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Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients

World Journal of Gastroenterology 2008年第35期14卷 5448-5453页

作者： Golnaz Bahramali Majid Sadeghizadeh Samad amini-Bavil-Olyaee Seyed-Moayed Alavian Abbas Behzad-Behbahani Ahmad Adeli Mohammad-Reza Aghasadeghi safieh amini Fereidoun Mahboudi Department of Genetics Faculty of Basic SciencesTarbiat Modares UniversityTehran 14115-175Iran Biotechnology Department Pasteur Institute of IranTehran 13164IranMohammad-Reza AghasadeghiSafieh AminiHepatitis and HIV DepartmentPasteur Institute of IranTehran 13164Iran Baqiyatallah Research Center for Gastroenterology and Liver Diseases Tehran Hepatitis CenterTehran 14155-3651Iran Medical Technology Research Center School of Paramedical SciencesShiraz University of Medical SciencesShiraz ***Iran Biotechnology Department Pasteur Institute of IranTehran 13164Iran Hepatitis and HIV Department Pasteur Institute of IranTehran 13164Iran

AIM： To characterize the clinical, serologic and virologic features of hepatitis B virus （HBV） infection in Iranian patients with different stages of liver disease.METHODS： Sixty two patients comprising of 12 inactive carriers, 30 chronic hepatitis patients, 13 patients with liver cirrhosis and 7 patients with hepatocellular carcinoma （HCC） were enrolled in the study. The HBV S, C and basal core promoter （BCP） regions were amplified and sequenced, and the clinical, serologic, phylogenetic and virologic characteristics were investigated.RESULTS： The study group consisted of 16 HBeAgpositive and 46 HBeAg-negative patients. Anti-HBepositive patients were older and had higher levels of ALT, ASL and bilirubin compared to HBeAg-positive patients. Phylogenetic analysis revealed that all patients were infected with genotype D （mostly ayw2）. The G1896A precore （PC） mutant was detected in 58.1% patients. HBeAg-negative patients showed a higher rate of PC mutant compared to HBeAg-positive patients （2,2 = 9.682, P = 0.003）. The majority of patients with HCC were HBeAg-negative and were infected with PC mutant variants. There was no significant difference in the occurrence of BCP mutation between the two groups, while the rate of BCP plus PC mutants was higher in HBeAg-negative patients （2,2 = 4.308, P = 0.04）. In the HBV S region, the genetic variability was low, and the marked substitution was P120T/S, with a rate of 9.7% （n = 6）.CONCLUSION： In conclusion, HBV/D is the predominant genotype in Iran, and the nucleotide variability in the BCP and PC regions may play a role in HBV disease outcome in HBeAg-negative patients.

关键词： Hepatitis B virus Clinical and virologic features Genetic variability Phylogenetic analysis

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