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Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis

World Journal of Gastroenterology 2012年第17期18卷 2026-2034页

作者： sahar K Hegazy Mohamed El-Bedewy Akira Yagi department of Clinical Pharmacy Faculty of PharmacyTanta UniversityTanta 8130Egypt department of Internal Medicine Faculty of MedicineTanta UniversityTanta 8130Egypt Placenta/Aloe Research Institute Japan Bio-Products Co.Ltd.1488-4Aikawa-machiKurume-shiFukuoka Bio Factory 204Fukuoka 839-0861Japan

AIM:To investigate the anti-oxidative and anti-fibrotic effects of aloe vera in patients with liver ***:Aloe vera high molecular weight fractions(ahm) were processed by patented hyper-dry system in combination of freeze-dry technique with microwave and far infrared-ray *** healthy volunteers as the control group and 40 patients were *** patients were randomly subdivided into two equal groups:the conventional group was treated with placebo(starch),and ahm group was treated with 0.15 gm/d ahm,both for 12 consecutive *** patients were investigated before and after *** activity of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP),hyaluronic acid(HA),transforming growth factor-β(TGF-β) and matrixmetalloproteinase-2(MMP-2) were *** reduced glutathione(GSH) and malondialdehyde(MdA) levels in liver were assayed and the expression of hepatic α-smooth muscle actin(α-SMA) was identified by ***:At the start of the study,the hematoxylin and eosin staining revealed fibro-proliferated bile ductules,thick fibrous septa and dense inflammatory cellular infiltration in the patients before *** use of ahm for 12 wk significantly ameliorated the fibrosis,inhibited the inflammation,and resulted in minimal infiltration and minimal fibrosis compared to the conventional *** enzyme activities of the liver(ALT,AST and ALP) were attenuated after treatment in both groups,and the decrease in the ahm group was more significant as compared with the conventional *** to the AST,the MdA levels were significantly higher before treatment,and were attenuated after treatment in both *** contrast,the hepatic glutathione content in the patients were decreased significantly in the ahm group compared to the *** serum levels of the fibrosis markers(HA,TGF-β and MMP-2) were also reduced significantly after *** expression of α-SMA was m

关键词： Hepatic fine periportal fibrosis Aloe vera α-smooth muscle actin Transforming growth factor-β Hyaluronic acid

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