising agents to substitute ginseng and notoginseng.

关键词： chikusetsusaponin ginsenoside Panax ginseng C.A.Mey Panax japonicas(T.Nees)C.A.Meyer Panax notoginseng(Burk.)F.H.Chen