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Hydrodynamic Assessment of A New Nature-Based Armour Unit on Rubble Mound Breakwater for Coastal Protection

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China Ocean Engineering 2024年第3期38卷 439-452页

作者： Ehsan safa alireza MOJTAHEDI Abdolmajid MOHAMMADIAN Mohamad ali Lotfollahi YAGHIN Department of Water Resources Engineering Faculty of Civil EngineeringUniversity of TabrizTabriz ***Iran Faculty of Civil Engineering University of OttawaOttawa K1H 8M5Canada

This research proposes a novel nature-based design of a new concrete armour unit for the cover layer of a rubblemoundbreakwater. Armour units are versatile with respect to shape, orientation, surface condition details, and ***, a detailed analysis is required to investigate the exact state of their hydraulic interactions and structuralresponses. In this regard, the performance results of several traditional armour units, including the Antifer cube,Tetrapod, X-block and natural stone, are considered for the first step of this study. Then, the related observed resultsare compared with those obtained for a newly designed (artificial coral) armour unit. The research methodology utilizesthe common wave flume test procedure. Furthermore, several verified numerical models in OpenFOAM code areused to gain the extra required data. The proposed armour is configured to provide an effective shore protection as anenvironmental-friendly coastal structure. Thus it is designed with a main trunk including deep grooves to imitate thetypical geometry of a coral type configuration, so as to attain desirable performance. The observed results and ananalytic hierarchy process (AHP) concept are used to compare the hydraulic performance of the studied traditionaland newly proposed (artificial coral) armour units. The results indicate that the artificial coral armour unit demonstratesacceptable performance. The widely used traditional armour units might be replaced by newer designs for betterwave energy dissipation, and more importantly, for fewer adverse effects on the marine environment.

关键词： rubble mound breakwater hydraulic interaction armour unit analytic hierarchy process numerical model

Advances in clinical applications of bioceramics in the new regenerative medicine era

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World Journal of Clinical Cases 2024年第11期12卷 1863-1869页

作者： Noha Elshazly Fayza Eid Nasr Ayat Hamdy safa Saied Mohamed Elshazly Tissue Engineering Laboratory Faculty of DentistryAlexandria UniversityAlexandria 21526Egypt Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandria 21526Egypt Public Dental Clinic Central Administration of DentistryMinistry of Health and PopulationAlexandria 21554Egypt Department of Surgery Faculty of Veterinary MedicineAlexandria 21526Egypt

In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and *** new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic *** these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue *** clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass *** results were promising and opened new frontiers for utilizing these materials on a larger *** same results were mentioned when using different forms and formulas of bioceramics in hard defect *** bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical *** this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

关键词： Regenerative medicine Bioceramics Chronic wounds Bone defects Clinical applications

Pyomyoma as a Complication of Uterine Artery Embolization (A Case Report)

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 29-35页

作者： Abrar Tooq Layla Rafeei Nusrat Kazi safa Hussain Mohamed al-Tabban Mariam Mahmood Salmanyia Medical Complex Manama Bahrain

Pyomoyoma is a rare complication of Uterine Artery Embolization (UAE). This case report reflects on this condition. A 45-year-old female, a known case of adenomyosis, presented with intermittent fever and foul vaginal discharge. These symptoms occurred shortly after the patient underwent UAE for menorrhagia secondary to adenomyosis. Computed tomography scan of the abdomen and pelvis aided in the diagnosis of Pyomyoma secondary to UAE. After a trial of broad spectrum antibiotics and Suction and Evacuation of the uterus had little to no help in the patient’s condition, she underwent Total Abdominal Hysterectomy in which a big, organized pus collection was removed from the uterus. Conclusion: Pyomyoma should be considered in the differentials for patients presenting with fever and vaginal discharge post UAE.

关键词： Pyomyoma Uterine Artery Embolization Adenomyosis

Etiology of Pancytopenia in Tabriz Shahid Ghazi Hospital:A Cross-sectional Study in Iran

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Proceedings of Anticancer Research 2024年第4期8卷 104-115页

作者： Hossein Azari Bostanabad safa Mousavi Mohammad Hossein Hosseini Sadra Sarandili ali Esfahani Babak Nejati Department of Hematology and Oncology Faculty of MedicineTabriz University of Medical SciencesTabrizIran Liqvan Health Center Tabriz University of Medical SciencesTabrizIran Hematology and Oncology Research Center Tabriz University of Medical SciencesTabrizIran Department of Health Sciences Curtin Medical SchoolCurtin UniversityPerthWAAustralia

Objective:Pancytopenia is characterized by a reduction in all three types of blood cells:erythrocytes,leukocytes,and *** is caused by a wide range of diseases,leading to diagnostic *** causes can range from drug reactions to life-threatening diseases such as aplastic anemia and *** study aims to investigate the causes of pancytopenia,specifically focusing on age and gender differences among ***:This cross-sectional study includes patients of all ages diagnosed with pancytopenia,as indicated by a CBC/H1 showing a WBC count less than 4,000/μL,platelet count less than 150,000/μL,and hemoglobin levels below 12 g/dL in women and less than 13 g/dL in *** study only included patients with pancytopenia who underwent bone marrow examination and were not subjected to chemotherapy or radiation ***:A total of 133 patients with pancytopenia were included in the *** average age was 47.35±17.62 years old,with 66%of the participants being male and 34%being *** leukemia,specifically acute myeloid leukemia(AML)and acute lymphoid leukemia(alL),was identified as the primary cause of pancytopenia,accounting for 31.5%of *** anemia was the second most common cause,accounting for 30%of cases,followed by aplastic anemia at 7.5%.Conclusion:Pancytopenia,a condition marked by the decrease in both erythrocytes and leukocytes as well as thrombocytes,can arise from a myriad of *** main findings of this study revealed that megaloblastic anemia,acute myeloid leukemia(AML),and acute lymphoid leukemia(alL)were the most common ***,a considerable proportion of cases of pancytopenia can be attributed to acute ***,expeditious and accurate diagnosis is imperative and has the potential to save lives in such cases.

关键词： Pancytopenia Leukemia Anemia Bone marrow Blood cells

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

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Animal Models and Experimental Medicine 2024年第5期 591-605页

作者： Mohammad Yasin Zamanian Niloofar Taheri Montather F.Ramadan Yasser Fakri Mustafa safa alkhayyat Klunko Nataliya Sergeevna Hashem O.alsaab Ahmed Hjazi Farnoosh Molavi Vasei Siamak Daneshvar Department of Physiology School of Medicine Hamadan University of Medical Sciences Department of Pharmacology and Toxicology School of Pharmacy Hamadan University of Medical Sciences School of Medicine Shahroud University of Medical Sciences College of Dentistry Al-Ayen University Department of Pharmaceutical Chemistry College of Pharmacy University of Mosul College of Pharmacy The Islamic University Department of Training of Scientific and Scientific-Pedagogical Personnel Russian New University Department of Pharmaceutics and Pharmaceutical Technology Taif University Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Department of Clinical Biochemistry School of Medicine Rafsanjan University of Medical Sciences Department of Surgery School of Medicine Hamadan University of Medical Sciences

Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription *** results of this study demonstrate that fisetin induces colon cancer cell apoptosis through multiple mechanisms. It impacts the p53 pathway, leading to increased levels of p53 and decreased levels of murine double minute 2, contributing to apoptosis induction. Fisetin also triggers the release of important components in the apoptotic process, such as second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI and cytochrome c. Furthermore, fisetin inhibits the cyclooxygenase-2 and wingless-related integration site(Wnt)/epidermal growth factor receptor/nuclear factor kappa B signaling pathways, reducing Wnt target gene expression and hindering colony formation. It achieves this by regulating the activities of cyclin-dependent kinase 2 and cyclin-dependent kinase 4, reducing retinoblastoma protein phosphorylation, decreasing cyclin E levels, and increasing p21 levels, ultimately influencing E2 promoter binding factor 1 and cell division cycle 2(CDC2) protein levels. Additionally, fisetin exhibits various effects on CRC cells, including inhibiting the phosphorylation of Y-box binding protein 1 and ribosomal S6 kinase, promoting the phosphorylation of extracellular signal-regulated kinase 1/2, and disrupting the repair process of DNA double-strand breaks. Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α(PIK3CA)-mutant CRC, resulting in a reduction in phosphatidylinositol-3 kinase(PI3K) expressio

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Thermoluminescent response of gamma irradiated Na^(+)–Cu^(+) ionexchanged silicate glass in large dose range

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Nuclear Science and Techniques 2023年第5期34卷 22-32页

作者： safa Toumi Khaled Farah Laboratoire de Physico‑Chimie des Matériaux Département de PhysiqueFacultédes Sciences de MonastirUniversitéde MonastirMonastirTunisia Institut Supérieur du Transport et de la Logistique de Sousse Universitéde Sousse4023 SousseTunisia Laboratoire de Recherche en Energie et Matière Développement des Sciences Nucléaires(LR16CNSTN02)Centre National des Sciences et Technologies Nucléaires2020 Sidi‑ThabetTunisia

The introduction of metals into vitreous matrices is the origin of various interesting phenomena;in particular,the presence of copper ions in glass has been the subject of considerable research because of its numerous *** ion-exchange process is primarily used to introduce copper ions into glass *** thermoluminescence(TL)of silicate glass was studied to evaluate its potential as gamma-sensitive material for dosimetric applications;the effect of copper doping on the thermoluminescent sensitivity was investigated using the Cu-Na ion-exchange technique for different concentrations and doping conditions,over a wide dose range of 10 mGy to 100 *** results showed that Cu doping significantly improved the sensitivity of the glasses to gamma *** the ion-exchange,two peaks appeared in the glow curves at approximately 175 and 230°C,respectively,which possibly originated from the Cu^(+) centers,along with a weak TL peak at around 320℃.We also attempted to explain the origin of the observed thermoluminescence by exploiting the Electron paramagnetic resonance(EPR)*** results clearly show quenching of the TL emission with increasing copper *** present work indicates that the thermoluminescence response of these glasses to gamma rays can be reasonably measured in the range of 0.001-100 *** study also facilitates the understanding of the basic TL mechanism in this glass system.

关键词： Cu-Na ion-exchange Silicate glass Thermoluminescence Gamma irradiation Electron paramagnetic resonance

Controlling chaos based on a novel intelligent integral terminal sliding mode control in a rod-type plasma torch

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Chinese Physics B 2016年第5期25卷 11-22页

作者： safa Khari Zahra Rahmani Behrooz Rezaie Intelligent Systems Research Group Faculty of Electrical and Computer EngineeringBabol Noshrivani University of Technology

An integral terminal sliding mode controller is proposed in order to control chaos in a rod-type plasma torch *** this method, a new sliding surface is defined based on a combination of the conventional sliding surface in terminal sliding mode control and a nonlinear function of the integral of the system states. It is assumed that the dynamics of a chaotic system are unknown and also the system is exposed to disturbance and unstructured uncertainty. To achieve a chattering-free and high-speed response for such an unknown system, an adaptive neuro-fuzzy inference system is utilized in the next step to approximate the unknown part of the nonlinear dynamics. Then, the proposed integral terminal sliding mode controller stabilizes the approximated system based on Lyapunov＇s stability theory. In addition, a Bee algorithm is used to select the coefficients of integral terminal sliding mode controller to improve the performance of the proposed method. Simulation results demonstrate the improvement in the response speed, chattering rejection, transient response,and robustness against uncertainties.

关键词： chaos rod-type plasma torch intelligent integral terminal sliding mode control Bee algorithm

Extraterrestrial Life in the Thermosphere: Plasmas, UAP, Pre-Life, Fourth State of Matter

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Journal of Modern Physics 2024年第3期15卷 322-376页

作者： R. Joseph C. Impey O. Planchon R. del Gaudio M. Abu safa A. R. Sumanarathna E. Ansbro D. Duvall G. Bianciardi C. H. Gibson R. Schild Astrobiology Research Center California USA Department of Astronomy University of Arizona Tucson USA Biogéosciences Laboratory University of Burgundy Dijon France Department of Biology University of Naples Federico II Naples Italy Department of Applied Physics Palestine Polytechnic University Hebron Palestine Department of Research and Innovation Eco Astronomy International Research Center Tetouan Morocco Space Exploration Ltd. Boyle County Roscommon Ireland Department of Zoology Oklahoma State University (Emeritus) Stillwater USA Department of Science and Medicine Università Degli Studi di Siena Tuscany Italy Center for Astrophysics and Space Sciences University of California (Emeritus) San Diego USA Center for Astrophysics Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer in size and behaving similarly to multicellular organisms have been filmed on 10 separate NASA space shuttle missions, over 200 miles above Earth within the thermosphere. These self-illuminated “plasmas” are attracted to and may “feed on” electromagnetic radiation. They have different morphologies: 1) cone, 2) cloud, 3) donut, 4) spherical-cylindrical;and have been filmed flying towards and descending from the thermosphere into thunderstorms;congregating by the hundreds and interacting with satellites generating electromagnetic activity;approaching the Space Shuttles. Computerized analysis of flight path trajectories documents these plasmas travel at different velocities from different directions and change their angle of trajectory making 45°, 90°, and 180° shifts and follow each other. They’ve been filmed accelerating, slowing down, stopping, congregating, engaging in “hunter-predatory” behavior and intersecting plasmas leaving a plasma dust trail in their wake. Similar life-like behaviors have been demonstrated by plasmas created experimentally. “Plasmas” may have been photographed in the 1940s by WWII pilots (identified as “Foo fighters”);repeatedly observed and filmed by astronauts and military pilots and classified as Unidentified Aerial—Anomalous Phenomenon. Plasmas are not biological but may represent a form of pre-life that via the incorporation of elements common in space, could result in the synthesis of RNA. Plasmas constitute a fourth state of matter, are attracted to electromagnetic activity, and when observed in the lower atmosphere likely account for many of the UFO-UAP sightings over the centuries.

关键词： Extraterrestrials Plasmas Dusty Plasmas Extremophiles Life in Space Abiogenesis Origins of Life RNA World

CFD simulation of an industrial hydrocyclone with Eulerian-Eulerian approach: A case study

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International Journal of Mining Science and Technology 2014年第5期24卷 643-648页

作者： safa Raziyeh Soltani Goharrizi Ataallah Department of Chemical Engineering College of Engineering Shahid Bahonar University of Kerman

In the present study, a three-dimensional computational fluid dynamics simulation together with experimental field measurements was applied to optimize the performance of an industrial hydrocyclone at Sarcheshmeh copper complex. In the simulation, the Eulerian–Eulerian approach was used for solid and liquid phases, the latter being water. In this approach, nine continuous phases were considered for the solid particles with different sizes and one continuous phase for water. The continuity and momentum equations with inclusion of buoyancy and drag forces were solved by the finite volume method. The k–e RNG turbulence model was used for modeling of turbulency. There was a good agreement between the simulation results and the experimental data. After validation of the model accuracy, the effect of inlet solid percentage, pulp inlet velocity, rod inserting in the middle of the hydrocyclone and apex diameter on hydrocyclone performance was investigated. The results showed that by decreasing the inlet solid percentage and increasing the pulp inlet velocity, the efficiency of hydrocyclone increased. Decreasing the apex diameter caused an increase in the hydrocyclone efficiency.

关键词： Hydrocyclone Finite volume method Computational fluid dynamics κ-ε RNC Sarcheshmeh copper complex