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Chinese Journal of Chemistry 2011年第6期29卷 1216-1220页

作者： Najma, Sultana Arayne, M. Saeed safila, naveed United Biotechnologies Karachi-75290 Pakistan Faculty of Pharmacy Hamdard University Karachi-74600 Pakistan

Lisinopril is found to be useful in hypertension and statins as cholesterol lowering drug. Present work was designed for the simultaneous determination of lisinopril in presence of pravastatin, atorvastatin, and rosuvastatin using RP-HPLC method. A Purospher star C 18 （5 μm, 25 × 0.46 cm） column was used with mobile phase consisting of acetonitrile ： water （60 ： 40 V/V, pH 3.0） with flow rate of 1.0 mLomin-1 and the quantitative evaluation was performed at 225 nm. The retention time of lisinopril was 2.0 min and for pravastatin, rosuvastatin and atorvastatin was found to be 3.1, 4.5 and 8.3 min respectively. Suitability of this method for the quantitative determination of the drugs was proved by validation in accordance with the requirements laid down by International Conference on Harmonization （ICH） guidelines. Application of the suggested procedures were successfully applied to the determination of these compounds in active pharmaceutical ingredient and in pharmaceutical preparations, with high percentage of recovery, good accuracy and precision.

关键词： Lisinopril statins method validation HPLC determination

Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

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Journal of Chinese Pharmaceutical Sciences 2015年第10期24卷 673-677页

作者： Farya Zafar Huma Ali Shabana Naz Shah safila naveed Shehla Siddiqui Faculty of Pharmacy Ziauddin University Martin Dow Pharmaceutical Pakistan Limited Jinnah University for Woman Karachi

In the present study, we aimed to determine the quality of different brands(Test1–Test6) of mefenamic acid, which are commercially available in local market of Karachi, Pakistan. Various quality evaluation tests, including weight variation, hardness, thickness, friability, disintegration, assay and drug release, were carried out. Results were found to be in acceptable limits. Moreover, release profiles were compared using different dissolution media, such as phosphate buffer pH 6.8, 7.4 and biorelevant media(FaSSGF, FaSSIF, FeSSIF and SCoF). Release profiles at pH 6.8 and 7.4 were evaluated by one--way ANOVA, model-independent and model--dependent methods. Results of ANOVA showed that no significant difference was found among tester and reference brands(Test1–Test6). Similarly, all the brands were found to be best fitted with Weibull model.

关键词：药学药剂学调剂学药品

Determination of the heavy metal content of Entoban herbal medicinal product

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Journal of Chinese Pharmaceutical Sciences 2015年第11期24卷 764-769页

作者： Sadia Shakeel Zeeshan Ahmed Sheikh Khan Usmanghani Nadeem Khalid Zafar Ali Somia Gul safila naveed Faculty of Pharmacy Dow University of Health Sciences Herbion Pakistan (Pvt.) Ltd. Faculty of Pharmacy Jinnah University for Women Karachi.

The levels of As, Cd, Pb and Hg were investigated in the medicinal herbal syrup Entoban, which is widely used in the management of non-specific diarrhea and acute intestinal infections of various etiologies. The ingredients in Entoban syrup include 6 potent herbal drugs: Aegle marmelose, Berberis aristata, Butea frondosa, Holarrhena antidysenterica, Myrtus communis, and Quercus infectoria. Entoban medicinal plant syrup was analyzed for As, Cd, Pb and Hg by flame atomic absorption spectroscopy(FAAS). Contents of heavy metals in the examined samples were in the range: As(0.074–10.0 ppm); Cd(0.020–0.3 ppm); Pb(0.00–10.0 ppm) and Hg(0.00–1.0 ppm). Results were compared with permissible limit acceptability intake(AHPA). According to determined amounts of heavy metals, the investigated Entoban syrup samples were validated and considered safe for human consumption.

关键词： Heavy metals, Flame atomic absorption spectroscopy, Medicinal plants, Entoban syrup

Degradation study of different brands of paracetamol by UV spectroscopy

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Journal of Coastal Life Medicine 2016年第5期4卷 377-379页

作者： safila naveed Humera Ishaq Sheeba Urooj Faculty of Pharmacy Jinnah University for WomenKarachiPakistan Faculty of Pharmacy Hamdard UniversityKarachiPakistan

Objective:To investgate the forced degradation study for the determination of degradation of the drug ***:Paracetamol was exposed to different conditions according to International Conference on Harmonization *** amount of degradation product can be calculated with the help of UV *** official test limits according to British Pharmacopoeia/United States Pharmacopoeia should not less than and should not more than lapelled *** degradation of drug substance was exposed to acidic and basic medium of *** degradation of drug substance of panadol,disprol and calpol were also observed negligible difference in availability on exposure to UV and *** method can be used successfully for studying the stress degradation *** this method is less time consuming and simple and cost effective ***:The brands ***,panadol and disprol,when they come in contact with different degradation parameters(before,acid,base,heat and UV treatments)according to statistical analysis,the result showed significant values(P<0.05)which indicated that there was no degradation in any of the ***:The result indicated there is no degradation found in these brands.

关键词： Paracetamol Degradation studies Different brands Spectrophotometer

In vivo and in vitro interaction studies of ibuprofen with enalapril

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Journal of Coastal Life Medicine 2016年第4期4卷 327-330页

作者： safila naveed Najma Sultana Muhammad Saeed Arayne Research Institute of Pharmaceutical Sciences Faculty of Pharmacy University of KarachiKarachi-75270Pakistan Faculty of Pharmacy Jinnah University for WomenKarachiPakistan Department of Chemistry University of KarachiKarachiPakistan

Objective:To study the in vitro interactions of ibuprofen with ***:In this study,we investigated synergistic effect of angiotensin-converting enzyme inhibitor(enalapril)with commonly used nonsteroidal anti-inflammatory drug,ibuprofen in carrageenan induced inflammation ***-inflammatory response was observed for ibuprofen when given simultaneously with enalapril by comparing decrease in paw ***:The results were expressed in percentage reduction in paw size for every hour and were calculated for edema rate and percentage reduction in *** vitro interaction studies were carried out using high performance liquid chromatography and both the drugs were analyzed by assaying both drugs alone and in *** combination of enalapril and ibuprofen showed increased action of ibuprofen as shown by the increase of percentage reduction and decrease in edema *** was also proved from analytical ultracentrifugation of the chromatogram of combining ***:This learning has certain restriction as a number of experienced animals were small and the period of inflammatory response was checked for ibuprofen alone and simultaneous with enalapril for 5 *** studies may be required to establish the strong relationship.

关键词： Interaction Ibuprofen Enalapril High performance liquid chromatography

RP-HPLC Method for the Simultaneous Determination of Lisinopril and NSAIDs in API, Pharmaceutical Formulations and Human Serum

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American Journal of Analytical Chemistry 2012年第2期3卷 147-152页

作者： Najma Sultana M. Saeed Arayne Rubina Siddiqui safila naveed Fatima Jinnah Medical and Dental College Karachi Pakistan Jinnah University for Women Karachi Pakistan United Biotechnologies Karachi Pakistan

High performance liquid chromatographic method was developed valdated and applied for the simultaneous determi- nation of lisinopril and NSAIDs in bulk, pharmaceuticals formulations and human serum. A Purospher star C18 (5 μm, 25 × 0.46 cm) column was used with mobile phase consisting of methanol: water: acetonitrile (80:17.5:2.5 v/v, pH 3.0) and quantitative evaluation was performed at 225 nm with a flow rate of 1.0 mL?min–1. The retention time of lisinopril was 2.2 min while naproxen, flurbiprofen, diclofenac sodium and mefenamic acid were found to be 4.0, 4.5, 5.0 and 6.7 min respectively. Suitability of this method for the quantitative determination of the drugs was proved by validation in accordance with the requirements laid down by International Conference on Harmonization (ICH) guidelines. The method is selective, precise, accurate and can be used for analysis of pharmaceutical preparations in quality control and clinical laboratories.

关键词： Lisinopril NSAIDs Method Validation HPLC Determination

Hypothyroidism—A Question towards Quality and Patient Centricity

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Open Journal of Endocrine and Metabolic Diseases 2015年第2期5卷 19-27页

作者： Hina Rehman Syed Junaid Rehan Humera Ishaq Sadia Shakeel Faraz Hashmi safila naveed Faculty of Pharmacy Jinnah University for Women Karachi Pakistan Faculty of Pharmacy Hamdard University Karachi Pakistan Jinnah Sindh Medical University Karachi Pakistan

The metabolic and endocrine disorders are either increasing across the globe or may have been observed with more focus in recent years. It is not uncommon now to find out neither patients of endocrine and metabolic disorders nor a physician of the associated diseases. There were 42 million people who had thyroid disorders including hypothyroidism according to the survey of endocrine society of India. Hypothyroidism is said when less activity of thyroid glands is observed then the normal. So, to evaluate the quality standard, empowerment and patient centricity in Pakistan with present prevalence of hypothyroidism in different age groups, gender along with the prescribed medication against pre diagnosed disease and associated co-morbidities, the study is designed with a questionnaire development including both qualitative and quantitative variables. Study was conducted on various OPD’s, profit and not for profit secondary and tertiary care hospitals and consultant clinics during July 2013 to Jan 2014 and it was given consideration to include people from all areas of life with minimization of any unforeseen biasness and comprehensive data. After full filling the inclusion criteria, 102 patients were selected as study participants. After completion and reviewing the questionnaire, data were analyzed by 21.00 SPSS version. Chi square/ fisher test, spearmen’s rank correlation were applied for categorical quantitative variable. Paired t test before and after were applied for qualitative variable. Highly significant reliability of items in the questionnaire was found along with inter item correlation (P < 0.05). Out of 102 patients of the study, 80 patients fell into the inclusion criteria, while 22 were excluded. A total of 80 patients were registered in the incorporate duration. Among the total samples 36 (42.9%) were males and 44 (52.4%) were females. Mean age males and females included in the study were 34.89 ± 17.73 and 33.36 ± 13.73 years respectively. The systolic an

关键词： Hypothyroidism Quality Patient Centricity Empowerment