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CNKSR2 intera.tome a.a.ysis indica.es its a.socia.ion with the centrosome/microtubule system

Neura. Regenera.ion Resea.ch 2025年第8期20卷 2420-2432页

作者： lin Yin Ya.a. Xu Jie Mu Yu Leng Lei Ma.Yu Zheng Ruizhi li Yin Wa.g Peifeng li Ha. Zhu Dong Wa.g Jing li Institute for Tra.sla.iona. Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Ba.ic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Depa.tment of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enha.cer of kina.e suppressor of Ra. 2(CNKSR2),present in both the postsyna.tic density a.d cytopla.m of neurons,is a.sca.folding protein with severa. protein-binding *** of the CNKSR2 gene ha.e been implica.ed in neurodevelopmenta. disorders,pa.ticula.ly intellectua. disa.ility,a.though the precise mecha.ism involved ha. not yet been fully *** ha. demonstra.ed tha. CNKSR2 pla.s a.role in fa.ilita.ing the loca.2}za.ion of postsyna.tic density protein complexes to the membra.e,thereby influencing syna.tic signa.2}ng a.d the morphogenesis of dendritic ***,the function of CNKSR2 in the cytopla.m rema.ns to be *** this study,we used immunoprecipita.ion a.d high-resolution liquid chroma.ogra.hy-ma.s spectrometry to identify the intera.tors of *** a.combina.ion of bioinforma.ic a.a.ysis a.d cytologica. experiments,we found tha. the CNKSR2 intera.tors were significa.tly enriched in the proteome of the *** a.so showed tha. CNKSR2 intera.ted with the microtubule protein DYNC1H1 a.d with the centrosome ma.ker *** coloca.2}za.ion a.a.ysis confirmed the centrosoma. loca.2}za.ion of *** we downregula.ed CNKSR2 expression in mouse neurobla.toma.cells(Neuro 2a.,we observed significa.t cha.ges in the expression of numerous centrosoma. *** ma.ipula.ion a.so a.fected centrosome-rela.ed functions,including cell size a.d sha.e,cell prolifera.ion,a.d ***,we found tha. CNKSR2 intera.tors were highly enriched in de novo va.ia.ts a.socia.ed with intellectua. disa.ility a.d a.tism spectrum *** findings esta.lish a.connection between CNKSR2 a.d the centrosome,a.d offer new insights into the underlying mecha.isms of neurodevelopmenta. disorders.

关键词： a.tism spectrum disorder centrosome CNKSR2 intellectua. disa.ility intera.tome ma.s spectrometry microtubule neurodevelopmenta. disea.e protein complexes protein-protein intera.tions

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Decision ma.ing module ba.ed on stocha.tic ma.netic tunnel junctions

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Science China.Physics,Mecha.ics & a.tronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifa. Mia. li Zha. Ya.un Zha.g Zhe Yua. Center for a.va.ced Qua.tum Studies a.d Depa.tment of Physics Beijing Normal University Institute for Na.oelectric Devices a.d Qua.tum Computing Fudan University Interdisciplina.y Center for Theoretica. Physics a.d Informa.ion Sciences Fudan University

In biologica. neura. systems, noise is ubiquitous but does not a.fect the correct decisions ma.e in the complex cognitive ***-ma.ing in biologica. neura. system is typica.ly a.hieved by a.cumula.ing input informa.ion over a.period of *** by recent developments in neurosciences, we design a.decision-ma.ing module ba.ed on spintronic devices, utilizing superpa.a.a.netic tunnel junctions a. a.tificia. neurons. The fea.ibility of this decision-ma.ing module is verified through circuit simula.ions. Ta.ing a.multi-la.er perceptron a. a. exa.ple, the module significa.tly improves the a.cura.y of the perceptron in the ha.dwritten digit recognition ta.k. Furthermore, the spintronic decision-ma.ing module offers a.va.ta.es over the conventiona. pooling methods, such a. a.a.tive decision time, high performa.ce a.d the a.sence of a.a.og-to-digita. conversion. The decision-ma.ing module is flexible to be integra.ed into a.tificia. neura. networks a.d provides a.genera. yet effective solution to enha.ce performa.ce a.a.nst device noise.

关键词： neuromorphic computing spintronics ma.netic tunnel junction neura. networks

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Engineering a.omic Rb-N configura.ions to tune ra.ica. pa.hwa.s for highly selective photoca.a.ytic H2O2 synthesis coupled with bioma.s va.oriza.ion

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Journa. of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jia.e li Shua.g Pa. Yihua.g Chen Qiong liu College of Chemistry a.d Ma.eria.s Engineering Wenzhou University Gua.gdong Provincia. Key La.ora.ory of Chemica. Mea.urement a.d Emergency Test Technology (China. Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photoca.a.ytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a.green a.d costeffective production ***,a.hieving highly selective H2O2synthesis rema.ns cha.lenging,necessita.ing precise control over free ra.ica. rea.tion pa.hwa.s a.d minimizing undesira.le oxida.ive ***,we report for the visible light-driven simulta.eous co-photoca.a.ytic reduction of O2to H2O2a.d oxida.ion of bioma.s using the a.omic rubidium-nitride modified ca.bon nitride（CNRb）.The optimized CNRb ca.a.yst demonstra.es a.record photoreduction ra.e of 8.01 mM h-1for H2O2genera.ion a.d photooxida.ion ra.e of 3.75 mM h-1for furfuryl a.cohol to furoic a.id,a.hieving a.rema.ka.le sola.-to-chemica. conversion （SCC） efficiency of up to 2.27%.Experimenta. cha.a.teriza.ions a.d DFT ca.cula.ion disclosed tha. the introducing a.omic Rb–N configura.ions a.lows for the high-selective genera.ion of superoxide ra.ica.s while suppressing hydroxyl free ra.ica. *** is beca.se the Rb–N serves a. the new a.terna.ive site to perceive a.stronger connection position for O2a.sorption a.d reinforce the ca.a.ility to extra.t protons,thereby triggering a.high selective redox product *** study holds grea. potentia. in precisely regula.ing rea.tive ra.ica. processes a. the a.omic level,thereby pa.ing the wa. for efficient synthesis of H2O2coupled with bioma.s va.oriza.ion.

关键词： Free ra.ica. rea.tions

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Periphera. blood RNa.bioma.kers ca. predict lesion severity in degenera.ive cervica. myelopa.hy

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jia.0}n Chen Jinghong Xu Bin Jia.g Lei li Ya.ei li Yulia.g Da. Bing Wa.g Depa.tment of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenera.ive cervica. myelopa.hy is a.common ca.se of spina. cord injury,with longer symptom dura.ion a.d higher myelopa.hy severity indica.ing a.worse *** numerous studies ha.e investiga.ed serologica. bioma.kers for a.ute spina. cord injury,few studies ha.e explored such bioma.kers for dia.nosing degenera.ive cervica. *** study involved 30 pa.ients with degenera.ive cervica. myelopa.hy(51.3±7.3 yea.s old,12 women a.d 18 men),seven hea.thy controls(25.7±1.7 yea.s old,one woma. a.d six men),a.d nine pa.ients with cervica. spondylotic ra.iculopa.hy(51.9±8.6 yea.s old,three women a.d six men).a.a.ysis of blood sa.ples from the three groups showed clea. differences in tra.scriptomic *** a.a.ysis identified 128 differentia.ly expressed genes tha. were enriched in pa.ients with neurologica. *** lea.t a.solute shrinka.e a.d selection opera.or a.a.ysis,we constructed a.five-gene model(TBCD,TPM2,PNKD,EIF4G2,a.d a.5Z1)to dia.nose degenera.ive cervica. myelopa.hy with a. a.cura.y of 93.5%.One-gene models(TCa. a.d SDHa.identified mild a.d severe degenera.ive cervica. myelopa.hy with a.cura.ies of 83.3%a.d 76.7%,*** of two immune cell types(memory B cells a.d memory-a.tiva.ed CD4^(+)T cells)predicted levels of lesions in degenera.ive cervica. myelopa.hy with 80%*** results suggest tha. periphera. blood RNa.bioma.kers could be used to predict lesion severity in degenera.ive cervica. myelopa.hy.

关键词： bioma.kers ca.dida.e genes degenera.ive cervica. myelopa.hy gene expression a.a.ysis immune cell types neurologica. disa.ilities periphera. blood RNa.profiles spina. cord injury

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Hypidone hydrochloride(YL-0919)a.eliora.es functiona. deficits a.ter tra.ma.ic bra.n injury in mice by a.tiva.ing the sigma.1 receptor for a.tioxida.ion

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2325-2336页

作者： Ya.a. Ba. Hui Ma.Yue Zha.g Jinfeng li Xia.jua. Hou Yixin Ya.g Guya. Wa.g Yunfeng li Depa.tment of a.esthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Ba.ic Medica. Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pha.ma.ology a.d Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Tra.ma.ic bra.n injury involves complex pa.hophysiologica. mecha.isms,a.ong which oxida.ive stress significa.tly contributes to the occurrence of seconda.y *** this study,we eva.ua.ed hypidone hydrochloride(YL-0919),a.self-developed a.tidepressa.t with selective sigma.1 receptor a.onist properties,a.d its a.socia.ed mecha.isms a.d ta.gets in tra.ma.ic bra.n *** experiments to a.sess functiona. deficits were followed by a.sessment of neurona. da.a.e through histologica. a.a.yses a.d exa.ina.ion of blood-bra.n ba.rier permea.ility a.d bra.n ***,we investiga.ed the a.tioxida.ive effects of YL-0919 by a.sessing the levels of tra.itiona. ma.kers of oxida.ive stress in vivo in mice a.d in vitro in HT22 ***,the ta.geted a.tion of YL-0919 wa. verified by employing a.sigma.1 receptor a.ta.onist(BD-1047).Our findings demonstra.ed tha. YL-0919 ma.kedly improved deficits in motor function a.d spa.ia. cognition on da. 3 post tra.ma.ic bra.n injury,while a.so decrea.ing neurona. morta.8}ty a.d reversing blood-bra.n ba.rier disruption a.d bra.n ***,YL-0919 effectively comba.ed oxida.ive stress both in vivo a.d in *** protective effects of YL-0919 were pa.tia.ly inhibited by *** results indica.ed tha. YL-0919 relieved impa.rments in motor a.d spa.ia. cognition by restra.ning oxida.ive stress,a.neuroprotective effect tha. wa. pa.tia.ly reversed by the sigma.1 receptor a.ta.onist ***-0919 ma. ha.e potentia. a. a.new trea.ment for tra.ma.ic bra.n injury.

关键词： a.tidepressa.t drug blood-bra.n ba.rier cognitive function hypidone hydrochloride(YL-0919) neurologica. function nuclea. fa.tor-erythroid 2 rela.ed fa.tor 2 oxida.ive stress sigma.1 receptor superoxide dismuta.e tra.ma.ic bra.n injury

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Prussia. Blue a.a.ogue‑Templa.ed Na.ocomposites for a.ka.2}‑Ion Ba.teries:Progress a.d Perspective

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Na.o-Micro Letters 2025年第1期17卷 216-261页

作者： Jia.‑En Zhou Yilin li Xia.ming lin Jia.e Ye Key La.ora.ory of Theoretica. Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry a.d Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Ma.eria.s Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

lithium-ion ba.teries(liBs)ha.e domina.ed the porta.le electronic a.d electrochemica. energy ma.kets since their commercia.0}sa.ion,whose high cost a.d lithium sca.city ha.e prompted the development of other a.ka.0}-ion ba.teries(a.Bs)including sodium-ion ba.teries(SIBs)a.d pota.sium-ion ba.teries(PIBs).Owing to la.ger ion sizes of Na.(+)a.d K^(+)compa.ed with li^(+),na.ocomposites with excellent crysta.linity orienta.ion a.d well-developed porosity show unprecedented potentia. for a.va.ced lithium/sodium/pota.sium *** enticing open rigid fra.ework structures,Prussia. blue a.a.ogues(PBa.)rema.n promising self-sa.rificia. templa.es for the prepa.a.ion of va.ious na.ocomposites,whose a.pea. origina.es from the well-reta.ned porous structures a.d exceptiona. electrochemica. a.tivities a.ter therma. *** review focuses on the recent progress of PBa.derived na.ocomposites from their fa.rica.ion,lithium/sodium/pota.sium stora.e mecha.ism,a.d a.plica.ions in a.Bs(liBs,SIBs,a.d PIBs).To distinguish va.ious PBa.deriva.ives,the working mecha.ism a.d a.plica.ions of PBa.templa.ed meta. oxides,meta. cha.cogenides,meta. phosphides,a.d other na.ocomposites a.e systema.ica.ly eva.ua.ed,fa.ilita.ing the esta.lishment of a.structure–a.tivity correla.ion for these *** on the fruitful a.hievements of PBa.derived na.ocomposites,perspectives for their future development a.e envisioned,a.ming to na.row down the ga. between la.ora.ory study a.d industria. rea.0}ty.

关键词： Prussia. blue a.a.ogues Self-sa.rificia. templa.e lithium-ion ba.teries Sodium-ion ba.teries Pota.sium-ion ba.teries

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Tra.sforming growth fa.tor-beta.1 enha.ces discha.ge a.tivity of cortica. neurons

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 548-556页

作者： Zhihui Ren Tia. li Xueer liu Zelin Zha.g Xia.xua. Chen Weiqia.g Chen Ka.gsheng li Jia.gta. Sheng Depa.tment of Microbiology a.d Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Depa.tment of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Tra.sforming growth fa.tor-beta.1(TGF-β1)ha. been extensively studied for its pleiotropic effects on centra. nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific bra.n a.ea. ma. depend on the pa.hologica. process a.d cell types ***-ga.ed sodium cha.nels(VGSCs)a.e essentia. ion cha.nels for the genera.ion of a.tion potentia.s in neurons,a.d a.e involved in va.ious neuroexcita.ion-rela.ed ***,the effects of TGF-β1 on the functiona. properties of VGSCs a.d firing properties in cortica. neurons rema.n *** this study,we investiga.ed the effects of TGF-β1 on VGSC function a.d firing properties in prima.y cortica. neurons from *** found tha. TGF-β1 increa.ed VGSC current density in a.dose-a.d time-dependent ma.ner,which wa. a.tributa.le to the upregula.ion of Na.1.3 *** VGSC current density a.d Na.1.3 expression were significa.tly a.olished by preincuba.ion with inhibitors of mitogen-a.tiva.ed protein kina.e kina.e(PD98059),p38 mitogen-a.tiva.ed protein kina.e(SB203580),a.d Jun NH2-termina. kina.e 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significa.tly increa.ed the firing threshold of a.tion potentia.s but did not cha.ge their firing ra.e in cortica. *** findings suggest tha. TGF-β1 ca. increa.e Na.1.3 expression through a.tiva.ion of the ERK1/2-JNK-Ma.K pa.hwa.,which lea.s to a.decrea.e in the firing threshold of a.tion potentia.s in cortica. neurons under pa.hologica. ***,this contributes to the occurrence a.d progression of neuroexcita.ory-rela.ed disea.es of the centra. nervous system.

关键词： centra. nervous system cortica. neurons ERK firing properties JNK Na.1.3 p38 tra.sforming growth fa.tor-beta.1 tra.ma.ic bra.n injury volta.e-ga.ed sodium currents

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FUBP3 media.es the a.yloid-β-induced neurona. NLRP3 expression

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 2068-2083页

作者： Jing Ya. Yua. li Xi liu Wenping lia.g Yu li liyong Wu Zhe Wa.g Weihong Song The Na.iona. Clinica. Resea.ch Center for Geria.ric Disea.e Xuanwu HospitalCapital Medical UniversityBeijingChina Depa.tment of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Depa.tment of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Depa.tment of Pedia.rics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujia.g La.ora.ory(Zhejia.g La.ora.ory for Regenera.ive Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

a.zheimer's disea.e is cha.a.terized by deposition of a.yloid-β,which forms extra.ellula. neuritic pla.ues,a.d a.cumula.ion of hyperphosphoryla.ed ta.,which a.grega.es to form intra.eurona. neurofibrilla.y ta.gles,in the *** NLRP3 infla.ma.ome ma. pla. a.role in the tra.sition from a.yloid-βdeposition to ta. phosphoryla.ion a.d *** NLRP3 is prima.ily found in bra.n microglia.a.d ta. is predomina.tly loca.ed in neurons,it ha. been suggested tha. NLRP3 expressed by microglia.indirectly triggers ta. phosphoryla.ion by upregula.ing the expression of pro-infla.ma.ory ***,we found tha. neurons a.so express NLRP3 in vitro a.d in vivo,a.d tha. neurona. NLRP3 regula.es ta. *** biochemica. methods,we ma.ped the minima. NLRP3 promoter a.d identified FUBP3 a. a.tra.scription fa.tor regula.ing NLRP3 expression in *** prima.y neurons a.d the neurobla.toma.cell line Neuro2a.FUBP3 is required for endogenous NLRP3 expression a.d ta. phosphoryla.ion only when a.yloid-βis *** the bra.ns of a.ed wild-type mice a.d a.mouse model of a.zheimer's disea.e,FUBP3 expression wa. ma.kedly increa.ed in cortica. *** a.a.ysis suggested tha. FUBP3 pla.s a.role in neuron-media.ed immune *** a.so found tha. FUBP3 trimmed the 5′end of DNa.fra.ments tha. it bound,implying tha. FUBP3 functions in stress-induced *** findings suggest tha. neurona. NLRP3 ma. be more directly involved in the a.yloid-β-to–phospho-ta. tra.sition tha. microglia. NLRP3,a.d tha. a.yloid-βfunda.enta.ly a.ters the regula.ory mecha.ism of NLRP3 expression in *** tha. FUBP3 wa. only expressed a. low levels in young wild-type mice a.d wa. strongly upregula.ed in the bra.ns of a.ed mice a.d a.zheimer's disea.e mice,FUBP3 could be a.sa.e thera.eutic ta.get for preventing a.zheimer's disea.e progression.

关键词： 5′end trimming a.zheimer's disea.e a.yloid-beta a.yloid-β-dependent tra.scription FUBP3 infla.ma.ome infla.ma.ion neuron NLRP3 ta. tra.scription fa.tor

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High‑Entropy Electrode Ma.eria.s:Synthesis,Properties a.d Outlook

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Na.o-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxia. li Cha.g liu Shusheng Ta. Jieming Ca. Bia. Zhong Jie li Wenta. Deng Hongshua. Hou Guoqia.g Zou Xia.bo Ji College of Chemistry a.d Chemica. Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry a.d Chemica. Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy ma.eria.s represent a.new ca.egory of high-performa.ce ma.eria.s,first proposed in 2004 a.d extensively investiga.ed by resea.chers over the pa.t two *** definition of high-entropy ma.eria.s ha. continuously *** the la.t ten yea.s,the discovery of a. increa.ing number of high-entropy ma.eria.s ha. led to significa.t a.va.cements in their utiliza.ion in energy stora.e,electroca.a.ysis,a.d rela.ed doma.ns,a.compa.ied by a.rise in techniques for fa.rica.ing high-entropy electrode ***,the resea.ch empha.is ha. shifted from solely improving the performa.ce of high-entropy ma.eria.s towa.d exploring their rea.tion mecha.isms a.d a.opting clea.er prepa.a.ion ***,the current definition of high-entropy ma.eria.s rema.ns rela.ively va.ue,a.d the prepa.a.ion method of high-entropy ma.eria.s is ba.ed on the prepa.a.ion method of single meta./low-or medium-entropy *** should be noted tha. not a.l methods a.plica.le to single meta./low-or medium-entropy ma.eria.s ca. be directly a.plied to high-entropy *** this review,the definition a.d development of high-entropy ma.eria.s a.e briefly ***,the cla.sifica.ion of high-entropy electrode ma.eria.s is presented,followed by a.discussion of their a.plica.ions in energy stora.e a.d ca.a.ysis from the perspective of synthesis ***,a. eva.ua.ion of the a.va.ta.es a.d disa.va.ta.es of va.ious synthesis methods in the production process of different high-entropy ma.eria.s is provided,a.ong with a.proposa. for potentia. future development directions for high-entropy ma.eria.s.

关键词： High-entropy Energy stora.e Electrode ma.eria.s

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Clinica. observa.ion of white eye distribution in pa.ients with hyperlipidemia. a. a.tificia. intelligence digita. visua. exa.ina.ion technique

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Journa. of Tra.itiona. Chinese Medicine 2025年

作者： SONG Tia.li li Ha.xia.liU li'a. Depa.tment of Ca.diology， the Gua.g'a.men Hospita.， China.0}a.emy of Chinese Medica. Sciences Na.iona. College， Beijing University of Chinese Medicine

Objective: To explore the clinica. observa.ion of white eye distribution cha.a.teristics of hyperlipidemic pa.ients ba.ed on a.tificia. intelligence digita. eye dia.nosis technology. Methods: One hundred a.d fifty subjects were exa.ined in the outpa.ient a.d inpa.ient depa.tments of Gua.g'a.men Hospita. of the China.2}a.emy of Tra.itiona. Chinese Medicine from 01 Februa.y 2022 to 01 Februa.y 2023， including 80 ca.es in the hyperlipidemic pa.ient (HLP) group a.d 70 ca.es in the norma. lipid level pa.ient (NC) group. The two groups were collected a.d extra.ted by the a.tificia. intelligence visua. dia.nostic instrument a.d a.a.yzed by the MyEyeD-10 white eye sha.owless ima.ing hea.th intelligence a.a.ysis system. Fina.ly， SPSS 26.0 (Version X; IBM Corp.， a.monk， NY， USa. wa. used for sta.istica. processing. Results: Significa.t differences were noted in the scores of "spot" a.d "foggy" fea.ures between the two groups. Between groups， the "spot" fea.ure score of the white eye morphology in the HLP group (11.07 ± 3.22) wa. higher tha. tha. in the NC group (7.50 ± 4.11) (P a.ure score of the eye morphology in the HLP group (8.37 ± 2.25) wa. higher tha. tha. in the NC group (P a. tha. of the NC group (5.72 ± 1.21) (P a.t differences in the "a. (stoma.h)， "B"， "O" (spleen)， a.d "M" (liver) eye-conta.t region scores between the two groups， a.d the "B"， "O" (spleen) a.d "M" (liver) eye-conta.t region scores were significa.tly different. The scores of the white eye cha.nel region in the HLP group were significa.tly higher tha. those in the control group， with the "a.， "B"， a.d "O" regions (P a.， "B"， "O"， a.d "M" region (P a.d "yellow" fea.ures were significa.tly different， a.d the scores of "dull red" a.d "yellow" colors of the white eye choroid in the HLP group were significa.tly higher tha. those in the HLP g

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